Nan Mei

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Differential mutagenicity of riddelliine in liver endothelial and parenchymal cells of transgenic big blue rats
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    Cancer Lett 215:151-8. 2004
  2. pmc The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
    Leming Shi
    National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    BMC Bioinformatics 9:S10. 2008
  3. pmc Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    BMC Bioinformatics 8:S4. 2007
  4. pmc Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver
    Lei Guo
    Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    BMC Bioinformatics 8:S22. 2007
  5. ncbi request reprint Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, United States
    Food Chem Toxicol 46:628-36. 2008
  6. pmc Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    BMC Bioinformatics 7:S16. 2006
  7. doi request reprint Cytotoxicity and mutagenicity of retinol with ultraviolet A irradiation in mouse lymphoma cells
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol In Vitro 24:439-44. 2010
  8. ncbi request reprint DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    Mutat Res 602:83-91. 2006
  9. doi request reprint Metabolism, genotoxicity, and carcinogenicity of comfrey
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    J Toxicol Environ Health B Crit Rev 13:509-26. 2010
  10. doi request reprint The genotoxicity of acrylamide and glycidamide in big blue rats
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Toxicol Sci 115:412-21. 2010

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Differential mutagenicity of riddelliine in liver endothelial and parenchymal cells of transgenic big blue rats
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    Cancer Lett 215:151-8. 2004
    ..These results suggest that the relatively high mutagenicity of riddelliine in rat liver endothelial cells may be partially responsible for the tumorigenic specificity of this agent...
  2. pmc The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
    Leming Shi
    National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    BMC Bioinformatics 9:S10. 2008
    ..The resultant variety of existing and emerging methods exacerbates confusion and continuing debate in the microarray community on the appropriate choice of methods for identifying reliable DEG lists...
  3. pmc Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    BMC Bioinformatics 8:S4. 2007
    ..Molecular analysis of the mutants indicated that there was a statistically significant difference between the mutational spectra from riddelliine-treated and control rats...
  4. pmc Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver
    Lei Guo
    Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    BMC Bioinformatics 8:S22. 2007
    ....
  5. ncbi request reprint Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, United States
    Food Chem Toxicol 46:628-36. 2008
    ....
  6. pmc Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    BMC Bioinformatics 7:S16. 2006
    ..Our previous study suggested that comfrey induces liver tumors by a genotoxic mechanism and that the pyrrolizidine alkaloids in the plant are responsible for mutation induction and tumor initiation in rat liver...
  7. doi request reprint Cytotoxicity and mutagenicity of retinol with ultraviolet A irradiation in mouse lymphoma cells
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol In Vitro 24:439-44. 2010
    ..These results suggest that retinol is mutagenic when exposed to UVA in mouse lymphoma cells through a clastogenic mode-of-action...
  8. ncbi request reprint DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    Mutat Res 602:83-91. 2006
    ..Although the same treatment does not produce tumors in rat liver, it does induce DNA adducts and mutations in this tissue, albeit at lower levels than in kidney...
  9. doi request reprint Metabolism, genotoxicity, and carcinogenicity of comfrey
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    J Toxicol Environ Health B Crit Rev 13:509-26. 2010
    ..Further, the two agents share common mechanisms of drug metabolism and carcinogenesis. Overall, comfrey is mutagenic in liver, and PA contained in comfrey appear to be responsible for comfrey-induced toxicity and tumor induction...
  10. doi request reprint The genotoxicity of acrylamide and glycidamide in big blue rats
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Toxicol Sci 115:412-21. 2010
    ..Although the genotoxicity in tumor target tissue was weak, in combination with the responses in surrogate tissues, the results are consistent with AA being a gene mutagen in the rat via metabolism to GA...
  11. ncbi request reprint Photomutagenicity of anhydroretinol and 5,6-epoxyretinyl palmitate in mouse lymphoma cells
    Nan Mei
    Division of Genetic, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Chem Res Toxicol 19:1435-40. 2006
    ..These results suggest that two of RP's photodecomposition products are photomutagenic in mouse lymphoma cells, causing events that affect a large segment of the chromosome...
  12. doi request reprint Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Environ Mol Mutagen 49:741-5. 2008
    ..The results provide more information about AA metabolism and further insight into the molecular mechanisms involved in AA-induced toxicity...
  13. pmc Gene expression profiles distinguish the carcinogenic effects of aristolochic acid in target (kidney) and non-target (liver) tissues in rats
    Tao Chen
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA
    BMC Bioinformatics 7:S20. 2006
    ..To evaluate whether microarray analysis can be used for distinguishing the tissue-specific carcinogenicity of AA, we examined gene expression profiles in kidney and liver of rats treated with carcinogenic doses of AA...
  14. ncbi request reprint Photomutagenicity of retinyl palmitate by ultraviolet a irradiation in mouse lymphoma cells
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079, USA
    Toxicol Sci 88:142-9. 2005
    ..These results suggest that RP is photomutagenic in combination with UVA exposure in mouse lymphoma cells, with a clastogenic mode-of-action...
  15. ncbi request reprint Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice
    Roberta A Mittelstaedt
    Division of Genetic and Reproductive Toxicology, U S Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutat Res 561:127-38. 2004
    ..The lack of increased micronucleus frequencies and lymphocyte Hprt mutants in female mice treated with leucomalachite green suggests that its genotoxicity is targeted to the tissue at risk for tumor induction...
  16. pmc Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies--changes in drug metabolizing genes and potential mechanisms linked to kava toxicity
    Lei Guo
    Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    Food Chem Toxicol 48:686-96. 2010
    ..Our results indicate that kava extract can significantly modulate drug metabolizing enzymes, potentially leading to herb-drug interactions and hepatotoxicity...
  17. pmc Mutagenicity of acrylamide and glycidamide in the testes of big blue mice
    Rui Sheng Wang
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Toxicol Sci 117:72-80. 2010
    ..These results suggest that AA possesses mutagenic effects on testes by virtue of its metabolism to GA, possibly targeting spermatogonial stem cells, but possibly via different pathways when compared mutations in liver...
  18. doi request reprint The mouse lymphoma assay detects recombination, deletion, and aneuploidy
    Jianyong Wang
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Toxicol Sci 109:96-105. 2009
    ..From this analysis, it is clear that mouse lymphoma Tk mutants can result from recombination, deletion, and aneuploidy...
  19. ncbi request reprint Mutations induced by carcinogenic doses of aristolochic acid in kidney of Big Blue transgenic rats
    Ling Chen
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, HFT 130, 3900 NCTR Road, Jefferson, AR 72079, USA
    Toxicol Lett 165:250-6. 2006
    ..These results suggest that AA induces kidney tumors in rats though a mutagenic mechanism of action...
  20. ncbi request reprint Rat toxicogenomic study reveals analytical consistency across microarray platforms
    Lei Guo
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Nat Biotechnol 24:1162-9. 2006
    ....
  21. doi request reprint Silver nanoparticle-induced mutations and oxidative stress in mouse lymphoma cells
    Nan Mei
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Environ Mol Mutagen 53:409-19. 2012
    ..These results suggest that 5 nm Ag-NPs are mutagenic in mouse lymphoma cells due to induction of oxidative stress by the Ag-NPs...
  22. doi request reprint Gene expression profiling as an initial approach for mechanistic studies of toxicity and tumorigenicity of herbal plants and herbal dietary supplements
    Lei Guo
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, FDA, AR 72079, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 28:60-87. 2010
    ..This review summarizes the current practices of microarray analysis of gene expressions in animals treated with herbal dietary supplements and discusses perspectives for the proposed strategy...
  23. doi request reprint Application of microarray-based analysis of gene expression in the field of toxicogenomics
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR, USA
    Methods Mol Biol 597:227-41. 2010
    ....
  24. doi request reprint Differential mutagenicity of aflatoxin B1 in the liver of neonatal and adult mice
    Tao Chen
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    Environ Mol Mutagen 51:156-63. 2010
    ....
  25. doi request reprint Mutagenicity and DNA adduct formation by aristolochic acid in the spleen of Big Blue® rats
    L Patrice McDaniel
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR, USA
    Environ Mol Mutagen 53:358-68. 2012
    ..These results indicate that AA is genotoxic in the spleen of rats exposed under conditions that result in DNA adduct formation and mutation induction in kidney and liver...
  26. doi request reprint Mutagenicity of 11 cigarette smoke condensates in two versions of the mouse lymphoma assay
    Xiaoqing Guo
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutagenesis 26:273-81. 2011
    ..These results indicate that the MLA identifies different genotoxic potencies among a variety of CSCs and that the results from both versions of the assay are comparable...
  27. pmc Ginkgo biloba extract induces gene expression changes in xenobiotics metabolism and the Myc-centered network
    Lei Guo
    Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079, USA
    OMICS 14:75-90. 2010
    ..In addition, the outcomes of pathway and network analysis may be used to elucidate the toxic mechanisms of Ginkgo biloba...
  28. ncbi request reprint Age-dependent sensitivity of Big Blue transgenic mice to the mutagenicity of N-ethyl-N-nitrosourea (ENU) in liver
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, HFT 130, NCTR FDA, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutat Res 572:14-26. 2005
    ..This period correlates well with the age-dependent sensitivity to carcinogenicity in mouse liver, suggesting that mutation is an important rate-limiting factor for age-related carcinogenesis...
  29. doi request reprint Nitroxide TEMPO: a genotoxic and oxidative stress inducer in cultured cells
    Xiaoqing Guo
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States
    Toxicol In Vitro 27:1496-502. 2013
    ..These results indicate that TEMPO is mutagenic in the MLA and induces micronuclei and hypodiploid nuclei in TK6 cells. Oxidative stress may account for part of the genotoxicity induced by TEMPO in both cell lines...
  30. ncbi request reprint Photodecomposition of vitamin A and photobiological implications for the skin
    Peter P Fu
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA
    Photochem Photobiol 83:409-24. 2007
    ..Relevant clinical studies or studies in animal models are therefore needed to establish whether the pro-oxidant activity of photoexcited vitamin A is observed in vivo, and to assess the related risks...
  31. doi request reprint Aristolochic acid-induced carcinogenesis examined by ACB-PCR quantification of H-Ras and K-Ras mutant fraction
    Yiying Wang
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, HFT 120, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutagenesis 26:619-28. 2011
    ....
  32. doi request reprint Genotoxicity of pyrrolizidine alkaloids
    Tao Chen
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    J Appl Toxicol 30:183-96. 2010
    ..The signature types of mutations are G : C --> T : A transversion and tandem base substitutions. Overall, PAs are mutagenic in vivo and in vitro and their mutagenicity appears to be responsible for the carcinogenesis of PAs...
  33. ncbi request reprint Mutations induced by the carcinogenic pyrrolizidine alkaloid riddelliine in the liver cII gene of transgenic big blue rats
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Chem Res Toxicol 17:814-8. 2004
    ..These results indicate that riddelliine is a genotoxic carcinogen in rat liver and that the types of mutations induced by riddelliine are consistent with riddelliine adducts involving G:C base pairs...
  34. ncbi request reprint Endogenous estrogen status, but not genistein supplementation, modulates 7,12-dimethylbenz[a]anthracene-induced mutation in the liver cII gene of transgenic big blue rats
    Tao Chen
    Division of Genetic and Reproductive Toxicology, Food and Drug Administration National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Environ Mol Mutagen 45:409-18. 2005
    ..These results suggest that endogenous ovarian hormones have an inhibitory effect on liver mutagenesis by DMBA, whereas dietary genistein does not modulate spontaneous or DMBA-induced mutagenesis in either intact or ovariectomized rats...
  35. doi request reprint Review of usnic acid and Usnea barbata toxicity
    Lei Guo
    National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 26:317-38. 2008
    ..At present, a toxicological evaluation of usnic acid is being conducted by the NTP. This review focuses on the recent findings of usnic acid-induced toxicities and their underlying mechanisms of action...
  36. doi request reprint Mechanism study of goldenseal-associated DNA damage
    Si Chen
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S FDA, Jefferson, AR 72079, USA
    Toxicol Lett 221:64-72. 2013
    ..Our findings suggest that the Topo II inhibitory effect may contribute to berberine- and goldenseal-induced genotoxicity and tumorigenicity...
  37. pmc The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
    Leming Shi
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Nat Biotechnol 24:1151-61. 2006
    ..This study provides a resource that represents an important first step toward establishing a framework for the use of microarrays in clinical and regulatory settings...
  38. ncbi request reprint Genetic predisposition to the cytotoxicity of arsenic: the role of DNA damage and ATM
    Nan Mei
    Department of Experimental Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada
    FASEB J 17:2310-2. 2003
    ..Furthermore, the lack of hypersensitivity to arsenic displayed by the other cell lines calls into question the hypothesis that DNA damage is a significant factor in arsenic cytotoxicity...
  39. ncbi request reprint Measurement of mutant frequency in T-cell receptor (TCR) gene by flow cytometry after X-irradiation on EL-4 mice lymphoma cells
    Naoki Kunugita
    Department of Health Information Science, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Toxicol Sci 32:377-86. 2007
    ..The method to detect mutation on TCR gene is quick and easy in comparison with other methods and is considered useful for the mutagenicity test...
  40. ncbi request reprint Mutagenic effects of 4-hydroxynonenal triacetate, a chemically protected form of the lipid peroxidation product 4-hydroxynonenal, as assayed in L5178Y/Tk+/- mouse lymphoma cells
    Sharda P Singh
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    J Pharmacol Exp Ther 313:855-61. 2005
    ....
  41. ncbi request reprint Analysis of 8-hydroxydeoxyguanosine 5'-monophosphate (8-OH-dGMP) as a reliable marker of cellular oxidative DNA damage after gamma-irradiation
    Nan Mei
    Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan
    Environ Mol Mutagen 41:332-8. 2003
    ..Using an endonuclease nicking assay, we also found that gamma-rays decreased 8-OH-Gua repair activity. The results indicate that 8-OH-dGMP is a useful and sensitive marker for estimating oxidative damage in DNA...
  42. ncbi request reprint Induction of OGG1 gene expression by HIV-1 Tat
    Kenichi Imai
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601
    J Biol Chem 280:26701-13. 2005
    ..These findings collectively indicate the possibility that Tat may play a role in maintenance of the genetic integrity of the proviral and host cellular genomes by up-regulating OGG1 as a feed-forward mechanism...
  43. ncbi request reprint N-ethyl-N-nitrosourea (ENU) increased brain mutations in prenatal and neonatal mice but not in the adults
    William Slikker
    College of Letters and Science, University of California, Los Angeles 90024, USA
    Toxicol Sci 81:112-20. 2004
    ..These results demonstrate a differential mutagenic effect of ENU on the mouse brain depending on the stages of development and suggest an enhanced susceptibility of brain cancer hazard for perinatal exposure to genotoxicants...