Genomes and Genes
Affiliation: Food and Drug Administration
- The tyrosine kinase inhibitor genistein blocks HIV-1 infection in primary human macrophagesTzanko S Stantchev
Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University Bethesda, 4301 Jones Bridge Road, MD 20814, USA
Virus Res 123:178-89. 2007..These findings suggest that other exploitable targets, or steps, of the HIV-1 infection process may exist and could serve as additional opportunities for the development of new therapeutics...
- Thiol/disulfide exchange is a prerequisite for CXCR4-tropic HIV-1 envelope-mediated T-cell fusion during viral entryIngrid Markovic
Center for Drug Evaluation and Research, Food and Drug Adminiatration, Bethesda, MD, USA
Blood 103:1586-94. 2004....
- Recent advances in understanding the molecular mechanisms of HIV-1 entry and fusion: revisiting current targets and considering new options for therapeutic interventionIngrid Markovic
Division of Monoclonal Antibodies, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 USA
Curr HIV Res 2:223-34. 2004....
- Advances in HIV-1 entry inhibitors: strategies to interfere with receptor and coreceptor engagementIngrid Markovic
Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration Building 29A, Room 2D16, 29 Lincoln Drive HFD 122, Bethesda, MD 20892, USA
Curr Pharm Des 12:1105-19. 2006..This review focuses on compounds blocking viral attachment to CD4, CCR5 or CXCR4, highlights the challenges they present, and attempts to offer possible solutions...
- Reversible stages of the low-pH-triggered conformational change in influenza virus hemagglutininEugenia Leikina
Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1855, USA
EMBO J 21:5701-10. 2002..The existence of the identified reversible stage of refolding can be crucial for allowing multiple copies of HA to synchronize their release of conformational energy, as required for fusion...
- Heterogeneity of early intermediates in cell-liposome fusion mediated by influenza hemagglutininMikhail A Zhukovsky
Laboratory of Cellular and Molecular Biophysics, Section on Membrane Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Biophys J 91:3349-58. 2006..This diversity of fusion intermediates emphasizes the importance of local membrane composition and local protein concentration in fusion of heterogeneous biological membranes...
- Influence of calcium on lipid mixing mediated by influenza hemagglutininMikhail A Zhukovsky
Section on Membrane Biology, Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Arch Biochem Biophys 465:101-8. 2007..We suggest that calcium promotes the transition from early and reversible conformation(s) of low pH-activated HA towards an irreversible conformation that underlies both HA-mediated lipid mixing and HA inactivation...