Larry Schmued

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint K114 inhibits A-beta aggregation and inflammation in vitro and in vivo in AD/Tg mice
    Yi Hong Zhang
    Division of Neurotoxicology, National Center for Toxicological Research NCTR FDA, Jefferson, AR 72079, USA
    Curr Alzheimer Res 11:299-308. 2014
  2. ncbi request reprint Efficacy and toxicity of clioquinol treatment and A-beta42 inoculation in the APP/PSI mouse model of Alzheimer's disease
    Yi Hong Zhang
    Division of Neurotoxicology, National Center for Toxicological Research NCTR FDA, Jefferson, AR 72079, USA
    Curr Alzheimer Res 10:494-506. 2013
  3. ncbi request reprint Characterization of myelin pathology in the hippocampal complex of a transgenic mouse model of Alzheimer's disease
    Larry C Schmued
    Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson AR 72079, USA
    Curr Alzheimer Res 10:30-7. 2013
  4. doi request reprint Introducing Amylo-Glo, a novel fluorescent amyloid specific histochemical tracer especially suited for multiple labeling and large scale quantification studies
    Larry Schmued
    Division of Neurotoxicology, NCTR FDA, Jefferson, AR 72079, USA
    J Neurosci Methods 209:120-6. 2012
  5. doi request reprint Introducing Black-Gold II, a highly soluble gold phosphate complex with several unique advantages for the histochemical localization of myelin
    Larry Schmued
    Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson AR 72079, USA
    Brain Res 1229:210-7. 2008
  6. doi request reprint Kainic acid and 3-Nitropropionic acid induced expression of laminin in vascular elements of the rat brain
    Sumit Sarkar
    Division of Neurotoxicology, National Center for Toxicological Research NCTR, Jefferson, AR 72079, USA
    Brain Res 1352:239-47. 2010
  7. ncbi request reprint Temporal progression of kainic acid induced changes in vascular laminin expression in rat brain with neuronal and glial correlates
    Sumit Sarkar
    Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, HFT 132, Jefferson, AR 72079, USA
    Curr Neurovasc Res 9:110-9. 2012
  8. doi request reprint In situ demonstration of Fluoro-Turquoise conjugated gelatin for visualizing brain vasculature and endothelial cells and their characterization in normal and kainic acid exposed animals
    Sumit Sarkar
    Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079, USA
    J Neurosci Methods 219:276-84. 2013
  9. ncbi request reprint L-carnitine and neuroprotection in the animal model of mitochondrial dysfunction
    Zbigniew Binienda
    Division of Neurotoxicology, HFT 132, National Center for Toxicology Research, Food and Drug Administration, Jefferson, Arkansas 72079 9502, USA
    Ann N Y Acad Sci 1053:174-82. 2005
  10. doi request reprint In vivo administration of fluorescent dextrans for the specific and sensitive localization of brain vascular pericytes and their characterization in normal and neurotoxin exposed brains
    Sumit Sarkar
    Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079, USA
    Neurotoxicology 33:436-43. 2012

Collaborators

Detail Information

Publications12

  1. ncbi request reprint K114 inhibits A-beta aggregation and inflammation in vitro and in vivo in AD/Tg mice
    Yi Hong Zhang
    Division of Neurotoxicology, National Center for Toxicological Research NCTR FDA, Jefferson, AR 72079, USA
    Curr Alzheimer Res 11:299-308. 2014
    ..Additionally, K114 significantly inhibited the typically observed plaque associated astrocytic activation, as revealed by GFAP immunohistochemistry, suggesting possible anti-inflammatory properties...
  2. ncbi request reprint Efficacy and toxicity of clioquinol treatment and A-beta42 inoculation in the APP/PSI mouse model of Alzheimer's disease
    Yi Hong Zhang
    Division of Neurotoxicology, National Center for Toxicological Research NCTR FDA, Jefferson, AR 72079, USA
    Curr Alzheimer Res 10:494-506. 2013
    ....
  3. ncbi request reprint Characterization of myelin pathology in the hippocampal complex of a transgenic mouse model of Alzheimer's disease
    Larry C Schmued
    Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson AR 72079, USA
    Curr Alzheimer Res 10:30-7. 2013
    ....
  4. doi request reprint Introducing Amylo-Glo, a novel fluorescent amyloid specific histochemical tracer especially suited for multiple labeling and large scale quantification studies
    Larry Schmued
    Division of Neurotoxicology, NCTR FDA, Jefferson, AR 72079, USA
    J Neurosci Methods 209:120-6. 2012
    ..Its brightness makes it ideal for low magnification quantification studies, while its unique excitation/emission profile and mild staining conditions makes it ideal for combination with multiple immunofluorescent labeling studies...
  5. doi request reprint Introducing Black-Gold II, a highly soluble gold phosphate complex with several unique advantages for the histochemical localization of myelin
    Larry Schmued
    Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson AR 72079, USA
    Brain Res 1229:210-7. 2008
    ..The study also incorporates the first application of such stains to examine peripheral nerves of control and acrylamide-exposed rats...
  6. doi request reprint Kainic acid and 3-Nitropropionic acid induced expression of laminin in vascular elements of the rat brain
    Sumit Sarkar
    Division of Neurotoxicology, National Center for Toxicological Research NCTR, Jefferson, AR 72079, USA
    Brain Res 1352:239-47. 2010
    ..Microglia may also contribute to the neurotoxic induced neovascularization and neurodegeneration...
  7. ncbi request reprint Temporal progression of kainic acid induced changes in vascular laminin expression in rat brain with neuronal and glial correlates
    Sumit Sarkar
    Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, HFT 132, Jefferson, AR 72079, USA
    Curr Neurovasc Res 9:110-9. 2012
    ..These data allow for speculation on possible mechanisms underlying these events...
  8. doi request reprint In situ demonstration of Fluoro-Turquoise conjugated gelatin for visualizing brain vasculature and endothelial cells and their characterization in normal and kainic acid exposed animals
    Sumit Sarkar
    Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079, USA
    J Neurosci Methods 219:276-84. 2013
    ....
  9. ncbi request reprint L-carnitine and neuroprotection in the animal model of mitochondrial dysfunction
    Zbigniew Binienda
    Division of Neurotoxicology, HFT 132, National Center for Toxicology Research, Food and Drug Administration, Jefferson, Arkansas 72079 9502, USA
    Ann N Y Acad Sci 1053:174-82. 2005
    ..Data analysis showed that LC was protective against 3-NPA-induced toxicity, as reflected by both reduced mortality and significantly reduced neuronal degeneration...
  10. doi request reprint In vivo administration of fluorescent dextrans for the specific and sensitive localization of brain vascular pericytes and their characterization in normal and neurotoxin exposed brains
    Sumit Sarkar
    Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079, USA
    Neurotoxicology 33:436-43. 2012
    ..These novel fluorochromes should be of use for studies involving the detection and localization of pericytes in both normal and pathological brain tissues...
  11. ncbi request reprint Neurotoxicity of ecstasy (MDMA): an overview
    Sumit Sarkar
    Department of Neurotoxicology, National Center for Toxicological Research Food and Drug Administration, Jefferson, AR 72079, USA
    Curr Pharm Biotechnol 11:460-9. 2010
    ....
  12. ncbi request reprint Neuroprotective effect of L-carnitine in the 3-nitropropionic acid (3-NPA)-evoked neurotoxicity in rats
    Zbigniew Binienda
    Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
    Neurosci Lett 367:264-7. 2004
    ..It appears that l-carnitine is protective against 3-NPA-induced toxicity, as reflected by both reduced mortality and significantly reduced neuronal degeneration...