Robert C Duncan

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint DNA microarray analysis of protozoan parasite gene expression: outcomes correlate with mechanisms of regulation
    Robert Duncan
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, 1401 Rockville Pike, Rockville, MD 20852, USA
    Trends Parasitol 20:211-5. 2004
  2. ncbi request reprint Rubella virus capsid protein induces apoptosis in transfected RK13 cells
    R Duncan
    Laboratory of Parasitic Biology and Biochemistry, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Virology 275:20-9. 2000
  3. ncbi request reprint Early response gene expression during differentiation of cultured Leishmania donovani
    R Duncan
    Laboratory of Bacterial, Parasitic and Unconventional Agents, FDA CBER, Bethesda, MD 20892, USA
    Parasitol Res 87:897-906. 2001
  4. ncbi request reprint The application of gene expression microarray technology to kinetoplastid research
    Robert C Duncan
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, CBER, FDA, Bethesda, MD, USA
    Curr Mol Med 4:611-21. 2004
  5. pmc Leishmania donovani argininosuccinate synthase is an active enzyme associated with parasite pathogenesis
    Inès Lakhal-Naouar
    Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, Bethesda, MD, USA
    PLoS Negl Trop Dis 6:e1849. 2012
  6. pmc A new model of progressive visceral leishmaniasis in hamsters by natural transmission via bites of vector sand flies
    Hamide Aslan
    Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Infect Dis 207:1328-38. 2013
  7. pmc Mitochondrial associated ubiquitin fold modifier-1 mediated protein conjugation in Leishmania donovani
    Sreenivas Gannavaram
    Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 6:e16156. 2011
  8. ncbi request reprint Upregulation of surface proteins in Leishmania donovani isolated from patients of post kala-azar dermal leishmaniasis
    Poonam Salotra
    Molecular Biology Laboratory, Institute of Pathology ICMR, Safdarjung Hospital Campus, New Delhi, India
    Microbes Infect 8:637-44. 2006

Collaborators

Detail Information

Publications8

  1. ncbi request reprint DNA microarray analysis of protozoan parasite gene expression: outcomes correlate with mechanisms of regulation
    Robert Duncan
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, 1401 Rockville Pike, Rockville, MD 20852, USA
    Trends Parasitol 20:211-5. 2004
  2. ncbi request reprint Rubella virus capsid protein induces apoptosis in transfected RK13 cells
    R Duncan
    Laboratory of Parasitic Biology and Biochemistry, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Virology 275:20-9. 2000
    ..Though apoptosis-inducing capsid constructs appear to have an ER sub-cellular localization, disruption of the ER calcium storage capacity does not correlate with cell death. Mechanisms consistent with these results are discussed...
  3. ncbi request reprint Early response gene expression during differentiation of cultured Leishmania donovani
    R Duncan
    Laboratory of Bacterial, Parasitic and Unconventional Agents, FDA CBER, Bethesda, MD 20892, USA
    Parasitol Res 87:897-906. 2001
    ..Changes in RNA level occurred within 2 h for each gene and continued in advance of morphological changes. The expression levels of these four genes in axenic amastigotes correlated with results from animal-derived parasites...
  4. ncbi request reprint The application of gene expression microarray technology to kinetoplastid research
    Robert C Duncan
    Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, CBER, FDA, Bethesda, MD, USA
    Curr Mol Med 4:611-21. 2004
    ....
  5. pmc Leishmania donovani argininosuccinate synthase is an active enzyme associated with parasite pathogenesis
    Inès Lakhal-Naouar
    Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, Bethesda, MD, USA
    PLoS Negl Trop Dis 6:e1849. 2012
    ..In order to characterize in detail this newly identified protein in Leishmania, we determined its enzymatic activity, subcellular localization in the parasite and affect on virulence in vivo...
  6. pmc A new model of progressive visceral leishmaniasis in hamsters by natural transmission via bites of vector sand flies
    Hamide Aslan
    Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Infect Dis 207:1328-38. 2013
    ..Protection of needle-challenged vaccinated mice was abrogated in vector-initiated cutaneous leishmaniasis, highlighting the importance of developing natural transmission models for VL...
  7. pmc Mitochondrial associated ubiquitin fold modifier-1 mediated protein conjugation in Leishmania donovani
    Sreenivas Gannavaram
    Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, U S Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 6:e16156. 2011
    ..Thus, Ufm1 conjugation pathway in Leishmania could be explored as a potential drug target in the control of Leishmaniasis...
  8. ncbi request reprint Upregulation of surface proteins in Leishmania donovani isolated from patients of post kala-azar dermal leishmaniasis
    Poonam Salotra
    Molecular Biology Laboratory, Institute of Pathology ICMR, Safdarjung Hospital Campus, New Delhi, India
    Microbes Infect 8:637-44. 2006
    ..Such differentially expressed genes hold the key to understanding the parasite genetic factors that contribute to the persistence after clinical cure of VL...