Research Topics
| Xiaowu PangSummaryAffiliation: Food and Drug Administration Country: USA Publications
| Collaborators
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Detail Information
Publications
Hitting HIV where it hidesAndrew I Dayton
Retrovirology 5:15. 2008..The recent finding that inhibitors of PI3/Akt can sensitize HIV infected macrophages to oxidative stress-induced cell death suggest a potential new therapeutic approach to targeting HIV reservoirs...- beta-Estradiol attenuates the anti-HIV-1 efficacy of Stavudine (D4T) in primary PBLMingjie Zhang
Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA
Retrovirology 5:82. 2008..Recent work suggests there are gender effects in HIV/AIDS progression. Here we ask whether the sex steroid hormone beta-estradiol affects the replication of HIV-1 or the efficacy of a common anti-retroviral drug, Stavudine (D4T)... - Development of Dengue virus type 2 replicons capable of prolonged expression in host cellsX Pang
Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA
BMC Microbiol 1:18. 2001.... - Within you, without you: HIV-1 Rev and RNA exportAndrew I Dayton
Center for Biologics Evaluation and Research, Food and Drug Administration, USA
Retrovirology 1:35. 2004..This suggests the ubiquity of RNA helicases in RNA export from the nucleus, and has novel mechanistic implications... - Beyond open access: open discourse, the next great equalizerAndrew I Dayton
Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, FDA, HFM 315 FDA CBER, 1401 Rockville Pike, Rockville, MD 20852 1448, USA
Retrovirology 3:55. 2006..The trend promises to give one and all access to read and contribute to cutting edge scientific criticism and debate... - Development of dengue virus replicons expressing HIV-1 gp120 and other heterologous genes: a potential future tool for dual vaccination against dengue virus and HIVX Pang
Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA
BMC Microbiol 1:28. 2001..Here we attempted to express heterologous genetic material from these replicons... 
In vitro evaluation of the protective role of human antibodies to West Nile virus (WNV) produced during natural WNV infectionM Rios
Laboratory of Molecular Virology Division of Emerging Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
J Infect Dis 198:1300-8. 2008..All but 1 documented WNV transmission by transfusion involved blood components negative for WNV antibodies, raising the question whether WNV antibody-positive blood components with low levels of WNV RNA are infectious...
Identification of a potential HIV-induced source of bystander-mediated apoptosis in T cells: upregulation of trail in primary human macrophages by HIV-1 tatM Zhang
Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA, Rockville, MD, USA
J Biomed Sci 8:290-6. 2001..The results suggest a model in which HIV-1-infected cells produce extracellular Tat protein, which in turn upregulates TRAIL in macrophages which then can induce apoptosis in bystander T cells...- Bcl-2 upregulation by HIV-1 Tat during infection of primary human macrophages in cultureMingjie Zhang
Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Rockville, MD 20852 1448, USA
J Biomed Sci 9:133-9. 2002..These results suggest that in infecting cells of the monocyte/macrophage lineage, HIV-1 may be benefiting from additional protection against apoptosis caused by specific upregulation of cellular anti-apoptotic genes... - HIV regulation of the IL-7R: a viral mechanism for enhancing HIV-1 replication in human macrophages in vitroMingjie Zhang
Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, MD 20852 1448, USA
J Leukoc Biol 79:1328-38. 2006..The results suggest that the effects of IL-7 on HIV replication in MDM should be considered when analyzing and designing clinical trials involving treatment of patients with IL-7 or Tat vaccines... - Monocytes-macrophages are a potential target in human infection with West Nile virus through blood transfusionMaria Rios
Laboratory of Molecular Virology LMV, Division of Emerging Transfusion Transmitted Diseases DETTD, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, Bethesda, MD 20892, USA
Transfusion 46:659-67. 2006..Whether primary monocyte-derived macrophages (MDMs) support WNV infection-replication and produce infectious virions, with an in vitro system, was investigated... - Human immunodeficiency virus type 1 Vpr interacts with antiapoptotic mitochondrial protein HAX-1Venkat S R K Yedavalli
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, Maryland 20892-0460, USA
J Virol 79:13735-46. 2005..Overexpression of Vpr in cells dislocates HAX-1 from its normal residence in mitochondria and creates mitochondrion instability and cell death. Conversely, overexpression of HAX-1 suppressed the proapoptotic activity of Vpr... - Polyarginine inhibits gp160 processing by furin and suppresses productive human immunodeficiency virus type 1 infectionKaren V Kibler
Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
J Biol Chem 279:49055-63. 2004..Taken together, our data support that inhibitors of proteolytic processing of gp160 may be useful for combating human immunodeficiency virus-1 and that polyarginine represents a lead example of such inhibitors...