Christian Sauder

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Susceptibility of Borna disease virus to the antiviral action of gamma-interferon: evidence for species-specific differences
    C Sauder
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Medical School, Freiburg, Germany
    Arch Virol 149:2171-86. 2004
  2. pmc Rat model of borna disease virus transmission: epidemiological implications
    Christian Sauder
    Department of Virology, University of Freiburg, D 79104 Freiburg, Germany
    J Virol 77:12886-90. 2003
  3. pmc Selective virus resistance conferred by expression of Borna disease virus nucleocapsid components
    Till Geib
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
    J Virol 77:4283-90. 2003
  4. ncbi request reprint Neurological disorder after Borna disease virus infection in the absence of either interferon-gamma, Fas, inducible NO synthase, or chemokine receptor CXCR3
    Jürgen Hausmann
    Department of Virology, University of Freiburg, Freiburg, Germany
    Viral Immunol 17:79-85. 2004
  5. pmc Changes in mumps virus gene sequence associated with variability in neurovirulent phenotype
    Steven A Rubin
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 77:11616-24. 2003
  6. ncbi request reprint High-avidity human serum antibodies recognizing linear epitopes of Borna disease virus proteins
    Christian Billich
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    Biol Psychiatry 51:979-87. 2002
  7. ncbi request reprint Identification of differentially expressed genes in brains of newborn Borna disease virus-infected rats in the absence of inflammation
    C Jehle
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    Arch Virol 148:45-63. 2003
  8. ncbi request reprint Upregulation of chemokine receptor gene expression in brains of Borna disease virus (BDV)-infected rats in the absence and presence of inflammation
    Mathias Rauer
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
    J Neurovirol 8:168-79. 2002
  9. ncbi request reprint A single nucleotide change in the mumps virus F gene affects virus fusogenicity in vitro and virulence in vivo
    Tahir Malik
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Neurovirol 13:513-21. 2007
  10. pmc Borna disease virus multiplication in mouse organotypic slice cultures is site-specifically inhibited by gamma interferon but not by interleukin-12
    Gregor Friedl
    Abteilung Neuropathologie, Pathologisches Institut, Universitat Freiburg, D 79106 Freiburg, Germany
    J Virol 78:1212-8. 2004

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Susceptibility of Borna disease virus to the antiviral action of gamma-interferon: evidence for species-specific differences
    C Sauder
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Medical School, Freiburg, Germany
    Arch Virol 149:2171-86. 2004
    ..These data suggest species-specific differences in the susceptibility of BDV to the antiviral action of IFNgamma...
  2. pmc Rat model of borna disease virus transmission: epidemiological implications
    Christian Sauder
    Department of Virology, University of Freiburg, D 79104 Freiburg, Germany
    J Virol 77:12886-90. 2003
    ..Thus, susceptible farm animals possibly acquire the virus from persistently infected rats...
  3. pmc Selective virus resistance conferred by expression of Borna disease virus nucleocapsid components
    Till Geib
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
    J Virol 77:4283-90. 2003
    ....
  4. ncbi request reprint Neurological disorder after Borna disease virus infection in the absence of either interferon-gamma, Fas, inducible NO synthase, or chemokine receptor CXCR3
    Jürgen Hausmann
    Department of Virology, University of Freiburg, Freiburg, Germany
    Viral Immunol 17:79-85. 2004
    ..Thus, BDV-induced disease may not result from the action of a single dominant T cell-dependent effector molecule. Disease rather reflects a combined influence of several as yet undefined factors from CD8 T cells...
  5. pmc Changes in mumps virus gene sequence associated with variability in neurovirulent phenotype
    Steven A Rubin
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 77:11616-24. 2003
    ..The potential role of these amino acid changes in neurotropism, neurovirulence, and neuroattenuation is discussed...
  6. ncbi request reprint High-avidity human serum antibodies recognizing linear epitopes of Borna disease virus proteins
    Christian Billich
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    Biol Psychiatry 51:979-87. 2002
    ..We further characterized the specificity of these antibodies...
  7. ncbi request reprint Identification of differentially expressed genes in brains of newborn Borna disease virus-infected rats in the absence of inflammation
    C Jehle
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    Arch Virol 148:45-63. 2003
    ..Employing cultured infected hippocampus slices and infected genetically modified mice, we provide evidence, that the observed upregulation of beta2m expression is not triggered by IFN-gamma, but rather by IFN-alpha/beta...
  8. ncbi request reprint Upregulation of chemokine receptor gene expression in brains of Borna disease virus (BDV)-infected rats in the absence and presence of inflammation
    Mathias Rauer
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
    J Neurovirol 8:168-79. 2002
    ..Fractalkine gene expression was found to be reduced to similar extents in brains of adult and newborn infected rats. These findings might be of relevance with respect to the selective neuronal cell loss observed in brains of PTI-NB rats...
  9. ncbi request reprint A single nucleotide change in the mumps virus F gene affects virus fusogenicity in vitro and virulence in vivo
    Tahir Malik
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Neurovirol 13:513-21. 2007
    ..This infectious clone system will serve as a key tool for further examination of the molecular basis for mumps virus neurovirulence and neuroattenuation...
  10. pmc Borna disease virus multiplication in mouse organotypic slice cultures is site-specifically inhibited by gamma interferon but not by interleukin-12
    Gregor Friedl
    Abteilung Neuropathologie, Pathologisches Institut, Universitat Freiburg, D 79106 Freiburg, Germany
    J Virol 78:1212-8. 2004
    ..They further show that IFN-gamma is a powerful inhibitor of BDV in the absence of blood-borne leukocytes in mouse cerebellar slice cultures...
  11. ncbi request reprint Characterization of the acute immune response in the retina of Borna disease virus infected Lewis rats
    Tobias Stahl
    Department of Veterinary Anatomy, University of Leipzig, An den Tierkliniken 43 D 04109 Leipzig, Germany
    J Neuroimmunol 137:67-78. 2003
    ..This suggests that similar immunopathological mechanisms are operating in retinae and brains of infected rats...
  12. ncbi request reprint Detection of anti-Borna disease virus antibodies by Western blot analysis
    Mimi Ghosh
    Psychiatry Res 134:105; author reply 106. 2005
  13. pmc Activation of microglia by borna disease virus infection: in vitro study
    Mikhail V Ovanesov
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, CMSC 8 121, Baltimore, MD 21287, USA
    J Virol 80:12141-8. 2006
    ..Taken together, the present data are the first in vitro evidence that persistent BDV infection of neurons and astrocytes rather than direct exposure to the virus or dying neurons is critical for activating microglia...
  14. ncbi request reprint Functional consequences of attenuating mutations in the haemagglutinin neuraminidase, fusion and polymerase proteins of a wild-type mumps virus strain
    Tahir Malik
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Gen Virol 88:2533-41. 2007
    ..These data suggest a polygenic component (i.e. specific and inter-related roles of these amino acid changes) to MuV neuroattenuation...
  15. ncbi request reprint Seroprevalence of Borna disease virus antibodies is not increased in patients with amyotrophic lateral sclerosis
    Johannes Prudlo
    J Neurol 249:1462-3. 2002
  16. doi request reprint Genetic contributions to influenza virus attenuation in the rat brain
    Li Qi
    CBER, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Neurovirol 14:136-42. 2008
    ..Further in vivo and in vitro examination of these five mutations, both individually and in combination, will likely provide important information on the role of specific virus genes in virulence and pathogenesis...