Jeffrey S Smith

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi A quantitative assay for measuring clearance of adenovirus vectors by Kupffer cells
    Jeffrey S Smith
    Division of Cellular and Gene Therapies, Food and Drug Administration, Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA
    J Virol Methods 147:54-60. 2008
  2. ncbi Rapid Kupffer cell death after intravenous injection of adenovirus vectors
    Elanchezhiyan Manickan
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Mol Ther 13:108-17. 2006
  3. ncbi Interaction of systemically delivered adenovirus vectors with Kupffer cells in mouse liver
    Jeffrey S Smith
    Division of Cellular and Gene Therapies, Food and Drug Administration Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA
    Hum Gene Ther 19:547-54. 2008
  4. ncbi The role of endosomal escape and mitogen-activated protein kinases in adenoviral activation of the innate immune response
    Jeffrey S Smith
    Division of Cellular and Gene Therapies, Food and Drug Administration Center for Biologics Evaluation and Research, Bethesda, Maryland, United States of America
    PLoS ONE 6:e26755. 2011
  5. ncbi Clearance of adenovirus by Kupffer cells is mediated by scavenger receptors, natural antibodies, and complement
    Zhili Xu
    Division of Cellular and Gene Therapies, FDA CBER, 8800 Rockville Pike, Bethesda, MD 20892, USA
    J Virol 82:11705-13. 2008
  6. ncbi Induction of shock after intravenous injection of adenovirus vectors: a critical role for platelet-activating factor
    Zhili Xu
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    Mol Ther 18:609-16. 2010
  7. ncbi Adenovirus activates complement by distinctly different mechanisms in vitro and in vivo: indirect complement activation by virions in vivo
    Jie Tian
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 83:5648-58. 2009
  8. ncbi Severe pulmonary pathology after intravenous administration of vectors in cirrhotic rats
    Jeffrey S Smith
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Mol Ther 9:932-41. 2004

Collaborators

Detail Information

Publications8

  1. ncbi A quantitative assay for measuring clearance of adenovirus vectors by Kupffer cells
    Jeffrey S Smith
    Division of Cellular and Gene Therapies, Food and Drug Administration, Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA
    J Virol Methods 147:54-60. 2008
    ..As an example of the utility of this method, it was found that pre-injecting mice with polyinosinic acid reduces accumulation of Ad in Kupffer cells by approximately 90%...
  2. ncbi Rapid Kupffer cell death after intravenous injection of adenovirus vectors
    Elanchezhiyan Manickan
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Mol Ther 13:108-17. 2006
    ..Together these results show that an intravenous injection of adenovirus vector causes synchronous and surprisingly rapid Kupffer cell death...
  3. ncbi Interaction of systemically delivered adenovirus vectors with Kupffer cells in mouse liver
    Jeffrey S Smith
    Division of Cellular and Gene Therapies, Food and Drug Administration Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA
    Hum Gene Ther 19:547-54. 2008
    ..We conclude that Ad vectors kill KCs at a postbinding step and that this cell death can be mitigated if downstream events in viral entry are blocked...
  4. ncbi The role of endosomal escape and mitogen-activated protein kinases in adenoviral activation of the innate immune response
    Jeffrey S Smith
    Division of Cellular and Gene Therapies, Food and Drug Administration Center for Biologics Evaluation and Research, Bethesda, Maryland, United States of America
    PLoS ONE 6:e26755. 2011
    ..Thus, even though p38 and ERK are rapidly activated after i.v. injection of AdV, cytokine and chemokine responses are mostly independent of these kinases...
  5. ncbi Clearance of adenovirus by Kupffer cells is mediated by scavenger receptors, natural antibodies, and complement
    Zhili Xu
    Division of Cellular and Gene Therapies, FDA CBER, 8800 Rockville Pike, Bethesda, MD 20892, USA
    J Virol 82:11705-13. 2008
    ....
  6. ncbi Induction of shock after intravenous injection of adenovirus vectors: a critical role for platelet-activating factor
    Zhili Xu
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    Mol Ther 18:609-16. 2010
    ..The identification of this novel pathway suggests strategies to improve the safety of systemic gene therapy with Ad vectors...
  7. ncbi Adenovirus activates complement by distinctly different mechanisms in vitro and in vivo: indirect complement activation by virions in vivo
    Jie Tian
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 83:5648-58. 2009
    ..In vitro studies are poorly predictive of in vivo mechanisms because Ad virions activate complement through indirect mechanisms in vivo...
  8. ncbi Severe pulmonary pathology after intravenous administration of vectors in cirrhotic rats
    Jeffrey S Smith
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Mol Ther 9:932-41. 2004
    ....