Christian J Sauder

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection
    Mikhail V Ovanesov
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neuroinflammation 5:50. 2008
  2. doi request reprint The IP10 (CXCL10) specific cDNA probe of the mCK-5c multiprobe RNase protection assay kit carries two nucleotide insertions that complicate the interpretation of results
    Christian Sauder
    Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Building 29A, Room 2C 20, HFM460, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Cytokine 41:182-6. 2008
  3. pmc Gene-specific contributions to mumps virus neurovirulence and neuroattenuation
    Christian J Sauder
    United States Food and Drug Administration, CBER, OVRR, DVP, 8800 Rockville Pike, Building 29A, HFM 460, Room 2C20, Bethesda, MD 20892, USA
    J Virol 85:7059-69. 2011
  4. doi request reprint Presence of lysine at aa 335 of the hemagglutinin-neuraminidase protein of mumps virus vaccine strain Urabe AM9 is not a requirement for neurovirulence
    Christian J Sauder
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Vaccine 27:5822-9. 2009
  5. ncbi request reprint Changes in mumps virus neurovirulence phenotype associated with quasispecies heterogeneity
    Christian J Sauder
    DVP Office of Vaccines Research and Review, Center for Biologics, Evaluation and Research, Food and Drug Administration, Building 29A, Room 1A 21, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Virology 350:48-57. 2006
  6. pmc Recent mumps outbreaks in vaccinated populations: no evidence of immune escape
    Steven A Rubin
    Division of Viral Products, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland, USA
    J Virol 86:615-20. 2012
  7. ncbi request reprint A single nucleotide change in the mumps virus F gene affects virus fusogenicity in vitro and virulence in vivo
    Tahir Malik
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Neurovirol 13:513-21. 2007
  8. ncbi request reprint Functional consequences of attenuating mutations in the haemagglutinin neuraminidase, fusion and polymerase proteins of a wild-type mumps virus strain
    Tahir Malik
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Gen Virol 88:2533-41. 2007
  9. pmc Changes in mumps virus gene sequence associated with variability in neurovirulent phenotype
    Steven A Rubin
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 77:11616-24. 2003
  10. pmc Selective virus resistance conferred by expression of Borna disease virus nucleocapsid components
    Till Geib
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
    J Virol 77:4283-90. 2003

Collaborators

  • Steven A Rubin
  • Tahir H Malik
  • P Staeheli
  • Georgios Amexis
  • Zhiping Ye
  • Markus Hofer
  • Candie Wolbert
  • Li Qi
  • Mikhail Ovanesov
  • Mikhail V Ovanesov
  • Joao A Pedras-Vasconcelos
  • Gregor Friedl
  • Till Geib
  • Daniela Verthelyi
  • Kathryn M Carbone
  • David Goucher
  • Krisztina Moldovan
  • Yavuz Ayhan
  • Mikhail V Pletnikov
  • Mikhail Pletnikov
  • Teresa Liu
  • Montserrat Puig
  • Bernd Auber
  • Jürgen Hausmann
  • Axel Pagenstecher
  • Martin Schwemmle
  • Christel Hässler
  • Sascha Venturelli

Detail Information

Publications13

  1. pmc Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection
    Mikhail V Ovanesov
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neuroinflammation 5:50. 2008
    ..The data are consistent with the hypothesis that microglia activation in the absence of neuronal damage may represent initial steps in the gradual neurodegeneration observed in brains of neonatally BDV-infected rats...
  2. doi request reprint The IP10 (CXCL10) specific cDNA probe of the mCK-5c multiprobe RNase protection assay kit carries two nucleotide insertions that complicate the interpretation of results
    Christian Sauder
    Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Building 29A, Room 2C 20, HFM460, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Cytokine 41:182-6. 2008
    ....
  3. pmc Gene-specific contributions to mumps virus neurovirulence and neuroattenuation
    Christian J Sauder
    United States Food and Drug Administration, CBER, OVRR, DVP, 8800 Rockville Pike, Building 29A, HFM 460, Room 2C20, Bethesda, MD 20892, USA
    J Virol 85:7059-69. 2011
    ....
  4. doi request reprint Presence of lysine at aa 335 of the hemagglutinin-neuraminidase protein of mumps virus vaccine strain Urabe AM9 is not a requirement for neurovirulence
    Christian J Sauder
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Vaccine 27:5822-9. 2009
    ....
  5. ncbi request reprint Changes in mumps virus neurovirulence phenotype associated with quasispecies heterogeneity
    Christian J Sauder
    DVP Office of Vaccines Research and Review, Center for Biologics, Evaluation and Research, Food and Drug Administration, Building 29A, Room 1A 21, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Virology 350:48-57. 2006
    ....
  6. pmc Recent mumps outbreaks in vaccinated populations: no evidence of immune escape
    Steven A Rubin
    Division of Viral Products, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland, USA
    J Virol 86:615-20. 2012
    ..Although the geometric mean neutralizing antibody titer of the sera was lower against some virus strains than others, all viruses were readily neutralized, arguing against immune escape...
  7. ncbi request reprint A single nucleotide change in the mumps virus F gene affects virus fusogenicity in vitro and virulence in vivo
    Tahir Malik
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Neurovirol 13:513-21. 2007
    ..This infectious clone system will serve as a key tool for further examination of the molecular basis for mumps virus neurovirulence and neuroattenuation...
  8. ncbi request reprint Functional consequences of attenuating mutations in the haemagglutinin neuraminidase, fusion and polymerase proteins of a wild-type mumps virus strain
    Tahir Malik
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Gen Virol 88:2533-41. 2007
    ..These data suggest a polygenic component (i.e. specific and inter-related roles of these amino acid changes) to MuV neuroattenuation...
  9. pmc Changes in mumps virus gene sequence associated with variability in neurovirulent phenotype
    Steven A Rubin
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 77:11616-24. 2003
    ..The potential role of these amino acid changes in neurotropism, neurovirulence, and neuroattenuation is discussed...
  10. pmc Selective virus resistance conferred by expression of Borna disease virus nucleocapsid components
    Till Geib
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
    J Virol 77:4283-90. 2003
    ....
  11. doi request reprint Genetic contributions to influenza virus attenuation in the rat brain
    Li Qi
    CBER, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Neurovirol 14:136-42. 2008
    ..Further in vivo and in vitro examination of these five mutations, both individually and in combination, will likely provide important information on the role of specific virus genes in virulence and pathogenesis...
  12. ncbi request reprint Immunotherapy with CpG oligonucleotides and antibodies to TNF-alpha rescues neonatal mice from lethal arenavirus-induced meningoencephalitis
    Joao A Pedras-Vasconcelos
    Laboratory of Immunology, Division of Therapeutic Proteins, Office of Biotechnology, Center for Drug Evaluation and Review, FDA, Bethesda, MD 20892, USA
    J Immunol 180:8231-40. 2008
    ..To our knowledge, this is the first demonstration of the use of innate immune modulators plus Abs to TNF-alpha as therapeutics for a lethal neurotropic viral infection...
  13. pmc Borna disease virus multiplication in mouse organotypic slice cultures is site-specifically inhibited by gamma interferon but not by interleukin-12
    Gregor Friedl
    Abteilung Neuropathologie, Pathologisches Institut, Universitat Freiburg, D 79106 Freiburg, Germany
    J Virol 78:1212-8. 2004
    ..They further show that IFN-gamma is a powerful inhibitor of BDV in the absence of blood-borne leukocytes in mouse cerebellar slice cultures...