Yu Ping WangSummaryAffiliation: Food and Drug Administration Country: USA Publications
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Metabolic activation of the tumorigenic pyrrolizidine alkaloid, retrorsine, leading to DNA adduct formation in vivoYu Ping Wang
National Center for Toxicological Research, Jefferson, AR 72079, USA
Int J Environ Res Public Health 2:74-9. 2005....- Riddelliine N-oxide is a phytochemical and mammalian metabolite with genotoxic activity that is comparable to the parent pyrrolizidine alkaloid riddelliineMing W Chou
Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
Toxicol Lett 145:239-47. 2003..Results presented in this paper indicate that riddelliine N-oxide, through its conversion to riddelliine, is also a potential genotoxic hepatocarcinogen... - Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloidYu-ping Wang
Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
Toxicol Lett 155:411-20. 2005.... - Metabolic activation of the tumorigenic pyrrolizidine alkaloid, monocrotaline, leading to DNA adduct formation in vivoYu-ping Wang
Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
Cancer Lett 226:27-35. 2005.... - Effect of N,N-didesmethyltamoxifen upon DNA adduct formation by tamoxifen and alpha-hydroxytamoxifenGonçalo Gamboa da Costa
Centro de Quimica Estrutural, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Av Rovisco Pais, 1049 001 Lisboa, Portugal
Cancer Lett 257:191-8. 2007..These results indicate that, with this experimental model, N,N-didesmethyltamoxifen does not impair the metabolism of tamoxifen to a reactive electrophile...