L Schmued

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons
    Larry C Schmued
    Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079, USA
    Brain Res 1035:24-31. 2005
  2. ncbi request reprint Black-gold: a simple, high-resolution histochemical label for normal and pathological myelin in brain tissue sections
    L Schmued
    Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
    Brain Res 837:289-97. 1999
  3. ncbi request reprint Demonstration and localization of neuronal degeneration in the rat forebrain following a single exposure to MDMA
    Larry C Schmued
    Department of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079, USA
    Brain Res 974:127-33. 2003
  4. ncbi request reprint The progression of neuronal, myelin, astrocytic, and immunological changes in the rat brain following exposure to aurothioglucose
    Larry C Schmued
    Department of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079, USA
    Brain Res 949:171-7. 2002
  5. ncbi request reprint Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration
    L C Schmued
    Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, 72079 9502, Jefferson, AR 72079 9502, USA
    Brain Res 874:123-30. 2000
  6. ncbi request reprint Neurohistochemical biomarkers of the marine neurotoxicant, domoic acid
    Andrew C Scallet
    Division of Neurotoxicology, National Center for Toxicological Research FDA 3900 NCTR Drive, Jefferson, Arkansas 72079, USA
    Neurotoxicol Teratol 27:745-52. 2005
  7. ncbi request reprint Fluoro-Ruby labeling prior to an amphetamine neurotoxic insult shows a definitive massive loss of dopaminergic terminals and axons in the caudate-putamen
    John F Bowyer
    Division of Neurotoxicology, National Center for Toxicological Research, HFT 132, Jefferson, AR 72079 9502, USA
    Brain Res 1075:236-9. 2006
  8. ncbi request reprint Neurotoxic-related changes in tyrosine hydroxylase, microglia, myelin, and the blood-brain barrier in the caudate-putamen from acute methamphetamine exposure
    John F Bowyer
    Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Synapse 62:193-204. 2008
  9. doi request reprint Brain region-specific neurodegenerative profiles showing the relative importance of amphetamine dose, hyperthermia, seizures, and the blood-brain barrier
    John F Bowyer
    Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA
    Ann N Y Acad Sci 1139:127-39. 2008
  10. ncbi request reprint The role of the N-methyl-D-aspartate receptor in ketamine-induced apoptosis in rat forebrain culture
    C Wang
    Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079 0502, USA
    Neuroscience 132:967-77. 2005

Detail Information

Publications11

  1. ncbi request reprint Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons
    Larry C Schmued
    Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079, USA
    Brain Res 1035:24-31. 2005
    ..Triple labeling was accomplished by staining degenerating neurons with Fluoro-Jade C, cell nuclei with DAPI and activated astrocytes with GFAP immunofluoresence...
  2. ncbi request reprint Black-gold: a simple, high-resolution histochemical label for normal and pathological myelin in brain tissue sections
    L Schmued
    Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
    Brain Res 837:289-97. 1999
    ..Advantages associated with the Black-Gold technique include high resolution, high contrast, short histochemical processing time, and consistent reproducibility...
  3. ncbi request reprint Demonstration and localization of neuronal degeneration in the rat forebrain following a single exposure to MDMA
    Larry C Schmued
    Department of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079, USA
    Brain Res 974:127-33. 2003
    ..The extent of neuronal degeneration observed generally correlated with the degree of hyperthermia achieved...
  4. ncbi request reprint The progression of neuronal, myelin, astrocytic, and immunological changes in the rat brain following exposure to aurothioglucose
    Larry C Schmued
    Department of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079, USA
    Brain Res 949:171-7. 2002
    ..The results of this study help resolve the mechanism of ATG toxicity as reflected by a cascade of pathologies that is consistent with disparate cell types exhibiting specific changes at specific times...
  5. ncbi request reprint Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration
    L C Schmued
    Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, 72079 9502, Jefferson, AR 72079 9502, USA
    Brain Res 874:123-30. 2000
    ..Like Fluoro-Jade, Fluoro-Jade B is compatible with a number of other labeling procedures including immunofluorescent and fluorescent Nissl techniques...
  6. ncbi request reprint Neurohistochemical biomarkers of the marine neurotoxicant, domoic acid
    Andrew C Scallet
    Division of Neurotoxicology, National Center for Toxicological Research FDA 3900 NCTR Drive, Jefferson, Arkansas 72079, USA
    Neurotoxicol Teratol 27:745-52. 2005
    ..We also observed that an impairment of blood-brain barrier integrity within the piriform cortex accompanied the onset of domoic acid neurotoxicity...
  7. ncbi request reprint Fluoro-Ruby labeling prior to an amphetamine neurotoxic insult shows a definitive massive loss of dopaminergic terminals and axons in the caudate-putamen
    John F Bowyer
    Division of Neurotoxicology, National Center for Toxicological Research, HFT 132, Jefferson, AR 72079 9502, USA
    Brain Res 1075:236-9. 2006
    ....
  8. ncbi request reprint Neurotoxic-related changes in tyrosine hydroxylase, microglia, myelin, and the blood-brain barrier in the caudate-putamen from acute methamphetamine exposure
    John F Bowyer
    Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Synapse 62:193-204. 2008
    ..The time course of microglial activation indicates a response to the neurodegeneration, myelin damage, and/or damaged DA terminals after loss of TH-IR...
  9. doi request reprint Brain region-specific neurodegenerative profiles showing the relative importance of amphetamine dose, hyperthermia, seizures, and the blood-brain barrier
    John F Bowyer
    Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA
    Ann N Y Acad Sci 1139:127-39. 2008
    ....
  10. ncbi request reprint The role of the N-methyl-D-aspartate receptor in ketamine-induced apoptosis in rat forebrain culture
    C Wang
    Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079 0502, USA
    Neuroscience 132:967-77. 2005
    ..These data suggest that NR1 antisense offers neuroprotection from apoptosis in vitro, and that upregulation of the NR1 following ketamine administration is, at least, partially responsible for the observed apoptosis...
  11. ncbi request reprint Relations between brain pathology and temporal lobe epilepsy
    Xia Zhang
    Neuropsychiatry Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E4
    J Neurosci 22:6052-61. 2002
    ....