Tucker A Patterson

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc Cross-platform comparability of microarray technology: intra-platform consistency and appropriate data analysis procedures are essential
    Leming Shi
    National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    BMC Bioinformatics 6:S12. 2005
  2. doi request reprint Toxicity assessment of pramipexole in juvenile rhesus monkeys
    Tucker A Patterson
    Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079, USA
    Toxicology 276:164-71. 2010
  3. ncbi request reprint Performance comparison of one-color and two-color platforms within the MicroArray Quality Control (MAQC) project
    Tucker A Patterson
    National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd, Jefferson, Arkansas 72079, USA
    Nat Biotechnol 24:1140-50. 2006
  4. doi request reprint Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain
    Xiaoju Zou
    Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    Int J Dev Neurosci 27:727-31. 2009
  5. pmc Potential neurotoxicity of ketamine in the developing rat brain
    Xiaoju Zou
    Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Toxicol Sci 108:149-58. 2009
  6. doi request reprint Protective effects of 7-nitroindazole on ketamine-induced neurotoxicity in rat forebrain culture
    Cheng Wang
    Division of Neurotoxicology, National Center for Toxicological Research US Food and Drug Administration, HFT 132 Jefferson, AR, USA
    Neurotoxicology 29:613-20. 2008
  7. pmc Ketamine-induced neuronal damage and altered N-methyl-D-aspartate receptor function in rat primary forebrain culture
    Fang Liu
    Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079 0502, USA
    Toxicol Sci 131:548-57. 2013
  8. ncbi request reprint Ketamine-induced neuronal cell death in the perinatal rhesus monkey
    William Slikker
    Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079 0502, USA
    Toxicol Sci 98:145-58. 2007
  9. doi request reprint Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey
    Xiaoju Zou
    Division of Neurotoxicology, National Center for Toxicological Research U S Food and Drug Administration, Jefferson, AR 72079, USA
    Neurotoxicol Teratol 33:592-7. 2011
  10. pmc Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity
    John F Bowyer
    Division of Neurotoxicology, National Center for Toxicological Research, U, S, Food and Drug Administration, Jefferson, AR 72079 9502, USA
    BMC Genomics 14:147. 2013

Detail Information

Publications26

  1. pmc Cross-platform comparability of microarray technology: intra-platform consistency and appropriate data analysis procedures are essential
    Leming Shi
    National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    BMC Bioinformatics 6:S12. 2005
    ..Nucleic Acids Res., 31, 5676-5684, 2003), portrays a disturbingly negative picture of the cross-platform comparability, and, hence, the reliability of microarray technology...
  2. doi request reprint Toxicity assessment of pramipexole in juvenile rhesus monkeys
    Tucker A Patterson
    Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079, USA
    Toxicology 276:164-71. 2010
    ..In summary, administration of PPX at doses of up to 2.0 mg/kg/day for 30 weeks to juvenile rhesus monkeys produced adverse findings which were attributable to its pharmacological properties, including hypoprolactinemia...
  3. ncbi request reprint Performance comparison of one-color and two-color platforms within the MicroArray Quality Control (MAQC) project
    Tucker A Patterson
    National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd, Jefferson, Arkansas 72079, USA
    Nat Biotechnol 24:1140-50. 2006
    ....
  4. doi request reprint Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain
    Xiaoju Zou
    Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    Int J Dev Neurosci 27:727-31. 2009
    ..However, anesthetic durations of 9h or greater are associated with significant brain cell death in the frontal cortex. Thus, the threshold duration below which no neurotoxicity would be expected is somewhere between 3 and 9h...
  5. pmc Potential neurotoxicity of ketamine in the developing rat brain
    Xiaoju Zou
    Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Toxicol Sci 108:149-58. 2009
    ..Ketamine-induced cell death appears to be apoptotic in nature and closely associated with enhanced NMDA receptor subunit mRNA expression...
  6. doi request reprint Protective effects of 7-nitroindazole on ketamine-induced neurotoxicity in rat forebrain culture
    Cheng Wang
    Division of Neurotoxicology, National Center for Toxicological Research US Food and Drug Administration, HFT 132 Jefferson, AR, USA
    Neurotoxicology 29:613-20. 2008
    ..These data indicate a role for nitric oxide in the enhanced degeneration induced by ketamine in vitro and also suggest that blocking neuronal nitric oxide synthase (nNOS) may help reduce the risk of ketamine in pediatrics...
  7. pmc Ketamine-induced neuronal damage and altered N-methyl-D-aspartate receptor function in rat primary forebrain culture
    Fang Liu
    Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079 0502, USA
    Toxicol Sci 131:548-57. 2013
    ..L-Carnitine appears to be a promising agent in preventing or reversing ketamine's toxic effects on neurons at an early developmental stage...
  8. ncbi request reprint Ketamine-induced neuronal cell death in the perinatal rhesus monkey
    William Slikker
    Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079 0502, USA
    Toxicol Sci 98:145-58. 2007
    ..However, a shorter duration of ketamine anesthesia (3 h) did not result in neuronal cell death in the 5-day-old monkey...
  9. doi request reprint Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey
    Xiaoju Zou
    Division of Neurotoxicology, National Center for Toxicological Research U S Food and Drug Administration, Jefferson, AR 72079, USA
    Neurotoxicol Teratol 33:592-7. 2011
    ..These data suggest that prolonged exposure to inhaled anesthetics (a combination of N(2)O and ISO) in the developing rhesus monkey results in neuronal damage, and that the cell death observed is apoptotic and necrotic in nature...
  10. pmc Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity
    John F Bowyer
    Division of Neurotoxicology, National Center for Toxicological Research, U, S, Food and Drug Administration, Jefferson, AR 72079 9502, USA
    BMC Genomics 14:147. 2013
    ..Since AMPH and EIH are so disruptive to vasculature, genes related to vasculature integrity and function were of interest...
  11. doi request reprint Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese, silver, or copper nanoparticles
    Jianyong Wang
    Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079 9502, USA
    Neurotoxicology 30:926-33. 2009
    ..These data suggest that Mn and Cu nanoparticles-induced dopaminergic neurotoxicity may share some common mechanisms associated with neurodegeneration...
  12. pmc The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
    Leming Shi
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Nat Biotechnol 24:1151-61. 2006
    ..This study provides a resource that represents an important first step toward establishing a framework for the use of microarrays in clinical and regulatory settings...
  13. ncbi request reprint Comparison of the time courses of selective gene expression and dopaminergic depletion induced by MPP+ in MN9D cells
    Jianyong Wang
    Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Neurochem Int 52:1037-43. 2008
    ....
  14. doi request reprint Endoplasmic reticulum stress responses differ in meninges and associated vasculature, striatum, and parietal cortex after a neurotoxic amphetamine exposure
    Monzy Thomas
    National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079 9502, USA
    Synapse 64:579-93. 2010
    ..Conversely, Pdia4, an enzyme protective in the ERSR, was only increased in MAV. The overall ERSR manifestation varied significantly between MAV, striatum, and parietal cortex after a neurotoxic exposure to AMPH...
  15. doi request reprint Preclinical assessment of ketamine
    Cheng Wang
    Division of Neurotoxicology, National Center for Toxicological Research NCTR FDA, Jefferson, AR 72079 9501, USA
    CNS Neurosci Ther 19:448-53. 2013
    ....
  16. ncbi request reprint Systems biology approaches for toxicology
    William Slikker
    National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079 9502, USA
    J Appl Toxicol 27:201-17. 2007
    ..Published in 2007 John Wiley & Sons, Ltd...
  17. doi request reprint Utilization of neural stem cell-derived models to study anesthesia-related toxicity and preventative approaches
    Cheng Wang
    Division of Neurotoxicology, National Center for Toxicological Research NCTR FDA, Jefferson, AR, USA
    Mol Neurobiol 48:302-7. 2013
    ....
  18. ncbi request reprint Gene expression profiling of MPP+-treated MN9D cells: a mechanism of toxicity study
    Jianyong Wang
    Neurochemistry Laboratory, Division of Neurotoxicology, HFT 132, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, AR 72079, USA
    Neurotoxicology 28:979-87. 2007
    ..These data also indicate that MPP+-induced toxicity shares common molecular mechanisms with the pathogenesis of PD and further pathway analyses will be conducted to explore these mechanisms...
  19. doi request reprint ACB-PCR quantification of K-RAS codon 12 GAT and GTT mutant fraction in colon tumor and non-tumor tissue
    Barbara L Parsons
    U S Food and Drug Administration, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, 3900 NCTR Road, Jefferson, AR 72079, USA
    Cancer Invest 28:364-75. 2010
    ..The results indicate K-RAS codon 12 GAT mutation is present at measurable levels in normal appearing mucosa. All tumors carried K-RAS mutation, in most cases as a mutant subpopulation...
  20. ncbi request reprint ACB-PCR quantification of K-RAS codon 12 GAT and GTT mutant fraction in colon tumor and non-tumor tissue
    Barbara L Parsons
    US FDA, National Center for Toxicological Research, Jefferson, Arkansas, USA
    Cancer Invest 120:364-75. 2010
    ..The results indicate K-RAS codon 12 GAT mutation is present at measurable levels in normal appearing mucosa. All tumors carried K-RAS mutation, in most cases as a mutant subpopulation...
  21. doi request reprint Concurrent determination of bisphenol A pharmacokinetics in maternal and fetal rhesus monkeys
    Tucker A Patterson
    Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 267:41-8. 2013
    ..This study in a non-human primate model provides additional pharmacokinetic data for use in PBPK modeling of perinatal exposures to BPA from food contact, medical devices, and other environmental sources...
  22. pmc Defining the phosphodiesterase superfamily members in rat brain microvessels
    Zhen He
    Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, United States
    ACS Chem Neurosci 2:600-7. 2011
    ..In conclusion, a filtration method followed by microarray analyses allows PDE components to be identified in brain microvessels, and confirmed that PDE4D and PDE5A are the primary forms expressed in rat brain microvessels...
  23. doi request reprint Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature
    Monzy Thomas
    US Food and Drug Administration, National Center for Toxicological Research, Division of Neurotoxicology, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    Synapse 63:881-94. 2009
    ..Thus, the vasculature and meninges surrounding the surface of the forebrain may be an important region in which AMPHs can disrupt vascular homeostasis...
  24. pmc A microarray study of MPP+-treated PC12 Cells: Mechanisms of toxicity (MOT) analysis using bioinformatics tools
    Zengjun Xu
    Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    BMC Bioinformatics 6:S8. 2005
    ..MPP+ depletes dopamine content and elicits cell death in PC12 cells. However, the mechanism of MPP+-induced neurotoxicity is still unclear...
  25. ncbi request reprint Blockade of N-methyl-D-aspartate receptors by ketamine produces loss of postnatal day 3 monkey frontal cortical neurons in culture
    Cheng Wang
    Division of Neurotoxicology, National Center for Toxicological Research Food and Drug Administration, Jefferson, Arkansas 72079 0502, USA
    Toxicol Sci 91:192-201. 2006
    ..Ketamine-induced effects were blocked by NR1 antisenses and SN-50. These data suggest that NR1 antisenses and SN-50 offer neuroprotection from the enhanced degeneration induced by ketamine in vitro...
  26. ncbi request reprint Application of proteomics to the study of molecular mechanisms in neurotoxicology
    Richard M LoPachin
    Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Moses 7, 111 E, 210th St, Bronx, NY 10467, USA
    Neurotoxicology 24:761-75. 2003
    ....