Research Topics
Genomes and GenesSpecies | Christian J SauderSummaryAffiliation: Food and Drug Administration Country: USA Publications
| Collaborators
|
Detail Information
Publications
Astrocytes play a key role in activation of microglia by persistent Borna disease virus infectionMikhail V Ovanesov
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Neuroinflammation 5:50. 2008..The data are consistent with the hypothesis that microglia activation in the absence of neuronal damage may represent initial steps in the gradual neurodegeneration observed in brains of neonatally BDV-infected rats...
The IP10 (CXCL10) specific cDNA probe of the mCK-5c multiprobe RNase protection assay kit carries two nucleotide insertions that complicate the interpretation of resultsChristian Sauder
Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Building 29A, Room 2C 20, HFM460, 8800 Rockville Pike, Bethesda, MD 20892, USA
Cytokine 41:182-6. 2008....- Gene-specific contributions to mumps virus neurovirulence and neuroattenuationChristian J Sauder
United States Food and Drug Administration, CBER, OVRR, DVP, 8800 Rockville Pike, Building 29A, HFM 460, Room 2C20, Bethesda, MD 20892, USA
J Virol 85:7059-69. 2011.... - Presence of lysine at aa 335 of the hemagglutinin-neuraminidase protein of mumps virus vaccine strain Urabe AM9 is not a requirement for neurovirulenceChristian J Sauder
DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Vaccine 27:5822-9. 2009.... 
Changes in mumps virus neurovirulence phenotype associated with quasispecies heterogeneityChristian J Sauder
DVP/Office of Vaccines Research and Review, Center for Biologics, Evaluation and Research, Food and Drug Administration, Building 29A, Room 1A-21, 8800 Rockville Pike, Bethesda, MD 20892, USA
Virology 350:48-57. 2006....- Recent mumps outbreaks in vaccinated populations: no evidence of immune escapeSteven A Rubin
Division of Viral Products, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland, USA
J Virol 86:615-20. 2012..Although the geometric mean neutralizing antibody titer of the sera was lower against some virus strains than others, all viruses were readily neutralized, arguing against immune escape... - A single nucleotide change in the mumps virus F gene affects virus fusogenicity in vitro and virulence in vivoTahir Malik
DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
J Neurovirol 13:513-21. 2007..This infectious clone system will serve as a key tool for further examination of the molecular basis for mumps virus neurovirulence and neuroattenuation... - Functional consequences of attenuating mutations in the haemagglutinin neuraminidase, fusion and polymerase proteins of a wild-type mumps virus strainTahir Malik
DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
J Gen Virol 88:2533-41. 2007..These data suggest a polygenic component (i.e. specific and inter-related roles of these amino acid changes) to MuV neuroattenuation... - Changes in mumps virus gene sequence associated with variability in neurovirulent phenotypeSteven A Rubin
DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
J Virol 77:11616-24. 2003..The potential role of these amino acid changes in neurotropism, neurovirulence, and neuroattenuation is discussed... - Selective virus resistance conferred by expression of Borna disease virus nucleocapsid componentsTill Geib
Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany
J Virol 77:4283-90. 2003.... - Genetic contributions to influenza virus attenuation in the rat brainLi Qi
CBER, Food and Drug Administration, Bethesda, Maryland 20892, USA
J Neurovirol 14:136-42. 2008..Further in vivo and in vitro examination of these five mutations, both individually and in combination, will likely provide important information on the role of specific virus genes in virulence and pathogenesis... - Immunotherapy with CpG oligonucleotides and antibodies to TNF-alpha rescues neonatal mice from lethal arenavirus-induced meningoencephalitisJoao A Pedras-Vasconcelos
Laboratory of Immunology, Division of Therapeutic Proteins, Office of Biotechnology, Center for Drug Evaluation and Review, FDA, Bethesda, MD 20892, USA
J Immunol 180:8231-40. 2008..To our knowledge, this is the first demonstration of the use of innate immune modulators plus Abs to TNF-alpha as therapeutics for a lethal neurotropic viral infection... - Borna disease virus multiplication in mouse organotypic slice cultures is site-specifically inhibited by gamma interferon but not by interleukin-12Gregor Friedl
Abteilung Neuropathologie, Pathologisches Institut, , D-79106 Freiburg, Germany
J Virol 78:1212-8. 2004..They further show that IFN-gamma is a powerful inhibitor of BDV in the absence of blood-borne leukocytes in mouse cerebellar slice cultures...