Manuel Osorio

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc Anthrax protective antigen delivered by Salmonella enterica serovar Typhi Ty21a protects mice from a lethal anthrax spore challenge
    Manuel Osorio
    Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Infect Immun 77:1475-82. 2009
  2. pmc Role of anthrax toxins in dissemination, disease progression, and induction of protective adaptive immunity in the mouse aerosol challenge model
    Crystal L Loving
    Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892, USA
    Infect Immun 77:255-65. 2009
  3. pmc Nod1/Nod2-mediated recognition plays a critical role in induction of adaptive immunity to anthrax after aerosol exposure
    Crystal L Loving
    Laboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic and Allergenic Products, CBER, FDA, Bethesda, Maryland, USA
    Infect Immun 77:4529-37. 2009
  4. ncbi request reprint Vaccine potential for inactivated shigellae
    Manuel Osorio
    Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852 1448, United States
    Vaccine 25:1581-92. 2007
  5. pmc Campylobacter jejuni induces maturation and cytokine production in human dendritic cells
    Lan Hu
    Laboratory of Enteric and Sexually Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, NIH Campus, Bethesda, MD 20892, USA
    Infect Immun 74:2697-705. 2006
  6. ncbi request reprint Core-linked LPS expression of Shigella dysenteriae serotype 1 O-antigen in live Salmonella Typhi vaccine vector Ty21a: preclinical evidence of immunogenicity and protection
    De Qi Xu
    Laboratory of Enteric and Sexually Transmitted Diseases, FDA CBER, Bethesda, MD 20892, United States
    Vaccine 25:6167-75. 2007
  7. pmc Cytokine response to infection with Bacillus anthracis spores
    Alison K Pickering
    Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Infect Immun 72:6382-9. 2004

Collaborators

  • Dennis J Kopecko
  • Molly A Hughes
  • Richard I Walker
  • Crystal L Loving
  • Tod J Merkel
  • De Qi Xu
  • Gloria M Lee
  • Lan Hu
  • Alison K Pickering
  • Taruna Khurana
  • Scott Stibitz
  • Yun Gi Kim
  • Vanessa K Kelly
  • Gabriel Nunez
  • John O Cisar
  • Tint T Wai
  • Mechelle D Bray
  • Vanessa K Grippe
  • Mechelle Bray

Detail Information

Publications7

  1. pmc Anthrax protective antigen delivered by Salmonella enterica serovar Typhi Ty21a protects mice from a lethal anthrax spore challenge
    Manuel Osorio
    Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Infect Immun 77:1475-82. 2009
    ..anthracis 7702. The ultimate goal is a temperature-stable, safe, oral human vaccine against anthrax infection that can be self-administered in a few doses over a short period of time...
  2. pmc Role of anthrax toxins in dissemination, disease progression, and induction of protective adaptive immunity in the mouse aerosol challenge model
    Crystal L Loving
    Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892, USA
    Infect Immun 77:255-65. 2009
    ..These results provide support for the utility of the mouse aerosol challenge model for the study of inhalational anthrax...
  3. pmc Nod1/Nod2-mediated recognition plays a critical role in induction of adaptive immunity to anthrax after aerosol exposure
    Crystal L Loving
    Laboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic and Allergenic Products, CBER, FDA, Bethesda, Maryland, USA
    Infect Immun 77:4529-37. 2009
    ..anthracis aerosol exposure, as mice deficient in Nod1/Nod2 were impaired in their ability to mount an anamnestic antibody response and were more susceptible to secondary lethal challenge than wild-type mice...
  4. ncbi request reprint Vaccine potential for inactivated shigellae
    Manuel Osorio
    Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852 1448, United States
    Vaccine 25:1581-92. 2007
    ..These in vivo and in vitro data indicate that inactivated shigellae retain the ability to interact effectively with key antigen presenting cells and induce protective immune responses in mice...
  5. pmc Campylobacter jejuni induces maturation and cytokine production in human dendritic cells
    Lan Hu
    Laboratory of Enteric and Sexually Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, NIH Campus, Bethesda, MD 20892, USA
    Infect Immun 74:2697-705. 2006
    ....
  6. ncbi request reprint Core-linked LPS expression of Shigella dysenteriae serotype 1 O-antigen in live Salmonella Typhi vaccine vector Ty21a: preclinical evidence of immunogenicity and protection
    De Qi Xu
    Laboratory of Enteric and Sexually Transmitted Diseases, FDA CBER, Bethesda, MD 20892, United States
    Vaccine 25:6167-75. 2007
    ..These data further demonstrate the utility of S. Typhi Ty21a as a live, bacterial vaccine delivery system for heterologous O-antigens, supporting the promise of a bifunctional oral vaccine for prevention of shigellosis and typhoid fever...
  7. pmc Cytokine response to infection with Bacillus anthracis spores
    Alison K Pickering
    Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Infect Immun 72:6382-9. 2004
    ..A mixture of Th1 and Th2 cytokines were detected in sera obtained from infected animals. In this study, we provide further evidence of an acute cytokine response when cells in culture and mice are infected with B. anthracis spores...