Ewan Plant

Summary

Affiliation: FDA
Location: Bethesda, USA
URL: http://www.linkedin.com/in/ewanplant
Summary:
research and review of influenza virus vaccines

Publications

  1. ncbi request reprint Severe acute respiratory syndrome coronavirus infection in vaccinated ferrets
    Miriam E R Darnell
    Laboratory of Hepatitis and Related Emerging Agents, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, CBER FDA, Bethesda, MD 20892, USA
    J Infect Dis 196:1329-38. 2007
  2. pmc The role of programmed-1 ribosomal frameshifting in coronavirus propagation
    Ewan P Plant
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Front Biosci 13:4873-81. 2008
  3. ncbi request reprint The SPL1 tRNA splicing gene of Candida maltosa and Candida albicans
    E P Plant
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Yeast 14:287-95. 1998
  4. doi request reprint Revisiting the 1976 "swine flu" vaccine clinical trials: cross-reactive hemagglutinin and neuraminidase antibodies and their role in protection against the 2009 H1N1 pandemic virus in mice
    Hang Xie
    Laboratory of Respiratory Viral Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland 20892, USA
    Clin Infect Dis 53:1179-87. 2011
  5. doi request reprint Interference of ribosomal frameshifting by antisense peptide nucleic acids suppresses SARS coronavirus replication
    Dae Gyun Ahn
    Department of Biotechnology and Translational Research Center for Protein Function Control, Yonsei University, Seoul, Republic of Korea
    Antiviral Res 91:1-10. 2011
  6. pmc Immunogenicity and cross-reactivity of 2009-2010 inactivated seasonal influenza vaccine in US adults and elderly
    Hang Xie
    Laboratory of Respiratory Viral Diseases, Division of Viral Products, Office of Vaccine Research and Review, United States Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 6:e16650. 2011
  7. pmc Persistent growth of a human plasma-derived hepatitis C virus genotype 1b isolate in cell culture
    Erica Silberstein
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    PLoS Pathog 6:e1000910. 2010
  8. pmc Achieving a golden mean: mechanisms by which coronaviruses ensure synthesis of the correct stoichiometric ratios of viral proteins
    Ewan P Plant
    Laboratory of Hepatitis and Related Emerging Agents, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, CBER, FDA, 8800 Rockville Pike, HFM310, Bethesda, Maryland 20892, USA
    J Virol 84:4330-40. 2010
  9. pmc Differentiating between near- and non-cognate codons in Saccharomyces cerevisiae
    Ewan P Plant
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 2:e517. 2007
  10. pmc Comparative study of the effects of heptameric slippery site composition on -1 frameshifting among different eukaryotic systems
    Ewan P Plant
    Department of Cell Biology and Molecular Genetics, Microbiology Building, Room 2135, University of Maryland, College Park, Maryland 20742, USA
    RNA 12:666-73. 2006

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Severe acute respiratory syndrome coronavirus infection in vaccinated ferrets
    Miriam E R Darnell
    Laboratory of Hepatitis and Related Emerging Agents, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, CBER FDA, Bethesda, MD 20892, USA
    J Infect Dis 196:1329-38. 2007
    ..Previous vaccine reports have noted robust neutralizing antibody and inflammatory responses in ferrets, resulting in enhanced hepatitis...
  2. pmc The role of programmed-1 ribosomal frameshifting in coronavirus propagation
    Ewan P Plant
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Front Biosci 13:4873-81. 2008
    ..Here we summarize current knowledge and add additional insight regarding the function of the programmed -1 ribosomal frameshift signal in the coronavirus lifecycle...
  3. ncbi request reprint The SPL1 tRNA splicing gene of Candida maltosa and Candida albicans
    E P Plant
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Yeast 14:287-95. 1998
  4. doi request reprint Revisiting the 1976 "swine flu" vaccine clinical trials: cross-reactive hemagglutinin and neuraminidase antibodies and their role in protection against the 2009 H1N1 pandemic virus in mice
    Hang Xie
    Laboratory of Respiratory Viral Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland 20892, USA
    Clin Infect Dis 53:1179-87. 2011
    ..Approximately 45 million people in the United States were vaccinated against NJ/76 30 years ago, but the impact of this nationwide immunization on the current pandemic is largely unknown...
  5. doi request reprint Interference of ribosomal frameshifting by antisense peptide nucleic acids suppresses SARS coronavirus replication
    Dae Gyun Ahn
    Department of Biotechnology and Translational Research Center for Protein Function Control, Yonsei University, Seoul, Republic of Korea
    Antiviral Res 91:1-10. 2011
    ..Our results demonstrate that -1 PRF, critical for SARS-CoV viral replication, can be inhibited by CPP-PNA, providing an effective antisense strategy for blocking -1 PRF signals...
  6. pmc Immunogenicity and cross-reactivity of 2009-2010 inactivated seasonal influenza vaccine in US adults and elderly
    Hang Xie
    Laboratory of Respiratory Viral Diseases, Division of Viral Products, Office of Vaccine Research and Review, United States Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 6:e16650. 2011
    ..The pandemic specific cross-reactive antibodies strongly correlated with the post-vaccination HAI titers against the seasonal H3N2 vaccine strain in all subjects...
  7. pmc Persistent growth of a human plasma-derived hepatitis C virus genotype 1b isolate in cell culture
    Erica Silberstein
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    PLoS Pathog 6:e1000910. 2010
    ..This virus constitutes a novel tool for the study of one of the most relevant strains of HCV, genotype 1b, which will now be available for HCV life cycle research and useful for the development of new therapeutics...
  8. pmc Achieving a golden mean: mechanisms by which coronaviruses ensure synthesis of the correct stoichiometric ratios of viral proteins
    Ewan P Plant
    Laboratory of Hepatitis and Related Emerging Agents, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, CBER, FDA, 8800 Rockville Pike, HFM310, Bethesda, Maryland 20892, USA
    J Virol 84:4330-40. 2010
    ..The findings of these analyses all support a "golden mean" model in which viruses use both programmed ribosomal frameshifting and translational attenuation to control the relative ratios of their encoded proteins...
  9. pmc Differentiating between near- and non-cognate codons in Saccharomyces cerevisiae
    Ewan P Plant
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 2:e517. 2007
    ..Although our understanding of what constitutes the correct or cognate aa-tRNA:mRNA interaction is well defined, a functional distinction between near-cognate or single mismatched, and unpaired or non-cognate interactions is lacking...
  10. pmc Comparative study of the effects of heptameric slippery site composition on -1 frameshifting among different eukaryotic systems
    Ewan P Plant
    Department of Cell Biology and Molecular Genetics, Microbiology Building, Room 2135, University of Maryland, College Park, Maryland 20742, USA
    RNA 12:666-73. 2006
    ....
  11. pmc A three-stemmed mRNA pseudoknot in the SARS coronavirus frameshift signal
    Ewan P Plant
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA
    PLoS Biol 3:e172. 2005
    ..The high degree of conservation of three-stemmed mRNA pseudoknot structures among the coronaviruses suggests that this presents a novel target for antiviral therapeutics...
  12. pmc Torsional restraint: a new twist on frameshifting pseudoknots
    Ewan P Plant
    Department of Cell Biology and Molecular Genetics Microbiology Building Room 2135 University of Maryland College Park, MD 20742, USA
    Nucleic Acids Res 33:1825-33. 2005
    ..The results of this study support the mechanistic hypothesis that -1 ribosomal frameshifting is enhanced by torsional resistance of the mRNA pseudoknot...
  13. pmc A programmed -1 ribosomal frameshift signal can function as a cis-acting mRNA destabilizing element
    Ewan P Plant
    Department of Cell Biology and Molecular Genetics, Microbiology Building Room 2135, University of Maryland, College Park, MD 20742, USA
    Nucleic Acids Res 32:784-90. 2004
    ..Analysis of the mRNA decay profiles of the frameshift-signal- containing reporter mRNAs also supports the notion that NMD remains active on mRNAs beyond the 'pioneer round' of translation in yeast...
  14. pmc The 9-A solution: how mRNA pseudoknots promote efficient programmed -1 ribosomal frameshifting
    Ewan P Plant
    Department of Cell Biology and Molecular Genetics, Microbiology Building, University of Maryland, College Park, MD 20742, USA
    RNA 9:168-74. 2003
    ..The observed result of the latter mechanism is a net shift of reading frame by one base in the 5' direction, that is, a -1 ribosomal frameshift...
  15. pmc The frameshift signal of HIV-1 involves a potential intramolecular triplex RNA structure
    Jonathan D Dinman
    Department of Cell Biology and Molecular Genetics, 2135 Microbiology Building, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 99:5331-6. 2002
    ..We suggest that the potential intramolecular triplex structure is essential for viral propagation and viability, and that small molecules targeted to this RNA structure may possess antiretroviral activities...
  16. ncbi request reprint Tca5, a Ty5-like retrotransposon from Candida albicans
    E P Plant
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Yeast 16:1509-18. 2000
    ..paradoxus. The nucleotide sequence of Tca5 has been submitted to GenBank under Accession No. AF093417...
  17. pmc Altering SARS coronavirus frameshift efficiency affects genomic and subgenomic RNA production
    Ewan P Plant
    Laboratory of Emerging Pathogens, Division of Transfusion Transmitted Diseases, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Viruses 5:279-94. 2013
    ..The data suggest that either the RNA sequence or the ratio of viral proteins resulting from different levels of frameshifting affects viral replication...