Research Topics
Species | Lei GuoSummaryAffiliation: Food and Drug Administration Country: USA Publications
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Detail Information
Publications
Tissue and cellular localization of a novel polycystic kidney disease-like gene product, polycystin-LNuria Basora
Renal Division and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Am Soc Nephrol 13:293-301. 2002..The expression pattern of PCL suggests that it is unlikely to be a candidate gene for ADPKD, but it remains a potential candidate for other as yet unmapped human cystic disorders...
SAD2, an importin -like protein, is required for UV-B response in Arabidopsis by mediating MYB4 nuclear traffickingJinfeng Zhao
State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100094, China
Plant Cell 19:3805-18. 2007....- Research on 3D modeling for head MRI image based on immune sphere-shaped support vector machineLei Guo
Province Ministry Joint Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability, Hebei University of Technology, Tianjin, China
Conf Proc IEEE Eng Med Biol Soc 2007:1082-5. 2007..As our experiment demonstrates, the models are constructed and reach satisfactory modeling accuracies. Theory and experiment indicate ISSSVM exhibits its great potential in image 3D modeling... - Enhancement of infrared image based on the Retinex theoryYing Li
Province Ministry Joint Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability, Hebei University of Technology, Tianjin 300130, China
Conf Proc IEEE Eng Med Biol Soc 2007:3315-8. 2007..The acceptable results are obtained and compared... - Estimating regional conductivity in 2D disc head model by multidemensional support vector regressionXueqin Shen
School of Electrical Engineering and Automation, Hebei University of Technology, 8 Guangrong Dao, Tianjin, Box 388, 300130 China
Conf Proc IEEE Eng Med Biol Soc 2007:4915-8. 2007..The estimation errors are all within a few percent... - Cross-platform comparison of SYBR Green real-time PCR with TaqMan PCR, microarrays and other gene expression measurement technologies evaluated in the MicroArray Quality Control (MAQC) studyEmi Arikawa
SuperArray Bioscience Corporation, Frederick, MD 21704, USA
BMC Genomics 9:328. 2008.... - Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonistsLei Guo
Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
BMC Bioinformatics 7:S18. 2006..The activation of PPARalpha leads to a cascade of events that result in the pharmacological (hypolipidemic) and adverse (carcinogenic) effects in rodent liver... - Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies--changes in drug metabolizing genes and potential mechanisms linked to kava toxicityLei Guo
Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
Food Chem Toxicol 48:686-96. 2010..Our results indicate that kava extract can significantly modulate drug metabolizing enzymes, potentially leading to herb-drug interactions and hepatotoxicity... - Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cellsLei Guo
Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
Mol Divers 10:349-60. 2006..Our work suggests that microarray analysis together with toxicological observations can be used to rank drugs for hepatotoxicity and to evaluate the safety of new compounds... 
Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extractLei Guo
Division of Systems Toxicology, National Center for Toxicological Research, FDA, 3900 NCTR Road, Jefferson, AR 72079, USA
Food Chem Toxicol 47:433-42. 2009..Our results indicate that kava extract can significantly modulate drug metabolizing enzymes, particularly the CYP isozymes, which could cause herb-drug interactions and may potentially lead to hepatotoxicity...- Review of usnic acid and Usnea barbata toxicityLei Guo
National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 26:317-38. 2008..At present, a toxicological evaluation of usnic acid is being conducted by the NTP. This review focuses on the recent findings of usnic acid-induced toxicities and their underlying mechanisms of action... - Gene expression profiling as an initial approach for mechanistic studies of toxicity and tumorigenicity of herbal plants and herbal dietary supplementsLei Guo
Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, FDA, AR 72079, USA
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 28:60-87. 2010..This review summarizes the current practices of microarray analysis of gene expressions in animals treated with herbal dietary supplements and discusses perspectives for the proposed strategy... - Comparison of gene expression profiles altered by comfrey and riddelliine in rat liverLei Guo
Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
BMC Bioinformatics 8:S22. 2007.... - Gene expression profiles distinguish the carcinogenic effects of aristolochic acid in target (kidney) and non-target (liver) tissues in ratsTao Chen
Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA
BMC Bioinformatics 7:S20. 2006..To evaluate whether microarray analysis can be used for distinguishing the tissue-specific carcinogenicity of AA, we examined gene expression profiles in kidney and liver of rats treated with carcinogenic doses of AA... - Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosoureaZhiguang Li
Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
BMC Genomics 11:609. 2010..However, there is little information as to if or when expression changes of miRNAs occur in normal tissues after carcinogen exposure... - Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)Nan Mei
Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
BMC Bioinformatics 7:S16. 2006..Our previous study suggested that comfrey induces liver tumors by a genotoxic mechanism and that the pyrrolizidine alkaloids in the plant are responsible for mutation induction and tumor initiation in rat liver... - Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue ratsNan Mei
Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
BMC Bioinformatics 8:S4. 2007..Molecular analysis of the mutants indicated that there was a statistically significant difference between the mutational spectra from riddelliine-treated and control rats... - Cross-platform comparability of microarray technology: intra-platform consistency and appropriate data analysis procedures are essentialLeming Shi
National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
BMC Bioinformatics 6:S12. 2005..Nucleic Acids Res., 31, 5676-5684, 2003), portrays a disturbingly negative picture of the cross-platform comparability, and, hence, the reliability of microarray technology... - Metabolism, genotoxicity, and carcinogenicity of comfreyNan Mei
Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
J Toxicol Environ Health B Crit Rev 13:509-26. 2010..Further, the two agents share common mechanisms of drug metabolism and carcinogenesis. Overall, comfrey is mutagenic in liver, and PA contained in comfrey appear to be responsible for comfrey-induced toxicity and tumor induction... - Application of microarray-based analysis of gene expression in the field of toxicogenomicsNan Mei
Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR, USA
Methods Mol Biol 597:227-41. 2010.... - Rat toxicogenomic study reveals analytical consistency across microarray platformsLei Guo
National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
Nat Biotechnol 24:1162-9. 2006.... - Similarities and differences in the expression of drug-metabolizing enzymes between human hepatic cell lines and primary human hepatocytesLei Guo
Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
Drug Metab Dispos 39:528-38. 2011.... - The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studiesLeming Shi
National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
BMC Bioinformatics 9:S10. 2008..The resultant variety of existing and emerging methods exacerbates confusion and continuing debate in the microarray community on the appropriate choice of methods for identifying reliable DEG lists... - Ginkgo biloba extract induces gene expression changes in xenobiotics metabolism and the Myc-centered networkLei Guo
Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079, USA
OMICS 14:75-90. 2010..In addition, the outcomes of pathway and network analysis may be used to elucidate the toxic mechanisms of Ginkgo biloba... - Self-self hybridization as an alternative experiment design to dye swap for two-color microarraysHong Fang
Division of Bioinformatics, Z Tech Corporation, Jefferson, Arkansas, USA
OMICS 11:14-24. 2007..For example, in larger toxicogenomic studies, only about half the chips are required for the self-self hybridization design compared to that needed in the dye swap design... - Systematic and simultaneous gene profiling of 84 drug-metabolizing genes in primary human hepatocytesBaitang Ning
Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
J Biomol Screen 13:194-201. 2008..In addition, increasing or decreasing the expression of drug-metabolizing enzymes by these 3 compounds was observed, and underlying mechanisms are discussed... - Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1Yan Li
Division of Systems Biology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
Toxicol Sci 124:388-99. 2011..The induction of CYP1A1 indicates a potential interaction between kava or kavalactones and CYP1A1-mediated chemical carcinogenesis... - Toxicity of kava kavaPeter P Fu
National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 26:89-112. 2008..At present toxicological evaluation of kava extract is being conducted by the NTP. The present review focuses on the recent findings on kava toxicity and the mechanisms by which kava induces hepatotoxicity... - Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamideNan Mei
Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
Environ Mol Mutagen 49:741-5. 2008..The results provide more information about AA metabolism and further insight into the molecular mechanisms involved in AA-induced toxicity... - Assessment of usnic acid toxicity in rat primary hepatocytes using ¹³C isotopomer distribution analysis of lactate, glutamate and glucoseBakary J Sonko
Division of Systems Biology, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA
Food Chem Toxicol 49:2968-74. 2011..Augmented oxidative phosphorylation at the lower UA concentrations may be an adaptive response by the cells to compensate for diminished mitochondrial function... - Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cellsNan Mei
Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, United States
Food Chem Toxicol 46:628-36. 2008.... - Mitochondrial dysfunction induced by sertraline, an antidepressant agentYan Li
Division of Genetic and Molecular Toxicology, National Center for Toxicological Research U S FDA, Jefferson, Arkansas 72079, USA
Toxicol Sci 127:582-91. 2012.... - Evaluation of external RNA controls for the assessment of microarray performanceWeida Tong
National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd, Jefferson, Arkansas 72079, USA
Nat Biotechnol 24:1132-9. 2006..This multiplatform investigation of the behavior and utility of ERCs provides a basis for articulating specific recommendations for their future use in evaluating assay performance across multiple platforms... - The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurementsLeming Shi
National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
Nat Biotechnol 24:1151-61. 2006..This study provides a resource that represents an important first step toward establishing a framework for the use of microarrays in clinical and regulatory settings... - Phototoxicity of kava - formation of reactive oxygen species leading to lipid peroxidation and DNA damageQingsu Xia
National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
Am J Chin Med 40:1271-88. 2012..The overall results suggest that kava is photocytotoxic and photogenotoxic, both mediated by free radicals generated during photoirradiation... - Microarray scanner calibration curves: characteristics and implicationsLeming Shi
National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
BMC Bioinformatics 6:S11. 2005..Microarray-based measurement of mRNA abundance assumes a linear relationship between the fluorescence intensity and the dye concentration. In reality, however, the calibration curve can be nonlinear... - ZFIQ: a software package for zebrafish biologyTianming Liu
The Methodist Hospital Research Institute and Department of Radiology, The Methodist Hospital
Bioinformatics 24:438-9. 2008..AVAILABILITY: ZFIQ is available for download at http://www.cbi-platform.net... - Threshold optimization of adaptive template filtering for MRI based on intelligent optimization algorithmLei Guo
Joint Key Lab of Electromagn Field and Electr Apparatus Reliability, Hebei Univ of Technol, Tianjin, China
Conf Proc IEEE Eng Med Biol Soc 1:4763-6. 2006..Through algorithm analysis, the performance of IA surpasses the performance of GA. As a new kind of IOA, IA exhibits its great potential in image processing... - An automated method for cell detection in zebrafishTianming Liu
The Center for Biomedical Informatics, The Methodist Hospital Research Institute, Houston, TX, USA
Neuroinformatics 6:5-21. 2008..Our results demonstrate the general applicability of this method to different data samples, including nuclear staining, immunohistochemistry, and cell death detection... - PID controller design for output PDFs of stochastic systems using linear matrix inequalitiesLei Guo
Control Systems Center, University of Manchester Institute of Science and Technology, Manchester M60 1QD, UK
IEEE Trans Syst Man Cybern B Cybern 35:65-71. 2005..Simulations are given to demonstrate the efficiency of the proposed approach and encouraging results have been obtained... - Reconstruction of central cortical surface from brain MRI images: method and applicationTianming Liu
The Center for Biotechnology and Informatics, The Methodist Hospital Research Institute, Houston, TX, USA
Neuroimage 40:991-1002. 2008..Experimental results show that the central cortical surface representation has better performance in detecting simulated atrophy than the traditionally used inner or outer cortical surface representations... - Study of injuries combining computer simulation in motorcycle-car collision accidentsLei Guo
School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
Forensic Sci Int 177:90-6. 2008..These results might be useful for forensic experts in dealing with similar motorcycle-car collision accidents in the future... - Steroidal alkaloids from Veratrum japonicum with genotoxicity on brain cell DNA of the cerebellum and cerebral cortex in miceYue Cong
Institute of Traditional Chinese Medica, School of Pharmacy, Henan University, Kaifeng, P R China
Planta Med 73:1588-91. 2007..Compounds 1 - 4 exhibited genotoxicity on brain cells in mice by using single-cell gel electrophoresis (Comet assay)... - Research on the segmentation of MRI image based on multi-classification support vector machineLei Guo
Province Ministry Joint Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability, Hebei University of Technology, Tianjin, China
Conf Proc IEEE Eng Med Biol Soc 2007:6020-3. 2007..As our experiment demonstrates, the boundaries of 7 kinds of encephalic tissues are extracted successfully, and it can reach satisfactory generalization accuracy. Thus, SVM exhibits its great potential in image segmentation... - Anti-hyperlipidemic properties of CM108 (a flavone derivative) in vitro and in vivoLei Guo
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
Eur J Pharmacol 551:80-6. 2006..01). In conclusion, CM108 can effectively elevate HDL levels and lower triglyceride levels in hyperlipidemic rats maybe by regulating a series of genes, receptors and proteins related to HDL... - A clinical and molecular-genetic analysis of Chinese patients with lattice corneal dystrophy and novel Thr538Pro mutation in the TGFBI (BIGH3) genePing Yu
Department of Medical Genetics, School of Medicine, Zhejiang University, Hangzhou 310006, China
J Genet 85:73-6. 2006 - Ex vivo adenoviral gene transfer of constitutively activated STAT3 reduces post-transplant liver injury and promotes regeneration in a 20% rat partial liver transplant modelKamrul A S M Huda
Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Shikata, Okayama, Japan
Transpl Int 19:415-23. 2006..Thus, the activation of STAT3 in the liver graft may be a potentially effective clinical strategy for improving the outcome of small-for-size liver transplantation... - Efficacy of engineered liver tissue based on poly-L-lactic acid scaffolds and fetal mouse liver cells cultured with oncostatin M, nicotinamide, and dimethyl sulfoxideJinlan Jiang
Institute of Industrial Science, University of Tokyo, Tokyo, Japan
Tissue Eng 10:1577-86. 2004.... - Significant enhancement by anti-ICOS antibody of suboptimal tacrolimus immunosuppression in rat liver transplantationLei Guo
Department of Innovative Surgery, National Research Institute for Child Health and Development, Tokyo, Japan
Liver Transpl 10:743-7. 2004.... - Improved hepatic regeneration with reduced injury by redox factor-1 in a rat small-sized liver transplant modelLei Guo
Department of Artificial Organ and Transplantation Surgery, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan
Am J Transplant 4:879-87. 2004..The results of the present study may open a new avenue to clinical transplantation of disproportionately sized grafts in living-related liver transplantation... - Xenogeneic direct hemoperfusion using whole swine liver for liver failure in dogsKatsutoshi Naruse
Division of Artificial Organs and Transplantation, Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan
J Surg Res 111:229-35. 2003.... - Response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N'-nitro-N-nitrosoguanidine and its role in mutagenesisFeng Zhu
Department of Pathophysiology, Zhejiang University School of Medicine, Hangzhou 310031, China
World J Gastroenterol 9:888-93. 2003..To understand the response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and its role in human mutagenesis... - Calreticulin in cardiac development and pathologyMarek Michalak
Canadian Institutes of Health Research Membrane Protein Research Group and Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
Biochim Biophys Acta 1600:32-7. 2002..Calreticulin and ER may play important role in cardiac development and postnatal pathologies... - MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammationMagdalena M Gorska
Division of Allergy and Immunology, Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Exp Med 204:1637-52. 2007..This pattern of activation is essential for many NF-kappaB-regulated genes and development of inflammation. Thus, the MK2-HSP27 pathway is an excellent target for therapeutic control of localized inflammatory diseases... - 3D cell nuclei segmentation based on gradient flow trackingGang Li
Center for Bioinformatics, Harvard Center for Neurodegeneration and Repair, Harvard Medical School, Boston, MA, USA
BMC Cell Biol 8:40. 2007..The segmentation approach has three stages: 1) a gradient diffusion procedure, 2) gradient flow tracking and grouping, and 3) local adaptive thresholding... - 3D reconstruction of head MRI based on one class support vector machine with immune algorithmLei Wang
Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability of Hebei Province in Hebei University of Technology, Tianjin, China, 300130
Conf Proc IEEE Eng Med Biol Soc 2007:6016-9. 2007..The experimental results demonstrate OCSVM is effective with high reconstruction accuracy... - Resistivity parameters estimation based on 2D real head model using improved differential evolution algorithmYing Li
Province Ministry Joint Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability, Hebei University of Technology, Tianjin 300130, China
Conf Proc IEEE Eng Med Biol Soc . 2006..Furthermore, the selection of the amplification parameters is much easier... - Adaptive template filtering method for MRILei Guo
Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability, Hebei University of Technology, Tianjin, China
Conf Proc IEEE Eng Med Biol Soc 1:1371-4. 2006..It can both effectively suppresses noise and best preserve useful information at the same time for MRI. Thus, ATFM can meet the need of clinical diagnosis and image processing... - Tissue conductivity estimation in two-dimension head model based on support vector machineYouxi Wu
School of Computer Science and Software, Hebei University of Technology, Tianjin, China
Conf Proc IEEE Eng Med Biol Soc 1:1130-3. 2006..Compared with wavelet neural network method, MSVM not only obtains higher accuracy of learning, it also has greater generalization ability and faster computing speed as our experiment demonstrates... - Brain tissue segmentation based on DTI dataTianming Liu
Department of Radiology, The Methodist Hospital, Houston, TX, USA
Neuroimage 38:114-23. 2007..Experimental results of applying this approach to brain tissue segmentation and deformable registration of DTI data and spoiled gradient-echo (SPGR) data are also provided...