Cynthia M Porter

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Characterization and expansion of baboon CD4+CD25+ Treg cells for potential use in a non-human primate xenotransplantation model
    Cynthia M Porter
    Division of Cellular and Gene Therapy, CBER, FDA, Bethesda, Mayland 20892, USA
    Xenotransplantation 14:298-308. 2007
  2. doi request reprint Characterization of baboon NK cells and their xenogeneic activity
    Sarah B Kennett
    Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Bethesda, MD, USA
    Xenotransplantation 17:288-99. 2010
  3. ncbi request reprint Lipophilic statins suppress cytotoxicity by freshly isolated natural killer cells through modulation of granule exocytosis
    Toru Tanaka
    Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies HFM 725, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Int Immunol 19:163-73. 2007
  4. ncbi request reprint Human NK cells can lyse porcine endothelial cells independent of their expression of Galalpha(1,3)-Gal and killing is enhanced by activation of either effector or target cells
    Judith A Horvath-Arcidiacono
    Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Bethesda, MD 20892, USA
    Xenotransplantation 13:318-27. 2006
  5. ncbi request reprint Human CD4+CD25+ regulatory T cells suppress anti-porcine xenogeneic responses
    Cynthia M Porter
    Laboratory of Immunology and Virology, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Bethesda, Maryland, USA
    Am J Transplant 5:2052-7. 2005
  6. ncbi request reprint Could heme-oxygenase-1 have a role in modulating the recipient immune response to embryonic stem cells?
    Wendy L Trigona
    Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Office of Cell, Gene, and Tissue Therapy, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892, USA
    Antioxid Redox Signal 9:751-6. 2007

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Characterization and expansion of baboon CD4+CD25+ Treg cells for potential use in a non-human primate xenotransplantation model
    Cynthia M Porter
    Division of Cellular and Gene Therapy, CBER, FDA, Bethesda, Mayland 20892, USA
    Xenotransplantation 14:298-308. 2007
    ..Baboons are a preferred preclinical animal model for xenogeneic organ transplantation experiments, and the characterization of baboon Treg cells will be beneficial to future tolerance studies in this animal model...
  2. doi request reprint Characterization of baboon NK cells and their xenogeneic activity
    Sarah B Kennett
    Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Bethesda, MD, USA
    Xenotransplantation 17:288-99. 2010
    ..In this study, we examined baboon NK cell function and developed methods for purifying and expanding these cells...
  3. ncbi request reprint Lipophilic statins suppress cytotoxicity by freshly isolated natural killer cells through modulation of granule exocytosis
    Toru Tanaka
    Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies HFM 725, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Int Immunol 19:163-73. 2007
    ..That lipophilic statins suppress NK cell activity through inhibition of the exocytosis pathway suggest an additional potential role for statins in inhibition of transplantation responses...
  4. ncbi request reprint Human NK cells can lyse porcine endothelial cells independent of their expression of Galalpha(1,3)-Gal and killing is enhanced by activation of either effector or target cells
    Judith A Horvath-Arcidiacono
    Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Bethesda, MD 20892, USA
    Xenotransplantation 13:318-27. 2006
    ..However, evidence for the role of alphaGal in the natural killer (NK) cell-mediated xenoresponse has been contradictory...
  5. ncbi request reprint Human CD4+CD25+ regulatory T cells suppress anti-porcine xenogeneic responses
    Cynthia M Porter
    Laboratory of Immunology and Virology, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Bethesda, Maryland, USA
    Am J Transplant 5:2052-7. 2005
    ..These results suggest a potential role for Treg cells in promoting xenograft survival...
  6. ncbi request reprint Could heme-oxygenase-1 have a role in modulating the recipient immune response to embryonic stem cells?
    Wendy L Trigona
    Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Office of Cell, Gene, and Tissue Therapy, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892, USA
    Antioxid Redox Signal 9:751-6. 2007
    ..These data suggest the hypothesis that HO-1 provides a mechanism for protecting hESCs in vivo...