William F Salminen

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. doi request reprint Green tea extract can potentiate acetaminophen-induced hepatotoxicity in mice
    William F Salminen
    Division of Systems Biology, US FDA National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Food Chem Toxicol 50:1439-46. 2012
  2. pmc Mouse liver protein sulfhydryl depletion after acetaminophen exposure
    Xi Yang
    Division of Systems Biology, National Center for Toxicological Research, Jefferson, Arkansas, USA
    J Pharmacol Exp Ther 344:286-94. 2013
  3. doi request reprint Identification of urinary microRNA profiles in rats that may diagnose hepatotoxicity
    Xi Yang
    Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Toxicol Sci 125:335-44. 2012
  4. doi request reprint Green tea epigallocatechin gallate binds to and inhibits respiratory complexes in swelling but not normal rat hepatic mitochondria
    Zuquan Weng
    Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Biochem Biophys Res Commun 443:1097-104. 2014
  5. ncbi request reprint Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes
    Qiang Shi
    Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Toxicol Sci 122:579-86. 2011
  6. pmc Changes in mouse liver protein glutathionylation after acetaminophen exposure
    Xi Yang
    Division of Systems Biology, Food and Drug Administration National Center for Toxicological Research, Jefferson, AR 72079, USA
    J Pharmacol Exp Ther 340:360-8. 2012
  7. doi request reprint Mechanisms for epigallocatechin gallate induced inhibition of drug metabolizing enzymes in rat liver microsomes
    Zuquan Weng
    Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Toxicol Lett 214:328-38. 2012
  8. doi request reprint Kava extract, an herbal alternative for anxiety relief, potentiates acetaminophen-induced cytotoxicity in rat hepatic cells
    Xi Yang
    Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Phytomedicine 18:592-600. 2011
  9. ncbi request reprint Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes
    Qiang Shi
    Division of Systems Biology, National Center for Toxicological Research, U S FDA, 3900 NCTR Road, Jefferson, AR, 72079, USA
    J Appl Toxicol 34:835-40. 2014
  10. doi request reprint Metabolomics evaluation of the effects of green tea extract on acetaminophen-induced hepatotoxicity in mice
    Yihong Lu
    Division of Systems Biology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    Food Chem Toxicol 62:707-21. 2013

Collaborators

Detail Information

Publications10

  1. doi request reprint Green tea extract can potentiate acetaminophen-induced hepatotoxicity in mice
    William F Salminen
    Division of Systems Biology, US FDA National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Food Chem Toxicol 50:1439-46. 2012
    ..These results highlight the potential for drug-dietary supplement interactions and the importance of testing multiple exposure scenarios to adequately model different types of potential interactions...
  2. pmc Mouse liver protein sulfhydryl depletion after acetaminophen exposure
    Xi Yang
    Division of Systems Biology, National Center for Toxicological Research, Jefferson, Arkansas, USA
    J Pharmacol Exp Ther 344:286-94. 2013
    ..These temporal and zonal pattern changes in protein sulfhydryl oxidation shed new light on the importance that changes in protein redox status might play in the pathogenesis of APAP hepatotoxicity...
  3. doi request reprint Identification of urinary microRNA profiles in rats that may diagnose hepatotoxicity
    Xi Yang
    Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Toxicol Sci 125:335-44. 2012
    ..In conclusion, the patterns of urinary miRNA may hold promise as biomarkers of hepatotoxicant-induced liver injury...
  4. doi request reprint Green tea epigallocatechin gallate binds to and inhibits respiratory complexes in swelling but not normal rat hepatic mitochondria
    Zuquan Weng
    Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Biochem Biophys Res Commun 443:1097-104. 2014
    ..This study identified hepatic RCCs as targets for EGCG in swelling but not normal mitochondria, suggesting EGCG may trigger hepatotoxicity by worsening pre-existing mitochondria abnormalities. ..
  5. ncbi request reprint Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes
    Qiang Shi
    Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Toxicol Sci 122:579-86. 2011
    ....
  6. pmc Changes in mouse liver protein glutathionylation after acetaminophen exposure
    Xi Yang
    Division of Systems Biology, Food and Drug Administration National Center for Toxicological Research, Jefferson, AR 72079, USA
    J Pharmacol Exp Ther 340:360-8. 2012
    ..These temporal and zonal pattern changes in protein glutathionylation after APAP exposure indicate that protein glutathionylation may play a role in protein homeostasis during APAP-induced hepatocellular injury...
  7. doi request reprint Mechanisms for epigallocatechin gallate induced inhibition of drug metabolizing enzymes in rat liver microsomes
    Zuquan Weng
    Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Toxicol Lett 214:328-38. 2012
    ..EGCG effects were partially abolished in the presence of 1mM glutathione, suggesting they are particularly relevant to the in vivo conditions when glutathione is depleted by toxicant insults...
  8. doi request reprint Kava extract, an herbal alternative for anxiety relief, potentiates acetaminophen-induced cytotoxicity in rat hepatic cells
    Xi Yang
    Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Phytomedicine 18:592-600. 2011
    ..These results highlight the potential for drug-dietary supplement interactions even with widely used over-the-counter drugs...
  9. ncbi request reprint Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes
    Qiang Shi
    Division of Systems Biology, National Center for Toxicological Research, U S FDA, 3900 NCTR Road, Jefferson, AR, 72079, USA
    J Appl Toxicol 34:835-40. 2014
    ..Published 2013. This article is a U.S. Government work and is in the public domain in the USA. ..
  10. doi request reprint Metabolomics evaluation of the effects of green tea extract on acetaminophen-induced hepatotoxicity in mice
    Yihong Lu
    Division of Systems Biology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    Food Chem Toxicol 62:707-21. 2013
    ..These studies demonstrate the complex interaction between GTE and APAP and the need to employ novel analytical strategies to understand the effects of dietary supplements on pharmaceutical compounds. ..