Yiping Jia

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Structural basis of peroxide-mediated changes in human hemoglobin: a novel oxidative pathway
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Biol Chem 282:4894-907. 2007
  2. ncbi request reprint Site-specific cross-linking of human and bovine hemoglobins differentially alters oxygen binding and redox side reactions producing rhombic heme and heme degradation
    Enika Nagababu
    Molecular Dynamics Section, National Institute on Aging NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Biochemistry 41:7407-15. 2002
  3. ncbi request reprint Oxygen binding and oxidation reactions of human hemoglobin conjugated to carboxylate dextran
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1672:164-73. 2004
  4. pmc Cross-linking with O-raffinose lowers oxygen affinity and stabilizes haemoglobin in a non-cooperative T-state conformation
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, Bethesda, Maryland 20892, USA
    Biochem J 384:367-75. 2004
  5. doi request reprint Effects of (-)-epigallocatechin gallate on the redox reactions of human hemoglobin
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health Campus, Bethesda, MD 20892, USA
    Free Radic Biol Med 45:659-66. 2008
  6. pmc Haptoglobin preferentially binds β but not α subunits cross-linked hemoglobin tetramers with minimal effects on ligand and redox reactions
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 8:e59841. 2013
  7. doi request reprint Effects of cross-linking and zero-link polymerization on oxygen transport and redox chemistry of bovine hemoglobin
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology LBVB, Division of Hematology, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, MD 20892, USA
    Biochim Biophys Acta 1794:1234-42. 2009
  8. ncbi request reprint Structural and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions
    Paul W Buehler
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, Bethesda, Maryland 20892, USA
    Anal Chem 77:3466-78. 2005
  9. pmc Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy
    Jin Hyen Baek
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland 20892, USA
    J Clin Invest 122:1444-58. 2012
  10. ncbi request reprint O-raffinose crosslinked hemoglobin lacks site-specific chemistry in the central cavity: structural and functional consequences of beta93Cys modification
    Robert A Boykins
    Laboratory of Biophysics, Division of Bacterial, Parasitic and Allergenic Products, Bethesda, Maryland 20892, USA
    Proteins 59:840-55. 2005

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Structural basis of peroxide-mediated changes in human hemoglobin: a novel oxidative pathway
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Biol Chem 282:4894-907. 2007
    ....
  2. ncbi request reprint Site-specific cross-linking of human and bovine hemoglobins differentially alters oxygen binding and redox side reactions producing rhombic heme and heme degradation
    Enika Nagababu
    Molecular Dynamics Section, National Institute on Aging NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Biochemistry 41:7407-15. 2002
    ..These findings establish the importance of these secondary oxidative reactions over autoxidation in evaluating the toxicity of HBOCs...
  3. ncbi request reprint Oxygen binding and oxidation reactions of human hemoglobin conjugated to carboxylate dextran
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1672:164-73. 2004
    ..However, the reduction in the allosteric function of this protein and the lack of apparent quaternary T-->R transition may hinder its physiological role as an oxygen transporter...
  4. pmc Cross-linking with O-raffinose lowers oxygen affinity and stabilizes haemoglobin in a non-cooperative T-state conformation
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, Bethesda, Maryland 20892, USA
    Biochem J 384:367-75. 2004
    ..Although the physiological ramifications of locking HbA(0) in the T conformation with the O-raffinose are still unknown, valuable insights into haemoglobin function are provided by these studies of O-R-polyHbA(0)...
  5. doi request reprint Effects of (-)-epigallocatechin gallate on the redox reactions of human hemoglobin
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health Campus, Bethesda, MD 20892, USA
    Free Radic Biol Med 45:659-66. 2008
    ..A balance between pro and antioxidant properties of EGCG should be taken into account if EGCG is used in combination therapy with redox active acellular Hbs...
  6. pmc Haptoglobin preferentially binds β but not α subunits cross-linked hemoglobin tetramers with minimal effects on ligand and redox reactions
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 8:e59841. 2013
    ..This may ultimately provide a safe oxidative inactivation and clearance pathway for chemically modified Hbs in circulation...
  7. doi request reprint Effects of cross-linking and zero-link polymerization on oxygen transport and redox chemistry of bovine hemoglobin
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology LBVB, Division of Hematology, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, MD 20892, USA
    Biochim Biophys Acta 1794:1234-42. 2009
    ....
  8. ncbi request reprint Structural and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions
    Paul W Buehler
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, Bethesda, Maryland 20892, USA
    Anal Chem 77:3466-78. 2005
    ..Structural modification imparted by glutaraldehyde resulted in nearly identical functional characteristics of PolyHbBv and its fractions with regard to oxygen equilibrium, ligand binding, and autoxidative kinetics...
  9. pmc Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy
    Jin Hyen Baek
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland 20892, USA
    J Clin Invest 122:1444-58. 2012
    ..Hb sequestration by Hp might therefore be a therapeutic modality for enhancing transfusion safety in severely ill or massively transfused patients...
  10. ncbi request reprint O-raffinose crosslinked hemoglobin lacks site-specific chemistry in the central cavity: structural and functional consequences of beta93Cys modification
    Robert A Boykins
    Laboratory of Biophysics, Division of Bacterial, Parasitic and Allergenic Products, Bethesda, Maryland 20892, USA
    Proteins 59:840-55. 2005
    ..Structural data presented here when taken together with the oxidative instability of O-R-PolyHbA0 may provide some basis for the reported toxicity of this oxygen carrier...
  11. pmc Familial secondary erythrocytosis due to increased oxygen affinity is caused by destabilization of the T state of hemoglobin Brigham (α₂β₂(Pro100Leu))
    Todd L Mollan
    Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Protein Sci 21:1444-55. 2012
    ..These kinetic data help explain the high O₂ affinity characteristics of Hb Brigham and provide further evidence for the importance of the contribution of Pro100 to intersubunit contacts and stabilization of the T quaternary structure...
  12. doi request reprint Isolated Hb Providence β82Asn and β82Asp fractions are more stable than native HbA(0) under oxidative stress conditions
    Bindu Abraham
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland 20892, United States
    Biochemistry 50:9752-66. 2011
    ....
  13. ncbi request reprint Stopped-flow fluorescence method for the detection of heme degradation products in solutions of chemically modified hemoglobins and peroxide
    Yiping Jia
    Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, Bethesda, Maryland 20892, USA
    Anal Biochem 308:186-8. 2002
  14. doi request reprint Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification
    Paul W Buehler
    Center for Biologics Evaluation and Research CBER, US Food and Drug Administration FDA, Washington, DC, USA
    Blood 113:2578-86. 2009
    ..In addition, our data provide in vivo evidence that unbound Hb is oxidatively modified within extravascular compartments consistent with our in vitro findings...
  15. pmc Synthesis, biophysical properties and pharmacokinetics of ultrahigh molecular weight tense and relaxed state polymerized bovine hemoglobins
    Paul W Buehler
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Biomaterials 31:3723-35. 2010
    ..Our findings also demonstrate that T-state PolybHb exhibited a longer circulating half-life, slower clearance and longer systemic exposure time compared to R-state PolybHb...
  16. ncbi request reprint The heme pocket geometry of Lucina pectinata hemoglobin II restricts nitric oxide and peroxide entry: model of ligand control for the design of a stable oxygen carrier
    Walleska De Jesus-Bonilla
    Department of Chemistry, University of Puerto Rico, Mayaguez Campus, P O Box 9019, Mayagüez 00681 9019, Puerto Rico
    Biochemistry 46:10451-60. 2007
    ..Engineering of second-generation Hb-based oxygen therapeutics that are resistant to NO/H2O2-driven oxidation may ultimately require further optimization of the heme pocket architecture to limit heme exposure to solvent...