Che Hung Lee
Affiliation: Food and Drug Administration
- Preparation and characterization of an immunogenic meningococcal group A conjugate vaccine for use in AfricaChe Hung Lee
Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA
Vaccine 27:726-32. 2009..Lancet 2003, 361:1092-4]. A phase 1 clinical trial of the manufactured Men A-TT conjugate vaccine has been successfully carried out in adults in India, and a phase 2 clinical trial in young children is currently underway in Africa...
- Effect of O acetylation of Neisseria meningitidis serogroup A capsular polysaccharide on development of functional immune responsesDavid S Berry
Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Bethesda, Maryland 20892, USA
Infect Immun 70:3707-13. 2002..Since levels of bactericidal antibodies are correlated with protection against disease, O-acetyl groups appear to be important in protection...
- Comparison of Neisseria meningitidis serogroup W135 polysaccharide-tetanus toxoid conjugate vaccines made by periodate activation of O-acetylated, non-O-acetylated and chemically de-O-acetylated polysaccharideSeshu K Gudlavalleti
Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Vaccine 25:7972-80. 2007..Thus, for W135, PS O-acetylation does not contribute a dominant immunogenic epitope. The OAc(-) PS may be a good starting material for preparing W135 PS-TT conjugate vaccines using periodate oxidation...
- Chemoenzymatic synthesis of immunogenic meningococcal group C polysialic acid-tetanus Hc fragment glycoconjugatesPumtiwitt C McCarthy
Laboratory of Bacterial Polysaccharides, CBER FDA, 8800 Rockville Pike, Bethesda, MD, 20892, USA
Glycoconj J 30:857-70. 2013..These results suggest that chemoenzymatic synthesis may provide a viable method for making defined meningococcal vaccine candidates...