E Shacter

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi Oxidative stress interferes with cancer chemotherapy: inhibition of lymphoma cell apoptosis and phagocytosis
    E Shacter
    Laboratory of Immunology, Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    Blood 96:307-13. 2000
  2. ncbi Re-processing of biological products: regulatory considerations from the CBER perspective
    E Shacter
    Division of Therapeutic Proteins, CBER, FDA, Rockville, Maryland 20852, USA
    Dev Biol (Basel) 113:105-7; discussion 115-6. 2003
  3. ncbi Chronic inflammation and cancer
    Emily Shacter
    Laboratory of Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892 4555, USA
    Oncology (Williston Park) 16:217-26, 229; discussion 230-2. 2002
  4. ncbi Oxidative stress inhibits the phagocytosis of apoptotic cells that have externalized phosphatidylserine
    H A Anderson
    Laboratory of Immunology, Division of Therapeutic Proteins, Bethesda, MD 20892, USA
    Cell Death Differ 9:616-25. 2002
  5. ncbi Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin
    Fabio Klamt
    Laboratory of Biochemistry, Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Nat Cell Biol 11:1241-6. 2009
  6. ncbi Rac1 inhibits apoptosis in human lymphoma cells by stimulating Bad phosphorylation on Ser-75
    Baolin Zhang
    Laboratory of Biochemistry, Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 4555, USA
    Mol Cell Biol 24:6205-14. 2004
  7. ncbi Caspase 3-mediated inactivation of rac GTPases promotes drug-induced apoptosis in human lymphoma cells
    Baolin Zhang
    Laboratory of Biochemistry, Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Mol Cell Biol 23:5716-25. 2003
  8. ncbi Rho GDP dissociation inhibitor protects cancer cells against drug-induced apoptosis
    Baolin Zhang
    Laboratory of Biochemistry, Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    Cancer Res 65:6054-62. 2005
  9. ncbi Mechanism of the guanine nucleotide exchange reaction of Ras GTPase--evidence for a GTP/GDP displacement model
    Baolin Zhang
    Laboratory of Biochemistry, Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Biochemistry 44:2566-76. 2005
  10. ncbi Desferal inhibits breast tumor growth and does not interfere with the tumoricidal activity of doxorubicin
    Eileen M Hoke
    Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20815, USA
    Free Radic Biol Med 39:403-11. 2005

Collaborators

Detail Information

Publications22

  1. ncbi Oxidative stress interferes with cancer chemotherapy: inhibition of lymphoma cell apoptosis and phagocytosis
    E Shacter
    Laboratory of Immunology, Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    Blood 96:307-13. 2000
    ..The results suggest that chemotherapy-induced apoptosis and phagocytosis of cancer cells may be enhanced by including certain antioxidant agents in the treatment protocol...
  2. ncbi Re-processing of biological products: regulatory considerations from the CBER perspective
    E Shacter
    Division of Therapeutic Proteins, CBER, FDA, Rockville, Maryland 20852, USA
    Dev Biol (Basel) 113:105-7; discussion 115-6. 2003
  3. ncbi Chronic inflammation and cancer
    Emily Shacter
    Laboratory of Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892 4555, USA
    Oncology (Williston Park) 16:217-26, 229; discussion 230-2. 2002
    ..A thorough understanding of the molecular basis of inflammation-associated neoplasia and progression can lead to novel approaches to the prevention and treatment of cancer...
  4. ncbi Oxidative stress inhibits the phagocytosis of apoptotic cells that have externalized phosphatidylserine
    H A Anderson
    Laboratory of Immunology, Division of Therapeutic Proteins, Bethesda, MD 20892, USA
    Cell Death Differ 9:616-25. 2002
    ..Another phagocytosis recognition factor must therefore exist to facilitate uptake of apoptotic cells, and this factor is sensitive to modification by H(2)O(2)...
  5. ncbi Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin
    Fabio Klamt
    Laboratory of Biochemistry, Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Nat Cell Biol 11:1241-6. 2009
    ..Exposure of cofilin to TnCl results in intramolecular disulphide bonding and oxidation of Met residues to Met sulphoxide, but only Cys oxidation causes cofilin to induce mitochondrial damage...
  6. ncbi Rac1 inhibits apoptosis in human lymphoma cells by stimulating Bad phosphorylation on Ser-75
    Baolin Zhang
    Laboratory of Biochemistry, Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 4555, USA
    Mol Cell Biol 24:6205-14. 2004
    ..These findings define a mechanism by which active Rac1 promotes lymphoma cell survival and inhibits apoptosis in response to cancer chemotherapy drugs...
  7. ncbi Caspase 3-mediated inactivation of rac GTPases promotes drug-induced apoptosis in human lymphoma cells
    Baolin Zhang
    Laboratory of Biochemistry, Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Mol Cell Biol 23:5716-25. 2003
    ..Thus, proteolytic inactivation of Rac GTPases represents a novel, irreversible mechanism of Rac downregulation that allows maximal cell death following drug treatment...
  8. ncbi Rho GDP dissociation inhibitor protects cancer cells against drug-induced apoptosis
    Baolin Zhang
    Laboratory of Biochemistry, Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    Cancer Res 65:6054-62. 2005
    ..Taken together, the data show that RhoGDI is an anti-apoptotic molecule that mediates cellular resistance to these chemotherapy agents...
  9. ncbi Mechanism of the guanine nucleotide exchange reaction of Ras GTPase--evidence for a GTP/GDP displacement model
    Baolin Zhang
    Laboratory of Biochemistry, Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Biochemistry 44:2566-76. 2005
    ..These results strongly support a GEF reaction mechanism by which nucleotide exchange occurs on Ras through a direct GTP/GDP displacement model...
  10. ncbi Desferal inhibits breast tumor growth and does not interfere with the tumoricidal activity of doxorubicin
    Eileen M Hoke
    Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20815, USA
    Free Radic Biol Med 39:403-11. 2005
    ..Furthermore, desferal may have utility as an adjunctive chemotherapy due to its ability to inhibit breast tumor growth and cardiotoxic side effects without compromising the tumor-killing activity of an anthracycline chemotherapy drug...
  11. ncbi Auto-oxidation and oligomerization of protein S on the apoptotic cell surface is required for Mer tyrosine kinase-mediated phagocytosis of apoptotic cells
    Hiroshi Uehara
    Laboratory of Biochemistry, Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892
    J Immunol 180:2522-30. 2008
    ..The requirement for oxidative modification of protein S can explain why this abundant blood protein does not constitutively activate MerTK in circulating monocytes and tissue macrophages...
  12. ncbi Regulation of macrophage interleukin-6 (IL-6) and IL-10 expression by prostaglandin E2: the role of p38 mitogen-activated protein kinase
    J A Williams
    Laboratory of Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda MD 20892, USA
    J Interferon Cytokine Res 20:291-8. 2000
    ..These results indicate that macrophage IL-10 and IL-6 expression is differentially regulated by PGE2 and p38 MAP kinase in murine inflammatory macrophages...
  13. ncbi Fas aggregation does not correlate with Fas-mediated apoptosis
    Y Lee
    Laboratory of Immunology, Division of Therapeutic Proteins, Food and Drug Administration, Center for Biologics and Evaluation and Research, Bethesda, MD 20892, USA
    J Immunol 167:82-9. 2001
    ..These results show that Fas aggregation and Fas-mediated apoptosis are not directly correlated and may even be inversely correlated...
  14. ncbi Taurine chloramine, an oxidant derived from neutrophils, induces apoptosis in human B lymphoma cells through mitochondrial damage
    Fabio Klamt
    Laboratory of Biochemistry, Division of Therapeutic Proteins, Center of Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Biol Chem 280:21346-52. 2005
    ..The data suggest that TN-Cl causes apoptosis through direct damage to the mitochondria...
  15. ncbi Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues
    Qi Chen
    Molecular and Clinical Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:13604-9. 2005
    ..These findings give plausibility to i.v. ascorbic acid in cancer treatment, and have unexpected implications for treatment of infections where H(2)O(2) may be beneficial...
  16. ncbi The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone
    V Ashutosh Rao
    Laboratory of Biochemistry, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Biol Chem 285:34447-59. 2010
    ..Keap1 and Nrf2 act as redox sensors for oxidative perturbations that lead to autophagy. MitoQ and similar compounds should be further evaluated for novel anticancer activity...
  17. ncbi Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells
    Howard A Anderson
    Laboratory of Biochemistry, Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Nat Immunol 4:87-91. 2003
    ..Protein S acted by binding to phosphatidylserine expressed on the apoptotic cell surface. Protein S is thus a multifunctional protein that can facilitate clearance of early apoptotic cells in addition to regulating blood coagulation...
  18. ncbi Induction of apoptosis by chemotherapeutic drugs without generation of reactive oxygen species
    Sema Senturker
    Laboratory of Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Arch Biochem Biophys 397:262-72. 2002
    ..The results demonstrate that, at least in B lymphoma cells, chemotherapy-induced apoptosis occurs using a mechanism that does not involve oxidants...
  19. ncbi The FDA's assessment of follow-on protein products: a historical perspective
    Janet Woodcock
    Food and Drug Administration, 5600 Fishers Lane, Rockville, Maryland 20857, USA
    Nat Rev Drug Discov 6:437-42. 2007
    ....
  20. ncbi Natural anticoagulant proteins in the regulation of autoimmunity: potential role of protein S
    Howard A Anderson
    Laboratory of Biochemistry, Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Curr Pharm Des 10:929-37. 2004
    ..This article will review the dual roles of protein S as an anticoagulant and in regulating phagocytosis of apoptotic cells, with emphasis on exposing a possible novel role in regulating autoimmunity...
  21. ncbi Distinct modes of cell death induced by different reactive oxygen species: amino acyl chloramines mediate hypochlorous acid-induced apoptosis
    Robert P Englert
    Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20815, USA
    J Biol Chem 277:20518-26. 2002
    ....
  22. ncbi Changes to biological source materials
    K Sewerin
    Biologics Consulting Group, Skaldev 17, 16771 Bromma, Sweden
    Biologicals 34:71-2. 2006