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Sue Jane Wang
Affiliation: Food and Drug Administration
Wang S, Peng H, Hung H. Evaluation of the extent of adaptation to sample size in clinical trials for cardiovascular and CNS diseases. Contemp Clin Trials. 2018;67:31-36 pubmed publisher
..Additionally, as a result of sample size increase, precision in treatment effect estimation was often improved for the primary endpoint and the key secondary endpoints. ..
Shi L, Jones W, Jensen R, Harris S, Perkins R, Goodsaid F, et al. The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies. BMC Bioinformatics. 2008;9 Suppl 9:S10 pubmed publisher
..Our results provide practical guidance to choose the appropriate FC and P-value cutoffs when selecting a given number of DEGs. The FC criterion enhances reproducibility, whereas the P criterion balances sensitivity and specificity. ..