Jing Han

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. pmc Establishment and characterization of a novel head and neck squamous cell carcinoma cell line USC-HN1
    Daniel J Liebertz
    Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA
    Head Neck Oncol 2:5. 2010
  2. pmc The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
    Leming Shi
    National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    BMC Bioinformatics 9:S10. 2008
  3. pmc Cross-platform comparability of microarray technology: intra-platform consistency and appropriate data analysis procedures are essential
    Leming Shi
    National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    BMC Bioinformatics 6:S12. 2005
  4. pmc Microarray scanner calibration curves: characteristics and implications
    Leming Shi
    National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    BMC Bioinformatics 6:S11. 2005
  5. pmc Identification of potential therapeutic targets in human head & neck squamous cell carcinoma
    Jing Han
    Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Head Neck Oncol 1:27. 2009
  6. ncbi request reprint Analysis of the quality of contact-pin fabricated oligonucleotide microarrays
    Amy X Yang
    Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, RM2NN20, Building 29B, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Mol Biotechnol 34:303-15. 2006
  7. pmc Diffuse myocardial fibrosis evaluation using cardiac magnetic resonance T1 mapping: sample size considerations for clinical trials
    Songtao Liu
    Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD, USA
    J Cardiovasc Magn Reson 14:90. 2012
  8. doi request reprint Bioreactor environment-sensitive sentinel genes as novel metrics for cell culture scale-down comparability
    Bhargavi Kondragunta
    Center for Advanced Sensor Technology and Dept of Chemical, Biochemical and Environmental Engineering, University of Maryland, Baltimore, MD 21250, USA
    Biotechnol Prog 28:1138-51. 2012
  9. ncbi request reprint Anaplasma phagocytophilum-induced gene expression in both human neutrophils and HL-60 cells
    Hin C Lee
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Genomics 92:144-51. 2008
  10. ncbi request reprint Quality prediction of cell substrate using gene expression profiling
    Jing Han
    Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29B, Room 2NN20, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Genomics 87:552-9. 2006

Collaborators

Detail Information

Publications20

  1. pmc Establishment and characterization of a novel head and neck squamous cell carcinoma cell line USC-HN1
    Daniel J Liebertz
    Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA
    Head Neck Oncol 2:5. 2010
    ..Detailed characterization of novel HNSCC cell lines is needed in order to provide researchers a concrete keystone on which to build their investigations...
  2. pmc The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
    Leming Shi
    National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    BMC Bioinformatics 9:S10. 2008
    ..The resultant variety of existing and emerging methods exacerbates confusion and continuing debate in the microarray community on the appropriate choice of methods for identifying reliable DEG lists...
  3. pmc Cross-platform comparability of microarray technology: intra-platform consistency and appropriate data analysis procedures are essential
    Leming Shi
    National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    BMC Bioinformatics 6:S12. 2005
    ..Nucleic Acids Res., 31, 5676-5684, 2003), portrays a disturbingly negative picture of the cross-platform comparability, and, hence, the reliability of microarray technology...
  4. pmc Microarray scanner calibration curves: characteristics and implications
    Leming Shi
    National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    BMC Bioinformatics 6:S11. 2005
    ..Microarray-based measurement of mRNA abundance assumes a linear relationship between the fluorescence intensity and the dye concentration. In reality, however, the calibration curve can be nonlinear...
  5. pmc Identification of potential therapeutic targets in human head & neck squamous cell carcinoma
    Jing Han
    Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Head Neck Oncol 1:27. 2009
    ..We have used high throughput microarray technology to search for candidate targets in HNSCC...
  6. ncbi request reprint Analysis of the quality of contact-pin fabricated oligonucleotide microarrays
    Amy X Yang
    Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, RM2NN20, Building 29B, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Mol Biotechnol 34:303-15. 2006
    ..Taken together, these results indicate that the quality of spotted oligonucleotide arrays should be assessed by at least two methods, autofluorescence and 9-mer hybridization before arrays are used for hybridization experiments...
  7. pmc Diffuse myocardial fibrosis evaluation using cardiac magnetic resonance T1 mapping: sample size considerations for clinical trials
    Songtao Liu
    Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD, USA
    J Cardiovasc Magn Reson 14:90. 2012
    ..The aim of this study is to determine the reproducibility and sample size of CMR fibrosis measurements that would be applicable in clinical trials...
  8. doi request reprint Bioreactor environment-sensitive sentinel genes as novel metrics for cell culture scale-down comparability
    Bhargavi Kondragunta
    Center for Advanced Sensor Technology and Dept of Chemical, Biochemical and Environmental Engineering, University of Maryland, Baltimore, MD 21250, USA
    Biotechnol Prog 28:1138-51. 2012
    ..Our results broadly show that based on the knowledge from transcriptomic changes of sentinel gene profiles, it is possible to improve bioreactor scale-down for more comparable processes...
  9. ncbi request reprint Anaplasma phagocytophilum-induced gene expression in both human neutrophils and HL-60 cells
    Hin C Lee
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Genomics 92:144-51. 2008
    ....
  10. ncbi request reprint Quality prediction of cell substrate using gene expression profiling
    Jing Han
    Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29B, Room 2NN20, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Genomics 87:552-9. 2006
    ..Our results demonstrate that gene expression profiling can assess the quality of cell substrates prior to large-scale production of a biological product...
  11. pmc Modified look-locker inversion recovery T1 mapping indices: assessment of accuracy and reproducibility between magnetic resonance scanners
    Fabio S Raman
    Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD 20892 1182, USA
    J Cardiovasc Magn Reson 15:64. 2013
    ..The purpose of this study was to investigate how scanner and field strength variation affect the accuracy and precision/reproducibility of T1 mapping indices...
  12. pmc Population dynamics of Salmonella enterica serotypes in commercial egg and poultry production
    Steven L Foley
    Division of Microbiology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Appl Environ Microbiol 77:4273-9. 2011
    ..In this review, we have highlighted bacterial genetic and host-related factors that may contribute to such shifts in Salmonella populations in commercial poultry and intervention strategies that could limit their colonization...
  13. ncbi request reprint Microarray analysis of virulence gene profiles in Salmonella serovars from food/food animal environment
    Wen Zou
    Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, United States
    J Infect Dev Ctries 5:94-105. 2011
    ....
  14. ncbi request reprint Development of a focused microarray to assess human embryonic stem cell differentiation
    Amy X Yang
    Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Stem Cells Dev 14:270-84. 2005
    ..We expect that the described array will be extremely useful in evaluating the extent of differentiation and the state of the hESC-derived population utilized for therapeutic purposes...
  15. doi request reprint Differentially expressed genes and pathways induced by organophosphates in human neuroblastoma cells
    Tianwei Li
    Tissue Safety Laboratory Program, Center for Biologics Evaluation and Research, Food and Drug Administration, NIH Building 29B, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Exp Biol Med (Maywood) 237:1413-23. 2012
    ..In addition, these results could also contribute to the development of new prevention and/or therapeutic regimens against OP toxicity...
  16. ncbi request reprint Novel multiple 5'-amino-modified primer for DNA microarrays
    Jing Han
    Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Bethesda, MD 20892, USA
    Genomics 86:252-8. 2005
    ..This primer can also be used to label nucleotides for other purposes...
  17. ncbi request reprint Identification and characterization of cancer stem cells in human head and neck squamous cell carcinoma
    Jing Han
    Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, NIH Bldg 29B, Rm 2NN20, 29 Lincoln Dr, Bethesda, MD, 20892, USA
    BMC Cancer 14:173. 2014
    ..We previously identified a small population of CD24+/CD44+ cells in HNSCC. In this study, we examined whether this population of cells may represent CSC in HNSCC...
  18. doi request reprint Genomic analysis of a hybridoma batch cell culture metabolic status in a standard laboratory 5 L bioreactor
    Bhargavi Kondragunta
    Center for Advanced Sensor Technology and Dept of Chemical and Biochemical Engineering, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Biotechnol Prog 28:1126-37. 2012
    ..The results of this study suggest that under predefined bioreactor culture conditions, significant gene changes from lag to log to stationary phase could be identified, which could then be used to track the culture state...
  19. pmc Myocardial T1 and extracellular volume fraction mapping at 3 tesla
    Jason J Lee
    Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD, USA
    J Cardiovasc Magn Reson 13:75. 2011
    ..To compare 11 heartbeat (HB) and 17 HB modified lock locker inversion recovery (MOLLI) pulse sequence at 3T and to establish preliminary reference values for myocardial T1 and the extracellular volume fraction (ECV)...
  20. ncbi request reprint Analysis of target genes induced by IL-13 cytotoxin in human glioblastoma cells
    Jing Han
    Laboratory of Molecular Tumor Biology, CBER NCI Genomics Program, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, CBER FDA, NIH, Bethesda, MD 20892, USA
    J Neurooncol 72:35-46. 2005
    ..On going studies will determine the role of associated genes and their products in the IL-13R functions in glioma cells...