Research Topics
Genomes and Genes | Raymond P DonnellySummaryAffiliation: Food and Drug Administration Country: USA Publications
| Collaborators
|
Detail Information
Publications
Interferon-lambda: a new addition to an old familyRaymond P Donnelly
Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
J Interferon Cytokine Res 30:555-64. 2010..In addition, preclinical studies by several groups indicate that IFN-lambda may also be useful as a potential therapeutic agent for other clinical indications, including certain types of cancer...
An overview of cytokines and cytokine antagonists as therapeutic agentsRaymond P Donnelly
Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
Ann N Y Acad Sci 1182:1-13. 2009..This issue of the Annals includes more than a dozen papers that summarize much of the information that was presented during this very informative two-day conference...- Interleukin-26: an IL-10-related cytokine produced by Th17 cellsRaymond P Donnelly
Division of Therapeutic Proteins, Center for Drug Evaluation and Research, U S Food and Drug Administration, Bethesda, MD 20892, USA
Cytokine Growth Factor Rev 21:393-401. 2010..Signaling through IL-26 receptor complexes results in the activation of STAT1 and STAT3 with subsequent induction of IL-26-responsive genes. The biological functions of IL-26 have only begun to be defined... - Interferon-lambda and therapy for chronic hepatitis C virus infectionRaymond P Donnelly
Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Trends Immunol 32:443-50. 2011.... - Oncostatin M regulates secretoglobin 3A1 and 3A2 expression in a bidirectional mannerTakeshi Tomita
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Am J Respir Cell Mol Biol 40:620-30. 2009..The differential regulation of Scgb3a1 and Scgb3a2 gene expression by OSM may explain the unique functions of these genes in the lung... 
Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1Achara Srisodsai
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:54358-68. 2004..1-dependent pathway. The results further suggest that UGRP1 might be a target for IL-10 anti-inflammatory activities in the lung...- Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivityIlkka S Junttila
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 205:2595-608. 2008..These findings provide an explanation for IL-13's principal function as an "effector" cytokine and IL-4's principal role as an "immunoregulatory" cytokine... - Alpha and lambda interferon together mediate suppression of CD4 T cells induced by respiratory syncytial virusBo Chi
Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA
J Virol 80:5032-40. 2006..Defining the mechanism of RSV-induced suppression may guide vaccine design and provide insight into previously uncharacterized human T-cell responses and activities of interferons... - Induction of uteroglobin-related protein 2 (Ugrp2) gene expression by the Th2 cytokines IL-4 and IL-13Atsushi Yamada
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 175:5708-15. 2005..These results indicate that Ugrp2 expression is enhanced by IL-4 and IL-13 through STAT6 binding to the proximal SBE located in the Ugrp2 gene promoter... - The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chainRaymond P Donnelly
Division of Therapeutic Proteins, HFM 538, 1401 Rockville Pike, Rockville, MD 20852, USA
J Leukoc Biol 76:314-21. 2004..Consequently, the receptors for these cytokines may provide novel targets for inhibiting the growth of certain types of cancer... - Interferon-lambda (IFN-λ) induces signal transduction and gene expression in human hepatocytes, but not in lymphocytes or monocytesHarold Dickensheets
Division of Therapeutic Proteins, Center for Drug Evaluation and Research, U S Food and Drug Administration, 29 Lincoln Dr, Bethesda, MD 20892, USA
J Leukoc Biol 93:377-85. 2013..This important functional difference may provide a clinical advantage for IFN-λ as a treatment for chronic HCV infection, as it is less likely to induce the leukopenias that are often associated with IFN-α therapy... - Hurdles and leaps for protein therapeuticsSteven Kozlowski
Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U S FDA, Silver Spring, Maryland 20993, USA
Ann N Y Acad Sci 1182:146-60. 2009..However clinical development remains a challenge. On the basis of the history of cytokine therapeutics, a number of strategies for future drug development are considered... - Leishmania donovani-induced expression of suppressor of cytokine signaling 3 in human macrophages: a novel mechanism for intracellular parasite suppression of activationSylvie Bertholet
Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Infect Immun 71:2095-101. 2003..The induction of SOCS3 provides a potent inhibitory mechanism by which intracellular microorganisms may suppress macrophage activation and interfere with the host immune response... - Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chainThirumalai R Ramalingam
Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
Nat Immunol 9:25-33. 2008..IL-13Ralpha1 was essential for allergen-induced airway hyperreactivity and mucus hypersecretion but not for fibroblast or alternative macrophage activation. Thus, type I and II IL-4 receptors exert distinct effects on immune responses... - Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2Faruk Sheikh
Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
J Immunol 172:2006-10. 2004..IL-10, IL-19, IL-20, IL-22, and IL-24 fail to signal through the combination of IL-10R2 and IL-20R1 proteins, demonstrating that this receptor combination is unique and specific for IL-26... - A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virusLudmila Prokunina-Olsson
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
Nat Genet 45:164-71. 2013..Our findings provide new insights into the genetic regulation of HCV clearance and its clinical management...