D K Hansen

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Antisense modulation of 5,10-methylenetetrahydrofolate reductase expression produces neural tube defects in mouse embryos
    D K Hansen
    Division of Genetic and Reproductive Toxicology, Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Rd, 72079 9502, Jefferson, AR, USA
    Reprod Toxicol 15:21-9. 2001
  2. ncbi request reprint Dose-response of retinoic acid induced stress protein synthesis and teratogenesis in mice
    D K Hansen
    National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, 3900 NCTR Road, 72079 9502, Jefferson, AR, USA
    Reprod Toxicol 15:31-41. 2001
  3. ncbi request reprint Lack of embryotoxicity of homocysteine thiolactone in mouse embryos in vitro
    D K Hansen
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079 9502, USA
    Reprod Toxicol 15:239-44. 2001
  4. ncbi request reprint Antisense modulation of the coding or regulatory sequence of the folate receptor (folate binding protein-1) in mouse embryos leads to neural tube defects
    Deborah K Hansen
    Division of Genetic and Reproductive Toxicology, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079 9502, USA
    Birth Defects Res A Clin Mol Teratol 67:475-87. 2003
  5. ncbi request reprint Retinoic acid-induced stress protein synthesis in the mouse
    J B LaBorde
    Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079 9502, USA
    Life Sci 56:1767-78. 1995
  6. ncbi request reprint Maternal folate deficiency results in selective upregulation of folate receptors and heterogeneous nuclear ribonucleoprotein-E1 associated with multiple subtle aberrations in fetal tissues
    Suhong Xiao
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5254, USA
    Birth Defects Res A Clin Mol Teratol 73:6-28. 2005
  7. ncbi request reprint Behavioral effects of prenatal folate deficiency in mice
    Sherry A Ferguson
    Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, AR 72079, USA
    Birth Defects Res A Clin Mol Teratol 73:249-52. 2005
  8. pmc Marginal maternal biotin deficiency in CD-1 mice reduces fetal mass of biotin-dependent carboxylases
    Wendy M Sealey
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Nutr 135:973-7. 2005

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Antisense modulation of 5,10-methylenetetrahydrofolate reductase expression produces neural tube defects in mouse embryos
    D K Hansen
    Division of Genetic and Reproductive Toxicology, Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Rd, 72079 9502, Jefferson, AR, USA
    Reprod Toxicol 15:21-9. 2001
    ..These results suggest that reduced expression of MTHFR may play a role in producing NTDs...
  2. ncbi request reprint Dose-response of retinoic acid induced stress protein synthesis and teratogenesis in mice
    D K Hansen
    National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, 3900 NCTR Road, 72079 9502, Jefferson, AR, USA
    Reprod Toxicol 15:31-41. 2001
    ..Each individual stress protein and the total stress protein response were highly correlated, across dose, with the respective malformations observed at term...
  3. ncbi request reprint Lack of embryotoxicity of homocysteine thiolactone in mouse embryos in vitro
    D K Hansen
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079 9502, USA
    Reprod Toxicol 15:239-44. 2001
    ..These data suggest that homocysteine does not produce NTDs in mouse embryos cultured in vitro and that early organogenesis-stage embryos are able to metabolize homocysteine...
  4. ncbi request reprint Antisense modulation of the coding or regulatory sequence of the folate receptor (folate binding protein-1) in mouse embryos leads to neural tube defects
    Deborah K Hansen
    Division of Genetic and Reproductive Toxicology, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079 9502, USA
    Birth Defects Res A Clin Mol Teratol 67:475-87. 2003
    ..We have employed antisense technology to alter expression of the gene for the folate receptor (folate binding protein-1 [Folbp1]) in mouse embryos cultured in vitro...
  5. ncbi request reprint Retinoic acid-induced stress protein synthesis in the mouse
    J B LaBorde
    Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079 9502, USA
    Life Sci 56:1767-78. 1995
    ..Therefore, it appears that there may be a correlation between tissue-specific SP synthesis early in organogenesis and the presence of a malformation later in gestation...
  6. ncbi request reprint Maternal folate deficiency results in selective upregulation of folate receptors and heterogeneous nuclear ribonucleoprotein-E1 associated with multiple subtle aberrations in fetal tissues
    Suhong Xiao
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5254, USA
    Birth Defects Res A Clin Mol Teratol 73:6-28. 2005
    ..Accordingly, we tested the hypothesis that sustained murine maternal folate deficiency would negatively impact pregnancy outcomes, upregulate FR, and selectively reduce fetal cell proliferation...
  7. ncbi request reprint Behavioral effects of prenatal folate deficiency in mice
    Sherry A Ferguson
    Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, AR 72079, USA
    Birth Defects Res A Clin Mol Teratol 73:249-52. 2005
    ..Accordingly, murine offspring were examined for the possible functional consequences of prenatal folate deficiency...
  8. pmc Marginal maternal biotin deficiency in CD-1 mice reduces fetal mass of biotin-dependent carboxylases
    Wendy M Sealey
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Nutr 135:973-7. 2005
    ..This study provides evidence that the decrease in carboxylase activities is attributable to a decrease in the abundance of biotinylated carboxylases; further, this effect is more severe in fetuses than dams...