Krishnamurthy Konduru

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc A simple and rapid Hepatitis A Virus (HAV) titration assay based on antibiotic resistance of infected cells: evaluation of the HAV neutralization potency of human immune globulin preparations
    Krishnamurthy Konduru
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, Maryland 20892, USA
    Virol J 5:155. 2008
  2. pmc Hepatitis A virus (HAV) packaging size limit
    Krishnamurthy Konduru
    Laboratory of Hepatitis and Related Emerging Agents, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Virol J 6:204. 2009
  3. pmc Binding of hepatitis A virus to its cellular receptor 1 inhibits T-regulatory cell functions in humans
    Mohanraj Manangeeswaran
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    Gastroenterology 142:1516-25.e3. 2012
  4. pmc The interaction of hepatitis A virus (HAV) with soluble forms of its cellular receptor 1 (HAVCR1) share the physiological requirements of infectivity in cell culture
    Erica Silberstein
    Laboratory of Hepatitis and Related Emerging Agents, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Virol J 6:175. 2009
  5. pmc Determinants in 3Dpol modulate the rate of growth of hepatitis A virus
    Krishnamurthy Konduru
    Laboratory of Hepatitis and Related Emerging Agents, DETTD OBRR, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 84:8342-7. 2010
  6. pmc Ebola virus glycoprotein Fc fusion protein confers protection against lethal challenge in vaccinated mice
    Krishnamurthy Konduru
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Vaccine 29:2968-77. 2011
  7. pmc Development and characterization of rabbit and mouse antibodies against ebolavirus envelope glycoproteins
    Wu Ou
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA
    J Virol Methods 174:99-109. 2011
  8. pmc Stable growth of wild-type hepatitis A virus in cell culture
    Krishnamurthy Konduru
    Laboratory of Hepatitis and Related Emerging Agents, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Virol 80:1352-60. 2006

Collaborators

Detail Information

Publications8

  1. pmc A simple and rapid Hepatitis A Virus (HAV) titration assay based on antibiotic resistance of infected cells: evaluation of the HAV neutralization potency of human immune globulin preparations
    Krishnamurthy Konduru
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, Maryland 20892, USA
    Virol J 5:155. 2008
    ..Simple HAV titration assays could be developed using currently available viral construct containing selectable markers...
  2. pmc Hepatitis A virus (HAV) packaging size limit
    Krishnamurthy Konduru
    Laboratory of Hepatitis and Related Emerging Agents, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Virol J 6:204. 2009
    ..However, the packaging size limit of HAV has not been determined. The purpose of the present study is to investigate the maximum size of additional sequences that the HAV genome can tolerate without loosing infectivity...
  3. pmc Binding of hepatitis A virus to its cellular receptor 1 inhibits T-regulatory cell functions in humans
    Mohanraj Manangeeswaran
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    Gastroenterology 142:1516-25.e3. 2012
    ..We investigated whether the interaction of HAV with its cellular receptor 1 (HAVCR1), a T-cell co-stimulatory molecule, inhibits the function of Treg cells to control HAV infection...
  4. pmc The interaction of hepatitis A virus (HAV) with soluble forms of its cellular receptor 1 (HAVCR1) share the physiological requirements of infectivity in cell culture
    Erica Silberstein
    Laboratory of Hepatitis and Related Emerging Agents, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Virol J 6:175. 2009
    ..Here, we used HAV soluble receptor neutralization and alteration assays to study the requirements of the HAV-HAVCR1 interaction and to determine whether HAVCR1 is also a receptor for wt HAV...
  5. pmc Determinants in 3Dpol modulate the rate of growth of hepatitis A virus
    Krishnamurthy Konduru
    Laboratory of Hepatitis and Related Emerging Agents, DETTD OBRR, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 84:8342-7. 2010
    ..Here, we identified a novel determinant(s) in 3D(pol) that controls the kinetics of HAV growth...
  6. pmc Ebola virus glycoprotein Fc fusion protein confers protection against lethal challenge in vaccinated mice
    Krishnamurthy Konduru
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Vaccine 29:2968-77. 2011
    ..Our data suggested that Filovirus GP Fc fusion proteins could be developed as a simple, safe, efficacious, and cost effective vaccine against Filovirus infection for human use...
  7. pmc Development and characterization of rabbit and mouse antibodies against ebolavirus envelope glycoproteins
    Wu Ou
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA
    J Virol Methods 174:99-109. 2011
    ..Together, our results suggest that this panel of antibodies may prove useful for both in vitro analyses of ebolavirus GP₁,₂, as well as analysis of clinically relevant samples...
  8. pmc Stable growth of wild-type hepatitis A virus in cell culture
    Krishnamurthy Konduru
    Laboratory of Hepatitis and Related Emerging Agents, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Virol 80:1352-60. 2006
    ..The cell lines susceptible to wt HAV growth may also be used to detect and isolate infectious virus from patient and environmental samples...