DARON I FREEDBERG

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Using nuclear magnetic resonance spectroscopy to characterize biologicals
    D I Freedberg
    Center for Biologicals, Evaluation and Research, Bethesda, MD 20892, USA
    Dev Biol (Basel) 122:77-83. 2005
  2. ncbi request reprint An alternative method for pucker determination in carbohydrates from residual dipolar couplings: a solution NMR study of the fructofuranosyl ring of sucrose
    DARON I FREEDBERG
    Laboratory of Biophysics, CBER FDA, 29 Lincoln Drive, Building 29 HFM 419, Bethesda, Maryland 20892, USA
    J Am Chem Soc 124:2358-62. 2002
  3. doi request reprint Constant time INEPT CT-HSQC (CTi-CT-HSQC) - A new NMR method to measure accurate one-bond J and RDCs with strong 1H-1H couplings in natural abundance
    Bingwu Yu
    Laboratory of Bacterial Polysaccharides, CBER FDA, Bethesda, MD 20892, United States
    J Magn Reson 228:159-65. 2013
  4. doi request reprint More accurate 1J(CH) coupling measurement in the presence of 3J(HH) strong coupling in natural abundance
    Bingwu Yu
    Laboratory of Bacterial Polysaccharides, CBER FDA, Bethesda, MD 20892, USA
    J Magn Reson 215:10-22. 2012
  5. pmc Rapid structural fluctuations of the free HIV protease flaps in solution: relationship to crystal structures and comparison with predictions of dynamics calculations
    DARON I FREEDBERG
    Molecular Structural Biology Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Protein Sci 11:221-32. 2002
  6. ncbi request reprint The utility of residual dipolar couplings in detecting motion in carbohydrates: application to sucrose
    Richard M Venable
    Laboratory of Biophysics, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, HFM 419, MD 20852, USA
    Carbohydr Res 340:863-74. 2005
  7. ncbi request reprint Direct assignment of the absolute configuration of a distinct class of deoxyribonucleoside cyclic N-acylphosphoramidites at phosphorus by M-GOESY nuclear magnetic resonance spectroscopy
    Andrzej Wilk
    Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892, USA
    J Am Chem Soc 124:1180-1. 2002
  8. ncbi request reprint Structural and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions
    Paul W Buehler
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, Bethesda, Maryland 20892, USA
    Anal Chem 77:3466-78. 2005
  9. pmc NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B
    Zheng Zhou
    Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Struct Mol Biol 15:868-9. 2008

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Using nuclear magnetic resonance spectroscopy to characterize biologicals
    D I Freedberg
    Center for Biologicals, Evaluation and Research, Bethesda, MD 20892, USA
    Dev Biol (Basel) 122:77-83. 2005
  2. ncbi request reprint An alternative method for pucker determination in carbohydrates from residual dipolar couplings: a solution NMR study of the fructofuranosyl ring of sucrose
    DARON I FREEDBERG
    Laboratory of Biophysics, CBER FDA, 29 Lincoln Drive, Building 29 HFM 419, Bethesda, Maryland 20892, USA
    J Am Chem Soc 124:2358-62. 2002
    ..Hence, when a sufficient number of residual dipolar coupling constants is measured, the outcome is a robust, reliable, and independent route for determining carbohydrate and nucleic acid structure by NMR spectroscopy...
  3. doi request reprint Constant time INEPT CT-HSQC (CTi-CT-HSQC) - A new NMR method to measure accurate one-bond J and RDCs with strong 1H-1H couplings in natural abundance
    Bingwu Yu
    Laboratory of Bacterial Polysaccharides, CBER FDA, Bethesda, MD 20892, United States
    J Magn Reson 228:159-65. 2013
    ..We demonstrate that RDCs can be obtained with higher accuracy by CTi-CT-HSQC, which compensates the limitation of simulation method...
  4. doi request reprint More accurate 1J(CH) coupling measurement in the presence of 3J(HH) strong coupling in natural abundance
    Bingwu Yu
    Laboratory of Bacterial Polysaccharides, CBER FDA, Bethesda, MD 20892, USA
    J Magn Reson 215:10-22. 2012
    ..We conclude that spectral simulation yields accurate (1)J(CH) with errors as low as 1% in the presence of strong coupling...
  5. pmc Rapid structural fluctuations of the free HIV protease flaps in solution: relationship to crystal structures and comparison with predictions of dynamics calculations
    DARON I FREEDBERG
    Molecular Structural Biology Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Protein Sci 11:221-32. 2002
    ..These results are compared with theoretical predictions of flap dynamics and the possible biological significance of the sub-ns time scale dynamics of the flap tips is discussed...
  6. ncbi request reprint The utility of residual dipolar couplings in detecting motion in carbohydrates: application to sucrose
    Richard M Venable
    Laboratory of Biophysics, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, HFM 419, MD 20852, USA
    Carbohydr Res 340:863-74. 2005
    ..Previously published 13C nuclear relaxation results suggesting that sucrose is rigid are not inconsistent with the present results when motional timescales are considered...
  7. ncbi request reprint Direct assignment of the absolute configuration of a distinct class of deoxyribonucleoside cyclic N-acylphosphoramidites at phosphorus by M-GOESY nuclear magnetic resonance spectroscopy
    Andrzej Wilk
    Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892, USA
    J Am Chem Soc 124:1180-1. 2002
    ..M-GOESY NMR data also confirm that the condensation of deoxyribonucleoside cyclic N-acylphosphoramidites with base-activated nucleosidic or nucleotidic 5'-hydroxyls proceeds via a single nucleophilic event...
  8. ncbi request reprint Structural and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions
    Paul W Buehler
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, Bethesda, Maryland 20892, USA
    Anal Chem 77:3466-78. 2005
    ..Structural modification imparted by glutaraldehyde resulted in nearly identical functional characteristics of PolyHbBv and its fractions with regard to oxygen equilibrium, ligand binding, and autoxidative kinetics...
  9. pmc NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B
    Zheng Zhou
    Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Struct Mol Biol 15:868-9. 2008
    ..A molecular model that docks Chz1 onto the nucleosome has implications for its potential functions...