Luis G Valerio

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc In silico toxicology models and databases as FDA Critical Path Initiative toolkits
    Luis G Valerio
    Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, White Oak 51, Room 4128, 10903 New Hampshire Avenue, Silver Spring, MD 20993 0002, USA
    Hum Genomics 5:200-7. 2011
  2. doi request reprint Development of cardiac safety translational tools for QT prolongation and torsade de pointes
    Luis G Valerio
    Center for Drug Evaluation and Research, Division of Metabolism and Endocrinology Products, Office of New Drugs, U S Food and Drug Administration, Silver Spring, MD 20903, USA
    Expert Opin Drug Metab Toxicol 9:801-15. 2013
  3. doi request reprint Predictive computational toxicology to support drug safety assessment
    Luis G Valerio
    Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U S Food and Drug Administration, Silver Spring, MD, USA
    Methods Mol Biol 930:341-54. 2013
  4. doi request reprint Chemoinformatics and chemical genomics: potential utility of in silico methods
    Luis G Valerio
    Science and Research Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, White Oak 51, Room 4128, 10903 New Hampshire Avenue, Silver Spring, MD 20993 0002, USA
    J Appl Toxicol 32:880-9. 2012
  5. doi request reprint Characterization and validation of an in silico toxicology model to predict the mutagenic potential of drug impurities
    Luis G Valerio
    Science and Research Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U S Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993 0002 USA
    Toxicol Appl Pharmacol 260:209-21. 2012
  6. ncbi request reprint The in silico prediction of human-specific metabolites from hepatotoxic drugs
    Luis G Valerio
    Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993 0002, USA
    Curr Drug Discov Technol 7:170-87. 2010
  7. doi request reprint A structural feature-based computational approach for toxicology predictions
    Luis G Valerio
    Informatics and Computational Safety Analysis Staff, Science and Research Staff, US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, 10903 New Hampshire Avenue, Silver Spring, MD 20993 0002, USA
    Expert Opin Drug Metab Toxicol 6:505-18. 2010
  8. doi request reprint Testing computational toxicology models with phytochemicals
    Luis G Valerio
    Informatics and Computational Safety Analysis Staff, Science and Research Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993 0002, USA
    Mol Nutr Food Res 54:186-94. 2010
  9. doi request reprint In silico toxicology for the pharmaceutical sciences
    Luis G Valerio
    Science and Research Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U S Food and Drug Administration, White Oak 51 Room 4128, 10903 New Hampshire Ave, Silver Spring, MD 20993 0002, USA
    Toxicol Appl Pharmacol 241:356-70. 2009
  10. ncbi request reprint Prediction of rodent carcinogenic potential of naturally occurring chemicals in the human diet using high-throughput QSAR predictive modeling
    Luis G Valerio
    Division of Biotechnology and GRAS Notice Review, US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, HFS 255, 5100 Paint Branch Parkway, College Park, MD 20740, USA
    Toxicol Appl Pharmacol 222:1-16. 2007

Detail Information

Publications17

  1. pmc In silico toxicology models and databases as FDA Critical Path Initiative toolkits
    Luis G Valerio
    Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, White Oak 51, Room 4128, 10903 New Hampshire Avenue, Silver Spring, MD 20993 0002, USA
    Hum Genomics 5:200-7. 2011
    ....
  2. doi request reprint Development of cardiac safety translational tools for QT prolongation and torsade de pointes
    Luis G Valerio
    Center for Drug Evaluation and Research, Division of Metabolism and Endocrinology Products, Office of New Drugs, U S Food and Drug Administration, Silver Spring, MD 20903, USA
    Expert Opin Drug Metab Toxicol 9:801-15. 2013
    ....
  3. doi request reprint Predictive computational toxicology to support drug safety assessment
    Luis G Valerio
    Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U S Food and Drug Administration, Silver Spring, MD, USA
    Methods Mol Biol 930:341-54. 2013
    ....
  4. doi request reprint Chemoinformatics and chemical genomics: potential utility of in silico methods
    Luis G Valerio
    Science and Research Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, White Oak 51, Room 4128, 10903 New Hampshire Avenue, Silver Spring, MD 20993 0002, USA
    J Appl Toxicol 32:880-9. 2012
    ..The great potential of these technologies to help address complex issues in the toxicological sciences is appreciated with the applied goal of the protection of public health...
  5. doi request reprint Characterization and validation of an in silico toxicology model to predict the mutagenic potential of drug impurities
    Luis G Valerio
    Science and Research Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U S Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993 0002 USA
    Toxicol Appl Pharmacol 260:209-21. 2012
    ..Overall, the model's predictive performance was found to be acceptable for screening drug impurities for Salmonella mutagenicity...
  6. ncbi request reprint The in silico prediction of human-specific metabolites from hepatotoxic drugs
    Luis G Valerio
    Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993 0002, USA
    Curr Drug Discov Technol 7:170-87. 2010
    ....
  7. doi request reprint A structural feature-based computational approach for toxicology predictions
    Luis G Valerio
    Informatics and Computational Safety Analysis Staff, Science and Research Staff, US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, 10903 New Hampshire Avenue, Silver Spring, MD 20993 0002, USA
    Expert Opin Drug Metab Toxicol 6:505-18. 2010
    ..These in silico tools are of interest in supporting regulatory review processes, and priority setting in research and product development...
  8. doi request reprint Testing computational toxicology models with phytochemicals
    Luis G Valerio
    Informatics and Computational Safety Analysis Staff, Science and Research Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993 0002, USA
    Mol Nutr Food Res 54:186-94. 2010
    ..This study suggests that complementary multiple computational toxicology software need to be carefully selected to improve global QSAR predictions for this complex toxicological endpoint...
  9. doi request reprint In silico toxicology for the pharmaceutical sciences
    Luis G Valerio
    Science and Research Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U S Food and Drug Administration, White Oak 51 Room 4128, 10903 New Hampshire Ave, Silver Spring, MD 20993 0002, USA
    Toxicol Appl Pharmacol 241:356-70. 2009
    ..How accurate are these approaches is both a statistical issue and challenge in toxicology. In this review, fundamental concepts and the current capabilities and limitations of this technology will be critically addressed...
  10. ncbi request reprint Prediction of rodent carcinogenic potential of naturally occurring chemicals in the human diet using high-throughput QSAR predictive modeling
    Luis G Valerio
    Division of Biotechnology and GRAS Notice Review, US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, HFS 255, 5100 Paint Branch Parkway, College Park, MD 20740, USA
    Toxicol Appl Pharmacol 222:1-16. 2007
    ....
  11. doi request reprint Computational science in drug metabolism and toxicology
    Luis G Valerio
    Center for Drug Evaluation and Research, US Food and Drug Administration, Office of Pharmaceutical Science, White Oak 51 Room 4128, 10903 New Hampshire Ave, Silver Spring, MD 20993 0002, USA
    Expert Opin Drug Metab Toxicol 6:781-4. 2010
    ..Computational science tools when properly validated and used judiciously can lend themselves as enablers to support drug safety assessment in investigative and applied settings...
  12. doi request reprint Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms
    Yun Jan Wang
    Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993 0002, USA
    Regul Toxicol Pharmacol 59:111-24. 2011
    ..This study will serve as regulatory decision support information for regulators at the FDA to help with the process of prioritizing chemicals for testing...
  13. ncbi request reprint Computational toxicology approaches at the US Food and Drug Administration
    Chihae Yang
    Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD, USA
    Altern Lab Anim 37:523-31. 2009
    ....
  14. doi request reprint In silico modeling to predict drug-induced phospholipidosis
    Sydney S Choi
    Science and Research Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U S Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993 0002, USA
    Toxicol Appl Pharmacol 269:195-204. 2013
    ..These models are intended to be utilized for regulatory toxicology applied science needs in screening new drugs for DIPL...
  15. ncbi request reprint Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis
    Luis G Valerio
    Division of Biotechnology and GRAS Notice Review, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, College Park, Maryland 20740, USA
    Toxicol Rev 24:11-35. 2005
    ....
  16. ncbi request reprint In silico toxicological screening of natural products
    Kirk B Arvidson
    Division of Food Contact Notifications, U S Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS 275, 5100 Paint Branch Parkway, College Park, MD, 20740, USA
    Toxicol Mech Methods 18:229-42. 2008
    ....
  17. ncbi request reprint Usefulness of studies on the molecular mechanism of action of herbals/botanicals: The case of St. John's wort
    Supratim Choudhuri
    Division of Biotechnology and GRAS Notice Review, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, College Park, MD 20740, USA
    J Biochem Mol Toxicol 19:1-11. 2005
    ..Scientists, physicians, and other health professionals can make use of the knowledge from such studies as an additional risk management tool...