M H Kothary

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc Characterization of the zinc-containing metalloprotease encoded by zpx and development of a species-specific detection method for Enterobacter sakazakii
    M H Kothary
    MOD 1 Facility, Virulence Mechanisms Branch, Division of Virulence Assessment, OARSA, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA
    Appl Environ Microbiol 73:4142-51. 2007
  2. pmc Identification and characterization of Cronobacter iron acquisition systems
    C J Grim
    CFSAN, FDA, Laurel, Maryland, USA
    Appl Environ Microbiol 78:6035-50. 2012
  3. pmc Characterization of putative virulence genes on the related RepFIB plasmids harbored by Cronobacter spp
    A A Franco
    Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, Laurel, MD, USA
    Appl Environ Microbiol 77:3255-67. 2011
  4. doi request reprint The Pathogen-annotated Tracking Resource Network (PATRN) system: a web-based resource to aid food safety, regulatory science, and investigations of foodborne pathogens and disease
    G Gopinath
    CFSAN, FDA, Laurel, MD 20708, USA
    Food Microbiol 34:303-18. 2013
  5. pmc Purification and characterization of a vulnificolysin-like cytolysin produced by Vibrio tubiashii
    M H Kothary
    Divisions of Virulence Assessment, Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, Washington, DC 20204, USA
    Appl Environ Microbiol 67:3707-11. 2001
  6. ncbi request reprint Two-step purification and partial characterization of a variant of the Vibrio cholerae non-O1 hemolysin
    B A McCardell
    Division of Virulence Assessment, Center for Food Safety and Applied Nutrition, FDA, Washington, DC 20204, USA
    FEMS Microbiol Lett 180:177-82. 1999
  7. ncbi request reprint Identification of a CHO cell-elongating factor produced by Vibrio cholerae O1
    B A McCardell
    U S Food and Drug Administration, Division of Virulence Assessment, 200 C St SW, Washington, DC 20204, USA
    Microb Pathog 29:1-8. 2000
  8. pmc Isolation and characterization of Vibrio tubiashii outer membrane proteins and determination of a toxR homolog
    J Jean Gilles Beaubrun
    Howard University, Washington, DC 20050, USA
    Appl Environ Microbiol 74:907-11. 2008
  9. ncbi request reprint Isolation and characterization of a zinc-containing metalloprotease expressed by Vibrio tubiashii
    R B Delston
    Division of Microbiological Studies, Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, College Park, MD 20740, USA
    Can J Microbiol 49:525-9. 2003
  10. pmc Characterization of Vibrio fluvialis-like strains implicated in limp lobster disease
    B D Tall
    Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, College Park, Maryland 20740, USA
    Appl Environ Microbiol 69:7435-46. 2003

Collaborators

Detail Information

Publications12

  1. pmc Characterization of the zinc-containing metalloprotease encoded by zpx and development of a species-specific detection method for Enterobacter sakazakii
    M H Kothary
    MOD 1 Facility, Virulence Mechanisms Branch, Division of Virulence Assessment, OARSA, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA
    Appl Environ Microbiol 73:4142-51. 2007
    ..23. The sequence possesses three well-characterized zinc-binding and active-site motifs present in other bacterial zinc metalloproteases...
  2. pmc Identification and characterization of Cronobacter iron acquisition systems
    C J Grim
    CFSAN, FDA, Laurel, Maryland, USA
    Appl Environ Microbiol 78:6035-50. 2012
    ..Taken together, these results support the proposition that C. sakazakii and C. malonaticus may be more associated with the human host and C. dublinensis and C. muytjensii with plants...
  3. pmc Characterization of putative virulence genes on the related RepFIB plasmids harbored by Cronobacter spp
    A A Franco
    Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, Laurel, MD, USA
    Appl Environ Microbiol 77:3255-67. 2011
    ..These results support the hypothesis that these plasmids have evolved from a single archetypical plasmid backbone through the cointegration, or deletion, of specific virulence traits in each species...
  4. doi request reprint The Pathogen-annotated Tracking Resource Network (PATRN) system: a web-based resource to aid food safety, regulatory science, and investigations of foodborne pathogens and disease
    G Gopinath
    CFSAN, FDA, Laurel, MD 20708, USA
    Food Microbiol 34:303-18. 2013
    ..In summary, PATRN is a web-based integrated platform containing tools for the management, analysis and visualization of data about foodborne pathogens...
  5. pmc Purification and characterization of a vulnificolysin-like cytolysin produced by Vibrio tubiashii
    M H Kothary
    Divisions of Virulence Assessment, Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, Washington, DC 20204, USA
    Appl Environ Microbiol 67:3707-11. 2001
    ..Twelve of the first 17 N-terminal amino acid residues (Asp-Asp-Tyr-Val-Pro-Val-Val-Glu-Lys-Val-Tyr-Tyr-Ile-Thr-Ser-Ser-Lys) are identical to those of the Vibrio vulnificus cytolysin...
  6. ncbi request reprint Two-step purification and partial characterization of a variant of the Vibrio cholerae non-O1 hemolysin
    B A McCardell
    Division of Virulence Assessment, Center for Food Safety and Applied Nutrition, FDA, Washington, DC 20204, USA
    FEMS Microbiol Lett 180:177-82. 1999
    ..3, respectively. The N-terminal amino acid sequence was ASPAPANSETNTLPHVAFYI. Purified toxin was cytolytic for Chinese hamster ovary cells and erythrocytes from several animal species...
  7. ncbi request reprint Identification of a CHO cell-elongating factor produced by Vibrio cholerae O1
    B A McCardell
    U S Food and Drug Administration, Division of Virulence Assessment, 200 C St SW, Washington, DC 20204, USA
    Microb Pathog 29:1-8. 2000
    ..Partly purified Cef did not increase cyclic AMP or prostaglandin E(2)levels in CHO cells which suggests that its mechanism of action differs from that of cholera toxin...
  8. pmc Isolation and characterization of Vibrio tubiashii outer membrane proteins and determination of a toxR homolog
    J Jean Gilles Beaubrun
    Howard University, Washington, DC 20050, USA
    Appl Environ Microbiol 74:907-11. 2008
    ..Results showed the presence of a 38- to 40-kDa OmpU-like protein and ompU gene, a maltoporin-like protein, several novel OMPs, and a regulatory toxR homolog...
  9. ncbi request reprint Isolation and characterization of a zinc-containing metalloprotease expressed by Vibrio tubiashii
    R B Delston
    Division of Microbiological Studies, Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, College Park, MD 20740, USA
    Can J Microbiol 49:525-9. 2003
    ..The N-terminal amino acid sequence (Ala-Gln-Ala-Thr-Gly-Thr-Gly- Pro-Gly-Gly-Asn-Gln-Lys-Thr-Gly-Gln- Tyr-Asn-Phe-Gly) has strong homology to other Vibrio proteases...
  10. pmc Characterization of Vibrio fluvialis-like strains implicated in limp lobster disease
    B D Tall
    Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, College Park, Maryland 20740, USA
    Appl Environ Microbiol 69:7435-46. 2003
    ..fluvialis-like organisms were responsible for the originally described systemic disease, which is now called limp lobster disease...
  11. pmc Cpa, the outer membrane protease of Cronobacter sakazakii, activates plasminogen and mediates resistance to serum bactericidal activity
    A A Franco
    Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, Laurel, Maryland, USA
    Infect Immun 79:1578-87. 2011
    ..These results strongly suggest that Cpa may be an important virulence factor involved in serum resistance, as well as in the spread and invasion of C. sakazakii...
  12. pmc Perkinsus marinus extracellular protease modulates survival of Vibrio vulnificus in Eastern oyster (Crassostrea virginica) hemocytes
    B D Tall
    Divisions of Microbiological Studies, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D C 20204, USA
    Appl Environ Microbiol 65:4261-3. 1999
    ..marinus suppresses the vibriocidal activity of oyster hemocytes to effectively eliminate V. vulnificus, potentially leading to conditions favoring higher numbers of vibrios in oyster tissues...