Research Topics
Species | Marian E MajorSummaryAffiliation: Food and Drug Administration Country: USA Publications
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Detail Information
Publications
Hepatitis C virus kinetics and host responses associated with disease and outcome of infection in chimpanzeesMarian E Major
Laboratory of Hepatitis Viruses, Division of Viral Products Center for Biologics Evaluation and Research Food and Drug Administration, Bethesda, MD, USA
Hepatology 39:1709-20. 2004..However, the pathogenesis of HCV may be determined by a more rapid onset of the induced response and the cell population that migrates to the liver...
Kinetics of CD4+ and CD8+ memory T-cell responses during hepatitis C virus rechallenge of previously recovered chimpanzeesMichelina Nascimbeni
Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 77:4781-93. 2003..The rate of HCV clearance following reexposure depends on the cellular immune response, the quality and quantity of which may vary among chimpanzees that recovered from HCV infection...- CD4+ immune escape and subsequent T-cell failure following chimpanzee immunization against hepatitis C virusMontserrat Puig
Laboratory of Hepatitis Viruses, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Hepatology 44:736-45. 2006..Vaccines that can induce strong T-cell responses prior to challenge will not necessarily prevent persistent HCV infection... - Previously infected and recovered chimpanzees exhibit rapid responses that control hepatitis C virus replication upon rechallengeMarian E Major
Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institute of Diabetes and Digestive and Kidney Diseases NIH, 8800 Rockville Pike, Bethesda, MD 20892, USA
J Virol 76:6586-95. 2002..These observations have encouraging implications for the development of a vaccine for HCV... - Long-term persistence of infection in chimpanzees inoculated with an infectious hepatitis C virus clone is associated with a decrease in the viral amino acid substitution rate and low levels of heterogeneityJavier Fernandez
Laboratory of Hepatitis Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29A, Room 1D10, HVM 448, 8800 Rockville Pike, Bethesda, MD 20892, USA
J Virol 78:9782-9. 2004..These data also indicate that immune pressure and selection continue throughout the chronic phase... - Immunization of chimpanzees with an envelope protein-based vaccine enhances specific humoral and cellular immune responses that delay hepatitis C virus infectionMontserrat Puig
Laboratory of Hepatitis Viruses, Division of Viral Products, CBER, FDA, Building 29A, Room 1D02, 8800 Rockville Pike, Bethesda, MD 20892, USA
Vaccine 22:991-1000. 2004..This data indicates that a strategy inducing a T-cell immune response combined with antibody responses to E1E2 would make a viable candidate for an HCV vaccine... - Sensitivity and reproducibility of HCV quantitation in chimpanzee sera using TaqMan real-time PCR assayMontserrat Puig
Laboratory of Hepatitis Viruses, Division of Viral Products, CBER, FDA, Building 29A, Room 1D02, 8800 Rockville Pike, Bethesda, MD 20892, USA
J Virol Methods 105:253-63. 2002.... 
Prospects for prophylactic and therapeutic vaccines against hepatitis C virusStephen M Feinstone
Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Clin Infect Dis 55:S25-32. 2012..This review summarizes the current state of HCV vaccines and the challenges faced for future development and clinical trial design...- New neutralizing antibody epitopes in hepatitis C virus envelope glycoproteins are revealed by dissecting peptide recognition profilesAlla Kachko
Laboratory of Hepatitis Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Vaccine 30:69-77. 2011.... - The NS3 protein of hepatitis C virus induces caspase-8-mediated apoptosis independent of its protease or helicase activitiesElena A Prikhod'ko
Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
Virology 329:53-67. 2004..These findings suggest that HCV NS3 promotes caspase-8 induced apoptosis at a pathway site distal to FADD, and that flavivirus NS3 may represent a new class of pro-apoptotic proteins... - Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitroBrett D Lindenbach
Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 103:3805-9. 2006..These results greatly extend the utility of the HCVcc genetic system to allow the complete in vitro and in vivo dissection of the HCV life cycle... - Analysis of mutant NS5B proteins encoded by isolates from chimpanzees chronically infected following clonal HCV RNA inoculationHong Lou
Department of Medicine and Genetics Program-Winship Cancer Center, Emory University School of Medicine, Atlanta, GA 30322, USA
Virology 317:65-72. 2003..The results demonstrate that some in vivo mutations of NS5B directly enhance in vitro RdRp activity. In addition, they suggest that the in vitro RdRp activity of NS5B may not always reflect in vivo activity within replication complexes...