Research Topics
| Patrick F McDermottSummaryAffiliation: Food and Drug Administration Country: USA Publications
| Collaborators
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Detail Information
Publications
Antimicrobials: modes of action and mechanisms of resistancePatrick F McDermott
Office of Research, Center for Veterinary Medicine, US Food and Drug Administration, Laurel, Maryland 20708, USA
Int J Toxicol 22:135-43. 2003..Successful management of current antimicrobials, and the continued development of new ones, is vital to protecting human and animal health against bacterial pathogens...- Ciprofloxacin resistance in Campylobacter jejuni evolves rapidly in chickens treated with fluoroquinolonesPatrick F McDermott
Division of Animal and Food Microbiology, Center for Veterinary Medicine, US Food and Drug Administration, Laurel, Maryland 20708, USA
J Infect Dis 185:837-40. 2002.... - Antimicrobial susceptibility and molecular characterization of avian pathogenic Escherichia coli isolatesShaohua Zhao
Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA
Vet Microbiol 107:215-24. 2005..Twenty-two distinct ribogroups were identified, with 61% of isolates clustering into four major ribogroups, indicating that quinolone resistance has emerged among multiple avian pathogenic E. coli serogroups and chromosomal backgrounds... - Identification of antimicrobial resistance and class 1 integrons in Shiga toxin-producing Escherichia coli recovered from humans and food animalsRuby Singh
Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, USA
J Antimicrob Chemother 56:216-9. 2005..CONCLUSIONS: Antimicrobial resistance is common in STEC. Class 1 integrons located on mobile plasmids have facilitated the emergence and dissemination of antimicrobial resistance among STEC in humans and food animals... - Heterogeneity of vat(E)-carrying plasmids in Enterococcus faecium recovered from human and animal sourcesShabbir Simjee
Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD, USA
Int J Antimicrob Agents 28:200-5. 2006..This study showed that the vat(E) gene, conferring resistance to Q/D, was carried on different plasmids in a heterogeneous group of E. faecium, some of which may be acquired by E. faecium capable of infecting humans... - The US national antimicrobial resistance monitoring systemJeffrey M Gilbert
Center for Veterinary Medicine, US FDA, Office of New Animal Drug Evaluation 7500 Standish Place Rockville, MD 20855, USA
Future Microbiol 2:493-500. 2007..These activities help insure that antimicrobials are used judiciously to promote human and animal health... 
Characterization of integron mediated antimicrobial resistance in Salmonella isolated from diseased swineDavid G White
Center for Veterinary Medicine, U S Food and Drug Administration, Office of Research, 8401 Muirkirk Road, Laurel, Maryland, USA 20708
Can J Vet Res 67:39-47. 2003..This research suggests that integrons contribute to antimicrobial resistance among specific swine Salmonella serotypes; however, they are not as widely disseminated among non-Typhimurium swine Salmonella serotypes as previously thought...- Antimicrobial resistance among gram-negative foodborne bacterial pathogens associated with foods of animal originDavid G White
Office of Research, Center for Veterinary Medicine, U S Food and Drug Administration, Laurel, Maryland 20708, USA
Foodborne Pathog Dis 1:137-52. 2004..A clearer understanding of the ecology of resistance is needed in order to support science-based assessments of the public health risks due to the use of antimicrobials in the animal husbandry environment... - Changes in antimicrobial susceptibility of native Enterococcus faecium in chickens fed virginiamycinPatrick F McDermott
Office of Research, Center for Veterinary Medicine, U S Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA
Appl Environ Microbiol 71:4986-91. 2005..faecium in the animals. The bases of resistance could not be explained by known genetic determinants... - Antimicrobial susceptibility and distribution of antimicrobial-resistance genes among Enterococcus and coagulase-negative Staphylococcus isolates recovered from poultry litterShabbir Simjee
Center for Veterinary Medicine, U S Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA
Avian Dis 51:884-92. 2007.... - Antimicrobial resistance of foodborne pathogensDavid G White
Office of Research, Center for Veterinary Medicine, US Food and Drug Administration, Laurel, MD 20708, USA
Microbes Infect 4:405-12. 2002.... - Broth microdilution susceptibility testing of Campylobacter jejuni and the determination of quality control ranges for fourteen antimicrobial agentsPatrick F McDermott
Center for Veterinary Medicine, U S Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA
J Clin Microbiol 43:6136-8. 2005..Cation-adjusted Mueller-Hinton broth containing 2.5% laked horse blood was the preferred medium, with incubation in a microaerobic atmosphere of 10% CO(2), 5% O(2), and 85% N(2) at 36 degrees C for 48 h or 42 degrees C for 24 h... - Genome sequences of five Salmonella enterica serovar Heidelberg isolates associated with a 2011 multistate outbreak in the United StatesMaria Hoffmann
Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U S Food and Drug Administration, Laurel, Maryland, USA
J Bacteriol 194:3274-5. 2012..Whole-genome sequence analysis of these isolates provides a tool for studying the short-term evolution of these epidemic clones... - Antimicrobial drug resistance in Escherichia coli from humans and food animals, United States, 1950-2002Daniel A Tadesse
Food and Drug Administration, Laurel, Maryland 20708, USA
Emerg Infect Dis 18:741-9. 2012..0%). These data describe the evolution of resistance after introduction of new antimicrobial agents into clinical medicine and help explain the range of resistance in modern E. coli isolates... - Rapid and widespread dissemination of multidrug-resistant blaCMY-2 Salmonella Typhimurium in MexicoMussaret B Zaidi
Depto de Investigacion, Laboratorio de Investigacion, Hospital General O Horan, Av Itzaes x Jacinto Canek, Mérida C P 97000, Yucatan, Mexico
J Antimicrob Chemother 60:398-401. 2007..We describe the emergence and dissemination of multidrug-resistant (MDR) Salmonella Typhimurium in humans, retail meat and food animals from Yucatan, Mexico... - Fitness of antimicrobial-resistant Campylobacter and SalmonellaQijing Zhang
Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA 50011, USA
Microbes Infect 8:1972-8. 2006.... - Characterization of Salmonella enterica serovar Heidelberg from turkey-associated sourcesPravin Kaldhone
Marshfield Clinic Research Foundation, 1000 North Oak Avenue, Marshfield, WI 54449, USA
Appl Environ Microbiol 74:5038-46. 2008..Conjugation experiments indicated that resistance to multiple antimicrobial agents was transferable among strains with diverse PFGE profiles... - The marC gene of Escherichia coli is not involved in multiple antibiotic resistancePatrick F McDermott
Antimicrob Agents Chemother 52:382-3. 2008 - Agar dilution and disk diffusion susceptibility testing of Campylobacter sppThomas R Fritsche
J Clin Microbiol 45:2758-9; author reply 2759. 2007 - Comparison of subtyping methods for differentiating Salmonella enterica serovar Typhimurium isolates obtained from food animal sourcesSteven L Foley
National Farm Medicine Center, Marshfield Clinic Research Foundation, Marshfield, WI 54449, USA
J Clin Microbiol 44:3569-77. 2006..enterica serovar Typhimurium isolates that genetically cluster according to one particular typing method... - Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobialsSheng Chen
Department of Nutrition and Food Science, 0112 Skinner Building, University of Maryland, College Park, MD 20742, USA
Antimicrob Agents Chemother 51:535-42. 2007.... - International spread of multidrug-resistant Salmonella Schwarzengrund in food productsFrank M Aarestrup
National Food Institute, Technical University of Denmark, Copenhagen, Denmark
Emerg Infect Dis 13:726-31. 2007..This study suggests spread of multidrug-resistant S. Schwarzengrund from chickens to persons in Thailand, and from imported Thai food products to persons in Denmark and the United States... - Effect of conventional and organic production practices on the prevalence and antimicrobial resistance of Campylobacter spp. in poultryTaradon Luangtongkum
Department of Veterinary Preventive Medicine, Ohio State University, 1920 Coffey Road, Columbus, OH 43210, USA
Appl Environ Microbiol 72:3600-7. 2006..Findings from this study clearly indicate the influence of conventional and organic poultry production practices on antimicrobial resistance of Campylobacter on poultry farms... - Nontyphoidal Salmonella from human clinical cases, asymptomatic children, and raw retail meats in Yucatan, MexicoMussaret B Zaidi
Laboratorio de Investigacion, Hospital General O Horan, Merida, Yucatan, Mexico
Clin Infect Dis 42:21-8. 2006..We report the results of a 3-year Salmonella surveillance study of persons with diarrhea; asymptomatic children; and retail pork, poultry, and beef in Yucatan, Mexico... - Characterization of chloramphenicol resistance in beta-hemolytic Escherichia coli associated with diarrhea in neonatal swineKenneth M Bischoff
Southern Plains Agricultural Research Center, Agricultural Research Service, U S Department of Agriculture, College Station, Texas 77845, USA
J Clin Microbiol 40:389-94. 2002..The identification of the cmlA gene among diverse hemolytic enterotoxigenic E. coli strains demonstrates its broad dissemination in the swine production environment and its persistence even in the absence of CHL selection pressure... - Comparison of the Etest and agar dilution for in vitro antimicrobial susceptibility testing of CampylobacterBeilei Ge
Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA
J Antimicrob Chemother 50:487-94. 2002..The study also showed that C. jejuni and C. coli isolates resistant to antimicrobials used for treating campylobacteriosis were common in retail raw meats... - Class 1 integron-associated tobramycin-gentamicin resistance in Campylobacter jejuni isolated from the broiler chicken house environmentMargie D Lee
Department of Medical Microbiology and Parasitology Athens Diagnostic Laboratory Department of Environmental Health Sciences, The University of Georgia, Athens, Georgia 30602, USA
Antimicrob Agents Chemother 46:3660-4. 2002..DNA sequencing demonstrated that all five isolates possessed the aminoglycoside resistance gene, aacA4... - Antimicrobial resistance of Escherichia coli O26, O103, O111, O128, and O145 from animals and humansCarl M Schroeder
University of Maryland, College Park, USA
Emerg Infect Dis 8:1409-14. 2002..Findings from this study suggest antimicrobial resistance is widespread among E. coli O26, O103, O111, O128, and O145 inhabiting humans and food animals... - Standardizing antimicrobial susceptibility testing of Campylobacter speciesPatrick F McDermott
J Clin Microbiol 41:1810. 2003 - Antimicrobial-resistant Campylobacter species from retail raw meatsBeilei Ge
Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA
Appl Environ Microbiol 69:3005-7. 2003..Campylobacter coli displayed significantly higher rates of resistance to ciprofloxacin and erythromycin than Campylobacter jejuni, and Campylobacter isolates from turkey meat showed a greater resistance than those from chicken meat... - Isolation of antimicrobial-resistant Escherichia coli from retail meats purchased in Greater Washington, DC, USACarl M Schroeder
Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA
Int J Food Microbiol 85:197-202. 2003..Findings from this study indicate that retail raw meats may often be contaminated with antimicrobial-resistant E. coli... - Characterization of multiple-antimicrobial-resistant salmonella serovars isolated from retail meatsSheng Chen
Department of Nutrition and Food Science, University of Maryland, College Park, Maryland 20742, USA
Appl Environ Microbiol 70:1-7. 2004..These mobile DNA elements have likely played an important role in transmission and dissemination of antimicrobial resistance determinants among Salmonella strains... - Evaluation of molecular typing methods for Escherichia coli O157:H7 isolates from cattle, food, and humansSteven L Foley
Department of Biology, University of Central Arkansas, Conway, Arkansas 72035, USA
J Food Prot 67:651-7. 2004..Additionally, there did not appear to be any correlation among the typing methods examined in this study. Therefore, to date, PFGE remains the technique of choice for molecular subtyping of E. coli O157:H7... - A DNA microarray for identification of virulence and antimicrobial resistance genes in Salmonella serovars and Escherichia coliSheng Chen
Department of Nutrition and Food Science, University of Maryland, 0112 Skinner Building, College Park, MD 20742, USA
Mol Cell Probes 19:195-201. 2005..Microarray analysis is an effective method to rapidly screen Salmonella and E. coli for multiple antimicrobial resistance and virulence genes... - Role of efflux pumps and topoisomerase mutations in fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coliBeilei Ge
Department of Nutrition and Food Science, 0112 Skinner Building, University of Maryland, College Park, MD 20742, USA
Antimicrob Agents Chemother 49:3347-54. 2005..These two mechanisms work synergistically in acquiring and maintaining fluoroquinolone resistance in Campylobacter species... - Antimicrobial resistance of Escherichia coli O157 isolated from humans, cattle, swine, and foodCarl M Schroeder
Department of Nutrition and Food Science, 3304 Marie Mount Hall, University of Maryland, College Park, MD 20742, USA
Appl Environ Microbiol 68:576-81. 2002....