Research Topics
Genomes and GenesSpecies | D W GaylorSummaryAffiliation: Food and Drug Administration Country: USA Publications
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Detail Information
Publications
The use of Haber's law in standard setting and risk assessmentD W Gaylor
National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, 72079, Jefferson, AR 72079, USA
Toxicology 149:17-9. 2000..Finally, a generalization of Haber's Law, exposure concentration raised to a power times exposure duration, is discussed...
U.S. Food and Drug Administration perspective of the inclusion of effects of low-level exposures in safety and risk assessmentD W Gaylor
National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079 9502, USA
Environ Health Perspect 106:391-4. 1998..Because of the wide diversity of legal and regulatory standards for various products regulated by the U.S. FDA agency-wide safety and risk assessment procedures and policies generally do not exist...- Dose-response trend tests for tumorigenesis, adjusted for body weightD W Gaylor
National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
Toxicol Sci 49:318-23. 1999..The simple procedure of analyzing tumor incidence within body-weight strata can reduce the bias introduced by weight differences across dose groups... - On interspecies correlations of carcinogenic potenciesR L Kodell
Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
J Toxicol Environ Health 48:231-7. 1996..This article explores the potential for appreciable underestimation of interspecies correlations, due to the experimental error that occurs in the estimation of carcinogenic potencies... - Combining uncertainty factors in deriving human exposure levels of noncarcinogenic toxicantsR L Kodell
Division of Biometry and Risk Assessment, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
Ann N Y Acad Sci 895:188-95. 1999..An appropriately selected upper percentile, for example, 95th or 99th, of the distribution of the product can be used as a combined uncertainty factor to replace the conventional product of default factors... - Percentiles of the product of uncertainty factors for establishing probabilistic reference dosesD W Gaylor
National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
Risk Anal 20:245-50. 2000..If near the 99th percentile is desired use another factor of 3. An additional factor may be needed for inadequate data or a modifying factor for other uncertainties (e.g., different routes of exposure) not covered above... - A mechanistic approach to modelling the risk of liver tumours in mice exposed to fumonisin B1 in the dietR L Kodell
National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
Food Addit Contam 18:237-53. 2001..The model was able to reproduce reasonably well the observed tumour rates in both female and male mice, predicting substantially increased rates above background only at the highest doses of fumonisin B1 in females... - Upregulation of apoptosis with dietary restriction: implications for carcinogenesis and agingS J James
Division of Biochemical Toxicology, U S Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA
Environ Health Perspect 106:307-12. 1998..If during tumor promotion an adaptive increase in apoptosis effectively balances the dysregulated increase proliferation, the risk of permanent genetic error and carcinogenesis would be minimized... - Dose-response trend tests for tumorigenesis adjusted for differences in survival and body weight across dosesD W Gaylor
National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA
Toxicol Sci 59:219-25. 2001..The simple procedure of analyzing tumor incidence within body weight strata can reduce the bias introduced by body weight differences across dose groups... - A comparison of the tumors induced by coal tar and benzo[a]pyrene in a 2-year bioassayS J Culp
National Center for Toxicological Research, Jefferson, AR 72079, USA
Carcinogenesis 19:117-24. 1998.... - Biologically-based dose-response model for neurotoxicity risk assessmentW Slikker
Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079 9502, USA
Toxicol Lett 102:429-33. 1998..This quantitative approach uses all the available data, takes into account the variability of the data and provides an actual risk at a given dose of domoic acid... - Correlation of blood cholinesterase levels with toxicity of sarin in ratsJ F Young
National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079 9502, USA
J Toxicol Environ Health A 62:161-74. 2001..Neither plasma or erythrocyte baseline cholinesterase levels nor relative or absolute cholinesterase decline values could be used as predictors of mortality from sarin administration in rats... - Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndromeS J James
Food and Drug Administration National Center for Toxicological Research, the Division of Biochemical Toxicology, Jefferson, AR 72079, USA
Am J Clin Nutr 70:495-501. 1999..Although advanced maternal age is a major risk factor for trisomy 21, most children with Down syndrome are born to mothers <30 y of age...