Jinhai Wang

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Human Notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain
    J Wang
    Laboratory of Gene Regulation, Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Immunol 167:289-95. 2001
  2. ncbi request reprint Synergistic induction of apoptosis in primary CD4(+) T cells by macrophage-tropic HIV-1 and TGF-beta1
    J Wang
    Laboratory of Gene Regulation, Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 167:3360-6. 2001
  3. ncbi request reprint Inhibition of CCR5 expression by IL-12 through induction of beta-chemokines in human T lymphocytes
    J Wang
    Laboratory of Cell and Viral Regulation, Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 163:5763-9. 1999
  4. ncbi request reprint Role of tyrosine phosphorylation in ligand-independent sequestration of CXCR4 in human primary monocytes-macrophages
    J Wang
    Laboratory of Gene Regulation, Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Biol Chem 276:49236-43. 2001
  5. ncbi request reprint Constitutive association of cell surface CCR5 and CXCR4 in the presence of CD4
    Jinhai Wang
    Division of Therapeutic Proteins, Center for Drug Evaluation and Research, FDA, NIH Building 29B, Room 4E12, HFM 541, 8800 Rockville Pike, Bethesda, MD 20892, USA
    J Cell Biochem 93:753-60. 2004
  6. ncbi request reprint CpG-independent synergistic induction of beta-chemokines and a dendritic cell phenotype by orthophosphorothioate oligodeoxynucleotides and granulocyte-macrophage colony-stimulating factor in elutriated human primary monocytes
    Jinhai Wang
    Laboratory of Immunology, Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Immunol 174:6113-21. 2005
  7. ncbi request reprint Dimerization of CXCR4 in living malignant cells: control of cell migration by a synthetic peptide that reduces homologous CXCR4 interactions
    Jinhai Wang
    Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Mol Cancer Ther 5:2474-83. 2006
  8. ncbi request reprint Control of in vitro immune responses by regulatory oligodeoxynucleotides through inhibition of pIII promoter directed expression of MHC class II transactivator in human primary monocytes
    Jinhai Wang
    Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA
    J Immunol 179:45-52. 2007
  9. ncbi request reprint Amino-terminal processing of MIP-1beta/CCL4 by CD26/dipeptidyl-peptidase IV
    Ennan Guan
    Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Cell Biochem 92:53-64. 2004
  10. pmc T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells
    E Guan
    Laboratory of Cell Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Exp Med 183:2025-32. 1996

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Human Notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain
    J Wang
    Laboratory of Gene Regulation, Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Immunol 167:289-95. 2001
    ....
  2. ncbi request reprint Synergistic induction of apoptosis in primary CD4(+) T cells by macrophage-tropic HIV-1 and TGF-beta1
    J Wang
    Laboratory of Gene Regulation, Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 167:3360-6. 2001
    ..These results show that TGF-beta1 promotes depletion of CD4(+) T cells after R5 HIV-1 infection by inducing apoptosis and suggest that TGF-beta1 might contribute to the pathogenesis of HIV-1 infection in vivo...
  3. ncbi request reprint Inhibition of CCR5 expression by IL-12 through induction of beta-chemokines in human T lymphocytes
    J Wang
    Laboratory of Cell and Viral Regulation, Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 163:5763-9. 1999
    ....
  4. ncbi request reprint Role of tyrosine phosphorylation in ligand-independent sequestration of CXCR4 in human primary monocytes-macrophages
    J Wang
    Laboratory of Gene Regulation, Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Biol Chem 276:49236-43. 2001
    ..Cytokine-induced endocytosis of chemokine receptors may be of therapeutic value in HIV-1 infection, inflammation, tumor metastasis, and defective hematopoiesis...
  5. ncbi request reprint Constitutive association of cell surface CCR5 and CXCR4 in the presence of CD4
    Jinhai Wang
    Division of Therapeutic Proteins, Center for Drug Evaluation and Research, FDA, NIH Building 29B, Room 4E12, HFM 541, 8800 Rockville Pike, Bethesda, MD 20892, USA
    J Cell Biochem 93:753-60. 2004
    ..Our data indicate that chemokine receptors interact with each other, which may modulate chemokine-chemokine receptor interactions and HIV-1 coreceptor functions...
  6. ncbi request reprint CpG-independent synergistic induction of beta-chemokines and a dendritic cell phenotype by orthophosphorothioate oligodeoxynucleotides and granulocyte-macrophage colony-stimulating factor in elutriated human primary monocytes
    Jinhai Wang
    Laboratory of Immunology, Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Immunol 174:6113-21. 2005
    ....
  7. ncbi request reprint Dimerization of CXCR4 in living malignant cells: control of cell migration by a synthetic peptide that reduces homologous CXCR4 interactions
    Jinhai Wang
    Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Mol Cancer Ther 5:2474-83. 2006
    ..Targeting chemokine receptor oligomerization and signal transduction for the treatment of cancer, HIV-1 infections, and other CXCR4 mediated inflammatory conditions warrants further investigation...
  8. ncbi request reprint Control of in vitro immune responses by regulatory oligodeoxynucleotides through inhibition of pIII promoter directed expression of MHC class II transactivator in human primary monocytes
    Jinhai Wang
    Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA
    J Immunol 179:45-52. 2007
    ..The inhibition of immune responses by regulatory oligodeoxynucleotides may be useful for the treatment of immune-mediated disorders including autoimmune diseases and graft rejection...
  9. ncbi request reprint Amino-terminal processing of MIP-1beta/CCL4 by CD26/dipeptidyl-peptidase IV
    Ennan Guan
    Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Cell Biochem 92:53-64. 2004
    ..Our results suggest that NH2-terminal processing of MIP-1beta and possibly other chemokines may depend on the balance between CD26/DPPIV enzymatic activity and cellular and viral proteins that modulate enzyme function...
  10. pmc T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells
    E Guan
    Laboratory of Cell Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Exp Med 183:2025-32. 1996
    ..These observations indicate that TAN-1C may directly engage NF-kappa B transcription factors and modulate nuclear gene expression...
  11. pmc Control of adaptive immune responses by Staphylococcus aureus through IL-10, PD-L1, and TLR2
    Jinhai Wang
    Laboratory of Immunology, Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Sci Rep 2:606. 2012
    ..IL-10 and PD-L1 antagonists may boost immunity to vaccines for S. aureus and other microbes...
  12. ncbi request reprint CD26 expression correlates with entry, replication and cytopathicity of monocytotropic HIV-1 strains in a T-cell line
    T Oravecz
    Division of Hematologic Products, Food and Drug Administration, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 1:919-26. 1995
    ..This study identifies CD26 as a key marker for M-tropic human immunodeficiency virus type 1 (HIV-1) infection and suggests a mechanism for the early loss of CD26-expressing cells in HIV-1-infected individuals...
  13. ncbi request reprint Natural truncation of the chemokine MIP-1 beta /CCL4 affects receptor specificity but not anti-HIV-1 activity
    Ennan Guan
    Division of Therapeutic Proteins, CBER, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Biol Chem 277:32348-52. 2002
    ....
  14. ncbi request reprint Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes
    M P Hayes
    Division of Cytokine Biology, Food and Drug Administration, Bethesda, MD 20892, USA
    Blood 86:646-50. 1995
    ..The selectivity of priming by IFN-gamma is in accord with a putative role for IL-12 in the initiation and amplification of TH1-type responses...
  15. ncbi request reprint Mechanisms of MLL gene rearrangement: site-specific DNA cleavage within the breakpoint cluster region is independent of chromosomal context
    M Stanulla
    Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Gaithersburg, MD 20877, USA
    Hum Mol Genet 10:2481-91. 2001
    ..We conclude that both nuclear DNA scaffold attachment as well as site-specific DNA cleavage can be directed by sequences contained within the MLL bcr, and that it is feasible to study these events using episomal shuttle vectors...
  16. pmc Caspase-10 is an initiator caspase in death receptor signaling
    J Wang
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N311, 10 Center Drive, MSC 1892, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:13884-8. 2001
    ..Nonetheless, we find that caspase-8 and -10 may have different apoptosis substrates and therefore potentially distinct roles in death receptor signaling or other cellular processes...
  17. doi request reprint Dimerization of chemokine receptors in living cells: key to receptor function and novel targets for therapy
    Jinhai Wang
    Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Drug Discov Today 13:625-32. 2008
    ..Therefore, TM peptides and possibly compounds that target dimers and/or signaling of chemokine receptors may have therapeutic applications...
  18. ncbi request reprint Estradiol alters transcription factor gene expression in primate prefrontal cortex
    J Wang
    Developmental Endocrinology Branch, National Institute of Child Health, Bethesda, Maryland, USA
    J Neurosci Res 76:306-14. 2004
    ..These data indicate that estrogen may have direct as well as indirect effects on neuronal gene expression in the primate prefrontal cortex...
  19. ncbi request reprint Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II
    J Wang
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 98:47-58. 1999
    ..These results provide evidence that inherited nonlethal caspase abnormalities cause pleiotropic apoptosis defects underlying autoimmunity in ALPS type II...
  20. ncbi request reprint Tumor necrosis factor-alpha and CD95 ligation suppress erythropoiesis in Fanconi anemia C gene knockout mice
    T Otsuki
    Hematology Branch, NHLBI, NIH, Bethesda, Maryland 20892, USA
    J Cell Physiol 179:79-86. 1999
    ..We conclude that mutation in the Fac protein induces heightened sensitivity to TNF-alpha and Fas receptor ligation, results that may explain the mechanism of anemia in FA-C patients...
  21. pmc Neutralizing antibodies to therapeutic enzymes: considerations for testing, prevention and treatment
    Jinhai Wang
    Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, NIH Building 29B, 8800 Rockville Pike, Bethesda, Maryland 20892, USA
    Nat Biotechnol 26:901-8. 2008
    ..For patients in whom neutralizing antibodies may cause severe adverse clinical outcomes, it is paramount to develop tolerance inducing protocols to preclude, where predictable, or treat such life-threatening responses...
  22. ncbi request reprint HIV Tat represses transcription of the beta 2-microglobulin promoter
    I R Carroll
    Molecular Regulation Section, Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Mol Immunol 35:1171-8. 1998
    ....
  23. ncbi request reprint Inhibition of Fas-mediated apoptosis by the B cell antigen receptor through c-FLIP
    J Wang
    Laboratory of Immunology National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA
    Eur J Immunol 30:155-63. 2000
    ..Thus, BCR signaling up-regulates c-FLIP(L) and suppresses the Fas- and TRAIL-receptor apoptosis pathways which could be important for tolerance and selection of antigen-specific B cells...
  24. ncbi request reprint Rapamycin control of transgene expression from a single AAV vector in mouse salivary glands
    J Wang
    Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, MD 20892, USA
    Gene Ther 13:187-90. 2006
    ..Our results suggest that the rapamycin transcriptional regulation system delivered in a single AAV2 vector to SGs may be valuable for systemic protein replacement applications...
  25. ncbi request reprint Primary culture of polarized human salivary epithelial cells for use in developing an artificial salivary gland
    S D Tran
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Tissue Eng 11:172-81. 2005
    ..We conclude that this culture method for obtaining autologous human salivary cells should be useful in developing an artificial salivary gland...
  26. ncbi request reprint Interleukin-2 and interleukin-7 augment the cytolytic activity and expand the antitumor killing spectrum of alpha CD3-induced activated killer cells: potential use in the immunotherapy of non-immunogenic tumors
    C C Ting
    Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Immunol Immunother 43:283-92. 1996
    ..Thus, these long-term-cultured CD3-AK cells may have the potential to be used for immunotherapy of a variety of tumors whatever their immunogenicity...
  27. pmc Effect of human vasoactive intestinal peptide gene transfer in a murine model of Sjogren's syndrome
    B M Lodde
    GTTB NIDCR, National Institutes of Health, 10 Center Drive, Room 1N114, MSC 1190, Bethesda, MD 20892 1190, USA
    Ann Rheum Dis 65:195-200. 2006
    ..The aetiology and pathogenesis are largely unknown; currently, only palliative treatment is available...
  28. pmc Essential lymphocyte function associated 1 (LFA-1): intercellular adhesion molecule interactions for T cell-mediated B cell apoptosis by Fas/APO-1/CD95
    J Wang
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1892, USA
    J Exp Med 186:1171-6. 1997
    ..Our results suggest that LFA-1/ICAM interactions are crucial for Th1 cell-mediated B cell apoptosis and may contribute to the maintenance of B cell homeostasis in vivo...
  29. ncbi request reprint Cellular patterns of insulin-like growth factor system gene expression in murine chondrogenesis and osteogenesis
    E Wang
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 136:2741-51. 1995
    ....
  30. ncbi request reprint Gender differences in serotype 2 adeno-associated virus biodistribution after administration to rodent salivary glands
    A Voutetakis
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Gene Ther 18:1109-18. 2007
    ..Sexual dimorphism is a factor of major significance that could potentially affect gene therapy clinical applications in SGs...
  31. pmc Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses
    G H Wang
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Virol 71:8928-32. 1997
    ..Furthermore, we show that BHV4 BORFE2 is a member of a family of DED-containing proteins that includes other gamma-2 herpesviruses, such as Kaposi's sarcoma-associated herpesvirus and herpesvirus saimiri...
  32. ncbi request reprint Molecules involved in cell death and peripheral tolerance
    J Wang
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Curr Opin Immunol 9:818-25. 1997
    ..These proteases appear to be the primary effector molecules responsible for carrying out lymphocyte apoptosis and may be critical for peripheral immunological tolerance...
  33. ncbi request reprint Competitive inhibition in vivo and skewing of the T cell repertoire of antigen-specific CTL priming by an anti-peptide-MHC monoclonal antibody
    D H Chung
    Laboratory of Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Immunol 167:699-707. 2001
    ..The ability of a specific MHC/peptide mAb to inhibit and divert the CD8(+) T cell response holds implications for vaccine design and approaches to modulate the immune response in autoimmunity...
  34. ncbi request reprint Reversible glutathionylation regulates actin polymerization in A431 cells
    J Wang
    Laboratory of Biochemistry, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-8012, USA
    J Biol Chem 276:47763-6. 2001
    ..Overall, this study revealed a novel physiological relevance of actin polymerization regulated by reversible glutathionylation of the penultimate cysteine mediated by growth factor stimulation...
  35. pmc Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia
    D A Martin
    Laboratory of Immunology, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:4552-7. 1999
    ..These data suggest that intracytoplasmic CD95 mutations in ALPS impair apoptosis chiefly by disrupting death-domain interactions with the signaling protein FADD/MORT1...
  36. ncbi request reprint Two intermediate-avidity cytotoxic T lymphocyte clones with a disparity between functional avidity and MHC tetramer staining
    M A Derby
    Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Int Immunol 13:817-24. 2001
    ....
  37. ncbi request reprint Activating CTL precursors to reveal CTL function without skewing the repertoire by in vitro expansion
    I M Belyakov
    Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1578, USA
    Eur J Immunol 31:3557-66. 2001
    ....
  38. ncbi request reprint Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer
    E Guan
    Laboratory of Gene Regulation, Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:12404-9. 2001
    ..Formation of heterodimers of MIP-1alpha/beta may have an impact on intracellular signaling events that contribute to CCR5 and possibly to other chemokine receptor functions...
  39. ncbi request reprint Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment
    M Lenardo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 17:221-53. 1999
    ..Immunological, cellular, and molecular evidence indicates that throughout the life of a T cell, apoptosis may be evoked in excessive, harmful, or useless clonotypes to preserve a healthy and balanced immune system...
  40. ncbi request reprint Rapamycin control of exocrine protein levels in saliva after adenoviral vector-mediated gene transfer
    J Wang
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD 20892 1190, USA
    Gene Ther 11:729-33. 2004
    ....
  41. ncbi request reprint Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies
    J Wang
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N311, MSC 1892, Bethesda, MD 20892 18892, USA
    J Cell Sci 113:753-7. 2000
    ..These studies suggest that caspases function in cell signaling events including apoptosis, cell growth and differentiation...
  42. ncbi request reprint High-level expression of Dok-1 in neurons of the primate prefrontal cortex and hippocampus
    A Smith
    Developmental Endocrinology Branch, National Institute of Child Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci Res 75:218-24. 2004
    ..These expression patterns are very similar to those of the IGF-1 receptor and suggest that Dok-1 could be among the downstream targets of IGF signaling in areas of the primate brain involved in learning and memory...