Research Topics
Genomes and Genes | Shixing TangSummaryAffiliation: Food and Drug Administration Country: USA Publications
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Detail Information
Publications
Nanoparticle-Based biobarcode amplification assay (BCA) for sensitive and early detection of human immunodeficiency type 1 capsid (p24) antigenShixing Tang
Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
J Acquir Immune Defic Syndr 46:231-7. 2007....
Characterization of immune responses to capsid protein p24 of human immunodeficiency virus type 1 and implications for detectionShixing Tang
Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA
Clin Vaccine Immunol 17:1244-51. 2010..The data provide the foundation for development and refinement of new assays for improved p24 antigen testing as future tools for rapid and accurate diagnosis as part of early intervention strategies and estimations of incidence...- Detection of anthrax toxin by an ultrasensitive immunoassay using europium nanoparticlesShixing Tang
Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
Clin Vaccine Immunol 16:408-13. 2009..These results indicate that the universal labeling technology based on europium nanoparticles and its application may provide a rapid and sensitive testing platform for clinical diagnosis and laboratory research... - Absence of detectable xenotropic murine leukemia virus-related virus in plasma or peripheral blood mononuclear cells of human immunodeficiency virus Type 1-infected blood donors or individuals in AfricaShixing Tang
Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
Transfusion 51:463-8. 2011.... - CRF22_01A1 is involved in the emergence of new HIV-1 recombinants in CameroonJiangqin Zhao
Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 RockvillePike, Bethesda, MD 20892, USA
J Acquir Immune Defic Syndr 60:344-50. 2012..Our studies show that novel recombinants between CRF22_01A1 and other clades and recombinant forms may be emerging in Cameroon that could contribute to the future global diversity of HIV-1 in this region and worldwide... - Absence of detectable XMRV and other MLV-related viruses in healthy blood donors in the United StatesShixing Tang
Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
PLoS ONE 6:e27391. 2011..S. These results imply that millions of persons in the U.S. may be carrying the nucleic acid sequences of XMRV and/or MLV-related viruses, which is a serious public health and blood safety concern... - Identification of new, emerging HIV-1 unique recombinant forms and drug resistant viruses circulating in CameroonViswanath Ragupathy
Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Virol J 8:185. 2011..The goal of our study was to determine recent trends in virus evolution and emergence of drug resistance in blood donors and HIV positive patients... 
Changes in the level of apoptosis-related proteins in Jurkat cells infected with HIV-1 versus HIV-2Xue Wang
Labaratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Mol Cell Biochem 337:175-83. 2010....- Identification and genetic characterization of a novel CRF22_01A1 recombinant form of HIV type 1 in CameroonJiangqin Zhao
Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
AIDS Res Hum Retroviruses 26:1033-45. 2010.... - Anthrax edema toxin impairs clearance in miceInka Sastalla
Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Infect Immun 80:529-38. 2012.... - Evaluation of FDA licensed HIV assays using plasma from Cameroonian blood donorsSherwin Lee
Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland 20892, USA
J Med Virol 78:S22-3. 2006..In addition, some nucleic acid tests (NAT) assays were not able to detect a few serologic reactive samples and all new variants including some CRF02_AG variants... - c-FLIPL regulates PKC via AP-2 to inhibit Bax-mediated apoptosis induced by HIV-1 gp120 in Jurkat cellsXue Wang
Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29B, Rm 4NN16, 8800 Rockville Pike, Bethesda, MD, 20892, USA
Mol Cell Biochem 330:23-9. 2009..Collectively, these findings further corroborate the concept that gp120 plays an important role, via involvement of molecules such as c-FLIPL, in apoptotic cell death due to HIV-1 infection... - Viremia associated with fatal outcomes in ferrets infected with avian H5N1 influenza virusXue Wang
Lab of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Food and Drug Administration, Bethesda, Maryland, USA
PLoS ONE 5:e12099. 2010..Our observations further substantiate pathogenicity of H5N1 and further indicate that viremia may be a bio-marker for fatal outcomes in H5N1 infection... - XMRV: usage of receptors and potential co-receptorsMohan Kumar Haleyur Giri Setty
Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Virol J 8:423. 2011..Although XMRV is thought to use XPR1 for cell entry, it infects A549 cells that do not express XPR1, suggesting usage of other receptors or co-receptors... - Multiplexed, rapid detection of H5N1 using a PCR-free nanoparticle-based genomic microarray assayJiangqin Zhao
Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
BMC Biotechnol 10:74. 2010.... - Nanoparticle-based immunoassays for sensitive and early detection of HIV-1 capsid (p24) antigenShixing Tang
Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
J Infect Dis 201:S59-64. 2010..5 pg/mL. These results indicate that the universal labeling technology based on NPs and its application may provide a rapid and sensitive testing platform for clinical diagnosis and laboratory research... - Novel approach for differential diagnosis of HIV infections in the face of vaccine-generated antibodies: utility for detection of diverse HIV-1 subtypesSurender Khurana
Division of Viral Products, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA
J Acquir Immune Defic Syndr 43:304-12. 2006..Therefore, HIV-SELECTEST could be an important differential diagnostic tool for HIV vaccine trials, blood banks, and population screening worldwide... - The interdomain linker region of HIV-1 capsid protein is a critical determinant of proper core assembly and stabilityJiyang Jiang
Section on Viral Gene Regulation, Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health, National Institutes of Health, Bethesda, MD 20892 2780, USA
Virology 421:253-65. 2011..Collectively, these findings demonstrate that the linker region is essential for proper assembly and stability of cores and efficient replication... - A second-site suppressor significantly improves the defective phenotype imposed by mutation of an aromatic residue in the N-terminal domain of the HIV-1 capsid proteinShixing Tang
Viral Gene Regulation Section, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Building 6B, Room 216, Bethesda, MD 20892 2780, USA
Virology 359:105-15. 2007..These findings describe a novel occurrence, namely suppression of a mutation in a hydrophobic residue that is critical for maintaining the structural integrity of CA and proper core assembly... - Testing strategies for detection of xenotropic murine leukemia virus-related virus infectionShixing Tang
Laboratory of Molecular Virology, CBER, Food and Drug Administration, Bethesda, MD 20892, USA
Adv Virol 2011:281425. 2011..Mouse DNA contamination should be carefully checked when testing human specimens in order to avoid false-positive detection of XMRV or MLV-like sequences... - Human immunodeficiency virus type 1 N-terminal capsid mutants containing cores with abnormally high levels of capsid protein and virtually no reverse transcriptaseShixing Tang
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
J Virol 77:12592-602. 2003..Thus, taken together with the almost complete absence of RT in mutant cores, these findings can account for the failure of the three CA mutants to synthesize viral DNA following virus entry into cells... - Increased genetic diversity and intersubtype recombinants of HIV-1 in blood donors from urban CameroonAna Machuca
J Acquir Immune Defic Syndr 45:361-3. 2007 - Circulating recombinant form (CRF) 37_cpx: an old strain in Cameroon composed of diverse, genetically distant lineages of subtypes A and GRebecca L R Powell
Department of Microbiology, New York University School of Medicine, New York, New York 10010, USA
AIDS Res Hum Retroviruses 23:923-33. 2007.... - Identification of a novel circulating recombinant form (CRF) 36_cpx in Cameroon that combines two CRFs (01_AE and 02_AG) with ancestral lineages of subtypes A and GRebecca L R Powell
Department of Microbiology, New York University School of Medicine, New York, New York 10010, USA
AIDS Res Hum Retroviruses 23:1008-19. 2007..The ancestral sequences present in CRF36_cpx represent a link to extinct strains, and, potentially, insight into the evolution of HIV-1... - HIV-1 capsid protein and cyclophilin a as new targets for anti-AIDS therapeutic agentsJiebo Li
State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing, 100083, China
Infect Disord Drug Targets 7:238-44. 2007..Here, we give an overview of HIV-1 CA protein and Cyp A as new targets for potential anti-AIDS therapeutic agents... - Effect of polypurine tract (PPT) mutations on human immunodeficiency virus type 1 replication: a virus with a completely randomized PPT retains low infectivityLesa R Miles
Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr. S. W, Atlanta, GA 30310, USA
J Virol 79:6859-67. 2005..Together, these experiments confirm that the 3' end of the PPT is important for plus-strand priming and that a virus that completely lacks a PPT can replicate at a low level...