Research Topics
| L MuskhelishviliSummaryAffiliation: Food and Drug Administration Country: USA Publications
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Detail Information
Publications
In situ hybridization and immunohistochemical analysis of cytochrome P450 1B1 expression in human normal tissuesL Muskhelishvili
Pathology Associates International, Jefferson, Arkansas 72079, USA
J Histochem Cytochem 49:229-36. 2001..J Histochem Cytochem 49:229-236, 2001)..- An immunohistochemical label to facilitate counting of ovarian folliclesLevan Muskhelishvili
Pathology Associates a Charles River Company, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
Toxicol Pathol 30:400-2. 2002..High-contrast and high-resolution labeling was achieved with routine immunohistochemical procedures using an avidin-biotin-peroxidase method on rat and mouse tissues fixed in 10% neutral buffered formalin... - Evaluation of cell proliferation in rat tissues with BrdU, PCNA, Ki-67(MIB-5) immunohistochemistry and in situ hybridization for histone mRNALevan Muskhelishvili
Charles River Laboratories, Jefferson, Arkansas 72079, USA
J Histochem Cytochem 51:1681-8. 2003..They can substitute for BrdU IHC when necessary... - Proliferating cell nuclear antigen--a marker for ovarian follicle countsLevan Muskhelishvili
Toxicologic Pathology Associates at National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
Toxicol Pathol 33:365-8. 2005..This translates into a significant decrease in variability of follicle counts, labor, and cost. Specifically, variability dropped from 11% to 0.2%, the counting time was reduced by 46%, and the cost by 48%... - Effects of acrylamide exposure on serum hormones, gene expression, cell proliferation, and histopathology in male reproductive tissues of Fischer 344 ratsL Camacho
Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
Toxicol Lett 211:135-43. 2012.... - Upregulation of apoptosis with dietary restriction: implications for carcinogenesis and agingS J James
Division of Biochemical Toxicology, U S Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA
Environ Health Perspect 106:307-12. 1998..If during tumor promotion an adaptive increase in apoptosis effectively balances the dysregulated increase proliferation, the risk of permanent genetic error and carcinogenesis would be minimized... - Sex differences in cytochrome P450 1B1, an estrogen-metabolizing enzyme, in the rhesus monkey telencephalonAndrew C Scallet
Division of Neurotoxicology, National Center for Toxicological Research, NCTR FDA, 3900 NCTR Drive, Jefferson, AR 72079, USA
J Chem Neuroanat 29:71-80. 2005..These results suggest that CYP1B1 may subserve widespread metabolic functions in the female primate brain but have more restricted actions within the hippocampal pyramidal neurons of the male... - The effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus-pituitary-thyroid axis of male Fischer 344 ratsJ F Bowyer
U S Food and Drug Administration, National Center for Toxicological Research, Division of Neurotoxicology, 3900 NCTR Road, Jefferson, AR 72079, USA
Toxicol Appl Pharmacol 230:208-15. 2008..Clarification of this mechanistic dichotomy may be useful in human cancer risk assessments for AA... - Pi-class glutathione-S-transferase-positive hepatocytes in aging B6C3F1 mice undergo apoptosis induced by dietary restrictionL Muskhelishvili
Division of Nutritional Toxicology, FDA National Center for Toxicological Research, Jefferson, Arkansas, USA
Am J Pathol 149:1585-91. 1996..These results suggest that spontaneous, potentially preneoplastic hepatocytes in tumor-prone B6C3F1 mice are eliminated by apoptosis with dietary restriction... - Effects of dietary soy and estrous cycle on adrenal cytochrome p450 1B1 expression and DMBA metabolism in adrenal glands and livers in female Sprague-Dawley ratsXin Fu
Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, HFT-110, Jefferson, AR 72079, USA
Chem Biol Interact 146:273-84. 2003..The use of different basal diets containing variable levels of soy components may affect certain toxicity assessments... - Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesisVolodymyr P Tryndyak
Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
Carcinogenesis 27:1713-20. 2006..These data indicate the importance of genotoxic and epigenetic alterations in the etiology of tamoxifen-induced hepatocarcinogenesis... - Methyl deficiency, alterations in global histone modifications, and carcinogenesisIgor P Pogribny
National Center for Toxicological Research, Jefferson, AR 72079, USA
J Nutr 137:216S-222S. 2007..These results illustrate the complexity and importance of histone modification changes in the etiology of hepatocarcinogenesis induced by MDD... - Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluoreneTetyana V Bagnyukova
Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
Carcinogenesis 29:638-46. 2008..In conclusion, we have demonstrated that exposure of rats to genotoxic hepatocarcinogen 2-AAF, in addition to formation of 2-AAF-specific DNA lesions, resulted in substantial alterations in cellular epigenetic status...