M G Paule

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc Behavioral toxicology of cognition: extrapolation from experimental animal models to humans: behavioral toxicology symposium overview
    Merle G Paule
    Divison of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, AR, United States
    Neurotoxicol Teratol 34:263-73. 2012
  2. pmc Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys
    M G Paule
    Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
    Neurotoxicol Teratol 33:220-30. 2011
  3. pmc The effects of chronic methylphenidate administration on operant test battery performance in juvenile rhesus monkeys
    J S Rodriguez
    Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, AR, United States
    Neurotoxicol Teratol 32:142-51. 2010
  4. ncbi request reprint Similar effects of amphetamine and methylphenidate on the performance of complex operant tasks in rats
    A J Mayorga
    Food and Drug Administration, National Center for Toxicological Research, Division of Neurotoxicology, HFT 132, Jefferson, AR 72079 9502, USA
    Behav Brain Res 109:59-68. 2000
  5. ncbi request reprint Functional effects of methylazoxymethanol-induced cerebellar hypoplasia in rats
    S A Ferguson
    Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Neurotoxicol Teratol 18:529-37. 1996
  6. ncbi request reprint Differential effects of two NMDA receptor antagonists on cognitive--behavioral performance in young nonhuman primates II
    E J Popke
    Division of Neurotoxicology, HFT-132, National Center for Toxicological Research, FDA, 3900 NCTR Road, Jefferson, AR 72079-9502, USA
    Neurotoxicol Teratol 23:333-47. 2001
  7. ncbi request reprint Differential effects of two NMDA receptor antagonists on cognitive-behavioral development in nonhuman primates I
    E J Popke
    Division of Neurotoxicology, HFT-132, National Center for Toxicological Research, US FDA, 3900 NCTR Road, Jefferson, AR 72079, USA
    Neurotoxicol Teratol 23:319-32. 2001
  8. ncbi request reprint Acute effects of LSD on rhesus monkey operant test battery performance
    D L Frederick
    Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079 9502, USA
    Pharmacol Biochem Behav 57:633-41. 1997
  9. doi request reprint Changes in gene expression after phencyclidine administration in developing rats: a potential animal model for schizophrenia
    F Liu
    Division of Neurotoxicology, National Center for Toxicological Research U S Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
    Int J Dev Neurosci 29:351-8. 2011
  10. ncbi request reprint Chronic marijuana smoke exposure in the rhesus monkey. IV: Neurochemical effects and comparison to acute and chronic exposure to delta-9-tetrahydrocannabinol (THC) in rats
    S F Ali
    Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079
    Pharmacol Biochem Behav 40:677-82. 1991

Detail Information

Publications31

  1. pmc Behavioral toxicology of cognition: extrapolation from experimental animal models to humans: behavioral toxicology symposium overview
    Merle G Paule
    Divison of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, AR, United States
    Neurotoxicol Teratol 34:263-73. 2012
    ..As the data continue to accumulate, it becomes more clear that our attempts to adapt animal-appropriate tasks for the study of important aspects of human cognition have proven to be very fruitful...
  2. pmc Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys
    M G Paule
    Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
    Neurotoxicol Teratol 33:220-30. 2011
    ..Supported by NICHD, CDER/FDA and NCTR/FDA...
  3. pmc The effects of chronic methylphenidate administration on operant test battery performance in juvenile rhesus monkeys
    J S Rodriguez
    Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, AR, United States
    Neurotoxicol Teratol 32:142-51. 2010
    ..Thus, the current data do not strongly suggest cognitive impairments following chronic MPH administration...
  4. ncbi request reprint Similar effects of amphetamine and methylphenidate on the performance of complex operant tasks in rats
    A J Mayorga
    Food and Drug Administration, National Center for Toxicological Research, Division of Neurotoxicology, HFT 132, Jefferson, AR 72079 9502, USA
    Behav Brain Res 109:59-68. 2000
    ..These data further validate the use of this battery of operant tasks for the characterization of pharmacological agents, and suggest that findings using these tasks may be predictive of what is seen in humans...
  5. ncbi request reprint Functional effects of methylazoxymethanol-induced cerebellar hypoplasia in rats
    S A Ferguson
    Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Neurotoxicol Teratol 18:529-37. 1996
    ....
  6. ncbi request reprint Differential effects of two NMDA receptor antagonists on cognitive--behavioral performance in young nonhuman primates II
    E J Popke
    Division of Neurotoxicology, HFT-132, National Center for Toxicological Research, FDA, 3900 NCTR Road, Jefferson, AR 72079-9502, USA
    Neurotoxicol Teratol 23:333-47. 2001
    ..Alternatively, these results may suggest that the concurrent antagonism of NMDA receptors and fast sodium channels may have more profound consequences for behavior than does the antagonism of NMDA receptors alone...
  7. ncbi request reprint Differential effects of two NMDA receptor antagonists on cognitive-behavioral development in nonhuman primates I
    E J Popke
    Division of Neurotoxicology, HFT-132, National Center for Toxicological Research, US FDA, 3900 NCTR Road, Jefferson, AR 72079, USA
    Neurotoxicol Teratol 23:319-32. 2001
    ..The fact that MK-801 did not alter learning suggests that NMDA antagonism alone may be insufficient to produce learning deficits in young monkeys and that such deficits may rely on the ancillary blockade of fast sodium channels...
  8. ncbi request reprint Acute effects of LSD on rhesus monkey operant test battery performance
    D L Frederick
    Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079 9502, USA
    Pharmacol Biochem Behav 57:633-41. 1997
    ....
  9. doi request reprint Changes in gene expression after phencyclidine administration in developing rats: a potential animal model for schizophrenia
    F Liu
    Division of Neurotoxicology, National Center for Toxicological Research U S Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
    Int J Dev Neurosci 29:351-8. 2011
    ..The changes in schizophrenia-relevant genes after repeated PCP exposure during development may provide important information concerning the validation of an animal model for this disorder...
  10. ncbi request reprint Chronic marijuana smoke exposure in the rhesus monkey. IV: Neurochemical effects and comparison to acute and chronic exposure to delta-9-tetrahydrocannabinol (THC) in rats
    S F Ali
    Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079
    Pharmacol Biochem Behav 40:677-82. 1991
    ..In the monkey brain, we found no alterations in the concentration of neurotransmitters in caudate nucleus, frontal cortex, hypothalamus or brain stem.(ABSTRACT TRUNCATED AT 250 WORDS)..
  11. doi request reprint The effects of L-carnitine on the combination of, inhalation anesthetic-induced developmental, neuronal apoptosis in the rat frontal cortex
    X Zou
    Division of Neurotoxicology, National Center for Toxicological Research, HFT 132, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Neuroscience 151:1053-65. 2008
    ....
  12. ncbi request reprint Operant test battery performance in children: correlation with IQ
    M G Paule
    Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079 9502, USA
    Neurotoxicol Teratol 21:223-30. 1999
    ....
  13. ncbi request reprint The effect of chronic cocaine exposure throughout pregnancy on maternal and infant outcomes in the rhesus monkey
    P Morris
    Division of Neurotoxicology, Food and Drug Administration, Jefferson, AR 72079, USA
    Neurotoxicol Teratol 19:47-57. 1997
    ..It was concluded that, in a rhesus monkey model, chronic cocaine exposure throughout pregnancy had no significant effect on maternal outcome, but did significantly affect infant outcome as assessed in this investigation...
  14. ncbi request reprint Adaptation of a primate operant test battery to the rat: effects of chlorpromazine
    A J Mayorga
    Food and Drug Administration, National Center for Toxicological Research, Division of Neurotoxicology, Jefferrson, AR 72079 9502, USA
    Neurotoxicol Teratol 22:31-9. 2000
    ..Further characterization of the rat OTB using prototypic pharmacological agents will further determine the extent to which drug effects on rat OTB performance can be generalized to primates...
  15. ncbi request reprint Effects of acute ethanol on indices of cognitive-behavioral performance in rats
    E J Popke
    Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    Alcohol 20:187-92. 2000
    ..These data suggest that ethanol can selectively impair performance on cognitive-behavioral tasks and that these effects can occur at doses that do not affect the subjects' ability to respond...
  16. ncbi request reprint Acute effects of dexfenfluramine (d-FEN) and methylenedioxymethamphetamine (MDMA) before and after short-course, high-dose treatment
    D L Frederick
    Division of Neurotoxicology, National Center for Toxicological Research, Jefferson Arkansas 72079, USA
    Ann N Y Acad Sci 844:183-90. 1998
    ..e., significant decreases of ca. 50% in serotonin in frontal cortex and hippocampus) were observed in all monkeys approximately six months after short-course, high-dose MDMA or d-FEN treatment...
  17. doi request reprint Gene expression profiling in the developing rat brain exposed to ketamine
    Q Shi
    Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Neuroscience 166:852-63. 2010
    ....
  18. ncbi request reprint The effects of cocaine on nonhuman primate brain function are age dependent
    M G Paule
    Behavioral Toxicology Laboratory, National Center for Toxicological Research FDA, Jefferson, Arkansas 72079, USA
    Ann N Y Acad Sci 844:178-82. 1998
    ..These data, along with preliminary data on levels of DA transporters, suggest that the age-related differences in sensitivity to cocaine lie in, 'downstream' from, the dopamine receptor...
  19. doi request reprint MicroPET imaging of ketamine-induced neuronal apoptosis with radiolabeled DFNSH
    X Zhang
    Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
    J Neural Transm 118:203-11. 2011
    ..This study demonstrates that microPET imaging is capable of distinguishing differences in retention of [(18)F]-DFNSH in ROI and suggests that this compound may serve as a minimally invasive biomarker of neuronal apoptosis in rodents...
  20. ncbi request reprint Effects of chlorpromazine and diazepam on time estimation behavior and motivation in rats
    S A Ferguson
    Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Pharmacol Biochem Behav 53:115-22. 1996
    ..The effects of chlorpromazine and diazepam in rats were similar to those previously noted in the monkey, indicating the potential utility of rat performance in these operant tasks to predict drug effects in the rhesus monkey...
  21. ncbi request reprint Central and peripheral neurochemical alterations and immune effects of prenatal ethanol exposure in rats
    P Clausing
    Division of Neurotoxicology, HFT 132, National Center for Toxicological Research, Jefferson, AR 72079 9502, USA
    Int J Dev Neurosci 14:461-9. 1996
    ..It is concluded that the decreases seen in splenic T cell percentages subsequent to prenatal ethanol exposure may be caused, at least partially, by impaired noradrenergic control of this organ...
  22. ncbi request reprint Neonatal dexamethasone on day 7 in rats causes behavioral alterations reflective of hippocampal, but not cerebellar, deficits
    S A Ferguson
    HFT 132, Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079, USA
    Neurotoxicol Teratol 23:57-69. 2001
    ..Open-field activity changes were inconsistent; however, DEX-treated rats were hyperactive during the dark period in running wheel tests. There were no indications of changes in reactivity or emotionality...
  23. ncbi request reprint The use of timing behaviors in animals and humans to detect drug and/or toxicant effects
    M G Paule
    Behavioral Toxicology Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079 9502, USA
    Neurotoxicol Teratol 21:491-502. 1999
    ....
  24. ncbi request reprint Analysis of methylphenidate and its metabolite ritalinic acid in monkey plasma by liquid chromatography/electrospray ionization mass spectrometry
    D R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Rapid Commun Mass Spectrom 14:619-23. 2000
    ..79 and 2.31 h, respectively) were not significantly different under acute vs. chronic dosing conditions and were comparable to values previously reported from human studies...
  25. ncbi request reprint L-carnitine protects neurons from 1-methyl-4-phenylpyridinium-induced neuronal apoptosis in rat forebrain culture
    C Wang
    Division of Neurotoxicology, HFT 132, National Center for Toxicological Research U S Food and Drug Administration, Jefferson, AR 72079, USA
    Neuroscience 144:46-55. 2007
    ..L-carnitine blocked these effects of MPP+ suggesting its potential therapeutic utility in degenerative disorders such as Parkinson's disease, Alzheimer's disease, ornithine transcarbamylase deficiency and other mitochondrial diseases...
  26. ncbi request reprint No alterations in the performance of two interval timing operant tasks after alpha-difluoromethylornithine (DFMO)-induced cerebellar stunting
    S A Ferguson
    Neurobehavioral Teratology Laboratory, Division of Neurotoxicology, National Center for Toxicological Research FDA, HFT 132, 3900 NCTR Road, Jefferson, AR 72079, USA
    Behav Brain Res 126:135-46. 2001
    ..Neurotoxicol Teratol, 2001; 23:57-69] indicating that developmental cerebellar stunting has few effects on time estimation within the range of seconds...
  27. ncbi request reprint Comparison of drug effects on the performance of two timing tasks in rats
    E J Popke
    Division of Neurotoxicology, National Center for Toxicological Research, FDA, HFT 132, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
    Pharmacol Biochem Behav 67:377-85. 2000
    ..These results suggest that the effects of drugs on DRL-LH and TRD performance may differ, even when temporal parameters are identical...
  28. ncbi request reprint Symposium overview: the use of delayed matching-to-sample procedures in studies of short-term memory in animals and humans
    M G Paule
    Behavioral Toxicology Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079 9502, USA
    Neurotoxicol Teratol 20:493-502. 1998
    ..Noninvasive imaging techniques such as positron emission tomography (PET) indicate that activity in specific brain areas is associated with DMTS task performance and may serve to confirm roles for such structures in mnemonic processes...
  29. ncbi request reprint Response sequence difficulty in an incremental repeated acquisition (learning) procedure
    L K M Wright
    Division of Neurotoxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
    Behav Processes 75:81-4. 2007
    ..These results provide strong evidence for differing levels of response sequence difficulty in IRA procedures with sequence difficulty seeming to be dependent on whether or not responses are required on adjacent levers...
  30. ncbi request reprint Assessing the potential toxicity of MK-801 and remacemide: chronic exposure in juvenile rhesus monkeys
    E J Popke
    Division of Neurotoxicology, HFT 132, National Center for Toxicological Research, U S FDA, 3900 NCTR Road, Jefferson, AR 72079 950, USA
    Neurotoxicol Teratol 24:193-207. 2002
    ..In the present case, the less obvious effects of these drugs on cognition defined the toxicologic response...
  31. ncbi request reprint Attention deficit/hyperactivity disorder: characteristics, interventions and models
    M G Paule
    Behavioral Toxicology Laboratory, Division of Neurotoxicology, HFT 132, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
    Neurotoxicol Teratol 22:631-51. 2000
    ....