L Muskhelishvili

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint In situ hybridization and immunohistochemical analysis of cytochrome P450 1B1 expression in human normal tissues
    L Muskhelishvili
    Pathology Associates International, Jefferson, Arkansas 72079, USA
    J Histochem Cytochem 49:229-36. 2001
  2. ncbi request reprint Evaluation of cell proliferation in rat tissues with BrdU, PCNA, Ki-67(MIB-5) immunohistochemistry and in situ hybridization for histone mRNA
    Levan Muskhelishvili
    Charles River Laboratories, Jefferson, Arkansas 72079, USA
    J Histochem Cytochem 51:1681-8. 2003
  3. ncbi request reprint An immunohistochemical label to facilitate counting of ovarian follicles
    Levan Muskhelishvili
    Pathology Associates a Charles River Company, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Toxicol Pathol 30:400-2. 2002
  4. ncbi request reprint Proliferating cell nuclear antigen--a marker for ovarian follicle counts
    Levan Muskhelishvili
    Toxicologic Pathology Associates at National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Toxicol Pathol 33:365-8. 2005
  5. doi request reprint Effects of acrylamide exposure on serum hormones, gene expression, cell proliferation, and histopathology in male reproductive tissues of Fischer 344 rats
    L Camacho
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Toxicol Lett 211:135-43. 2012
  6. pmc Upregulation of apoptosis with dietary restriction: implications for carcinogenesis and aging
    S J James
    Division of Biochemical Toxicology, U S Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Environ Health Perspect 106:307-12. 1998
  7. ncbi request reprint Sex differences in cytochrome P450 1B1, an estrogen-metabolizing enzyme, in the rhesus monkey telencephalon
    Andrew C Scallet
    Division of Neurotoxicology, National Center for Toxicological Research, NCTR FDA, 3900 NCTR Drive, Jefferson, AR 72079, USA
    J Chem Neuroanat 29:71-80. 2005
  8. doi request reprint The effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus-pituitary-thyroid axis of male Fischer 344 rats
    J F Bowyer
    U S Food and Drug Administration, National Center for Toxicological Research, Division of Neurotoxicology, 3900 NCTR Road, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 230:208-15. 2008
  9. pmc Pi-class glutathione-S-transferase-positive hepatocytes in aging B6C3F1 mice undergo apoptosis induced by dietary restriction
    L Muskhelishvili
    Division of Nutritional Toxicology, FDA National Center for Toxicological Research, Jefferson, Arkansas, USA
    Am J Pathol 149:1585-91. 1996
  10. ncbi request reprint Effects of dietary soy and estrous cycle on adrenal cytochrome p450 1B1 expression and DMBA metabolism in adrenal glands and livers in female Sprague-Dawley rats
    Xin Fu
    Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, HFT 110, Jefferson, AR 72079, USA
    Chem Biol Interact 146:273-84. 2003

Collaborators

Detail Information

Publications13

  1. ncbi request reprint In situ hybridization and immunohistochemical analysis of cytochrome P450 1B1 expression in human normal tissues
    L Muskhelishvili
    Pathology Associates International, Jefferson, Arkansas 72079, USA
    J Histochem Cytochem 49:229-36. 2001
    ..J Histochem Cytochem 49:229-236, 2001)..
  2. ncbi request reprint Evaluation of cell proliferation in rat tissues with BrdU, PCNA, Ki-67(MIB-5) immunohistochemistry and in situ hybridization for histone mRNA
    Levan Muskhelishvili
    Charles River Laboratories, Jefferson, Arkansas 72079, USA
    J Histochem Cytochem 51:1681-8. 2003
    ..They can substitute for BrdU IHC when necessary...
  3. ncbi request reprint An immunohistochemical label to facilitate counting of ovarian follicles
    Levan Muskhelishvili
    Pathology Associates a Charles River Company, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Toxicol Pathol 30:400-2. 2002
    ..High-contrast and high-resolution labeling was achieved with routine immunohistochemical procedures using an avidin-biotin-peroxidase method on rat and mouse tissues fixed in 10% neutral buffered formalin...
  4. ncbi request reprint Proliferating cell nuclear antigen--a marker for ovarian follicle counts
    Levan Muskhelishvili
    Toxicologic Pathology Associates at National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Toxicol Pathol 33:365-8. 2005
    ..This translates into a significant decrease in variability of follicle counts, labor, and cost. Specifically, variability dropped from 11% to 0.2%, the counting time was reduced by 46%, and the cost by 48%...
  5. doi request reprint Effects of acrylamide exposure on serum hormones, gene expression, cell proliferation, and histopathology in male reproductive tissues of Fischer 344 rats
    L Camacho
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Toxicol Lett 211:135-43. 2012
    ....
  6. pmc Upregulation of apoptosis with dietary restriction: implications for carcinogenesis and aging
    S J James
    Division of Biochemical Toxicology, U S Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Environ Health Perspect 106:307-12. 1998
    ..If during tumor promotion an adaptive increase in apoptosis effectively balances the dysregulated increase proliferation, the risk of permanent genetic error and carcinogenesis would be minimized...
  7. ncbi request reprint Sex differences in cytochrome P450 1B1, an estrogen-metabolizing enzyme, in the rhesus monkey telencephalon
    Andrew C Scallet
    Division of Neurotoxicology, National Center for Toxicological Research, NCTR FDA, 3900 NCTR Drive, Jefferson, AR 72079, USA
    J Chem Neuroanat 29:71-80. 2005
    ..These results suggest that CYP1B1 may subserve widespread metabolic functions in the female primate brain but have more restricted actions within the hippocampal pyramidal neurons of the male...
  8. doi request reprint The effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus-pituitary-thyroid axis of male Fischer 344 rats
    J F Bowyer
    U S Food and Drug Administration, National Center for Toxicological Research, Division of Neurotoxicology, 3900 NCTR Road, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 230:208-15. 2008
    ..Clarification of this mechanistic dichotomy may be useful in human cancer risk assessments for AA...
  9. pmc Pi-class glutathione-S-transferase-positive hepatocytes in aging B6C3F1 mice undergo apoptosis induced by dietary restriction
    L Muskhelishvili
    Division of Nutritional Toxicology, FDA National Center for Toxicological Research, Jefferson, Arkansas, USA
    Am J Pathol 149:1585-91. 1996
    ..These results suggest that spontaneous, potentially preneoplastic hepatocytes in tumor-prone B6C3F1 mice are eliminated by apoptosis with dietary restriction...
  10. ncbi request reprint Effects of dietary soy and estrous cycle on adrenal cytochrome p450 1B1 expression and DMBA metabolism in adrenal glands and livers in female Sprague-Dawley rats
    Xin Fu
    Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, HFT 110, Jefferson, AR 72079, USA
    Chem Biol Interact 146:273-84. 2003
    ..The use of different basal diets containing variable levels of soy components may affect certain toxicity assessments...
  11. ncbi request reprint Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis
    Volodymyr P Tryndyak
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Carcinogenesis 27:1713-20. 2006
    ..These data indicate the importance of genotoxic and epigenetic alterations in the etiology of tamoxifen-induced hepatocarcinogenesis...
  12. ncbi request reprint Methyl deficiency, alterations in global histone modifications, and carcinogenesis
    Igor P Pogribny
    National Center for Toxicological Research, Jefferson, AR 72079, USA
    J Nutr 137:216S-222S. 2007
    ..These results illustrate the complexity and importance of histone modification changes in the etiology of hepatocarcinogenesis induced by MDD...
  13. doi request reprint Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene
    Tetyana V Bagnyukova
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Carcinogenesis 29:638-46. 2008
    ..In conclusion, we have demonstrated that exposure of rats to genotoxic hepatocarcinogen 2-AAF, in addition to formation of 2-AAF-specific DNA lesions, resulted in substantial alterations in cellular epigenetic status...