Jennifer L Reed

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc Cytosolic, autocrine alpha-1 proteinase inhibitor (A1PI) inhibits caspase-1 and blocks IL-1β dependent cytokine release in monocytes
    Yonggang Wang
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    PLoS ONE 7:e51078. 2012
  2. doi request reprint Eczema vaccinatum
    Jennifer L Reed
    Laboratory of Plasma Derivatives, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20892, USA
    Clin Infect Dis 54:832-40. 2012
  3. doi request reprint Innate immune signals modulate antiviral and polyreactive antibody responses during severe respiratory syncytial virus infection
    Jennifer L Reed
    Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA
    J Infect Dis 199:1128-38. 2009
  4. doi request reprint Macrophage impairment underlies airway occlusion in primary respiratory syncytial virus bronchiolitis
    Jennifer L Reed
    Respiratory, Inflammation, and Autoimmunity Group, MedImmune, Gaithersburg, Maryland, USA
    J Infect Dis 198:1783-93. 2008
  5. doi request reprint Respiratory syncytial virus and influenza virus infections: observations from tissues of fatal infant cases
    Timothy P Welliver
    MedImmune, Inc, Gaithersburg, MD, USA
    Pediatr Infect Dis J 27:S92-6. 2008
  6. pmc Epitope mapping by random peptide phage display reveals essential residues for vaccinia extracellular enveloped virion spread
    Yong He
    Laboratory of Plasma Derivatives, Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, FDA CBER OBRR DH LPD, HFM 345, 1401 Rockville Pike, Rockville, MD 20852, USA
    Virol J 9:217. 2012
  7. doi request reprint Mucosal antibody responses are directed by viral burden in children with acute influenza infection
    Yong He
    Food and Drug Administration, Center for Biologics Evaluation and Research, Bethesda, MD, USA
    Influenza Other Respir Viruses 7:46-54. 2013
  8. ncbi request reprint Severe human lower respiratory tract illness caused by respiratory syncytial virus and influenza virus is characterized by the absence of pulmonary cytotoxic lymphocyte responses
    Timothy P Welliver
    MedImmune, Inc, Gaithersburg, MD, USA
    J Infect Dis 195:1126-36. 2007
  9. doi request reprint MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function
    Roland Kolbeck
    Department of Respiratory, Inflammation and Autoimmunity, MedImmune, LLC, Gaithersburg, MD 20878, USA
    J Allergy Clin Immunol 125:1344-1353.e2. 2010
  10. pmc Isolation and characterization of monoclonal antibodies which neutralize human metapneumovirus in vitro and in vivo
    Nancy D Ulbrandt
    MedImmune, Inc, 1 MedImmune Way, Gaithersburg, MD 20878, USA
    J Virol 80:7799-806. 2006

Collaborators

Detail Information

Publications11

  1. pmc Cytosolic, autocrine alpha-1 proteinase inhibitor (A1PI) inhibits caspase-1 and blocks IL-1β dependent cytokine release in monocytes
    Yonggang Wang
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    PLoS ONE 7:e51078. 2012
    ..These studies examine the relationship between A1PI expression in primary monocytes and monocytic cell lines, and inflammatory cytokine expression in response to inflammasome directed stimuli...
  2. doi request reprint Eczema vaccinatum
    Jennifer L Reed
    Laboratory of Plasma Derivatives, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20892, USA
    Clin Infect Dis 54:832-40. 2012
    ..We conclude by considering how its occurrence might be minimized in the event of a return to universal vaccination...
  3. doi request reprint Innate immune signals modulate antiviral and polyreactive antibody responses during severe respiratory syncytial virus infection
    Jennifer L Reed
    Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA
    J Infect Dis 199:1128-38. 2009
    ..We conclude that B lymphocyte-stimulating factors derived from infected epithelium are primary determinants of the mucosal antibody response in infant RSV bronchiolitis...
  4. doi request reprint Macrophage impairment underlies airway occlusion in primary respiratory syncytial virus bronchiolitis
    Jennifer L Reed
    Respiratory, Inflammation, and Autoimmunity Group, MedImmune, Gaithersburg, Maryland, USA
    J Infect Dis 198:1783-93. 2008
    ..Together, our data suggest that innate, rather than adaptive, immune responses are critical determinants of the severity of RSV bronchiolitis...
  5. doi request reprint Respiratory syncytial virus and influenza virus infections: observations from tissues of fatal infant cases
    Timothy P Welliver
    MedImmune, Inc, Gaithersburg, MD, USA
    Pediatr Infect Dis J 27:S92-6. 2008
    ..Severe infantile RSV and influenza virus LRTI is characterized by inadequate (rather than excessive) adaptive immune responses, robust viral replication and apoptotic crisis...
  6. pmc Epitope mapping by random peptide phage display reveals essential residues for vaccinia extracellular enveloped virion spread
    Yong He
    Laboratory of Plasma Derivatives, Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, FDA CBER OBRR DH LPD, HFM 345, 1401 Rockville Pike, Rockville, MD 20852, USA
    Virol J 9:217. 2012
    ..In this study, we utilized a random phage display library to investigate the epitope recognized by MAb-1G10 that is critical for facilitating cell-to-cell spread of the vaccinia virus...
  7. doi request reprint Mucosal antibody responses are directed by viral burden in children with acute influenza infection
    Yong He
    Food and Drug Administration, Center for Biologics Evaluation and Research, Bethesda, MD, USA
    Influenza Other Respir Viruses 7:46-54. 2013
    ..While mucosal antibodies can limit influenza-associated infection and disease, little is known about acute mucosal antibody responses to influenza infection...
  8. ncbi request reprint Severe human lower respiratory tract illness caused by respiratory syncytial virus and influenza virus is characterized by the absence of pulmonary cytotoxic lymphocyte responses
    Timothy P Welliver
    MedImmune, Inc, Gaithersburg, MD, USA
    J Infect Dis 195:1126-36. 2007
    ..It is widely believed that both viral replication and inappropriately enhanced immune responses contribute to disease severity. In infants, RSV LRTI is known to be more severe than influenza virus LRTI...
  9. doi request reprint MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function
    Roland Kolbeck
    Department of Respiratory, Inflammation and Autoimmunity, MedImmune, LLC, Gaithersburg, MD 20878, USA
    J Allergy Clin Immunol 125:1344-1353.e2. 2010
    ....
  10. pmc Isolation and characterization of monoclonal antibodies which neutralize human metapneumovirus in vitro and in vivo
    Nancy D Ulbrandt
    MedImmune, Inc, 1 MedImmune Way, Gaithersburg, MD 20878, USA
    J Virol 80:7799-806. 2006
    ..The data suggest that a monoclonal antibody could be used prophylactically to prevent lower respiratory tract disease caused by hMPV...
  11. ncbi request reprint Safety and immunogenicity of a recombinant parvovirus B19 vaccine formulated with MF59C.1
    W Ripley Ballou
    Clinical Development, MedImmune, Gaithersburg, Maryland 20878, USA
    J Infect Dis 187:675-8. 2003
    ..5 or 25 microg MEDI-491 at 0, 1, and 6 months. MEDI-491 was safe and immunogenic. All volunteers developed neutralizing antibody titers that peaked after the third immunization and were sustained through study day 364...