Beverly D Lyn-Cook

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Increased expression of Toll-like receptors (TLRs) 7 and 9 and other cytokines in systemic lupus erythematosus (SLE) patients: ethnic differences and potential new targets for therapeutic drugs
    Beverly D Lyn-Cook
    FDA National Center for Toxicological Research, Jefferson, AR, United States Electronic address
    Mol Immunol 61:38-43. 2014
  2. ncbi request reprint Gender differences in gemcitabine (Gemzar) efficacy in cancer cells: effect of indole-3-carbinol
    Beverly D Lyn-Cook
    FDA National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Anticancer Res 30:4907-13. 2010
  3. pmc Ethnic differences in DNA methyltransferases expression in patients with systemic lupus erythematosus
    Kenneth L Wiley
    FDA National Center for Toxicological Research, Jefferson, AR 72079, USA
    J Clin Immunol 33:342-8. 2013
  4. ncbi request reprint Enhanced efficacy of gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrative nucleoside transporter 1
    Honggang Wang
    Office of Regulatory Activities, FDA National Center for Toxicological Research, Jefferson, Arkansas 72079, U S A
    Anticancer Res 31:3171-80. 2011
  5. ncbi request reprint Age and gender affect DNMT3a and DNMT3b expression in human liver
    Yongmei Xiao
    Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Cell Biol Toxicol 24:265-72. 2008
  6. ncbi request reprint Increased expression of heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP) in pancreatic tissue from smokers and pancreatic tumor cells
    Yan Yan-Sanders
    Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Cancer Lett 183:215-20. 2002
  7. doi request reprint Cigarette smoke condensate induces differential expression and promoter methylation profiles of critical genes involved in lung cancer in NL-20 lung cells in vitro: short-term and chronic exposure
    Beverly Word
    HFT 100, Office of Regulatory Activities, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Int J Toxicol 32:23-31. 2013
  8. ncbi request reprint Modulation of the constitutive activated STAT3 transcription factor in pancreatic cancer prevention: effects of indole-3-carbinol (I3C) and genistein
    Jian P Lian
    National Center for Toxicological Research, Jefferson, AR 72079, USA
    Anticancer Res 24:133-7. 2004

Collaborators

  • Beverly Word
  • Honggang Wang
  • Kenneth L Wiley
  • George Hammons
  • Yongmei Xiao
  • Jian P Lian
  • George J Hammons
  • Yan Yan-Sanders
  • Kayihura Manigaba
  • Bibi Mwamba
  • Lascelles E Lyn-Cook
  • Edward Treadwell
  • Beverly R Word
  • Atena Starlard-Davenport
  • Aaron Haefele
  • Skeetora Taylor

Detail Information

Publications8

  1. ncbi request reprint Increased expression of Toll-like receptors (TLRs) 7 and 9 and other cytokines in systemic lupus erythematosus (SLE) patients: ethnic differences and potential new targets for therapeutic drugs
    Beverly D Lyn-Cook
    FDA National Center for Toxicological Research, Jefferson, AR, United States Electronic address
    Mol Immunol 61:38-43. 2014
    ..Increased expression in these lupus patients provides an opportunity for targeting with antagonist as a new therapy for systemic lupus erythematous. ..
  2. ncbi request reprint Gender differences in gemcitabine (Gemzar) efficacy in cancer cells: effect of indole-3-carbinol
    Beverly D Lyn-Cook
    FDA National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Anticancer Res 30:4907-13. 2010
    ..This study demonstrated the potential of I3C, a possible non-toxic hypomethylating agent, combined with the anticancer agent, gemcitabine, to be a powerful strategy for treating pancreatic cancer...
  3. pmc Ethnic differences in DNA methyltransferases expression in patients with systemic lupus erythematosus
    Kenneth L Wiley
    FDA National Center for Toxicological Research, Jefferson, AR 72079, USA
    J Clin Immunol 33:342-8. 2013
    ..Furthermore, differential expression in one of the DNMTs was found in a subset of lupus patients on dehydroepiandrosterone (DHEA) therapy...
  4. ncbi request reprint Enhanced efficacy of gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrative nucleoside transporter 1
    Honggang Wang
    Office of Regulatory Activities, FDA National Center for Toxicological Research, Jefferson, Arkansas 72079, U S A
    Anticancer Res 31:3171-80. 2011
    ..This study demonstrates that up-regulation of hENT1 expression may be a novel mechanism involved in the additive effect of I3C and gemcitabine...
  5. ncbi request reprint Age and gender affect DNMT3a and DNMT3b expression in human liver
    Yongmei Xiao
    Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Cell Biol Toxicol 24:265-72. 2008
    ..The findings from this study suggest that ageing and gender may be important factors influencing DNA methylation status...
  6. ncbi request reprint Increased expression of heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP) in pancreatic tissue from smokers and pancreatic tumor cells
    Yan Yan-Sanders
    Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Cancer Lett 183:215-20. 2002
    ..Over-expression of hnRNP has been suggested as evidence that normal transcriptional regulation is altered...
  7. doi request reprint Cigarette smoke condensate induces differential expression and promoter methylation profiles of critical genes involved in lung cancer in NL-20 lung cells in vitro: short-term and chronic exposure
    Beverly Word
    HFT 100, Office of Regulatory Activities, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Int J Toxicol 32:23-31. 2013
    ..This study provides critical data suggesting that epigenetic changes could serve as an early biomarker of harm due to exposure to cigarette smoke...
  8. ncbi request reprint Modulation of the constitutive activated STAT3 transcription factor in pancreatic cancer prevention: effects of indole-3-carbinol (I3C) and genistein
    Jian P Lian
    National Center for Toxicological Research, Jefferson, AR 72079, USA
    Anticancer Res 24:133-7. 2004
    ..The signal transducer and activator of transcription 3 (STAT3) is a latent transcription factor required in proliferation and differentiation. STAT3 is activated constitutively in a number of cancers...