Lei Guo

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Tissue and cellular localization of a novel polycystic kidney disease-like gene product, polycystin-L
    Nuria Basora
    Renal Division and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 13:293-301. 2002
  2. pmc SAD2, an importin -like protein, is required for UV-B response in Arabidopsis by mediating MYB4 nuclear trafficking
    Jinfeng Zhao
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100094, China
    Plant Cell 19:3805-18. 2007
  3. ncbi request reprint Research on 3D modeling for head MRI image based on immune sphere-shaped support vector machine
    Lei Guo
    Province Ministry Joint Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability, Hebei University of Technology, Tianjin, China
    Conf Proc IEEE Eng Med Biol Soc 2007:1082-5. 2007
  4. ncbi request reprint Enhancement of infrared image based on the Retinex theory
    Ying Li
    Province Ministry Joint Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability, Hebei University of Technology, Tianjin 300130, China
    Conf Proc IEEE Eng Med Biol Soc 2007:3315-8. 2007
  5. ncbi request reprint Estimating regional conductivity in 2D disc head model by multidemensional support vector regression
    Xueqin Shen
    School of Electrical Engineering and Automation, Hebei University of Technology, 8 Guangrong Dao, Tianjin, Box 388, 300130 China
    Conf Proc IEEE Eng Med Biol Soc 2007:4915-8. 2007
  6. pmc Cross-platform comparison of SYBR Green real-time PCR with TaqMan PCR, microarrays and other gene expression measurement technologies evaluated in the MicroArray Quality Control (MAQC) study
    Emi Arikawa
    SuperArray Bioscience Corporation, Frederick, MD 21704, USA
    BMC Genomics 9:328. 2008
  7. pmc Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists
    Lei Guo
    Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    BMC Bioinformatics 7:S18. 2006
  8. doi request reprint Gene expression profiling as an initial approach for mechanistic studies of toxicity and tumorigenicity of herbal plants and herbal dietary supplements
    Lei Guo
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, FDA, AR 72079, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 28:60-87. 2010
  9. pmc Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver
    Lei Guo
    Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    BMC Bioinformatics 8:S22. 2007
  10. ncbi request reprint Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells
    Lei Guo
    Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    Mol Divers 10:349-60. 2006

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Tissue and cellular localization of a novel polycystic kidney disease-like gene product, polycystin-L
    Nuria Basora
    Renal Division and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 13:293-301. 2002
    ..The expression pattern of PCL suggests that it is unlikely to be a candidate gene for ADPKD, but it remains a potential candidate for other as yet unmapped human cystic disorders...
  2. pmc SAD2, an importin -like protein, is required for UV-B response in Arabidopsis by mediating MYB4 nuclear trafficking
    Jinfeng Zhao
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100094, China
    Plant Cell 19:3805-18. 2007
    ....
  3. ncbi request reprint Research on 3D modeling for head MRI image based on immune sphere-shaped support vector machine
    Lei Guo
    Province Ministry Joint Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability, Hebei University of Technology, Tianjin, China
    Conf Proc IEEE Eng Med Biol Soc 2007:1082-5. 2007
    ..As our experiment demonstrates, the models are constructed and reach satisfactory modeling accuracies. Theory and experiment indicate ISSSVM exhibits its great potential in image 3D modeling...
  4. ncbi request reprint Enhancement of infrared image based on the Retinex theory
    Ying Li
    Province Ministry Joint Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability, Hebei University of Technology, Tianjin 300130, China
    Conf Proc IEEE Eng Med Biol Soc 2007:3315-8. 2007
    ..The acceptable results are obtained and compared...
  5. ncbi request reprint Estimating regional conductivity in 2D disc head model by multidemensional support vector regression
    Xueqin Shen
    School of Electrical Engineering and Automation, Hebei University of Technology, 8 Guangrong Dao, Tianjin, Box 388, 300130 China
    Conf Proc IEEE Eng Med Biol Soc 2007:4915-8. 2007
    ..The estimation errors are all within a few percent...
  6. pmc Cross-platform comparison of SYBR Green real-time PCR with TaqMan PCR, microarrays and other gene expression measurement technologies evaluated in the MicroArray Quality Control (MAQC) study
    Emi Arikawa
    SuperArray Bioscience Corporation, Frederick, MD 21704, USA
    BMC Genomics 9:328. 2008
    ....
  7. pmc Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists
    Lei Guo
    Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    BMC Bioinformatics 7:S18. 2006
    ..The activation of PPARalpha leads to a cascade of events that result in the pharmacological (hypolipidemic) and adverse (carcinogenic) effects in rodent liver...
  8. doi request reprint Gene expression profiling as an initial approach for mechanistic studies of toxicity and tumorigenicity of herbal plants and herbal dietary supplements
    Lei Guo
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, FDA, AR 72079, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 28:60-87. 2010
    ..This review summarizes the current practices of microarray analysis of gene expressions in animals treated with herbal dietary supplements and discusses perspectives for the proposed strategy...
  9. pmc Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver
    Lei Guo
    Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    BMC Bioinformatics 8:S22. 2007
    ....
  10. ncbi request reprint Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells
    Lei Guo
    Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    Mol Divers 10:349-60. 2006
    ..Our work suggests that microarray analysis together with toxicological observations can be used to rank drugs for hepatotoxicity and to evaluate the safety of new compounds...
  11. doi request reprint Review of usnic acid and Usnea barbata toxicity
    Lei Guo
    National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 26:317-38. 2008
    ..At present, a toxicological evaluation of usnic acid is being conducted by the NTP. This review focuses on the recent findings of usnic acid-induced toxicities and their underlying mechanisms of action...
  12. doi request reprint Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract
    Lei Guo
    Division of Systems Toxicology, National Center for Toxicological Research, FDA, 3900 NCTR Road, Jefferson, AR 72079, USA
    Food Chem Toxicol 47:433-42. 2009
    ..Our results indicate that kava extract can significantly modulate drug metabolizing enzymes, particularly the CYP isozymes, which could cause herb-drug interactions and may potentially lead to hepatotoxicity...
  13. pmc Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies--changes in drug metabolizing genes and potential mechanisms linked to kava toxicity
    Lei Guo
    Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    Food Chem Toxicol 48:686-96. 2010
    ..Our results indicate that kava extract can significantly modulate drug metabolizing enzymes, potentially leading to herb-drug interactions and hepatotoxicity...
  14. pmc Gene expression profiles distinguish the carcinogenic effects of aristolochic acid in target (kidney) and non-target (liver) tissues in rats
    Tao Chen
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA
    BMC Bioinformatics 7:S20. 2006
    ..To evaluate whether microarray analysis can be used for distinguishing the tissue-specific carcinogenicity of AA, we examined gene expression profiles in kidney and liver of rats treated with carcinogenic doses of AA...
  15. pmc Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
    Zhiguang Li
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    BMC Genomics 11:609. 2010
    ..However, there is little information as to if or when expression changes of miRNAs occur in normal tissues after carcinogen exposure...
  16. pmc Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    BMC Bioinformatics 7:S16. 2006
    ..Our previous study suggested that comfrey induces liver tumors by a genotoxic mechanism and that the pyrrolizidine alkaloids in the plant are responsible for mutation induction and tumor initiation in rat liver...
  17. pmc The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
    Leming Shi
    National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    BMC Bioinformatics 9:S10. 2008
    ..The resultant variety of existing and emerging methods exacerbates confusion and continuing debate in the microarray community on the appropriate choice of methods for identifying reliable DEG lists...
  18. pmc Cross-platform comparability of microarray technology: intra-platform consistency and appropriate data analysis procedures are essential
    Leming Shi
    National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    BMC Bioinformatics 6:S12. 2005
    ..Nucleic Acids Res., 31, 5676-5684, 2003), portrays a disturbingly negative picture of the cross-platform comparability, and, hence, the reliability of microarray technology...
  19. pmc Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    BMC Bioinformatics 8:S4. 2007
    ..Molecular analysis of the mutants indicated that there was a statistically significant difference between the mutational spectra from riddelliine-treated and control rats...
  20. ncbi request reprint Rat toxicogenomic study reveals analytical consistency across microarray platforms
    Lei Guo
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Nat Biotechnol 24:1162-9. 2006
    ....
  21. pmc Similarities and differences in the expression of drug-metabolizing enzymes between human hepatic cell lines and primary human hepatocytes
    Lei Guo
    Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
    Drug Metab Dispos 39:528-38. 2011
    ....
  22. doi request reprint Application of microarray-based analysis of gene expression in the field of toxicogenomics
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR, USA
    Methods Mol Biol 597:227-41. 2010
    ....
  23. doi request reprint Metabolism, genotoxicity, and carcinogenicity of comfrey
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    J Toxicol Environ Health B Crit Rev 13:509-26. 2010
    ..Further, the two agents share common mechanisms of drug metabolism and carcinogenesis. Overall, comfrey is mutagenic in liver, and PA contained in comfrey appear to be responsible for comfrey-induced toxicity and tumor induction...
  24. pmc Ginkgo biloba extract induces gene expression changes in xenobiotics metabolism and the Myc-centered network
    Lei Guo
    Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079, USA
    OMICS 14:75-90. 2010
    ..In addition, the outcomes of pathway and network analysis may be used to elucidate the toxic mechanisms of Ginkgo biloba...
  25. ncbi request reprint Self-self hybridization as an alternative experiment design to dye swap for two-color microarrays
    Hong Fang
    Division of Bioinformatics, Z Tech Corporation, Jefferson, Arkansas, USA
    OMICS 11:14-24. 2007
    ..For example, in larger toxicogenomic studies, only about half the chips are required for the self-self hybridization design compared to that needed in the dye swap design...
  26. doi request reprint Mechanism study of goldenseal-associated DNA damage
    Si Chen
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S FDA, Jefferson, AR 72079, USA
    Toxicol Lett 221:64-72. 2013
    ..Our findings suggest that the Topo II inhibitory effect may contribute to berberine- and goldenseal-induced genotoxicity and tumorigenicity...
  27. doi request reprint Systematic and simultaneous gene profiling of 84 drug-metabolizing genes in primary human hepatocytes
    Baitang Ning
    Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
    J Biomol Screen 13:194-201. 2008
    ..In addition, increasing or decreasing the expression of drug-metabolizing enzymes by these 3 compounds was observed, and underlying mechanisms are discussed...
  28. doi request reprint Nitroxide TEMPO: a genotoxic and oxidative stress inducer in cultured cells
    Xiaoqing Guo
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States
    Toxicol In Vitro 27:1496-502. 2013
    ..These results indicate that TEMPO is mutagenic in the MLA and induces micronuclei and hypodiploid nuclei in TK6 cells. Oxidative stress may account for part of the genotoxicity induced by TEMPO in both cell lines...
  29. doi request reprint Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1
    Yan Li
    Division of Systems Biology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Toxicol Sci 124:388-99. 2011
    ..The induction of CYP1A1 indicates a potential interaction between kava or kavalactones and CYP1A1-mediated chemical carcinogenesis...
  30. doi request reprint Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Environ Mol Mutagen 49:741-5. 2008
    ..The results provide more information about AA metabolism and further insight into the molecular mechanisms involved in AA-induced toxicity...
  31. doi request reprint Toxicity of kava kava
    Peter P Fu
    National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 26:89-112. 2008
    ..At present toxicological evaluation of kava extract is being conducted by the NTP. The present review focuses on the recent findings on kava toxicity and the mechanisms by which kava induces hepatotoxicity...
  32. pmc The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
    Leming Shi
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Nat Biotechnol 24:1151-61. 2006
    ..This study provides a resource that represents an important first step toward establishing a framework for the use of microarrays in clinical and regulatory settings...
  33. doi request reprint Assessment of usnic acid toxicity in rat primary hepatocytes using ¹³C isotopomer distribution analysis of lactate, glutamate and glucose
    Bakary J Sonko
    Division of Systems Biology, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA
    Food Chem Toxicol 49:2968-74. 2011
    ..Augmented oxidative phosphorylation at the lower UA concentrations may be an adaptive response by the cells to compensate for diminished mitochondrial function...
  34. ncbi request reprint Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, United States
    Food Chem Toxicol 46:628-36. 2008
    ....
  35. doi request reprint Next-generation sequencing in the clinic: promises and challenges
    Jiekun Xuan
    School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Cancer Lett 340:284-95. 2013
    ..Common issues in NGS workflows are also discussed to guide the selection of NGS platforms and pipelines for specific research purposes. ..
  36. doi request reprint Phototoxicity of kava - formation of reactive oxygen species leading to lipid peroxidation and DNA damage
    Qingsu Xia
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    Am J Chin Med 40:1271-88. 2012
    ..The overall results suggest that kava is photocytotoxic and photogenotoxic, both mediated by free radicals generated during photoirradiation...
  37. doi request reprint Mitochondrial dysfunction induced by sertraline, an antidepressant agent
    Yan Li
    Division of Genetic and Molecular Toxicology, National Center for Toxicological Research U S FDA, Jefferson, Arkansas 72079, USA
    Toxicol Sci 127:582-91. 2012
    ....
  38. ncbi request reprint Evaluation of external RNA controls for the assessment of microarray performance
    Weida Tong
    National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd, Jefferson, Arkansas 72079, USA
    Nat Biotechnol 24:1132-9. 2006
    ..This multiplatform investigation of the behavior and utility of ERCs provides a basis for articulating specific recommendations for their future use in evaluating assay performance across multiple platforms...
  39. pmc Microarray scanner calibration curves: characteristics and implications
    Leming Shi
    National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    BMC Bioinformatics 6:S11. 2005
    ..Microarray-based measurement of mRNA abundance assumes a linear relationship between the fluorescence intensity and the dye concentration. In reality, however, the calibration curve can be nonlinear...
  40. ncbi request reprint Threshold optimization of adaptive template filtering for MRI based on intelligent optimization algorithm
    Lei Guo
    Joint Key Lab of Electromagn Field and Electr Apparatus Reliability, Hebei Univ of Technol, Tianjin, China
    Conf Proc IEEE Eng Med Biol Soc 1:4763-6. 2006
    ..Through algorithm analysis, the performance of IA surpasses the performance of GA. As a new kind of IOA, IA exhibits its great potential in image processing...
  41. ncbi request reprint ZFIQ: a software package for zebrafish biology
    Tianming Liu
    The Methodist Hospital Research Institute and Department of Radiology, The Methodist Hospital
    Bioinformatics 24:438-9. 2008
    ..The zebrafish image quantitator (ZFIQ) software provides streamlined data processing and analysis capability for developmental biology and disease modeling using zebrafish model...
  42. pmc Reconstruction of central cortical surface from brain MRI images: method and application
    Tianming Liu
    The Center for Biotechnology and Informatics, The Methodist Hospital Research Institute, Houston, TX, USA
    Neuroimage 40:991-1002. 2008
    ..Experimental results show that the central cortical surface representation has better performance in detecting simulated atrophy than the traditionally used inner or outer cortical surface representations...
  43. ncbi request reprint PID controller design for output PDFs of stochastic systems using linear matrix inequalities
    Lei Guo
    Control Systems Center, University of Manchester Institute of Science and Technology, Manchester M60 1QD, UK
    IEEE Trans Syst Man Cybern B Cybern 35:65-71. 2005
    ..Simulations are given to demonstrate the efficiency of the proposed approach and encouraging results have been obtained...
  44. doi request reprint An automated method for cell detection in zebrafish
    Tianming Liu
    The Center for Biomedical Informatics, The Methodist Hospital Research Institute, Houston, TX, USA
    Neuroinformatics 6:5-21. 2008
    ..Our results demonstrate the general applicability of this method to different data samples, including nuclear staining, immunohistochemistry, and cell death detection...
  45. ncbi request reprint Study of injuries combining computer simulation in motorcycle-car collision accidents
    Lei Guo
    School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
    Forensic Sci Int 177:90-6. 2008
    ..These results might be useful for forensic experts in dealing with similar motorcycle-car collision accidents in the future...
  46. ncbi request reprint Tissue conductivity estimation in two-dimension head model based on support vector machine
    Youxi Wu
    School of Computer Science and Software, Hebei University of Technology, Tianjin, China
    Conf Proc IEEE Eng Med Biol Soc 1:1130-3. 2006
    ..Compared with wavelet neural network method, MSVM not only obtains higher accuracy of learning, it also has greater generalization ability and faster computing speed as our experiment demonstrates...
  47. ncbi request reprint Anti-hyperlipidemic properties of CM108 (a flavone derivative) in vitro and in vivo
    Lei Guo
    State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
    Eur J Pharmacol 551:80-6. 2006
    ..01). In conclusion, CM108 can effectively elevate HDL levels and lower triglyceride levels in hyperlipidemic rats maybe by regulating a series of genes, receptors and proteins related to HDL...
  48. ncbi request reprint A clinical and molecular-genetic analysis of Chinese patients with lattice corneal dystrophy and novel Thr538Pro mutation in the TGFBI (BIGH3) gene
    Ping Yu
    Department of Medical Genetics, School of Medicine, Zhejiang University, Hangzhou 310006, China
    J Genet 85:73-6. 2006
  49. ncbi request reprint Ex vivo adenoviral gene transfer of constitutively activated STAT3 reduces post-transplant liver injury and promotes regeneration in a 20% rat partial liver transplant model
    Kamrul A S M Huda
    Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Shikata, Okayama, Japan
    Transpl Int 19:415-23. 2006
    ..Thus, the activation of STAT3 in the liver graft may be a potentially effective clinical strategy for improving the outcome of small-for-size liver transplantation...
  50. ncbi request reprint Efficacy of engineered liver tissue based on poly-L-lactic acid scaffolds and fetal mouse liver cells cultured with oncostatin M, nicotinamide, and dimethyl sulfoxide
    Jinlan Jiang
    Institute of Industrial Science, University of Tokyo, Tokyo, Japan
    Tissue Eng 10:1577-86. 2004
    ....
  51. ncbi request reprint Significant enhancement by anti-ICOS antibody of suboptimal tacrolimus immunosuppression in rat liver transplantation
    Lei Guo
    Department of Innovative Surgery, National Research Institute for Child Health and Development, Tokyo, Japan
    Liver Transpl 10:743-7. 2004
    ....
  52. ncbi request reprint Improved hepatic regeneration with reduced injury by redox factor-1 in a rat small-sized liver transplant model
    Lei Guo
    Department of Artificial Organ and Transplantation Surgery, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Transplant 4:879-87. 2004
    ..The results of the present study may open a new avenue to clinical transplantation of disproportionately sized grafts in living-related liver transplantation...
  53. ncbi request reprint Xenogeneic direct hemoperfusion using whole swine liver for liver failure in dogs
    Katsutoshi Naruse
    Division of Artificial Organs and Transplantation, Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Surg Res 111:229-35. 2003
    ....
  54. ncbi request reprint Response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N'-nitro-N-nitrosoguanidine and its role in mutagenesis
    Feng Zhu
    Department of Pathophysiology, Zhejiang University School of Medicine, Hangzhou 310031, China
    World J Gastroenterol 9:888-93. 2003
    ..To understand the response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and its role in human mutagenesis...
  55. ncbi request reprint Calreticulin in cardiac development and pathology
    Marek Michalak
    Canadian Institutes of Health Research Membrane Protein Research Group and Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Biochim Biophys Acta 1600:32-7. 2002
    ..Calreticulin and ER may play important role in cardiac development and postnatal pathologies...
  56. pmc MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation
    Magdalena M Gorska
    Division of Allergy and Immunology, Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Exp Med 204:1637-52. 2007
    ..This pattern of activation is essential for many NF-kappaB-regulated genes and development of inflammation. Thus, the MK2-HSP27 pathway is an excellent target for therapeutic control of localized inflammatory diseases...
  57. pmc 3D cell nuclei segmentation based on gradient flow tracking
    Gang Li
    Center for Bioinformatics, Harvard Center for Neurodegeneration and Repair, Harvard Medical School, Boston, MA, USA
    BMC Cell Biol 8:40. 2007
    ..The segmentation approach has three stages: 1) a gradient diffusion procedure, 2) gradient flow tracking and grouping, and 3) local adaptive thresholding...
  58. pmc Brain tissue segmentation based on DTI data
    Tianming Liu
    Department of Radiology, The Methodist Hospital, Houston, TX, USA
    Neuroimage 38:114-23. 2007
    ..Experimental results of applying this approach to brain tissue segmentation and deformable registration of DTI data and spoiled gradient-echo (SPGR) data are also provided...
  59. ncbi request reprint Steroidal alkaloids from Veratrum japonicum with genotoxicity on brain cell DNA of the cerebellum and cerebral cortex in mice
    Yue Cong
    Institute of Traditional Chinese Medica, School of Pharmacy, Henan University, Kaifeng, P R China
    Planta Med 73:1588-91. 2007
    ..Compounds 1 - 4 exhibited genotoxicity on brain cells in mice by using single-cell gel electrophoresis (Comet assay)...
  60. ncbi request reprint Research on the segmentation of MRI image based on multi-classification support vector machine
    Lei Guo
    Province Ministry Joint Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability, Hebei University of Technology, Tianjin, China
    Conf Proc IEEE Eng Med Biol Soc 2007:6020-3. 2007
    ..As our experiment demonstrates, the boundaries of 7 kinds of encephalic tissues are extracted successfully, and it can reach satisfactory generalization accuracy. Thus, SVM exhibits its great potential in image segmentation...
  61. ncbi request reprint 3D reconstruction of head MRI based on one class support vector machine with immune algorithm
    Lei Wang
    Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability of Hebei Province in Hebei University of Technology, Tianjin, China, 300130
    Conf Proc IEEE Eng Med Biol Soc 2007:6016-9. 2007
    ..The experimental results demonstrate OCSVM is effective with high reconstruction accuracy...
  62. ncbi request reprint Resistivity parameters estimation based on 2D real head model using improved differential evolution algorithm
    Ying Li
    Province Ministry Joint Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability, Hebei University of Technology, Tianjin 300130, China
    Conf Proc IEEE Eng Med Biol Soc . 2006
    ..Furthermore, the selection of the amplification parameters is much easier...
  63. ncbi request reprint Adaptive template filtering method for MRI
    Lei Guo
    Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability, Hebei University of Technology, Tianjin, China
    Conf Proc IEEE Eng Med Biol Soc 1:1371-4. 2006
    ..It can both effectively suppresses noise and best preserve useful information at the same time for MRI. Thus, ATFM can meet the need of clinical diagnosis and image processing...