Suzanne M Morris

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice
    Roberta A Mittelstaedt
    Division of Genetic and Reproductive Toxicology, U S Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutat Res 561:127-38. 2004
  2. doi request reprint Effect of p53 genotype on gene expression profiles in murine liver
    Suzanne M Morris
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States
    Mutat Res 640:54-73. 2008
  3. doi request reprint The genetic toxicity of methylphenidate: a review of the current literature
    Suzanne M Morris
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA
    J Appl Toxicol 32:756-64. 2012
  4. doi request reprint The genetic toxicology of methylphenidate hydrochloride in non-human primates
    Suzanne M Morris
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States
    Mutat Res 673:59-66. 2009
  5. doi request reprint Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks
    Mugimane G Manjanatha
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research NCTR, US Food and Drug Administration, Jefferson, AR 72079, United States
    Mutat Res 680:43-8. 2009
  6. doi request reprint Pharmacokinetics, dose-range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice
    Mugimane G Manjanatha
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA
    Environ Mol Mutagen 49:585-93. 2008
  7. ncbi request reprint Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine
    Linda S Von Tungeln
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA
    Environ Mol Mutagen 48:258-69. 2007
  8. ncbi request reprint Micronucleated erythrocyte frequency in control and azidothymidine-treated Tk+/+, Tk+/- and Tk-/- mice
    Vasily N Dobrovolsky
    Division of Genetic and Reproductive Toxicology, U S Food and Drug Administration National Center for Toxicological Research, HFT 120, 3900 NCTR Rd, Jefferson, AR 72079, USA
    Mutat Res 570:227-35. 2005
  9. doi request reprint Evaluation of Macaca mulatta as a model for genotoxicity studies
    Vasily N Dobrovolsky
    US FDA, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, 3900 NCTR Rd, HFT 120, Jefferson, AR 72079, USA
    Mutat Res 673:21-8. 2009
  10. ncbi request reprint Alterations in gene expression profiles and the DNA-damage response in ionizing radiation-exposed TK6 cells
    Gregory S Akerman
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Environ Mol Mutagen 45:188-205. 2005

Detail Information

Publications16

  1. ncbi request reprint Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice
    Roberta A Mittelstaedt
    Division of Genetic and Reproductive Toxicology, U S Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutat Res 561:127-38. 2004
    ..The lack of increased micronucleus frequencies and lymphocyte Hprt mutants in female mice treated with leucomalachite green suggests that its genotoxicity is targeted to the tissue at risk for tumor induction...
  2. doi request reprint Effect of p53 genotype on gene expression profiles in murine liver
    Suzanne M Morris
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States
    Mutat Res 640:54-73. 2008
    ..This may indicate that alternate pathways are brought into play in the unperturbed liver when loss or reduction in p53 levels occurs...
  3. doi request reprint The genetic toxicity of methylphenidate: a review of the current literature
    Suzanne M Morris
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA
    J Appl Toxicol 32:756-64. 2012
    ..Published 2012. This article is a US Government work and is in the public domain in the USA...
  4. doi request reprint The genetic toxicology of methylphenidate hydrochloride in non-human primates
    Suzanne M Morris
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States
    Mutat Res 673:59-66. 2009
    ..3 microg/ml. No significant increases in the frequencies of MN-RETs, HPRT mutants, or chromosome aberrations were detected in the treated animals compared to the control animals over the 20-month exposure period...
  5. doi request reprint Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks
    Mugimane G Manjanatha
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research NCTR, US Food and Drug Administration, Jefferson, AR 72079, United States
    Mutat Res 680:43-8. 2009
    ..These results suggest that MPH is not mutagenic in mice and that the induction of tumors as previously reported in the liver is probably through a nongenotoxic mode of action...
  6. doi request reprint Pharmacokinetics, dose-range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice
    Mugimane G Manjanatha
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA
    Environ Mol Mutagen 49:585-93. 2008
    ..05). There was no significant increase in either the Hprt mutant frequency or the micronucleus frequency in the treated animals. These results indicated that although MPH induced liver hypertrophy in mice, no genotoxicity was observed...
  7. ncbi request reprint Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine
    Linda S Von Tungeln
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA
    Environ Mol Mutagen 48:258-69. 2007
    ..These data indicate that AZT, 3TC, and the combination of AZT and 3TC are transplacental mutagens and that the increase in mutants resulting from AZT is due mainly to large-scale genetic alterations...
  8. ncbi request reprint Micronucleated erythrocyte frequency in control and azidothymidine-treated Tk+/+, Tk+/- and Tk-/- mice
    Vasily N Dobrovolsky
    Division of Genetic and Reproductive Toxicology, U S Food and Drug Administration National Center for Toxicological Research, HFT 120, 3900 NCTR Rd, Jefferson, AR 72079, USA
    Mutat Res 570:227-35. 2005
    ..The elevated spontaneous MN frequencies in Tk-/- mice suggest the presence of an endogenous genotoxic activity in these mice...
  9. doi request reprint Evaluation of Macaca mulatta as a model for genotoxicity studies
    Vasily N Dobrovolsky
    US FDA, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, 3900 NCTR Rd, HFT 120, Jefferson, AR 72079, USA
    Mutat Res 673:21-8. 2009
    ....
  10. ncbi request reprint Alterations in gene expression profiles and the DNA-damage response in ionizing radiation-exposed TK6 cells
    Gregory S Akerman
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Environ Mol Mutagen 45:188-205. 2005
    ....
  11. doi request reprint Evaluation of p53 genotype on gene expression in the testis, liver, and heart from male C57BL/6 mice
    Dayton M Petibone
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR, USA
    Transgenic Res 21:257-63. 2012
    ..These data indicate that gene expression in unperturbed tissue is influenced by the status of p53 genotype, and relates, at least partially, to the function of the tissue...
  12. doi request reprint In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
    Wei Ding
    Division of Genetic and Molecular Toxicology, US FDA National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 261:164-71. 2012
    ....
  13. ncbi request reprint Mutagenicity of food-derived carcinogens and the effect of antioxidant vitamins
    Beverly A Montgomery
    Division of Genetic and Reproductive Toxicology, Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Nutr Cancer 43:103-10. 2002
    ....
  14. ncbi request reprint Detection of mutation in transgenic CHO cells using green fluorescent protein as a reporter
    Vasily N Dobrovolsky
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, 3900 NCTR Road, HFT 120, Jefferson, AR 72079, USA
    Mutat Res 518:55-64. 2002
    ..A similar approach may be useful for making high-throughput in vivo models for mutation detection...
  15. ncbi request reprint A role for p53 in the frequency and mechanism of mutation
    Suzanne M Morris
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutat Res 511:45-62. 2002
    ..In addition, the types of mutation that occur within the p53 gene are also of importance in determining the mutant frequency and the pathways leading to mutation...
  16. pmc Dye bias correction in dual-labeled cDNA microarray gene expression measurements
    Barry A Rosenzweig
    Center for Drug Evaluation and Research, Division of Applied Pharmacology Research, U S Food and Drug Administration, 10903 New Hampshire Avenue, Life Sciences Building 64, Silver Spring, MD 20993, USA
    Environ Health Perspect 112:480-7. 2004
    ..These data support a practical and more efficient experimental design to measure and mathematically correct for dye bias...