Tahir H Malik

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Functional consequences of attenuating mutations in the haemagglutinin neuraminidase, fusion and polymerase proteins of a wild-type mumps virus strain
    Tahir Malik
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Gen Virol 88:2533-41. 2007
  2. ncbi request reprint A single nucleotide change in the mumps virus F gene affects virus fusogenicity in vitro and virulence in vivo
    Tahir Malik
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Neurovirol 13:513-21. 2007
  3. doi request reprint Single amino acid changes in the mumps virus haemagglutinin-neuraminidase and polymerase proteins are associated with neuroattenuation
    Tahir H Malik
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Gen Virol 90:1741-7. 2009
  4. pmc Discrimination of mumps virus small hydrophobic gene deletion effects from gene translation effects on virus virulence
    Tahir Malik
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Virol 85:6082-5. 2011
  5. ncbi request reprint Changes in mumps virus neurovirulence phenotype associated with quasispecies heterogeneity
    Christian J Sauder
    DVP Office of Vaccines Research and Review, Center for Biologics, Evaluation and Research, Food and Drug Administration, Building 29A, Room 1A 21, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Virology 350:48-57. 2006
  6. pmc Changes in mumps virus gene sequence associated with variability in neurovirulent phenotype
    Steven A Rubin
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 77:11616-24. 2003
  7. pmc A mouse-based assay for the pre-clinical neurovirulence assessment of vaccinia virus-based smallpox vaccines
    Cheryl X Zhang
    FDA, Division of Viral Products, Lincoln Drive, Bethesda, MD 20892, USA
    Biologicals 38:278-83. 2010

Detail Information

Publications7

  1. ncbi request reprint Functional consequences of attenuating mutations in the haemagglutinin neuraminidase, fusion and polymerase proteins of a wild-type mumps virus strain
    Tahir Malik
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Gen Virol 88:2533-41. 2007
    ..These data suggest a polygenic component (i.e. specific and inter-related roles of these amino acid changes) to MuV neuroattenuation...
  2. ncbi request reprint A single nucleotide change in the mumps virus F gene affects virus fusogenicity in vitro and virulence in vivo
    Tahir Malik
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Neurovirol 13:513-21. 2007
    ..This infectious clone system will serve as a key tool for further examination of the molecular basis for mumps virus neurovirulence and neuroattenuation...
  3. doi request reprint Single amino acid changes in the mumps virus haemagglutinin-neuraminidase and polymerase proteins are associated with neuroattenuation
    Tahir H Malik
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Gen Virol 90:1741-7. 2009
    ..This report provides additional supporting evidence for the role of the HN protein as a virulence factor and, as far as is known, is the first report to associate an amino acid change in the L protein with mumps virus neuroattenuation...
  4. pmc Discrimination of mumps virus small hydrophobic gene deletion effects from gene translation effects on virus virulence
    Tahir Malik
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Virol 85:6082-5. 2011
    ..These data indicate that the MuV SH protein is not a neurovirulence factor and highlight the importance of distinguishing gene deletion effects from protein-specific effects...
  5. ncbi request reprint Changes in mumps virus neurovirulence phenotype associated with quasispecies heterogeneity
    Christian J Sauder
    DVP Office of Vaccines Research and Review, Center for Biologics, Evaluation and Research, Food and Drug Administration, Building 29A, Room 1A 21, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Virology 350:48-57. 2006
    ....
  6. pmc Changes in mumps virus gene sequence associated with variability in neurovirulent phenotype
    Steven A Rubin
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 77:11616-24. 2003
    ..The potential role of these amino acid changes in neurotropism, neurovirulence, and neuroattenuation is discussed...
  7. pmc A mouse-based assay for the pre-clinical neurovirulence assessment of vaccinia virus-based smallpox vaccines
    Cheryl X Zhang
    FDA, Division of Viral Products, Lincoln Drive, Bethesda, MD 20892, USA
    Biologicals 38:278-83. 2010
    ..Our data indicate that testing of 10-100 pfu of virus in mice following intracranial inoculation reliably assesses the virus's neurovirulence potential for humans...