Research Topics
| Ewan PlantSummaryAffiliation: FDA Location: Bethesda, USA URL: http://www.linkedin.com/in/ewanplant Summary: research and review of influenza virus vaccines Publications
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Detail Information
Publications
Severe acute respiratory syndrome coronavirus infection in vaccinated ferretsMiriam E R Darnell
Laboratory of Hepatitis and Related Emerging Agents, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, CBER FDA, Bethesda, MD 20892, USA
J Infect Dis 196:1329-38. 2007..Previous vaccine reports have noted robust neutralizing antibody and inflammatory responses in ferrets, resulting in enhanced hepatitis...
The role of programmed-1 ribosomal frameshifting in coronavirus propagationEwan P Plant
Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
Front Biosci 13:4873-81. 2008..Here we summarize current knowledge and add additional insight regarding the function of the programmed -1 ribosomal frameshift signal in the coronavirus lifecycle...- The SPL1 tRNA splicing gene of Candida maltosa and Candida albicansE P Plant
Department of Biochemistry, University of Otago, Dunedin, New Zealand
Yeast 14:287-95. 1998 
Revisiting the 1976 "swine flu" vaccine clinical trials: cross-reactive hemagglutinin and neuraminidase antibodies and their role in protection against the 2009 H1N1 pandemic virus in miceHang Xie
Laboratory of Respiratory Viral Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland 20892, USA
Clin Infect Dis 53:1179-87. 2011..Approximately 45 million people in the United States were vaccinated against NJ/76 30 years ago, but the impact of this nationwide immunization on the current pandemic is largely unknown...- Interference of ribosomal frameshifting by antisense peptide nucleic acids suppresses SARS coronavirus replicationDae Gyun Ahn
Department of Biotechnology and Translational Research Center for Protein Function Control, Yonsei University, Seoul, Republic of Korea
Antiviral Res 91:1-10. 2011..Our results demonstrate that -1 PRF, critical for SARS-CoV viral replication, can be inhibited by CPP-PNA, providing an effective antisense strategy for blocking -1 PRF signals... - Immunogenicity and cross-reactivity of 2009-2010 inactivated seasonal influenza vaccine in US adults and elderlyHang Xie
Laboratory of Respiratory Viral Diseases, Division of Viral Products, Office of Vaccine Research and Review, United States Food and Drug Administration, Bethesda, Maryland, United States of America
PLoS ONE 6:e16650. 2011..The pandemic specific cross-reactive antibodies strongly correlated with the post-vaccination HAI titers against the seasonal H3N2 vaccine strain in all subjects... - Persistent growth of a human plasma-derived hepatitis C virus genotype 1b isolate in cell cultureErica Silberstein
Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
PLoS Pathog 6:e1000910. 2010..This virus constitutes a novel tool for the study of one of the most relevant strains of HCV, genotype 1b, which will now be available for HCV life cycle research and useful for the development of new therapeutics... - Achieving a golden mean: mechanisms by which coronaviruses ensure synthesis of the correct stoichiometric ratios of viral proteinsEwan P Plant
Laboratory of Hepatitis and Related Emerging Agents, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, CBER, FDA, 8800 Rockville Pike, HFM310, Bethesda, Maryland 20892, USA
J Virol 84:4330-40. 2010..The findings of these analyses all support a "golden mean" model in which viruses use both programmed ribosomal frameshifting and translational attenuation to control the relative ratios of their encoded proteins... - Differentiating between near- and non-cognate codons in Saccharomyces cerevisiaeEwan P Plant
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America
PLoS ONE 2:e517. 2007..Although our understanding of what constitutes the correct or cognate aa-tRNA:mRNA interaction is well defined, a functional distinction between near-cognate or single mismatched, and unpaired or non-cognate interactions is lacking... - Comparative study of the effects of heptameric slippery site composition on -1 frameshifting among different eukaryotic systemsEwan P Plant
Department of Cell Biology and Molecular Genetics, Microbiology Building, Room 2135, University of Maryland, College Park, Maryland 20742, USA
RNA 12:666-73. 2006.... - A three-stemmed mRNA pseudoknot in the SARS coronavirus frameshift signalEwan P Plant
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA
PLoS Biol 3:e172. 2005..The high degree of conservation of three-stemmed mRNA pseudoknot structures among the coronaviruses suggests that this presents a novel target for antiviral therapeutics... - Torsional restraint: a new twist on frameshifting pseudoknotsEwan P Plant
Department of Cell Biology and Molecular Genetics Microbiology Building Room 2135 University of Maryland College Park, MD 20742, USA
Nucleic Acids Res 33:1825-33. 2005..The results of this study support the mechanistic hypothesis that -1 ribosomal frameshifting is enhanced by torsional resistance of the mRNA pseudoknot... - A programmed -1 ribosomal frameshift signal can function as a cis-acting mRNA destabilizing elementEwan P Plant
Department of Cell Biology and Molecular Genetics, Microbiology Building Room 2135, University of Maryland, College Park, MD 20742, USA
Nucleic Acids Res 32:784-90. 2004..Analysis of the mRNA decay profiles of the frameshift-signal- containing reporter mRNAs also supports the notion that NMD remains active on mRNAs beyond the 'pioneer round' of translation in yeast... - The 9-A solution: how mRNA pseudoknots promote efficient programmed -1 ribosomal frameshiftingEwan P Plant
Department of Cell Biology and Molecular Genetics, Microbiology Building, University of Maryland, College Park, MD 20742, USA
RNA 9:168-74. 2003..The observed result of the latter mechanism is a net shift of reading frame by one base in the 5' direction, that is, a -1 ribosomal frameshift... - The frameshift signal of HIV-1 involves a potential intramolecular triplex RNA structureJonathan D Dinman
Department of Cell Biology and Molecular Genetics, 2135 Microbiology Building, University of Maryland, College Park, MD 20742, USA
Proc Natl Acad Sci U S A 99:5331-6. 2002..We suggest that the potential intramolecular triplex structure is essential for viral propagation and viability, and that small molecules targeted to this RNA structure may possess antiretroviral activities... - Tca5, a Ty5-like retrotransposon from Candida albicansE P Plant
Department of Biochemistry, University of Otago, Dunedin, New Zealand
Yeast 16:1509-18. 2000..paradoxus. The nucleotide sequence of Tca5 has been submitted to GenBank under Accession No. AF093417... - Altering SARS coronavirus frameshift efficiency affects genomic and subgenomic RNA productionEwan P Plant
Laboratory of Emerging Pathogens, Division of Transfusion Transmitted Diseases, Food and Drug Administration, Bethesda, Maryland 20892, USA
Viruses 5:279-94. 2013..The data suggest that either the RNA sequence or the ratio of viral proteins resulting from different levels of frameshifting affects viral replication...