I P Pogribny


Affiliation: Food and Drug Administration
Country: USA


  1. Tryndyak V, Kindrat I, Dreval K, Churchwell M, Beland F, Pogribny I. Effect of aflatoxin B1, benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018;121:214-223 pubmed publisher
    ..This approach may substantially enhance the identification and assessment of potential liver carcinogens. ..
  2. de Conti A, Tryndyak V, Churchwell M, Melnyk S, Latendresse J, Muskhelishvili L, et al. Genotoxic, epigenetic, and transcriptomic effects of tamoxifen in mouse liver. Toxicology. 2014;325:12-20 pubmed publisher
  3. Koturbash I, Beland F, Pogribny I. Role of microRNAs in the regulation of drug metabolizing and transporting genes and the response to environmental toxicants. Expert Opin Drug Metab Toxicol. 2012;8:597-606 pubmed publisher
  4. Marrone A, Beland F, Pogribny I. The role for microRNAs in drug toxicity and in safety assessment. Expert Opin Drug Metab Toxicol. 2015;11:601-11 pubmed publisher
    ..With the increasing interests in translational research, the field of miRNA biomarker research will continue to expand and become an important part of the investigation of human drug toxicity. ..
  5. Shpyleva S, Pogribna M, Cozart C, Bryant M, Muskhelishvili L, Tryndyak V, et al. Interstrain differences in the progression of nonalcoholic steatohepatitis to fibrosis in mice are associated with altered hepatic iron metabolism. J Nutr Biochem. 2014;25:1235-42 pubmed publisher
    ..The results of this study demonstrate that the interstrain variability in the extent of fibrogenesis was associated with a strain-dependent deregulation of hepatic iron homeostasis. ..
  6. Pogribny I, Beland F. Role of microRNAs in the regulation of drug metabolism and disposition genes in diabetes and liver disease. Expert Opin Drug Metab Toxicol. 2013;9:713-24 pubmed publisher
  7. de Conti A, Kobets T, Tryndyak V, Burnett S, Han T, Fuscoe J, et al. Persistence of furan-induced epigenetic aberrations in the livers of F344 rats. Toxicol Sci. 2015;144:217-26 pubmed publisher
  8. Pogribny I, Beland F, Rusyn I. The role of microRNAs in the development and progression of chemical-associated cancers. Toxicol Appl Pharmacol. 2016;312:3-10 pubmed publisher
    ..It also emphasizes the potential for miRNA changes as early indicators of the carcinogenic process, markers for carcinogen exposure, and identification of chemical carcinogenic hazards. ..
  9. Pogribny I, Tryndyak V, Boureiko A, Melnyk S, Bagnyukova T, Montgomery B, et al. Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver. Mutat Res. 2008;644:17-23 pubmed publisher

More Information


  1. Tryndyak V, Han T, Fuscoe J, Ross S, Beland F, Pogribny I. Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice. BMC Genomics. 2016;17:298 pubmed publisher
  2. Tryndyak V, Marrone A, Latendresse J, Muskhelishvili L, Beland F, Pogribny I. MicroRNA changes, activation of progenitor cells and severity of liver injury in mice induced by choline and folate deficiency. J Nutr Biochem. 2016;28:83-90 pubmed publisher
    ..These findings suggest that miRNAs may be crucial regulators responsible for the progression of NAFLD and may be useful as noninvasive diagnostic indicators of the severity and progression of NAFLD. ..
  3. Pogribny I, Filkowski J, Tryndyak V, Golubov A, Shpyleva S, Kovalchuk O. Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin. Int J Cancer. 2010;127:1785-94 pubmed publisher
    ..These results suggest that dysregulated miRNA expression may underlie the abnormal functioning of critical cellular processes associated with the cisplatin-resistant phenotype. ..
  4. Chango A, Pogribny I. Considering maternal dietary modulators for epigenetic regulation and programming of the fetal epigenome. Nutrients. 2015;7:2748-70 pubmed publisher
  5. Pogribny I, Beland F. DNA hypomethylation in the origin and pathogenesis of human diseases. Cell Mol Life Sci. 2009;66:2249-61 pubmed publisher
    ..This review presents evidence suggesting the involvement of DNA hypomethylation in the pathogenesis of several major human pathologies, including cancer, atherosclerosis, Alzheimer's disease, and psychiatric disorders. ..
  6. Marrone A, Tryndyak V, Beland F, Pogribny I. MicroRNA Responses to the Genotoxic Carcinogens Aflatoxin B1 and Benzo[a]pyrene in Human HepaRG Cells. Toxicol Sci. 2016;149:496-502 pubmed publisher
  7. Tryndyak V, de Conti A, Doerge D, Olson G, Beland F, Pogribny I. Furan-induced transcriptomic and gene-specific DNA methylation changes in the livers of Fischer 344 rats in a 2-year carcinogenicity study. Arch Toxicol. 2017;91:1233-1243 pubmed publisher
    ..Our findings illustrate that gene-specific DNA methylation changes have functional consequences and may be an important component of furan hepatotoxicity and hepatocarcinogenicity. ..
  8. Pogribny I, Rusyn I. Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma. Cancer Lett. 2014;342:223-30 pubmed publisher
  9. Pogribny I, Tryndyak V, Muskhelishvili L, Rusyn I, Ross S. Methyl deficiency, alterations in global histone modifications, and carcinogenesis. J Nutr. 2007;137:216S-222S pubmed publisher
    ..These results illustrate the complexity and importance of histone modification changes in the etiology of hepatocarcinogenesis induced by MDD. ..
  10. Pogribny I, Muskhelishvili L, Tryndyak V, Beland F. The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation. Toxicol Appl Pharmacol. 2009;235:305-11 pubmed publisher
  11. Pogribny I, Kutanzi K, Melnyk S, de Conti A, Tryndyak V, Montgomery B, et al. Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury. FASEB J. 2013;27:2233-43 pubmed publisher
  12. Pogribny I, Tryndyak V, Bagnyukova T, Melnyk S, Montgomery B, Ross S, et al. Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet. J Hepatol. 2009;51:176-86 pubmed publisher
  13. de Conti A, Tryndyak V, Doerge D, Beland F, Pogribny I. Irreversible down-regulation of miR-375 in the livers of Fischer 344 rats after chronic furan exposure. Food Chem Toxicol. 2016;98:2-10 pubmed publisher
    ..The results of the present study support the hypothesis of the non-genotoxic mode of action of furan and emphasize the importance of epigenetic alterations in the mechanism of furan hepatotoxicity. ..
  14. Dreval K, de Conti A, Furuya S, Beland F, Rusyn I, Pogribny I. miR-1247 blocks SOX9-mediated regeneration in alcohol- and fibrosis-associated acute kidney injury in mice. Toxicology. 2017;384:40-49 pubmed publisher
    ..The results of the present study demonstrate a functional role of epigenetic mechanisms in AKI and indicate the importance of correcting the epigenetic dysregulation for proper renal tubule maintenance and repair. ..
  15. de Conti A, Dreval K, Tryndyak V, Orisakwe O, Ross S, Beland F, et al. Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation. Mol Cancer Res. 2017;15:1163-1172 pubmed publisher
    ..b>Implications: Histone H4K16 deacetylation induces silencing of genes related to the cell death that occurred during the development of NASH-related HCC. Mol Cancer Res; 15(9); 1163-72. ©2017 AACR. ..
  16. de Conti A, Beland F, Pogribny I. The role of epigenomic alterations in furan-induced hepatobiliary pathologies. Food Chem Toxicol. 2017;109:677-682 pubmed publisher
    ..It also illustrates the potential role of epigenetic alterations as indicators for carcinogen exposure and for identification of carcinogens, especially those with non-genotoxic mechanisms of action. ..
  17. Kindrat I, Dreval K, Shpyleva S, Tryndyak V, de Conti A, Mudalige T, et al. Effect of methapyrilene hydrochloride on hepatic intracellular iron metabolism in vivo and in vitro. Toxicol Lett. 2017;281:65-73 pubmed publisher
  18. Pogribny I, Dreval K, Kindrat I, Melnyk S, Jimenez L, de Conti A, et al. Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma. FASEB J. 2017;: pubmed publisher
    ..James, S. J., Rusyn, I., Beland, F. A. Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma. ..