Research Topics
| M G PauleSummaryAffiliation: Food and Drug Administration Country: USA Publications
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Detail Information
Publications
Chronic drug exposures during development in nonhuman primates: models of brain dysfunction in humansMerle G Paule
Behavioral Toxicology Laboratories, Division of Neurotoxicology, HFT 132, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, Arkansas 72079 9502, USA
Front Biosci 10:2240-9. 2005....- The effects of cocaine on nonhuman primate brain function are age dependentM G Paule
Behavioral Toxicology Laboratory, National Center for Toxicological Research FDA, Jefferson, Arkansas 72079, USA
Ann N Y Acad Sci 844:178-82. 1998..These data, along with preliminary data on levels of DA transporters, suggest that the age-related differences in sensitivity to cocaine lie in, 'downstream' from, the dopamine receptor... - Operant test battery performance in children: correlation with IQM G Paule
Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079 9502, USA
Neurotoxicol Teratol 21:223-30. 1999.... - Symposium overview: the use of delayed matching-to-sample procedures in studies of short-term memory in animals and humansM G Paule
Behavioral Toxicology Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079 9502, USA
Neurotoxicol Teratol 20:493-502. 1998..Noninvasive imaging techniques such as positron emission tomography (PET) indicate that activity in specific brain areas is associated with DMTS task performance and may serve to confirm roles for such structures in mnemonic processes... - Attention deficit/hyperactivity disorder: characteristics, interventions and modelsM G Paule
Behavioral Toxicology Laboratory, Division of Neurotoxicology, HFT 132, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
Neurotoxicol Teratol 22:631-51. 2000.... - Chronic exposure to NMDA receptor and sodium channel blockers during development in monkeys and rats: long-term effects on cognitive functionMerle G Paule
Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079, USA
Ann N Y Acad Sci 993:116-22; discussion 123-4. 2003..These data contrast markedly with those obtained for the monkey and suggest, at least for some drug classes, that the rat might not be a good predictor of effects in primates... - Effects of drug countermeasures for space motion sickness on working memory in humansMerle G Paule
Behavioral Toxicology Laboratories, Division of Neurotoxicology, HFT 132, USFDA s National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
Neurotoxicol Teratol 26:825-37. 2004..Lorazepam alone decreased speed, and with spinning, decreased Acc. The data suggest that, at clinically useful doses, the rank order of the drugs with the best cognitive profiles is meclizine>scopolamine>promethazine>lorazepam... - The use of timing behaviors in animals and humans to detect drug and/or toxicant effectsM G Paule
Behavioral Toxicology Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079 9502, USA
Neurotoxicol Teratol 21:491-502. 1999.... - Differential effects of two NMDA receptor antagonists on cognitive--behavioral performance in young nonhuman primates IIE J Popke
Division of Neurotoxicology, HFT-132, National Center for Toxicological Research, FDA, 3900 NCTR Road, Jefferson, AR 72079-9502, USA
Neurotoxicol Teratol 23:333-47. 2001..Alternatively, these results may suggest that the concurrent antagonism of NMDA receptors and fast sodium channels may have more profound consequences for behavior than does the antagonism of NMDA receptors alone... - Similar effects of amphetamine and methylphenidate on the performance of complex operant tasks in ratsA J Mayorga
Food and Drug Administration, National Center for Toxicological Research, Division of Neurotoxicology, HFT 132, Jefferson, AR 72079 9502, USA
Behav Brain Res 109:59-68. 2000..These data further validate the use of this battery of operant tasks for the characterization of pharmacological agents, and suggest that findings using these tasks may be predictive of what is seen in humans... 
The effects of chronic methylphenidate administration on operant test battery performance in juvenile rhesus monkeysJ S Rodriguez
Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, AR, United States
Neurotoxicol Teratol 32:142-51. 2010..Thus, the current data do not strongly suggest cognitive impairments following chronic MPH administration...- Functional effects of methylazoxymethanol-induced cerebellar hypoplasia in ratsS A Ferguson
Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
Neurotoxicol Teratol 18:529-37. 1996.... - Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeysM G Paule
Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
Neurotoxicol Teratol 33:220-30. 2011..Supported by NICHD, CDER/FDA and NCTR/FDA... - Differential effects of two NMDA receptor antagonists on cognitive-behavioral development in nonhuman primates IE J Popke
Division of Neurotoxicology, HFT-132, National Center for Toxicological Research, US FDA, 3900 NCTR Road, Jefferson, AR 72079, USA
Neurotoxicol Teratol 23:319-32. 2001..The fact that MK-801 did not alter learning suggests that NMDA antagonism alone may be insufficient to produce learning deficits in young monkeys and that such deficits may rely on the ancillary blockade of fast sodium channels... - Acute effects of LSD on rhesus monkey operant test battery performanceD L Frederick
Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079 9502, USA
Pharmacol Biochem Behav 57:633-41. 1997.... - The effect of chronic cocaine exposure throughout pregnancy on maternal and infant outcomes in the rhesus monkeyP Morris
Division of Neurotoxicology, Food and Drug Administration, Jefferson, AR 72079, USA
Neurotoxicol Teratol 19:47-57. 1997..It was concluded that, in a rhesus monkey model, chronic cocaine exposure throughout pregnancy had no significant effect on maternal outcome, but did significantly affect infant outcome as assessed in this investigation... - Chronic marijuana smoke exposure in the rhesus monkey. IV: Neurochemical effects and comparison to acute and chronic exposure to delta-9-tetrahydrocannabinol (THC) in ratsS F Ali
Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079
Pharmacol Biochem Behav 40:677-82. 1991..In the monkey brain, we found no alterations in the concentration of neurotransmitters in caudate nucleus, frontal cortex, hypothalamus or brain stem.(ABSTRACT TRUNCATED AT 250 WORDS).. - Adaptation of a primate operant test battery to the rat: effects of chlorpromazineA J Mayorga
Food and Drug Administration, National Center for Toxicological Research, Division of Neurotoxicology, Jefferrson, AR 72079 9502, USA
Neurotoxicol Teratol 22:31-9. 2000..Further characterization of the rat OTB using prototypic pharmacological agents will further determine the extent to which drug effects on rat OTB performance can be generalized to primates... 
Changes in gene expression after phencyclidine administration in developing rats: a potential animal model for schizophreniaF Liu
Division of Neurotoxicology, National Center for Toxicological Research U S Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
Int J Dev Neurosci 29:351-8. 2011..The changes in schizophrenia-relevant genes after repeated PCP exposure during development may provide important information concerning the validation of an animal model for this disorder...- The effects of L-carnitine on the combination of, inhalation anesthetic-induced developmental, neuronal apoptosis in the rat frontal cortexX Zou
Division of Neurotoxicology, National Center for Toxicological Research, HFT 132, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
Neuroscience 151:1053-65. 2008.... - Effects of acute ethanol on indices of cognitive-behavioral performance in ratsE J Popke
Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
Alcohol 20:187-92. 2000..These data suggest that ethanol can selectively impair performance on cognitive-behavioral tasks and that these effects can occur at doses that do not affect the subjects' ability to respond... - Acute effects of dexfenfluramine (d-FEN) and methylenedioxymethamphetamine (MDMA) before and after short-course, high-dose treatmentD L Frederick
Division of Neurotoxicology, National Center for Toxicological Research, Jefferson Arkansas 72079, USA
Ann N Y Acad Sci 844:183-90. 1998..e., significant decreases of ca. 50% in serotonin in frontal cortex and hippocampus) were observed in all monkeys approximately six months after short-course, high-dose MDMA or d-FEN treatment... - Gene expression profiling in the developing rat brain exposed to ketamineQ Shi
Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
Neuroscience 166:852-63. 2010.... - Effects of chlorpromazine and diazepam on time estimation behavior and motivation in ratsS A Ferguson
Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
Pharmacol Biochem Behav 53:115-22. 1996..The effects of chlorpromazine and diazepam in rats were similar to those previously noted in the monkey, indicating the potential utility of rat performance in these operant tasks to predict drug effects in the rhesus monkey... - MicroPET imaging of ketamine-induced neuronal apoptosis with radiolabeled DFNSHX Zhang
Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
J Neural Transm 118:203-11. 2011..This study demonstrates that microPET imaging is capable of distinguishing differences in retention of [(18)F]-DFNSH in ROI and suggests that this compound may serve as a minimally invasive biomarker of neuronal apoptosis in rodents... - Neonatal dexamethasone on day 7 in rats causes behavioral alterations reflective of hippocampal, but not cerebellar, deficitsS A Ferguson
HFT 132, Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079, USA
Neurotoxicol Teratol 23:57-69. 2001..Open-field activity changes were inconsistent; however, DEX-treated rats were hyperactive during the dark period in running wheel tests. There were no indications of changes in reactivity or emotionality... - Central and peripheral neurochemical alterations and immune effects of prenatal ethanol exposure in ratsP Clausing
Division of Neurotoxicology, HFT 132, National Center for Toxicological Research, Jefferson, AR 72079 9502, USA
Int J Dev Neurosci 14:461-9. 1996..It is concluded that the decreases seen in splenic T cell percentages subsequent to prenatal ethanol exposure may be caused, at least partially, by impaired noradrenergic control of this organ... - No alterations in the performance of two interval timing operant tasks after alpha-difluoromethylornithine (DFMO)-induced cerebellar stuntingS A Ferguson
Neurobehavioral Teratology Laboratory, Division of Neurotoxicology, National Center for Toxicological Research FDA, HFT 132, 3900 NCTR Road, Jefferson, AR 72079, USA
Behav Brain Res 126:135-46. 2001..Neurotoxicol Teratol, 2001; 23:57-69] indicating that developmental cerebellar stunting has few effects on time estimation within the range of seconds... - Assessing the potential toxicity of MK-801 and remacemide: chronic exposure in juvenile rhesus monkeysE J Popke
Division of Neurotoxicology, HFT-132, National Center for Toxicological Research, U.S. FDA, 3900 NCTR Road, Jefferson, AR 72079-950, USA
Neurotoxicol Teratol 24:193-207. 2002..In the present case, the less obvious effects of these drugs on cognition defined the toxicologic response... - Analysis of methylphenidate and its metabolite ritalinic acid in monkey plasma by liquid chromatography/electrospray ionization mass spectrometryD R Doerge
Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
Rapid Commun Mass Spectrom 14:619-23. 2000..79 and 2.31 h, respectively) were not significantly different under acute vs. chronic dosing conditions and were comparable to values previously reported from human studies... - Plasma levels of parent compound and metabolites after doses of either d-fenfluramine or d-3,4-methylenedioxymethamphetamine (MDMA) that produce long-term serotonergic alterationsJohn F Bowyer
Division of Neurotoxicology and Biometry and Risk Assessment, National Center for Toxicological Research FDA, 72079 9502, Jefferson, AR, USA
Neurotoxicology 24:379-90. 2003..There were 80% reductions in the plasma membrane-associated 5-HT transporters 6 months after either the FEN or MDMA dosing regimen indicating that both treatments produced long-term serotonergic effects... - Comparison of drug effects on the performance of two timing tasks in ratsE J Popke
Division of Neurotoxicology, National Center for Toxicological Research, FDA, HFT 132, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
Pharmacol Biochem Behav 67:377-85. 2000..These results suggest that the effects of drugs on DRL-LH and TRD performance may differ, even when temporal parameters are identical... - Response sequence difficulty in an incremental repeated acquisition (learning) procedureL K M Wright
Division of Neurotoxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
Behav Processes 75:81-4. 2007..These results provide strong evidence for differing levels of response sequence difficulty in IRA procedures with sequence difficulty seeming to be dependent on whether or not responses are required on adjacent levers... - Effects of chronic oral acrylamide exposure on incremental repeated acquisition (learning) task performance in Fischer 344 ratsJoan Garey
Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72211, United States
Neurotoxicol Teratol 32:220-5. 2010.... - Effect of pair-housing on operant behavior task performance by rhesus monkeysCharlotte E Hotchkiss
National Center for Toxicological Research, Jefferson, AR 72079-9502, USA
Contemp Top Lab Anim Sci 42:38-41. 2003..However, housing condition may affect some test parameters, and this must be taken into consideration during experimental design... - Ketamine-induced neuronal cell death in the perinatal rhesus monkeyWilliam Slikker
Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079 0502, USA
Toxicol Sci 98:145-58. 2007..However, a shorter duration of ketamine anesthesia (3 h) did not result in neuronal cell death in the 5-day-old monkey... - Blockade of N-methyl-D-aspartate receptors by ketamine produces loss of postnatal day 3 monkey frontal cortical neurons in cultureCheng Wang
Division of Neurotoxicology, National Center for Toxicological Research Food and Drug Administration, Jefferson, Arkansas 72079 0502, USA
Toxicol Sci 91:192-201. 2006..Ketamine-induced effects were blocked by NR1 antisenses and SN-50. These data suggest that NR1 antisenses and SN-50 offer neuroprotection from the enhanced degeneration induced by ketamine in vitro... - Female mini-pig performance of temporal response differentiation, incremental repeated acquisition, and progressive ratio operant tasksSherry A Ferguson
Division of Neurotoxicology, HFT 132, National Center for Toxicological Research FDA, Jefferson, AR 72079, USA
Behav Processes 80:28-34. 2009..PR response rates were higher than those typically reported for rats, but lower than for adult rhesus monkeys or children. Physical differences in the way that each species responds likely account for these differences... - L-carnitine protects neurons from 1-methyl-4-phenylpyridinium-induced neuronal apoptosis in rat forebrain cultureC Wang
Division of Neurotoxicology, HFT 132, National Center for Toxicological Research U S Food and Drug Administration, Jefferson, AR 72079, USA
Neuroscience 144:46-55. 2007..L-carnitine blocked these effects of MPP+ suggesting its potential therapeutic utility in degenerative disorders such as Parkinson's disease, Alzheimer's disease, ornithine transcarbamylase deficiency and other mitochondrial diseases... - Protective effects of 7-nitroindazole on ketamine-induced neurotoxicity in rat forebrain cultureCheng Wang
Division of Neurotoxicology, National Center for Toxicological Research US Food and Drug Administration, HFT 132 Jefferson, AR, USA
Neurotoxicology 29:613-20. 2008..These data indicate a role for nitric oxide in the enhanced degeneration induced by ketamine in vitro and also suggest that blocking neuronal nitric oxide synthase (nNOS) may help reduce the risk of ketamine in pediatrics... - Systems biology approaches for toxicologyWilliam Slikker
National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079 9502, USA
J Appl Toxicol 27:201-17. 2007..Published in 2007 John Wiley & Sons, Ltd... - Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brainXiaoju Zou
Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
Int J Dev Neurosci 27:727-31. 2009..However, anesthetic durations of 9h or greater are associated with significant brain cell death in the frontal cortex. Thus, the threshold duration below which no neurotoxicity would be expected is somewhere between 3 and 9h... - Effects of chronic low-dose acrylamide exposure on progressive ratio performance in adolescent ratsJoan Garey
Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, HFT 132, Jefferson, AR 72079, USA
Neurotoxicology 28:998-1002. 2007..0mg/kg/day group than in controls. No effects of ACR were observed on post-reinforcement pause. These data suggest that daily ACR exposure at 5.0mg/kg/day can produce measurable decrements on aspects of food-motivated behavior... - Potential neurotoxicity of ketamine in the developing rat brainXiaoju Zou
Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
Toxicol Sci 108:149-58. 2009..Ketamine-induced cell death appears to be apoptotic in nature and closely associated with enhanced NMDA receptor subunit mRNA expression... - Anesthetic-induced oxidative stress and potential protectionCheng Wang
National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR, USA
ScientificWorldJournal 10:1473-82. 2010..However, more evidence is necessary to in order verify the role of the NMDA receptor subunit NR1 and ROS in anesthetic-induced neurodegeneration... - Toxicity assessment of pramipexole in juvenile rhesus monkeysTucker A Patterson
Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079, USA
Toxicology 276:164-71. 2010..In summary, administration of PPX at doses of up to 2.0 mg/kg/day for 30 weeks to juvenile rhesus monkeys produced adverse findings which were attributable to its pharmacological properties, including hypoprolactinemia... - Ontogeny of the N-methyl-D-aspartate (NMDA) receptor system and susceptibility to neurotoxicityKathleen A Haberny
Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland 20857, USA
Toxicol Sci 68:9-17. 2002.... - The effects of prenatal cocaine exposure on reversal learning using a simple visual discrimination task in rhesus monkeysJohn J Chelonis
Department of Psychology, University of Arkansas at Little Rock, 2801 South University Avenue, Little Rock, AR 72204, USA
Neurotoxicol Teratol 25:437-46. 2003.... - Developmental aspects of timing behavior in childrenJohn J Chelonis
Department of Psychology, University of Arkansas at Little Rock, 2801 South University Avenue, Little Rock, AR 72204, USA
Neurotoxicol Teratol 26:461-76. 2004..The use of this timing task in children, which also has been widely used in animal models, provides unique opportunities for interspecies comparisons... - Effect of methylphenidate on time perception in children with attention-deficit/hyperactivity disorderRonald L Baldwin
Department of Pediatrics, University of Arkansas for Medical Sciences Arkansas Children s Hospital, Little Rock, AR 72202, USA
Exp Clin Psychopharmacol 12:57-64. 2004..These results indicate that administration of MPH resulted in more precise timing performance without changing the mean duration of lever holds, suggesting an enhancement in working memory...