Elena Karnaukhova

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Recombinant human alpha-1 proteinase inhibitor: towards therapeutic use
    E Karnaukhova
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Amino Acids 30:317-32. 2006
  2. doi request reprint Heme binding to human alpha-1 proteinase inhibitor
    Elena Karnaukhova
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1820:2020-9. 2012
  3. doi request reprint Interactions of alpha1-proteinase inhibitor with small ligands of therapeutic potential: binding with retinoic acid
    Elena Karnaukhova
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Amino Acids 38:1011-20. 2010
  4. ncbi request reprint Interactions of human serum albumin with retinoic acid, retinal and retinyl acetate
    Elena Karnaukhova
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Biochem Pharmacol 73:901-10. 2007
  5. ncbi request reprint Development and evaluation of an ELISA for quantification of human alpha-1-proteinase inhibitor in complex biological mixtures
    Elena Karnaukhova
    Division of Hematology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Biologicals 35:285-95. 2007
  6. pmc Expression of human alpha1-proteinase inhibitor in Aspergillus niger
    Elena Karnaukhova
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, 20892 USA
    Microb Cell Fact 6:34. 2007
  7. doi request reprint Production, purification, and characterization of human alpha1 proteinase inhibitor from Aspergillus niger
    Liat Chill
    Biotechnology Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 14A Room 170, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    Biotechnol Bioeng 102:828-44. 2009
  8. pmc Mapping the binding region on the low density lipoprotein receptor for blood coagulation factor VIII
    James H Kurasawa
    Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852, USA
    J Biol Chem 288:22033-41. 2013
  9. pmc Oversulfated chondroitin sulfate binds to chemokines and inhibits stromal cell-derived factor-1 mediated signaling in activated T cells
    Zhao Hua Zhou
    Division of Monoclonal Antibodies, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 9:e94402. 2014
  10. pmc Oversulfated chondroitin sulfate inhibits the complement classical pathway by potentiating C1 inhibitor
    Zhao Hua Zhou
    Division of Monoclonal Antibodies, Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America
    PLoS ONE 7:e47296. 2012

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Recombinant human alpha-1 proteinase inhibitor: towards therapeutic use
    E Karnaukhova
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Amino Acids 30:317-32. 2006
    ....
  2. doi request reprint Heme binding to human alpha-1 proteinase inhibitor
    Elena Karnaukhova
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1820:2020-9. 2012
    ..While heme binding by hemopexin, albumin and α(1)-microglobulin has been extensively studied, the role of other plasma proteins remains largely unknown...
  3. doi request reprint Interactions of alpha1-proteinase inhibitor with small ligands of therapeutic potential: binding with retinoic acid
    Elena Karnaukhova
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Amino Acids 38:1011-20. 2010
    ....
  4. ncbi request reprint Interactions of human serum albumin with retinoic acid, retinal and retinyl acetate
    Elena Karnaukhova
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Biochem Pharmacol 73:901-10. 2007
    ....
  5. ncbi request reprint Development and evaluation of an ELISA for quantification of human alpha-1-proteinase inhibitor in complex biological mixtures
    Elena Karnaukhova
    Division of Hematology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Biologicals 35:285-95. 2007
    ....
  6. pmc Expression of human alpha1-proteinase inhibitor in Aspergillus niger
    Elena Karnaukhova
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, 20892 USA
    Microb Cell Fact 6:34. 2007
    ..abstract:..
  7. doi request reprint Production, purification, and characterization of human alpha1 proteinase inhibitor from Aspergillus niger
    Liat Chill
    Biotechnology Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 14A Room 170, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    Biotechnol Bioeng 102:828-44. 2009
    ..The Galactofuranose-containing high-mannnose type N-glycans are typical structures, which recently have been found as part of several glycoproteins produced by Aspergillus niger...
  8. pmc Mapping the binding region on the low density lipoprotein receptor for blood coagulation factor VIII
    James H Kurasawa
    Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852, USA
    J Biol Chem 288:22033-41. 2013
    ..In conclusion, the region of CR.2-5 of LDLR was defined as the binding site for FVIII and RAP. ..
  9. pmc Oversulfated chondroitin sulfate binds to chemokines and inhibits stromal cell-derived factor-1 mediated signaling in activated T cells
    Zhao Hua Zhou
    Division of Monoclonal Antibodies, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 9:e94402. 2014
    ....
  10. pmc Oversulfated chondroitin sulfate inhibits the complement classical pathway by potentiating C1 inhibitor
    Zhao Hua Zhou
    Division of Monoclonal Antibodies, Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America
    PLoS ONE 7:e47296. 2012
    ..This effect on C1inh may play a role in inhibiting inflammation as well as impacting bacterial clearance...
  11. doi request reprint Potentiation of C1-esterase inhibitor by heparin and interactions with C1s protease as assessed by surface plasmon resonance
    Mohsen Rajabi
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1820:56-63. 2012
    ..To advance a SPR for multiple-unit interaction studies of C1-INH we have developed a novel (consecutive double capture) approach exploring different immobilization and layout...
  12. doi request reprint Human cellular prion protein interacts directly with clusterin protein
    Fei Xu
    Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD, USA
    Biochim Biophys Acta 1782:615-20. 2008
    ..These findings provide new insights into the molecular mechanisms of interaction between prion and clusterin protein and contribute to the understanding of prion protein's physiological function...
  13. doi request reprint Blood aging, safety, and transfusion: capturing the "radical" menace
    Paul W Buehler
    Division of Hematology, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Bethesda, Maryland 20892, USA
    Antioxid Redox Signal 14:1713-28. 2011
    ..Furthermore, some of the same naturally occurring protective mechanisms can potentially be employed to oxidatively inactivate this redox active protein and control its damaging side reactions when released outside of the RBC...
  14. ncbi request reprint Circular dichroism of heterochromophoric and partially regenerated purple membrane: search for exciton coupling
    Elena Karnaukhova
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Chirality 18:72-83. 2006
    ....