Cheng Wang

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint L-carnitine protects neurons from 1-methyl-4-phenylpyridinium-induced neuronal apoptosis in rat forebrain culture
    C Wang
    Division of Neurotoxicology, HFT 132, National Center for Toxicological Research U S Food and Drug Administration, Jefferson, AR 72079, USA
    Neuroscience 144:46-55. 2007
  2. pmc Advanced pre-clinical research approaches and models to studying pediatric anesthetic neurotoxicity
    Cheng Wang
    Division of Neurotoxicology, National Center for Toxicological Research, United States Food and Drug Administration Jefferson, AR, USA
    Front Neurol 3:142. 2012
  3. doi request reprint Utilization of neural stem cell-derived models to study anesthesia-related toxicity and preventative approaches
    Cheng Wang
    Division of Neurotoxicology, National Center for Toxicological Research NCTR FDA, Jefferson, AR, USA
    Mol Neurobiol 48:302-7. 2013
  4. doi request reprint Preclinical assessment of ketamine
    Cheng Wang
    Division of Neurotoxicology, National Center for Toxicological Research NCTR FDA, Jefferson, AR 72079 9501, USA
    CNS Neurosci Ther 19:448-53. 2013
  5. ncbi request reprint Blockade of N-methyl-D-aspartate receptors by ketamine produces loss of postnatal day 3 monkey frontal cortical neurons in culture
    Cheng Wang
    Division of Neurotoxicology, National Center for Toxicological Research Food and Drug Administration, Jefferson, Arkansas 72079 0502, USA
    Toxicol Sci 91:192-201. 2006
  6. doi request reprint Strategies and experimental models for evaluating anesthetics: effects on the developing nervous system
    Cheng Wang
    Division of Neurotoxicology, National Center for Toxicological Research F3900 NCTR Road, Jefferson, AR 72079 9502, USA
    Anesth Analg 106:1643-58. 2008
  7. doi request reprint Protective effects of 7-nitroindazole on ketamine-induced neurotoxicity in rat forebrain culture
    Cheng Wang
    Division of Neurotoxicology, National Center for Toxicological Research US Food and Drug Administration, HFT 132 Jefferson, AR, USA
    Neurotoxicology 29:613-20. 2008
  8. doi request reprint Anesthetic-induced oxidative stress and potential protection
    Cheng Wang
    National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR, USA
    ScientificWorldJournal 10:1473-82. 2010
  9. doi request reprint Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain
    Xiaoju Zou
    Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    Int J Dev Neurosci 27:727-31. 2009
  10. ncbi request reprint Ketamine-induced neuronal cell death in the perinatal rhesus monkey
    William Slikker
    Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079 0502, USA
    Toxicol Sci 98:145-58. 2007

Collaborators

Detail Information

Publications46

  1. ncbi request reprint L-carnitine protects neurons from 1-methyl-4-phenylpyridinium-induced neuronal apoptosis in rat forebrain culture
    C Wang
    Division of Neurotoxicology, HFT 132, National Center for Toxicological Research U S Food and Drug Administration, Jefferson, AR 72079, USA
    Neuroscience 144:46-55. 2007
    ..L-carnitine blocked these effects of MPP+ suggesting its potential therapeutic utility in degenerative disorders such as Parkinson's disease, Alzheimer's disease, ornithine transcarbamylase deficiency and other mitochondrial diseases...
  2. pmc Advanced pre-clinical research approaches and models to studying pediatric anesthetic neurotoxicity
    Cheng Wang
    Division of Neurotoxicology, National Center for Toxicological Research, United States Food and Drug Administration Jefferson, AR, USA
    Front Neurol 3:142. 2012
    ....
  3. doi request reprint Utilization of neural stem cell-derived models to study anesthesia-related toxicity and preventative approaches
    Cheng Wang
    Division of Neurotoxicology, National Center for Toxicological Research NCTR FDA, Jefferson, AR, USA
    Mol Neurobiol 48:302-7. 2013
    ....
  4. doi request reprint Preclinical assessment of ketamine
    Cheng Wang
    Division of Neurotoxicology, National Center for Toxicological Research NCTR FDA, Jefferson, AR 72079 9501, USA
    CNS Neurosci Ther 19:448-53. 2013
    ....
  5. ncbi request reprint Blockade of N-methyl-D-aspartate receptors by ketamine produces loss of postnatal day 3 monkey frontal cortical neurons in culture
    Cheng Wang
    Division of Neurotoxicology, National Center for Toxicological Research Food and Drug Administration, Jefferson, Arkansas 72079 0502, USA
    Toxicol Sci 91:192-201. 2006
    ..Ketamine-induced effects were blocked by NR1 antisenses and SN-50. These data suggest that NR1 antisenses and SN-50 offer neuroprotection from the enhanced degeneration induced by ketamine in vitro...
  6. doi request reprint Strategies and experimental models for evaluating anesthetics: effects on the developing nervous system
    Cheng Wang
    Division of Neurotoxicology, National Center for Toxicological Research F3900 NCTR Road, Jefferson, AR 72079 9502, USA
    Anesth Analg 106:1643-58. 2008
    ..Our focus on ketamine should not be construed as implying that the risk of neurodegeneration with ketamine is greater, or less, than with other anesthetics. We are simply describing the effects where we have the most preclinical data...
  7. doi request reprint Protective effects of 7-nitroindazole on ketamine-induced neurotoxicity in rat forebrain culture
    Cheng Wang
    Division of Neurotoxicology, National Center for Toxicological Research US Food and Drug Administration, HFT 132 Jefferson, AR, USA
    Neurotoxicology 29:613-20. 2008
    ..These data indicate a role for nitric oxide in the enhanced degeneration induced by ketamine in vitro and also suggest that blocking neuronal nitric oxide synthase (nNOS) may help reduce the risk of ketamine in pediatrics...
  8. doi request reprint Anesthetic-induced oxidative stress and potential protection
    Cheng Wang
    National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR, USA
    ScientificWorldJournal 10:1473-82. 2010
    ..However, more evidence is necessary to in order verify the role of the NMDA receptor subunit NR1 and ROS in anesthetic-induced neurodegeneration...
  9. doi request reprint Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain
    Xiaoju Zou
    Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    Int J Dev Neurosci 27:727-31. 2009
    ..However, anesthetic durations of 9h or greater are associated with significant brain cell death in the frontal cortex. Thus, the threshold duration below which no neurotoxicity would be expected is somewhere between 3 and 9h...
  10. ncbi request reprint Ketamine-induced neuronal cell death in the perinatal rhesus monkey
    William Slikker
    Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079 0502, USA
    Toxicol Sci 98:145-58. 2007
    ..However, a shorter duration of ketamine anesthesia (3 h) did not result in neuronal cell death in the 5-day-old monkey...
  11. pmc Potential neurotoxicity of ketamine in the developing rat brain
    Xiaoju Zou
    Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Toxicol Sci 108:149-58. 2009
    ..Ketamine-induced cell death appears to be apoptotic in nature and closely associated with enhanced NMDA receptor subunit mRNA expression...
  12. pmc Ketamine-induced neuronal damage and altered N-methyl-D-aspartate receptor function in rat primary forebrain culture
    Fang Liu
    Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079 0502, USA
    Toxicol Sci 131:548-57. 2013
    ..L-Carnitine appears to be a promising agent in preventing or reversing ketamine's toxic effects on neurons at an early developmental stage...
  13. doi request reprint Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey
    Xiaoju Zou
    Division of Neurotoxicology, National Center for Toxicological Research U S Food and Drug Administration, Jefferson, AR 72079, USA
    Neurotoxicol Teratol 33:592-7. 2011
    ..These data suggest that prolonged exposure to inhaled anesthetics (a combination of N(2)O and ISO) in the developing rhesus monkey results in neuronal damage, and that the cell death observed is apoptotic and necrotic in nature...
  14. doi request reprint A minimally invasive, translational biomarker of ketamine-induced neuronal death in rats: microPET Imaging using 18F-annexin V
    Xuan Zhang
    Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Toxicol Sci 111:355-61. 2009
    ....
  15. doi request reprint Application of microPET imaging approaches in the study of pediatric anesthetic-induced neuronal toxicity
    Xuan Zhang
    Division of Neurotoxicology, National Center for Toxicological Research NCTR FDA, Jefferson, AR 72079, USA
    J Appl Toxicol 33:861-8. 2013
    ..The main aim of this review was to describe molecular imaging approaches that have been used in the study of pediatric anesthetic-induced neuronal toxicity...
  16. ncbi request reprint Systems biology approaches for toxicology
    William Slikker
    National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079 9502, USA
    J Appl Toxicol 27:201-17. 2007
    ..Published in 2007 John Wiley & Sons, Ltd...
  17. doi request reprint Phototoxicity of kava - formation of reactive oxygen species leading to lipid peroxidation and DNA damage
    Qingsu Xia
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    Am J Chin Med 40:1271-88. 2012
    ..The overall results suggest that kava is photocytotoxic and photogenotoxic, both mediated by free radicals generated during photoirradiation...
  18. ncbi request reprint Effect of prolonged ketamine exposure on cardiovascular physiology in pregnant and infant rhesus monkeys (Macaca mulatta)
    Charlotte E Hotchkiss
    The Bionetics Corporation, National Center for Toxicological Research FDA, Jefferson, AR, USA
    J Am Assoc Lab Anim Sci 46:21-8. 2007
    ..Investigators should consider these effects when designing experiments and evaluating experimental outcomes in monkeys...
  19. doi request reprint MicroPET imaging of ketamine-induced neuronal apoptosis with radiolabeled DFNSH
    X Zhang
    Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
    J Neural Transm 118:203-11. 2011
    ..This study demonstrates that microPET imaging is capable of distinguishing differences in retention of [(18)F]-DFNSH in ROI and suggests that this compound may serve as a minimally invasive biomarker of neuronal apoptosis in rodents...
  20. ncbi request reprint Systems biology/systems toxicology: application to developmental neurotoxicology/neuroprotection
    William Slikker
    Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    Ann N Y Acad Sci 1053:309-10. 2005
  21. ncbi request reprint Nanoscale ZnO induces cytotoxicity and DNA damage in human cell lines and rat primary neuronal cells
    Hsiu Mei Chiang
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    J Nanosci Nanotechnol 12:2126-35. 2012
    ..These results indicate that the cause of cytotoxicity is medium dependent and imply that cellular growth conditions may play a significant role in induction of cytotoxicity and DNA damage by nano-ZnO...
  22. ncbi request reprint Application of a systems biology approach to developmental neurotoxicology
    William Slikker
    Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
    Reprod Toxicol 19:305-19. 2005
    ....
  23. ncbi request reprint The role of the N-methyl-D-aspartate receptor in ketamine-induced apoptosis in rat forebrain culture
    C Wang
    Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079 0502, USA
    Neuroscience 132:967-77. 2005
    ..These data suggest that NR1 antisense offers neuroprotection from apoptosis in vitro, and that upregulation of the NR1 following ketamine administration is, at least, partially responsible for the observed apoptosis...
  24. pmc Ketamine-induced neurotoxicity and changes in gene expression in the developing rat brain
    Fang Liu
    Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Curr Neuropharmacol 9:256-61. 2011
    ..Quantitative RT-PCR confirmed the microarray results. These data suggest that repeated exposures to high doses of ketamine can cause compensatory up-regulation of NMDA receptors and subsequently trigger apoptosis in developing neurons...
  25. doi request reprint The effects of L-carnitine on the combination of, inhalation anesthetic-induced developmental, neuronal apoptosis in the rat frontal cortex
    X Zou
    Division of Neurotoxicology, National Center for Toxicological Research, HFT 132, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Neuroscience 151:1053-65. 2008
    ....
  26. ncbi request reprint In situ hybridization and immunohistochemical analysis of cytochrome P450 1B1 expression in human normal tissues
    L Muskhelishvili
    Pathology Associates International, Jefferson, Arkansas 72079, USA
    J Histochem Cytochem 49:229-36. 2001
    ..J Histochem Cytochem 49:229-236, 2001)..
  27. ncbi request reprint The role of NMDA receptor upregulation in phencyclidine-induced cortical apoptosis in organotypic culture
    Cheng Wang
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555 1031, USA
    Biochem Pharmacol 69:1373-83. 2005
    ....
  28. ncbi request reprint Blockade of phencyclidine-induced cortical apoptosis and deficits in prepulse inhibition by M40403, a superoxide dismutase mimetic
    Cheng Wang
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555 1031, USA
    J Pharmacol Exp Ther 304:266-71. 2003
    ..These data suggest that perinatal PCP treatment leads to long-lasting changes in the pathway(s), leading to cell death and behavioral deficits, and that the superoxide radical plays a critical role in the underlying mechanism...
  29. ncbi request reprint [Research advances on BVOCs emission from forest]
    Guangfa Qie
    Research Institute of Forestry, Chinese Academy of Forestry, Beijing 100091, China
    Ying Yong Sheng Tai Xue Bao 16:1151-5. 2005
    ..The ecological significance of forest BVOCs emission was further discussed, and some suggestions were proposed on ecological healthcare forest resources exploitation and urban forest construction...
  30. ncbi request reprint Experimental study on the function of cardiomyocytes
    Cheng Wang
    Institute of Microcirculation, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
    Clin Hemorheol Microcirc 29:369-74. 2003
    ....
  31. ncbi request reprint The clinical characteristics and therapy of syndrome of craniocerebral-cervical vertebral injury
    Sheng Liu
    Department of Neurosurgery, Beijing University Shenzhen Hospital, Shenzhen 518036, China
    Chin J Traumatol 8:183-5. 2005
    ..To explore the clinical characteristics and new treatment for syndrome of craniocerebral-cervical vertebral injury...
  32. ncbi request reprint Adiponectin modulates carnitine palmitoyltransferase-1 through AMPK signaling cascade in rat cardiomyocytes
    Li Li
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100083, China
    Regul Pept 139:72-9. 2007
    ..When AMPK and/or p38MAPK was inhibited, gAd-enhanced mRNA expression of CPT-1 was partially reduced. In conclusion, our study suggests that the activation of AMPK signaling cascade participates in the promotion effect of gAd on CPT-1...
  33. ncbi request reprint Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities
    Cheng Wang
    Neurodegeneration Research Laboratory, National Neuroscience Institute, Singapore 308433
    J Neurosci 27:8563-70. 2007
    ....
  34. pmc Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation
    Angiola Petrone
    Department of Pharmacology, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
    EMBO J 22:4121-31. 2003
    ..Mice lacking RPTPalpha also underperform in the radial-arm water-maze test. These studies identify RPTPalpha as a key mediator of neuronal migration and synaptic plasticity...
  35. ncbi request reprint The role of superoxide and nuclear factor-kappaB signaling in N-methyl-D-aspartate-induced necrosis and apoptosis
    Justin McInnis
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas
    J Pharmacol Exp Ther 301:478-87. 2002
    ....
  36. ncbi request reprint Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function
    Cheng Wang
    Neurodegeneration Research Laboratory, National Neuroscience Institute, Singapore
    Hum Mol Genet 14:3885-97. 2005
    ..Mechanistically, our results provide a link between the influence of environmental and intrinsic factors and genetic susceptibilities in PD pathogenesis...
  37. ncbi request reprint Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions
    Ho Jane Shue
    Chemical Research Department, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Bioorg Med Chem Lett 16:1065-9. 2006
    ..Several compounds with high affinity and sustained in vivo activity were identified...
  38. ncbi request reprint Serum IgA1 from IgA nephropathy patients induces apoptosis in podocytes through direct and indirect pathways
    Cheng Wang
    Department of Nephrology, the 3rd affiliated hospitalof Sun Yat Sen University, Guangzhou, Guangdong, China
    Clin Invest Med 30:E240-9. 2007
    ..To investigate apoptosis of podocytes induced by IgA1 isolated from IgA nephropathy (IgAN) patients through direct and indirect pathways...
  39. pmc Sensory neuron targeting by self-complementary AAV8 via lumbar puncture for chronic pain
    Benjamin Storek
    Department of Medicine and Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 105:1055-60. 2008
    ..Therefore, gene transfer by LP may be suitable for developing gene therapy-based treatments for chronic pain...
  40. ncbi request reprint Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations
    Esther S P Wong
    Neurodegeneration Research Laboratory and Parkinson s Disease and Movement Disorders Center, National Neuroscience Institute, Singapore 308433
    J Biol Chem 282:12310-8. 2007
    ..However, parkin appears to be uniquely sensitive to DA-mediated stress, the specificity of which is likely due to DA modification of 2 Cys residues on parkin (Cys-268 and Cys-323) that are distinct from other RING-IBR-RING members...
  41. ncbi request reprint Arsenic accumulation by ferns: a field survey in southern China
    Chao Yang Wei
    Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, A11 Datun Road, Anwai, Chaoyang District, Beijing, 100101, China
    Environ Geochem Health 29:169-77. 2007
    ..cretica, P. multifida, C. acuminatus, P. aquilinum and D. dichotoma, respectively. The association between Fe accumulation and As accumulation and tolerance in these ferns indicates the unique role of Fe in As-hyperaccumulation...
  42. pmc G protein-coupled receptor 30 expression is required for estrogen stimulation of primordial follicle formation in the hamster ovary
    Cheng Wang
    Department of Obstetrics Gynecology, University of Nebraska Medical Center, Omaha, Nebraska 68198 4515, USA
    Endocrinology 149:4452-61. 2008
    ..These results suggest that a membrane estrogen receptor, GPR30, is expressed in the ovary during perinatal development and mediates E2 action on primordial follicle formation...
  43. ncbi request reprint Development of primordial follicles in the hamster: role of estradiol-17beta
    Cheng Wang
    Department of Obstetrics, Durham Research Center, University of Nebraska Medical Center, 984515 Nebraska Medical Center, Omaha, Nebraska 68198 4515, USA
    Endocrinology 148:1707-16. 2007
    ..This supportive action of E2 is lost when hormone levels increase above a threshold...
  44. ncbi request reprint [Application value of organic ground surface mulch in urban forestry construction]
    Cheng Wang
    Research Institute of Forestry, Chinese Academy of Forestry, Beijing, China
    Ying Yong Sheng Tai Xue Bao 16:2213-7. 2005
    ..The problems in the application process of organic ground surface mulch were discussed, and the actual impendence and broad development space of its production and application in our urban forestry construction were pointed out...
  45. pmc Intrathecal long-term gene expression by self-complementary adeno-associated virus type 1 suitable for chronic pain studies in rats
    Benjamin Storek
    Department of Medicine Hematology Oncology, Mount Sinai School of Medicine, New York, NY, USA
    Mol Pain 2:4. 2006
    ..Our studies focused on recombinant adeno-associated virus (rAAV), one of the most promising vector types for clinical use...
  46. ncbi request reprint Hypoxia induces mitochondrial DNA damage and stimulates expression of a DNA repair enzyme, the Escherichia coli MutY DNA glycosylase homolog (MYH), in vivo, in the rat brain
    Heung Man Lee
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77550, USA
    J Neurochem 80:928-37. 2002
    ....