Roger D Plaut

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc Whole genome sequencing of phage resistant Bacillus anthracis mutants reveals an essential role for cell surface anchoring protein CsaB in phage AP50c adsorption
    Kimberly A Bishop-Lilly
    NMRC Frederick, 8400 Research Plaza, Ft, Detrick, MD 21702, USA
    Virol J 9:246. 2012
  2. pmc Stably luminescent Staphylococcus aureus clinical strains for use in bioluminescent imaging
    Roger D Plaut
    Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    PLoS ONE 8:e59232. 2013
  3. pmc Evaluation of genetically inactivated alpha toxin for protection in multiple mouse models of Staphylococcus aureus infection
    Rebecca A Brady
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    PLoS ONE 8:e63040. 2013
  4. pmc Epicutaneous model of community-acquired Staphylococcus aureus skin infections
    Ranjani Prabhakara
    Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland, USA
    Infect Immun 81:1306-15. 2013
  5. pmc Genetic evidence for the involvement of the S-layer protein gene sap and the sporulation genes spo0A, spo0B, and spo0F in Phage AP50c infection of Bacillus anthracis
    Roger D Plaut
    Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    J Bacteriol 196:1143-54. 2014
  6. pmc Dissemination bottleneck in a murine model of inhalational anthrax
    Roger D Plaut
    Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    Infect Immun 80:3189-93. 2012

Collaborators

Detail Information

Publications6

  1. pmc Whole genome sequencing of phage resistant Bacillus anthracis mutants reveals an essential role for cell surface anchoring protein CsaB in phage AP50c adsorption
    Kimberly A Bishop-Lilly
    NMRC Frederick, 8400 Research Plaza, Ft, Detrick, MD 21702, USA
    Virol J 9:246. 2012
    ..Spontaneous Bacillus anthracis mutants resistant to infection by phage AP50c (AP50R) exhibit a mucoid colony phenotype and secrete an extracellular matrix...
  2. pmc Stably luminescent Staphylococcus aureus clinical strains for use in bioluminescent imaging
    Roger D Plaut
    Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    PLoS ONE 8:e59232. 2013
    ..Similar strains were engineered using other sequenced clinical strains. Because these strains are stably luminescent, they should prove useful in animal models of infection...
  3. pmc Evaluation of genetically inactivated alpha toxin for protection in multiple mouse models of Staphylococcus aureus infection
    Rebecca A Brady
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    PLoS ONE 8:e63040. 2013
    ..aureus disease without conferring protection against other disease presentations and thus underscore a significant challenge in S. aureus vaccine development...
  4. pmc Epicutaneous model of community-acquired Staphylococcus aureus skin infections
    Ranjani Prabhakara
    Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland, USA
    Infect Immun 81:1306-15. 2013
    ..In vivo neutrophil depletion demonstrated that neutrophils play a protective role in preventing bacterial dissemination and fatal invasive infection...
  5. pmc Genetic evidence for the involvement of the S-layer protein gene sap and the sporulation genes spo0A, spo0B, and spo0F in Phage AP50c infection of Bacillus anthracis
    Roger D Plaut
    Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    J Bacteriol 196:1143-54. 2014
    ..Based on these data, we postulate that Sap is involved in AP50c infectivity, most likely acting as the phage receptor, and that the spo0 genes may regulate synthesis of Sap and/or formation of the S layer. ..
  6. pmc Dissemination bottleneck in a murine model of inhalational anthrax
    Roger D Plaut
    Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    Infect Immun 80:3189-93. 2012
    ..Such dominance of one strain over the other two was also found at early time points in the cervical lymph nodes but not in the mediastinal lymph nodes. These results support the existence of a bottleneck in the infectious process...