Research Topics
Species | Christian SauderSummaryAffiliation: Food and Drug Administration Country: USA Publications
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Publications
Susceptibility of Borna disease virus to the antiviral action of gamma-interferon: evidence for species-specific differencesC Sauder
Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Medical School, Freiburg, Germany
Arch Virol 149:2171-86. 2004..These data suggest species-specific differences in the susceptibility of BDV to the antiviral action of IFNgamma...
Rat model of borna disease virus transmission: epidemiological implicationsChristian Sauder
Department of Virology, University of Freiburg, D 79104 Freiburg, Germany
J Virol 77:12886-90. 2003..Thus, susceptible farm animals possibly acquire the virus from persistently infected rats...- Selective virus resistance conferred by expression of Borna disease virus nucleocapsid componentsTill Geib
Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
J Virol 77:4283-90. 2003.... - Neurological disorder after Borna disease virus infection in the absence of either interferon-gamma, Fas, inducible NO synthase, or chemokine receptor CXCR3Jürgen Hausmann
Department of Virology, University of Freiburg, Freiburg, Germany
Viral Immunol 17:79-85. 2004..Thus, BDV-induced disease may not result from the action of a single dominant T cell-dependent effector molecule. Disease rather reflects a combined influence of several as yet undefined factors from CD8 T cells... - Changes in mumps virus gene sequence associated with variability in neurovirulent phenotypeSteven A Rubin
DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
J Virol 77:11616-24. 2003..The potential role of these amino acid changes in neurotropism, neurovirulence, and neuroattenuation is discussed... - High-avidity human serum antibodies recognizing linear epitopes of Borna disease virus proteinsChristian Billich
Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
Biol Psychiatry 51:979-87. 2002..CONCLUSIONS: These data suggest that reactive antibodies found in psychiatric patients indeed indicate infection with BDV or a BDV-like agent. However, the poor affinity maturation of BDV-specific human antibodies remains unexplained... - Identification of differentially expressed genes in brains of newborn Borna disease virus-infected rats in the absence of inflammationC Jehle
Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
Arch Virol 148:45-63. 2003..Employing cultured infected hippocampus slices and infected genetically modified mice, we provide evidence, that the observed upregulation of beta2m expression is not triggered by IFN-gamma, but rather by IFN-alpha/beta... - Upregulation of chemokine receptor gene expression in brains of Borna disease virus (BDV)-infected rats in the absence and presence of inflammationMathias Rauer
Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
J Neurovirol 8:168-79. 2002..Fractalkine gene expression was found to be reduced to similar extents in brains of adult and newborn infected rats. These findings might be of relevance with respect to the selective neuronal cell loss observed in brains of PTI-NB rats... - A single nucleotide change in the mumps virus F gene affects virus fusogenicity in vitro and virulence in vivoTahir Malik
DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
J Neurovirol 13:513-21. 2007..This infectious clone system will serve as a key tool for further examination of the molecular basis for mumps virus neurovirulence and neuroattenuation... - Borna disease virus multiplication in mouse organotypic slice cultures is site-specifically inhibited by gamma interferon but not by interleukin-12Gregor Friedl
Abteilung Neuropathologie, Pathologisches Institut, , D-79106 Freiburg, Germany
J Virol 78:1212-8. 2004..They further show that IFN-gamma is a powerful inhibitor of BDV in the absence of blood-borne leukocytes in mouse cerebellar slice cultures... - Characterization of the acute immune response in the retina of Borna disease virus infected Lewis ratsTobias Stahl
Department of Veterinary Anatomy, University of Leipzig, An den Tierkliniken 43 D 04109 Leipzig, Germany
J Neuroimmunol 137:67-78. 2003..This suggests that similar immunopathological mechanisms are operating in retinae and brains of infected rats... - Detection of anti-Borna disease virus antibodies by Western blot analysisMimi Ghosh
Psychiatry Res 134:105; author reply 106. 2005 - Activation of microglia by borna disease virus infection: in vitro studyMikhail V Ovanesov
Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, CMSC 8-121, Baltimore, MD 21287, USA
J Virol 80:12141-8. 2006..Taken together, the present data are the first in vitro evidence that persistent BDV infection of neurons and astrocytes rather than direct exposure to the virus or dying neurons is critical for activating microglia... - Functional consequences of attenuating mutations in the haemagglutinin neuraminidase, fusion and polymerase proteins of a wild-type mumps virus strainTahir Malik
DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
J Gen Virol 88:2533-41. 2007..These data suggest a polygenic component (i.e. specific and inter-related roles of these amino acid changes) to MuV neuroattenuation... - Seroprevalence of Borna disease virus antibodies is not increased in patients with amyotrophic lateral sclerosisJohannes Prudlo
J Neurol 249:1462-3. 2002 
Genetic contributions to influenza virus attenuation in the rat brainLi Qi
CBER, Food and Drug Administration, Bethesda, Maryland 20892, USA
J Neurovirol 14:136-42. 2008..Further in vivo and in vitro examination of these five mutations, both individually and in combination, will likely provide important information on the role of specific virus genes in virulence and pathogenesis...