S A Rubin

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint The rat-based neurovirulence safety test for the assessment of mumps virus neurovirulence in humans: an international collaborative study
    Steven A Rubin
    Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Adminstration, Bethesda, Maryland 20892, USA
    J Infect Dis 191:1123-8. 2005
  2. ncbi request reprint The mumps virus neurovirulence safety test in Rhesus monkeys: a comparison of mumps virus strains
    S A Rubin
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Infect Dis 180:521-5. 1999
  3. ncbi request reprint Wild-type and attenuated influenza virus infection of the neonatal rat brain
    Steven Rubin
    DVP OVRR CBER FDA, Bethesda, Maryland 20892, USA
    J Neurovirol 10:305-14. 2004
  4. pmc Evaluation of a neonatal rat model for prediction of mumps virus neurovirulence in humans
    S A Rubin
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 74:5382-4. 2000
  5. ncbi request reprint Serological and phylogenetic evidence of monotypic immune responses to different mumps virus strains
    Steven Rubin
    Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA
    Vaccine 24:2662-8. 2006
  6. pmc Changes in mumps virus gene sequence associated with variability in neurovirulent phenotype
    Steven A Rubin
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 77:11616-24. 2003
  7. ncbi request reprint Changes in mumps virus neurovirulence phenotype associated with quasispecies heterogeneity
    Christian J Sauder
    DVP Office of Vaccines Research and Review, Center for Biologics, Evaluation and Research, Food and Drug Administration, Building 29A, Room 1A 21, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Virology 350:48-57. 2006
  8. doi request reprint Presence of lysine at aa 335 of the hemagglutinin-neuraminidase protein of mumps virus vaccine strain Urabe AM9 is not a requirement for neurovirulence
    Christian J Sauder
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Vaccine 27:5822-9. 2009
  9. ncbi request reprint Persistent neonatal Borna disease virus (BDV) infection of the brain causes chronic emotional abnormalities in adult rats
    M V Pletnikov
    Laboratory of Pediatric and Respiratory Viral Diseases, CBER, FDA, Bethesda, MD 20892, USA
    Physiol Behav 66:823-31. 1999
  10. ncbi request reprint Borna disease virus (BDV)-induced model of autism: application to vaccine safety test design
    K M Carbone
    Dept of Psychiatry, The Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Mol Psychiatry 7:S36-7. 2002

Detail Information

Publications24

  1. ncbi request reprint The rat-based neurovirulence safety test for the assessment of mumps virus neurovirulence in humans: an international collaborative study
    Steven A Rubin
    Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Adminstration, Bethesda, Maryland 20892, USA
    J Infect Dis 191:1123-8. 2005
    ..Results indicate that the assay correctly assesses the neurovirulence potential of mumps viruses in humans and is robust and reproducible...
  2. ncbi request reprint The mumps virus neurovirulence safety test in Rhesus monkeys: a comparison of mumps virus strains
    S A Rubin
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Infect Dis 180:521-5. 1999
    ..Results indicated the need for further examination and refinement of the MNVT or for development of alternative MNVTs...
  3. ncbi request reprint Wild-type and attenuated influenza virus infection of the neonatal rat brain
    Steven Rubin
    DVP OVRR CBER FDA, Bethesda, Maryland 20892, USA
    J Neurovirol 10:305-14. 2004
    ....
  4. pmc Evaluation of a neonatal rat model for prediction of mumps virus neurovirulence in humans
    S A Rubin
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 74:5382-4. 2000
    ..The relative human neurovirulence of these strains was proportional to the severity of hydrocephalus in rats but not to lesion scores in the monkeys...
  5. ncbi request reprint Serological and phylogenetic evidence of monotypic immune responses to different mumps virus strains
    Steven Rubin
    Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA
    Vaccine 24:2662-8. 2006
    ....
  6. pmc Changes in mumps virus gene sequence associated with variability in neurovirulent phenotype
    Steven A Rubin
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 77:11616-24. 2003
    ..The potential role of these amino acid changes in neurotropism, neurovirulence, and neuroattenuation is discussed...
  7. ncbi request reprint Changes in mumps virus neurovirulence phenotype associated with quasispecies heterogeneity
    Christian J Sauder
    DVP Office of Vaccines Research and Review, Center for Biologics, Evaluation and Research, Food and Drug Administration, Building 29A, Room 1A 21, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Virology 350:48-57. 2006
    ....
  8. doi request reprint Presence of lysine at aa 335 of the hemagglutinin-neuraminidase protein of mumps virus vaccine strain Urabe AM9 is not a requirement for neurovirulence
    Christian J Sauder
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Vaccine 27:5822-9. 2009
    ....
  9. ncbi request reprint Persistent neonatal Borna disease virus (BDV) infection of the brain causes chronic emotional abnormalities in adult rats
    M V Pletnikov
    Laboratory of Pediatric and Respiratory Viral Diseases, CBER, FDA, Bethesda, MD 20892, USA
    Physiol Behav 66:823-31. 1999
    ..The findings indicate that neonatally BDV-infected adult rats are hyperreactive to aversive stimuli, possibly as a result of chronic emotional abnormalities...
  10. ncbi request reprint Borna disease virus (BDV)-induced model of autism: application to vaccine safety test design
    K M Carbone
    Dept of Psychiatry, The Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Mol Psychiatry 7:S36-7. 2002
  11. ncbi request reprint Developmental brain injury associated with abnormal play behavior in neonatally Borna disease virus-infected Lewis rats: a model of autism
    M V Pletnikov
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Behav Brain Res 100:43-50. 1999
    ..These data demonstrate deficits in play behavior and other social interactions following BDV-associated developmental brain injury, thus supporting the value of the neonatally BDV-infected rat as an animal model of autism...
  12. ncbi request reprint Effects of neonatal rat Borna disease virus (BDV) infection on the postnatal development of the brain monoaminergic systems
    M V Pletnikov
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Brain Res Dev Brain Res 119:179-85. 2000
    ..This pattern of changes is consistent with the previously reported behavioral abnormalities resulting from neonatal BDV infection...
  13. ncbi request reprint Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. I. Brain pathology and behavioral deficits
    Mikhail V Pletnikov
    Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Brain Res 944:97-107. 2002
    ..The present data demonstrate that the same environmental insult can produce differential neuroanatomical and behavioral abnormalities in genetically different inbred rat strains...
  14. pmc A mouse-based assay for the pre-clinical neurovirulence assessment of vaccinia virus-based smallpox vaccines
    Cheryl X Zhang
    FDA, Division of Viral Products, Lincoln Drive, Bethesda, MD 20892, USA
    Biologicals 38:278-83. 2010
    ..Our data indicate that testing of 10-100 pfu of virus in mice following intracranial inoculation reliably assesses the virus's neurovirulence potential for humans...
  15. ncbi request reprint Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. II. Neurochemical alterations and responses to pharmacological treatments
    Mikhail V Pletnikov
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Brain Res 944:108-23. 2002
    ..The present data provide new insights into the pathogenic events that lead to differential responses to pharmacological treatments in genetically different animals following exposure to the same environmental challenge...
  16. doi request reprint Neurovirulence safety testing of mumps vaccines--historical perspective and current status
    S A Rubin
    Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, USA
    Vaccine 29:2850-5. 2011
    ..This review summarizes the current status of mumps vaccine neurovirulence safety testing and insights into models currently approved and those under development...
  17. ncbi request reprint Mouse neurotoxicity test for vaccinia-based smallpox vaccines
    Zhongqi Li
    Laboratory of Pediatric and Respiratory Viral Diseases, OD Center for Biologics Evaluation and Research, Food and Drug Administration, HFM 460, Bldg 29B, Room 5NN22, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Vaccine 22:1486-93. 2004
    ..With further validation, this assay incorporating a licensed vaccine reference standard and positive control strain may provide important pre-clinical neurotoxicity data on new vaccinia-based smallpox vaccine strains...
  18. doi request reprint Antibody induced by immunization with the Jeryl Lynn mumps vaccine strain effectively neutralizes a heterologous wild-type mumps virus associated with a large outbreak
    Steven A Rubin
    Division of Viral Products, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Infect Dis 198:508-15. 2008
    ....
  19. ncbi request reprint Borna disease: virus-induced neurobehavioral disease pathogenesis
    K M Carbone
    FDA CBER, Laboratory of Pediatric and Respiratory Viral Diseases, HFM 460, 8800 Rockville Pike, Bethesda, Maryland 20892, USA
    Curr Opin Microbiol 4:467-75. 2001
    ..Data and debate continue to be forthcoming about the role of Borna disease virus in human infection and psychiatric disease...
  20. doi request reprint Genetic contributions to influenza virus attenuation in the rat brain
    Li Qi
    CBER, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Neurovirol 14:136-42. 2008
    ..Further in vivo and in vitro examination of these five mutations, both individually and in combination, will likely provide important information on the role of specific virus genes in virulence and pathogenesis...
  21. ncbi request reprint Functional consequences of attenuating mutations in the haemagglutinin neuraminidase, fusion and polymerase proteins of a wild-type mumps virus strain
    Tahir Malik
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Gen Virol 88:2533-41. 2007
    ..These data suggest a polygenic component (i.e. specific and inter-related roles of these amino acid changes) to MuV neuroattenuation...
  22. ncbi request reprint Exploring the cerebellum with a new tool: neonatal Borna disease virus (BDV) infection of the rat's brain
    Mikhail V Pletnikov
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cerebellum 2:62-70. 2003
    ....
  23. pmc Enhanced neurovirulence of borna disease virus variants associated with nucleotide changes in the glycoprotein and L polymerase genes
    Yoshii Nishino
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 76:8650-8. 2002
    ..These results suggest that small numbers of genomic differences between BDV variants in the G protein and/or L polymerase can contribute to the variability in BD outcomes...
  24. pmc Activation of microglia by borna disease virus infection: in vitro study
    Mikhail V Ovanesov
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, CMSC 8 121, Baltimore, MD 21287, USA
    J Virol 80:12141-8. 2006
    ..Taken together, the present data are the first in vitro evidence that persistent BDV infection of neurons and astrocytes rather than direct exposure to the virus or dying neurons is critical for activating microglia...