Ingrid Markovic

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc The tyrosine kinase inhibitor genistein blocks HIV-1 infection in primary human macrophages
    Tzanko S Stantchev
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University Bethesda, 4301 Jones Bridge Road, MD 20814, USA
    Virus Res 123:178-89. 2007
  2. ncbi request reprint Thiol/disulfide exchange is a prerequisite for CXCR4-tropic HIV-1 envelope-mediated T-cell fusion during viral entry
    Ingrid Markovic
    Center for Drug Evaluation and Research, Food and Drug Adminiatration, Bethesda, MD, USA
    Blood 103:1586-94. 2004
  3. ncbi request reprint Recent advances in understanding the molecular mechanisms of HIV-1 entry and fusion: revisiting current targets and considering new options for therapeutic intervention
    Ingrid Markovic
    Division of Monoclonal Antibodies, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 USA
    Curr HIV Res 2:223-34. 2004
  4. ncbi request reprint Advances in HIV-1 entry inhibitors: strategies to interfere with receptor and coreceptor engagement
    Ingrid Markovic
    Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration Building 29A, Room 2D16, 29 Lincoln Drive HFD 122, Bethesda, MD 20892, USA
    Curr Pharm Des 12:1105-19. 2006
  5. pmc Reversible stages of the low-pH-triggered conformational change in influenza virus hemagglutinin
    Eugenia Leikina
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1855, USA
    EMBO J 21:5701-10. 2002
  6. pmc Heterogeneity of early intermediates in cell-liposome fusion mediated by influenza hemagglutinin
    Mikhail A Zhukovsky
    Laboratory of Cellular and Molecular Biophysics, Section on Membrane Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biophys J 91:3349-58. 2006
  7. pmc Influence of calcium on lipid mixing mediated by influenza hemagglutinin
    Mikhail A Zhukovsky
    Section on Membrane Biology, Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Biochem Biophys 465:101-8. 2007

Collaborators

Detail Information

Publications7

  1. pmc The tyrosine kinase inhibitor genistein blocks HIV-1 infection in primary human macrophages
    Tzanko S Stantchev
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University Bethesda, 4301 Jones Bridge Road, MD 20814, USA
    Virus Res 123:178-89. 2007
    ..These findings suggest that other exploitable targets, or steps, of the HIV-1 infection process may exist and could serve as additional opportunities for the development of new therapeutics...
  2. ncbi request reprint Thiol/disulfide exchange is a prerequisite for CXCR4-tropic HIV-1 envelope-mediated T-cell fusion during viral entry
    Ingrid Markovic
    Center for Drug Evaluation and Research, Food and Drug Adminiatration, Bethesda, MD, USA
    Blood 103:1586-94. 2004
    ....
  3. ncbi request reprint Recent advances in understanding the molecular mechanisms of HIV-1 entry and fusion: revisiting current targets and considering new options for therapeutic intervention
    Ingrid Markovic
    Division of Monoclonal Antibodies, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 USA
    Curr HIV Res 2:223-34. 2004
    ....
  4. ncbi request reprint Advances in HIV-1 entry inhibitors: strategies to interfere with receptor and coreceptor engagement
    Ingrid Markovic
    Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration Building 29A, Room 2D16, 29 Lincoln Drive HFD 122, Bethesda, MD 20892, USA
    Curr Pharm Des 12:1105-19. 2006
    ..This review focuses on compounds blocking viral attachment to CD4, CCR5 or CXCR4, highlights the challenges they present, and attempts to offer possible solutions...
  5. pmc Reversible stages of the low-pH-triggered conformational change in influenza virus hemagglutinin
    Eugenia Leikina
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1855, USA
    EMBO J 21:5701-10. 2002
    ..The existence of the identified reversible stage of refolding can be crucial for allowing multiple copies of HA to synchronize their release of conformational energy, as required for fusion...
  6. pmc Heterogeneity of early intermediates in cell-liposome fusion mediated by influenza hemagglutinin
    Mikhail A Zhukovsky
    Laboratory of Cellular and Molecular Biophysics, Section on Membrane Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biophys J 91:3349-58. 2006
    ..This diversity of fusion intermediates emphasizes the importance of local membrane composition and local protein concentration in fusion of heterogeneous biological membranes...
  7. pmc Influence of calcium on lipid mixing mediated by influenza hemagglutinin
    Mikhail A Zhukovsky
    Section on Membrane Biology, Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Biochem Biophys 465:101-8. 2007
    ..We suggest that calcium promotes the transition from early and reversible conformation(s) of low pH-activated HA towards an irreversible conformation that underlies both HA-mediated lipid mixing and HA inactivation...