Maryna Eichelberger

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Distinct cellular immune responses following primary and secondary influenza virus challenge in cotton rats
    Maryna C Eichelberger
    Virion Systems Inc, 9610 Medical Center Drive, Rockville, MD 20850, USA
    Cell Immunol 243:67-74. 2006
  2. ncbi request reprint The cotton rat as a model to study influenza pathogenesis and immunity
    Maryna C Eichelberger
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Viral Immunol 20:243-9. 2007
  3. ncbi request reprint A miniaturized assay for influenza neuraminidase-inhibiting antibodies utilizing reverse genetics-derived antigens
    Matthew R Sandbulte
    Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD, USA
    Influenza Other Respir Viruses 3:233-40. 2009
  4. pmc Comparison of the effectiveness of antibody and cell-mediated immunity against inhaled and instilled influenza virus challenge
    Katie Rivers
    Division of Viral Products, OVRR, CBER, FDA, 8800 Rockville Pike, Building 29A 1D24, Bethesda, MD 20892, USA
    Virol J 10:198. 2013
  5. pmc Intramuscular immunization of mice with live influenza virus is more immunogenic and offers greater protection than immunization with inactivated virus
    Katie Harris
    Division of Viral Products, Office of Vaccine Review and Research, Center for Biologics Evaluation and Research, Food and Drug Administration, USA
    Virol J 8:251. 2011
  6. pmc Antibody contributes to heterosubtypic protection against influenza A-induced tachypnea in cotton rats
    Timothy M Straight
    Department of Clinical Investigation, Brooke Army Medical Center, Fort Sam Houston, TX, USA
    Virol J 5:44. 2008
  7. pmc Comparison of airway measurements during influenza-induced tachypnea in infant and adult cotton rats
    Elman L Trias
    Children s National Medical Center, Washington, DC 20010, USA
    BMC Pulm Med 9:28. 2009
  8. doi request reprint Animal models to assess the toxicity, immunogenicity and effectiveness of candidate influenza vaccines
    Maryna C Eichelberger
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Expert Opin Drug Metab Toxicol 7:1117-27. 2011
  9. pmc Neuraminidase activity provides a practical read-out for a high throughput influenza antiviral screening assay
    Maryna C Eichelberger
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    Virol J 5:109. 2008
  10. ncbi request reprint The cotton rat provides a useful small-animal model for the study of influenza virus pathogenesis
    Martin G Ottolini
    Department of Pediatrics, F Edward Hebert School of Medicine, The Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    J Gen Virol 86:2823-30. 2005

Research Grants

  1. INITIATION OF VIRUS SPECIFIC CD8+ T CELL RESPONSES
    Maryna Eichelberger; Fiscal Year: 2002
  2. Accelerated Viral Inhibition Assay
    Maryna Eichelberger; Fiscal Year: 2006

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Distinct cellular immune responses following primary and secondary influenza virus challenge in cotton rats
    Maryna C Eichelberger
    Virion Systems Inc, 9610 Medical Center Drive, Rockville, MD 20850, USA
    Cell Immunol 243:67-74. 2006
    ..These studies are the first to show evidence of a memory T cell response to influenza infection in cotton rats and show quantitative and qualitative differences between the recall response to homosubtypic and heterosubtypic viruses...
  2. ncbi request reprint The cotton rat as a model to study influenza pathogenesis and immunity
    Maryna C Eichelberger
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Viral Immunol 20:243-9. 2007
    ..This review describes innate and adaptive responses to influenza in infected cotton rats, and points out immune mechanisms that contribute to protection against disease...
  3. ncbi request reprint A miniaturized assay for influenza neuraminidase-inhibiting antibodies utilizing reverse genetics-derived antigens
    Matthew R Sandbulte
    Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD, USA
    Influenza Other Respir Viruses 3:233-40. 2009
    ..In addition, the assay is complicated by the need to use virus of a hemagglutinin (HA) subtype novel to the host to detect NA-specific antibodies only...
  4. pmc Comparison of the effectiveness of antibody and cell-mediated immunity against inhaled and instilled influenza virus challenge
    Katie Rivers
    Division of Viral Products, OVRR, CBER, FDA, 8800 Rockville Pike, Building 29A 1D24, Bethesda, MD 20892, USA
    Virol J 10:198. 2013
    ....
  5. pmc Intramuscular immunization of mice with live influenza virus is more immunogenic and offers greater protection than immunization with inactivated virus
    Katie Harris
    Division of Viral Products, Office of Vaccine Review and Research, Center for Biologics Evaluation and Research, Food and Drug Administration, USA
    Virol J 8:251. 2011
    ..A 2-dose regime of trivalent inactivated vaccine is required to generate protective levels of hemagglutination inhibiting (HAI) antibodies. A vaccine preparation with enhanced immunogenicity is therefore desirable...
  6. pmc Antibody contributes to heterosubtypic protection against influenza A-induced tachypnea in cotton rats
    Timothy M Straight
    Department of Clinical Investigation, Brooke Army Medical Center, Fort Sam Houston, TX, USA
    Virol J 5:44. 2008
    ..Alternatively, H1N1-immune animals are protected from H3N2-induced tachypnea. The experiments described in this report were designed to elucidate the immune mechanism that prevents this very early sign of disease...
  7. pmc Comparison of airway measurements during influenza-induced tachypnea in infant and adult cotton rats
    Elman L Trias
    Children s National Medical Center, Washington, DC 20010, USA
    BMC Pulm Med 9:28. 2009
    ..We hypothesized that age-dependent differences in lung mechanics result in differences in ventilatory characteristics following influenza infection...
  8. doi request reprint Animal models to assess the toxicity, immunogenicity and effectiveness of candidate influenza vaccines
    Maryna C Eichelberger
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Expert Opin Drug Metab Toxicol 7:1117-27. 2011
    ..To prevent adverse events that may be associated with these new vaccines, it is important to evaluate the toxicity of new formulations in animal models...
  9. pmc Neuraminidase activity provides a practical read-out for a high throughput influenza antiviral screening assay
    Maryna C Eichelberger
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    Virol J 5:109. 2008
    ..To broaden the search for antivirals, cell-based replication assays can be performed, but these are often labor intensive and have limited throughput...
  10. ncbi request reprint The cotton rat provides a useful small-animal model for the study of influenza virus pathogenesis
    Martin G Ottolini
    Department of Pediatrics, F Edward Hebert School of Medicine, The Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    J Gen Virol 86:2823-30. 2005
    ..These results indicate that cotton rats will be useful for further studies of influenza pathogenesis and immunity...
  11. ncbi request reprint Influenza-induced tachypnea is prevented in immune cotton rats, but cannot be treated with an anti-inflammatory steroid or a neuraminidase inhibitor
    Maryna C Eichelberger
    Virion Systems Inc, Rockville MD 21205, USA
    Virology 322:300-7. 2004
    ..Therapeutic approaches need to be tailored to clear airway obstruction and restore an intact epithelium...
  12. doi request reprint Label-free mass spectrometry-based quantification of hemagglutinin and neuraminidase in influenza virus preparations and vaccines
    Melkamu Getie-Kebtie
    Division of Cellular and Gene Therapies, OCTGT CBER FDA, Bethesda, MD, USA
    Influenza Other Respir Viruses 7:521-30. 2013
    ..An accurate rapid method to determine hemagglutinin (HA) concentration would facilitate reference antigen preparation and consequently expedite availability of seasonal as well as pandemic vaccines...
  13. pmc Rapid detection and differentiation of swine-origin influenza A virus (H1N1/2009) from other seasonal influenza A viruses
    Jiangqin Zhao
    Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Viruses 4:3012-9. 2012
    ..This new method may be useful for simultaneous detection and subtyping of influenza A viruses and can be rapidly modified to detect other emerging influenza strains in public health settings...
  14. doi request reprint A practical influenza neutralization assay to simultaneously quantify hemagglutinin and neuraminidase-inhibiting antibody responses
    Arash Hassantoufighi
    Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA
    Vaccine 28:790-7. 2010
    ..The AVINA assay is therefore a practical, comprehensive method to determine influenza vaccine immunogenicity and potential efficacy...
  15. ncbi request reprint Co-infection of the cotton rat (Sigmodon hispidus) with Staphylococcus aureus and influenza A virus results in synergistic disease
    LoRanee E Braun
    Department of Pediatrics, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Microb Pathog 43:208-16. 2007
    ..aureus co-infection, with increased mortality and hypothermia as well as prolonged bacterial duration indicative of synergistic disease that may be the result of increased induction of both pro- and anti-inflammatory cytokines...
  16. pmc Comparative glycomics analysis of influenza Hemagglutinin (H5N1) produced in vaccine relevant cell platforms
    Yanming An
    Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Proteome Res 12:3707-20. 2013
    ....
  17. doi request reprint Confronting the next pandemic-Workshop on lessons learned from potency testing of pandemic (H1N1) 2009 influenza vaccines and considerations for future potency tests, Ottawa, Canada, July 27-29, 2010
    Stephanie Hardy
    Health Canada, Biologics and Genetic Therapies Directorate, Ottawa, ON, Canada US Food and Drug Administration, Center for Biologics Evaluation and Research, Bethesda, MD, USA World Health Organization, Geneva, Switzerland
    Influenza Other Respi Viruses 5:438-42. 2011
    ..Influenza and Other Respiratory Viruses 5(6), 438-442...
  18. doi request reprint FDA/NIH/WHO public workshop on immune correlates of protection against influenza A viruses in support of pandemic vaccine development, Bethesda, Maryland, US, December 10-11, 2007
    Maryna Eichelberger
    US Food and Drug Administration, Center for Biologics Evaluation and Research Office of Vaccines Research and Review, Division of Viral Products, Bethesda, MD 20892, USA
    Vaccine 26:4299-303. 2008
    ....
  19. pmc Rapid selection of a transmissible multidrug-resistant influenza A/H3N2 virus in an immunocompromised host
    Matthew J Memoli
    Respiratory Virus Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MSC 3203 33 North Dr, Bethesda, MD 20892 3203, USA
    J Infect Dis 201:1397-403. 2010
    ..Antigenic drift and genetic variations during prolonged influenza infection have been demonstrated. In this report we describe a multidrug-resistant H3N2 influenza virus isolated from an immunocompromised patient after 5 days of therapy...
  20. pmc Rapid selection of oseltamivir- and peramivir-resistant pandemic H1N1 virus during therapy in 2 immunocompromised hosts
    Matthew J Memoli
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 3203, USA
    Clin Infect Dis 50:1252-5. 2010
    ..We describe rapid selection for the H275Y resistance mutation during therapy in 2 immunocompromised individuals at 9 and 14 days of therapy, as well as the first described case of clinically significant resistance to peramivir...
  21. ncbi request reprint Antigen-dependent proliferation and cytokine induction in respiratory syncytial virus-infected cotton rats reflect the presence of effector-memory T cells
    Bettina W M Richter
    Virion Systems, Inc, Rockville, MD 20850 3347, USA
    Virology 337:102-10. 2005
    ..This supports the idea that the presence of effector-memory rather than central-memory T cells contributes to the ineffectiveness of the immune response to RSV...
  22. ncbi request reprint Evidence of a cross-protective immune response to influenza A in the cotton rat model
    Timothy M Straight
    Department of Clinical Investigation, Brooke Army Medical Center, 3400 Rawley E Chambers Avenue, Fort Sam Houston, TX 78234, USA
    Vaccine 24:6264-71. 2006
    ..Identification of the mechanisms that contribute to cross-protection in cotton rats may lead to the development of influenza vaccine strategies that are broadly protective...
  23. ncbi request reprint Clinical evaluation of a single oral dose of human-bovine (UK) reassortant rotavirus vaccines Wa x UK (P1A[8],G6) and Wa x (DS-1 x UK) (P1A[8],G2)
    Maryna C Eichelberger
    Center for Immunization Research, Department of International Health, Johns Hopkins School of Public Health, Baltimore, Maryland, USA
    J Med Virol 66:407-16. 2002
    ..Each of these vaccines appeared to be well-tolerated and immunogenic in infants less than 6 months of age following a single oral dose, and therefore should be evaluated further as vaccine candidates...

Research Grants2

  1. INITIATION OF VIRUS SPECIFIC CD8+ T CELL RESPONSES
    Maryna Eichelberger; Fiscal Year: 2002
    ..This proposal is designed as an essential step towards the development of more effective influenza vaccine. ..
  2. Accelerated Viral Inhibition Assay
    Maryna Eichelberger; Fiscal Year: 2006
    ....