Research Topics
Genomes and GenesSpecies | Haruhiko MurataSummaryAffiliation: Food and Drug Administration Country: USA Publications
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Detail Information
Publications
Plaque purification as a method to mitigate the risk of adventitious-agent contamination in influenza vaccine virus seedsHaruhiko Murata
Laboratory of DNA Viruses, Division of Viral Products, CBER, FDA, Bethesda, MD 20892, USA
Vaccine 29:3155-61. 2011....
A quantitative PCR assay for SV40 neutralization adaptable for high-throughput applicationsHaruhiko Murata
Laboratory of DNA Viruses, Division of Viral Products, CBER, FDA, Bethesda, MD 20892, USA
J Virol Methods 162:236-44. 2009..A similar high-throughput approach might be feasible for related polyomaviruses (e.g., BKV and JCV) as well as for other families of viruses...
Identification of a neutralization epitope in the VP1 capsid protein of SV40Haruhiko Murata
Laboratory of DNA Viruses, Division of Viral Products CBER, FDA Bethesda, MD 20892, USA
Virology 381:116-22. 2008..Structural information regarding the neutralization epitope should be useful for clarifying the extent of cross-reactivity exhibited by the humoral immune response towards related primate polyomaviruses (e.g., SV40, BKV, and JCV)...
Recovery of strains of the polyomavirus SV40 from rhesus monkey kidney cells dating from the 1950s to the early 1960sKeith Peden
Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Virology 370:63-76. 2008..These results, and those of others, suggest that a limited number of SV40 strains might exist in rhesus macaques in the United States, and thus determining the origin of the SV40 sequences detected in human tumors might be difficult...
Patterns of microRNA expression in non-human primate cells correlate with neoplastic development in vitroBelete Teferedegne
Laboratory of DNA Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
PLoS ONE 5:e14416. 2010..These results may prove to be relevant to the biology of neoplastic development. In addition, one or more of these miRNAs could be biomarkers for the expression of a tumorigenic phenotype...
Identification of a mutation in the SV40 capsid protein VP1 that influences plaque morphology, vacuolization, and receptor usageHaruhiko Murata
Cancer Prevention Fellowship Program, Office of Preventive Oncology, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Virology 370:343-51. 2008..This VP1 mutation was identified as a genetic determinant influencing a number of phenotypes associated with SV40-LP(KT) such as plaque morphology, intracellular vacuole formation, and ganglioside receptor usage...
Development of a neutralization assay for influenza virus using an endpoint assessment based on quantitative reverse-transcription PCRBelete Teferedegne
Laboratory of DNA Viruses, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
PLoS ONE 8:e56023. 2013..Finally, our qRT-PCR-based approach may be broadly applicable to the development of neutralization assays for a wide variety of viruses...
