J Simak

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi Elevated circulating endothelial membrane microparticles in paroxysmal nocturnal haemoglobinuria
    Jan Simak
    Laboratory of Cellular Hematology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    Br J Haematol 125:804-13. 2004
  2. ncbi Cell membrane microparticles in blood and blood products: potentially pathogenic agents and diagnostic markers
    Jan Simak
    Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    Transfus Med Rev 20:1-26. 2006
  3. ncbi Circulating endothelial microparticles in acute ischemic stroke: a link to severity, lesion volume and outcome
    J Simak
    Laboratory of Cellular Hematology, CBER, FDA, HFM 335, Rockville, MD 20852 1448, USA
    J Thromb Haemost 4:1296-302. 2006
  4. ncbi CD34+ cells from paroxysmal nocturnal hemoglobinuria (PNH) patients are deficient in surface expression of cellular prion protein (PrPc)
    Antonio M Risitano
    Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Exp Hematol 31:65-72. 2003
  5. ncbi Elevated endothelial microparticles in Fabry children decreased after enzyme replacement therapy
    Monique P Gelderman
    Arterioscler Thromb Vasc Biol 27:e138-9. 2007
  6. ncbi Activated platelets of patients with paroxysmal nocturnal hemoglobinuria express cellular prion protein
    Karel Holada
    Laboratory of Cellular Hematology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Blood 100:341-3. 2002
  7. ncbi Divergent expression of cellular prion protein on blood cells of human and nonhuman primates
    Karel Holada
    Department of Immunology and Microbiology, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Transfusion 47:2223-32. 2007
  8. ncbi Adverse effects of fullerenes on endothelial cells: fullerenol C60(OH)24 induced tissue factor and ICAM-I membrane expression and apoptosis in vitro
    Monique P Gelderman
    CBER, FDA, 1401 Rockville Pike, HFM 335, Rockville, MD 20852 1448, USA
    Int J Nanomedicine 3:59-68. 2008

Detail Information

Publications8

  1. ncbi Elevated circulating endothelial membrane microparticles in paroxysmal nocturnal haemoglobinuria
    Jan Simak
    Laboratory of Cellular Hematology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    Br J Haematol 125:804-13. 2004
    ..Analysis of circulating ECMP appears promising to provide useful information on the status of the vascular endothelium in PNH and SCD...
  2. ncbi Cell membrane microparticles in blood and blood products: potentially pathogenic agents and diagnostic markers
    Jan Simak
    Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    Transfus Med Rev 20:1-26. 2006
    ..Thus, the investigation of potentially pathogenic effects of MPs in blood products and of MP release associated with blood product processing and storage have yet to come...
  3. ncbi Circulating endothelial microparticles in acute ischemic stroke: a link to severity, lesion volume and outcome
    J Simak
    Laboratory of Cellular Hematology, CBER, FDA, HFM 335, Rockville, MD 20852 1448, USA
    J Thromb Haemost 4:1296-302. 2006
    ..Endothelial membrane microparticles (EMP) in plasma are elevated in several vascular diseases...
  4. ncbi CD34+ cells from paroxysmal nocturnal hemoglobinuria (PNH) patients are deficient in surface expression of cellular prion protein (PrPc)
    Antonio M Risitano
    Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Exp Hematol 31:65-72. 2003
    ..Conversely, PrP(c) is a good model to elucidate the fate of GPI-AP in PIG-A-deficient cells...
  5. ncbi Elevated endothelial microparticles in Fabry children decreased after enzyme replacement therapy
    Monique P Gelderman
    Arterioscler Thromb Vasc Biol 27:e138-9. 2007
  6. ncbi Activated platelets of patients with paroxysmal nocturnal hemoglobinuria express cellular prion protein
    Karel Holada
    Laboratory of Cellular Hematology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Blood 100:341-3. 2002
    ..Our results indicate that in the absence of GPI anchor, PrPc can be expressed intracellularly and up-regulated on the platelet membrane, likely in a transmembrane form with the C-terminal part of the molecule inserted into the cytoplasm...
  7. ncbi Divergent expression of cellular prion protein on blood cells of human and nonhuman primates
    Karel Holada
    Department of Immunology and Microbiology, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Transfusion 47:2223-32. 2007
    ..Nonhuman primates are the most relevant models of human prion diseases...
  8. ncbi Adverse effects of fullerenes on endothelial cells: fullerenol C60(OH)24 induced tissue factor and ICAM-I membrane expression and apoptosis in vitro
    Monique P Gelderman
    CBER, FDA, 1401 Rockville Pike, HFM 335, Rockville, MD 20852 1448, USA
    Int J Nanomedicine 3:59-68. 2008
    ..In conclusion, fullerenol C60(OH)24 had both pro-inflammatory and pro-apoptotic effects on HUVECs, indicating possible adverse effects of fullerenes on the endothelium...