Xiaowu Pang

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc Hitting HIV where it hides
    Andrew I Dayton
    Retrovirology 5:15. 2008
  2. pmc beta-Estradiol attenuates the anti-HIV-1 efficacy of Stavudine (D4T) in primary PBL
    Mingjie Zhang
    Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA
    Retrovirology 5:82. 2008
  3. pmc Development of Dengue virus type 2 replicons capable of prolonged expression in host cells
    X Pang
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA
    BMC Microbiol 1:18. 2001
  4. pmc Within you, without you: HIV-1 Rev and RNA export
    Andrew I Dayton
    Center for Biologics Evaluation and Research, Food and Drug Administration, USA
    Retrovirology 1:35. 2004
  5. pmc Beyond open access: open discourse, the next great equalizer
    Andrew I Dayton
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, FDA, HFM 315 FDA CBER, 1401 Rockville Pike, Rockville, MD 20852 1448, USA
    Retrovirology 3:55. 2006
  6. pmc Development of dengue virus replicons expressing HIV-1 gp120 and other heterologous genes: a potential future tool for dual vaccination against dengue virus and HIV
    X Pang
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA
    BMC Microbiol 1:28. 2001
  7. doi request reprint In vitro evaluation of the protective role of human antibodies to West Nile virus (WNV) produced during natural WNV infection
    M Rios
    Laboratory of Molecular Virology Division of Emerging Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    J Infect Dis 198:1300-8. 2008
  8. ncbi request reprint Identification of a potential HIV-induced source of bystander-mediated apoptosis in T cells: upregulation of trail in primary human macrophages by HIV-1 tat
    M Zhang
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA, Rockville, MD, USA
    J Biomed Sci 8:290-6. 2001
  9. ncbi request reprint Bcl-2 upregulation by HIV-1 Tat during infection of primary human macrophages in culture
    Mingjie Zhang
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Rockville, MD 20852 1448, USA
    J Biomed Sci 9:133-9. 2002
  10. ncbi request reprint HIV regulation of the IL-7R: a viral mechanism for enhancing HIV-1 replication in human macrophages in vitro
    Mingjie Zhang
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, MD 20852 1448, USA
    J Leukoc Biol 79:1328-38. 2006

Collaborators

Detail Information

Publications13

  1. pmc Hitting HIV where it hides
    Andrew I Dayton
    Retrovirology 5:15. 2008
    ..The recent finding that inhibitors of PI3/Akt can sensitize HIV infected macrophages to oxidative stress-induced cell death suggest a potential new therapeutic approach to targeting HIV reservoirs...
  2. pmc beta-Estradiol attenuates the anti-HIV-1 efficacy of Stavudine (D4T) in primary PBL
    Mingjie Zhang
    Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA
    Retrovirology 5:82. 2008
    ..Recent work suggests there are gender effects in HIV/AIDS progression. Here we ask whether the sex steroid hormone beta-estradiol affects the replication of HIV-1 or the efficacy of a common anti-retroviral drug, Stavudine (D4T)...
  3. pmc Development of Dengue virus type 2 replicons capable of prolonged expression in host cells
    X Pang
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA
    BMC Microbiol 1:18. 2001
    ....
  4. pmc Within you, without you: HIV-1 Rev and RNA export
    Andrew I Dayton
    Center for Biologics Evaluation and Research, Food and Drug Administration, USA
    Retrovirology 1:35. 2004
    ..This suggests the ubiquity of RNA helicases in RNA export from the nucleus, and has novel mechanistic implications...
  5. pmc Beyond open access: open discourse, the next great equalizer
    Andrew I Dayton
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, FDA, HFM 315 FDA CBER, 1401 Rockville Pike, Rockville, MD 20852 1448, USA
    Retrovirology 3:55. 2006
    ..The trend promises to give one and all access to read and contribute to cutting edge scientific criticism and debate...
  6. pmc Development of dengue virus replicons expressing HIV-1 gp120 and other heterologous genes: a potential future tool for dual vaccination against dengue virus and HIV
    X Pang
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA
    BMC Microbiol 1:28. 2001
    ..Here we attempted to express heterologous genetic material from these replicons...
  7. doi request reprint In vitro evaluation of the protective role of human antibodies to West Nile virus (WNV) produced during natural WNV infection
    M Rios
    Laboratory of Molecular Virology Division of Emerging Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    J Infect Dis 198:1300-8. 2008
    ..All but 1 documented WNV transmission by transfusion involved blood components negative for WNV antibodies, raising the question whether WNV antibody-positive blood components with low levels of WNV RNA are infectious...
  8. ncbi request reprint Identification of a potential HIV-induced source of bystander-mediated apoptosis in T cells: upregulation of trail in primary human macrophages by HIV-1 tat
    M Zhang
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA, Rockville, MD, USA
    J Biomed Sci 8:290-6. 2001
    ..The results suggest a model in which HIV-1-infected cells produce extracellular Tat protein, which in turn upregulates TRAIL in macrophages which then can induce apoptosis in bystander T cells...
  9. ncbi request reprint Bcl-2 upregulation by HIV-1 Tat during infection of primary human macrophages in culture
    Mingjie Zhang
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Rockville, MD 20852 1448, USA
    J Biomed Sci 9:133-9. 2002
    ..These results suggest that in infecting cells of the monocyte/macrophage lineage, HIV-1 may be benefiting from additional protection against apoptosis caused by specific upregulation of cellular anti-apoptotic genes...
  10. ncbi request reprint HIV regulation of the IL-7R: a viral mechanism for enhancing HIV-1 replication in human macrophages in vitro
    Mingjie Zhang
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, MD 20852 1448, USA
    J Leukoc Biol 79:1328-38. 2006
    ..The results suggest that the effects of IL-7 on HIV replication in MDM should be considered when analyzing and designing clinical trials involving treatment of patients with IL-7 or Tat vaccines...
  11. ncbi request reprint Monocytes-macrophages are a potential target in human infection with West Nile virus through blood transfusion
    Maria Rios
    Laboratory of Molecular Virology LMV, Division of Emerging Transfusion Transmitted Diseases DETTD, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, Bethesda, MD 20892, USA
    Transfusion 46:659-67. 2006
    ..Whether primary monocyte-derived macrophages (MDMs) support WNV infection-replication and produce infectious virions, with an in vitro system, was investigated...
  12. pmc Human immunodeficiency virus type 1 Vpr interacts with antiapoptotic mitochondrial protein HAX-1
    Venkat S R K Yedavalli
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, Maryland 20892 0460, USA
    J Virol 79:13735-46. 2005
    ..Overexpression of Vpr in cells dislocates HAX-1 from its normal residence in mitochondria and creates mitochondrion instability and cell death. Conversely, overexpression of HAX-1 suppressed the proapoptotic activity of Vpr...
  13. ncbi request reprint Polyarginine inhibits gp160 processing by furin and suppresses productive human immunodeficiency virus type 1 infection
    Karen V Kibler
    Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Biol Chem 279:49055-63. 2004
    ..Taken together, our data support that inhibitors of proteolytic processing of gp160 may be useful for combating human immunodeficiency virus-1 and that polyarginine represents a lead example of such inhibitors...