Research Topics
| Angamuthu SelvapandiyanSummaryAffiliation: Food and Drug Administration Country: USA Publications
| Collaborators
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Detail Information
Publications
A novel semiquantitative fluorescence-based multiplex polymerase chain reaction assay for rapid simultaneous detection of bacterial and parasitic pathogens from bloodAngamuthu Selvapandiyan
Division of Emerging and Transfusion Transmitted Disease, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
J Mol Diagn 7:268-75. 2005..The time necessary for performing this assay including sample preparation was less than 1.5 hours, making this a potentially useful method for rapidly diagnosing and monitoring the efficacy of drugs or vaccines in infected individuals...
A Leishmania minicircle DNA footprint assay for sensitive detection and rapid speciation of clinical isolatesAngamuthu Selvapandiyan
Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
Transfusion 48:1787-98. 2008..Diversity in clinical outcome, due to different species of Leishmania, and its presence in asymptomatic blood donors in endemic areas warrant development of methods that are sensitive and can rapidly identify infecting species...
Genetically modified live attenuated parasites as vaccines for leishmaniasisAngamuthu Selvapandiyan
Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research, Bethesda, MD 20892, USA
Indian J Med Res 123:455-66. 2006....- A multiplex polymerase chain reaction microarray assay to detect bioterror pathogens in bloodKeiko Tomioka
Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
J Mol Diagn 7:486-94. 2005..This study represents proof of the concept of microarray technology to screen simultaneously for multiple bioterror pathogens in blood samples... - Intracellular replication-deficient Leishmania donovani induces long lasting protective immunity against visceral leishmaniasisAngamuthu Selvapandiyan
Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
J Immunol 183:1813-20. 2009..braziliensis that causes mucocutaneous leishmaniasis. Results indicate that LdCen1(-/-) can be a safe and effective vaccine candidate against VL as well as mucocutaneous leishmaniasis causing parasites... - Characterization of metacaspases with trypsin-like activity and their putative role in programmed cell death in the protozoan parasite LeishmaniaNancy Lee
Laboratory of Bacterial, Parasitic, and Unconventional Agents, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA
Eukaryot Cell 6:1745-57. 2007..These findings suggest that Leishmania metacaspases are not responsible for the caspase-like activities reported in this organism and suggest a possible role for LdMCs as effector molecules in Leishmania PCD... - Role of centrins 2 and 3 in organelle segregation and cytokinesis in Trypanosoma bruceiAngamuthu Selvapandiyan
Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
PLoS ONE 7:e45288. 2012..Therefore, both centrin2 and 3 are involved in organelle segregation similar to centrin1 as was previously observed. In addition, we identified their role in kinetoplast division which may be also linked to overall mis-segregation... - Centrins, cell cycle regulation proteins in human malaria parasite Plasmodium falciparumBabita Mahajan
Division of Emerging and Transfusion Transmitted Diseases, Food and Drug Administration, Rockville, Maryland 20852, USA
J Biol Chem 283:31871-83. 2008..These results provide the opportunity to further explore the role of centrins in cell division in malaria parasites and suggest novel targets to construct genetically modified, live attenuated malaria vaccines... - Centrin1 is required for organelle segregation and cytokinesis in Trypanosoma bruceiAngamuthu Selvapandiyan
Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Mol Biol Cell 18:3290-301. 2007..brucei... - Microarray multiplex assay for the simultaneous detection and discrimination of hepatitis B, hepatitis C, and human immunodeficiency type-1 viruses in human blood samplesChu Chieh Hsia
Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Review, Food and Drug Administration, Bethesda, MD 20892, USA
Biochem Biophys Res Commun 356:1017-23. 2007..Our data represent a proof-of-concept for the possible use of highly sensitive multiplex microarray assay to screen and confirm the presence of these viruses in blood donors and patients... - Centrin gene disruption impairs stage-specific basal body duplication and cell cycle progression in LeishmaniaAngamuthu Selvapandiyan
Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Food and Drug Administration, Bethesda, MD 20892, USA
J Biol Chem 279:25703-10. 2004..The centrin null mutant defective in amastigote growth could be useful as a vaccine candidate against leishmaniasis... - Cloning and characterization of angiotensin converting enzyme related dipeptidylcarboxypeptidase from Leishmania donovaniNeena Goyal
Division of Biochemistry, Central Drug Research Institute, Lucknow 226001, Uttar Pradesh, India
Mol Biochem Parasitol 145:147-57. 2006..Further, identification of LdDCP now provides an opportunity to investigate Leishmania peptidases for their potential as drug and vaccine targets...