R P Donnelly

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes
    R P Donnelly
    Division of Cytokine Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Interferon Cytokine Res 19:563-73. 1999
  2. ncbi request reprint The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain
    Raymond P Donnelly
    Division of Therapeutic Proteins, HFM 538, 1401 Rockville Pike, Rockville, MD 20852, USA
    J Leukoc Biol 76:314-21. 2004
  3. ncbi request reprint Suppressor of cytokine signaling-1 is an IL-4-inducible gene in macrophages and feedback inhibits IL-4 signaling
    H Dickensheets
    Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    Genes Immun 8:21-7. 2007
  4. ncbi request reprint Differential regulation of IL-1 production in human monocytes by IFN-gamma and IL-4
    R P Donnelly
    Division of Cytokine Biology, Food and Drug Administration, Bethesda, MD 20892
    J Immunol 145:569-75. 1990
  5. ncbi request reprint Inhibition of IL-4-inducible gene expression in human monocytes by type I and type II interferons
    H L Dickensheets
    Division of Cytokine Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    J Leukoc Biol 65:307-12. 1999
  6. pmc Distinct and overlapping genomic profiles and antiviral effects of Interferon-λ and -α on HCV-infected and noninfected hepatoma cells
    A Kohli
    Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA
    J Viral Hepat 19:843-53. 2012
  7. pmc Leishmania donovani-induced expression of suppressor of cytokine signaling 3 in human macrophages: a novel mechanism for intracellular parasite suppression of activation
    Sylvie Bertholet
    Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Infect Immun 71:2095-101. 2003
  8. ncbi request reprint IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex
    Sergei V Kotenko
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Nat Immunol 4:69-77. 2003
  9. ncbi request reprint Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-Maf fibrosarcoma
    Shanjin Cao
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Immunol 169:5715-25. 2002
  10. ncbi request reprint Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2
    Faruk Sheikh
    Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Immunol 172:2006-10. 2004

Collaborators

  • S Kottilil
  • X Zhang
  • J Yang
  • H L Dickensheets
  • J J Ryan
  • S V Kotenko
  • Michele Boniotto
  • Alexander Zdanov
  • Grant Gallagher
  • JOHN J O'SHEA
  • Peter Murray
  • M Ernst
  • M J Fenton
  • Jean Christophe Renauld
  • J A Langer
  • Mark R Walter
  • Faruk Sheikh
  • A Kohli
  • Stephen G Maher
  • Karim C El Kasmi
  • Ahmed Lasfar
  • Sung Il Yoon
  • Bo Chi
  • Atsushi Yamada
  • Anita Lewis-Antes
  • Sergey V Smirnov
  • Laure Dumoutier
  • Shubha Anantha
  • Shioko Kimura
  • Achara Srisodsai
  • Sylvie Bertholet
  • Shanjin Cao
  • A Sherman
  • R S Russell
  • T Imamichi
  • F Sheikh
  • H Masur
  • R A Lempicki
  • H Young
  • Anthony J Scarzello
  • Darren P Baker
  • Ana L Romero-Weaver
  • Ana M Gamero
  • Lisa Mielke
  • Kenneth Reuhl
  • Ronald L Rabin
  • Warren Alexander
  • Jeff Holst
  • Elizabeth Raveche
  • Cindy Luongo
  • Robert Rutschman
  • Maryaline Coffre
  • Walid Abushahba
  • Amber M Smith
  • Mario Roederer
  • Yuhong Shen
  • Stephanie S Watowich
  • Douglas J Hilton
  • Peter L Collins
  • Antoine de Pauw
  • Deepak Kaushal
  • Judy A Beeler
  • Bin Tian
  • Nouara Lhocine
  • Martin G Myers
  • Marc A Alston
  • Dario A A Vignali
  • Kirsten M Spann
  • Naomi J Logsdon
  • Takashi Suda
  • Jiaying Huang
  • Tomoaki Niimi
  • Francesco J DeMayo
  • Achsah D Keegan
  • Howard A Young
  • Reiko Kurotani
  • Vitaliy V Baurin
  • Yoshihiko Chiba
  • Nital K Shah
  • Richard T Kenney
  • Albert A Gam
  • Jianguo Liu
  • I cheng Ho
  • Peter Leif Bergsagel
  • Marta Chesi
  • Xiaojing Ma

Detail Information

Publications18

  1. ncbi request reprint The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes
    R P Donnelly
    Division of Cytokine Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Interferon Cytokine Res 19:563-73. 1999
    ..Thus, the ability of IL-10 to inhibit gene expression in monocytes is associated with its ability to rapidly induce synthesis of SOCS-3...
  2. ncbi request reprint The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain
    Raymond P Donnelly
    Division of Therapeutic Proteins, HFM 538, 1401 Rockville Pike, Rockville, MD 20852, USA
    J Leukoc Biol 76:314-21. 2004
    ..Consequently, the receptors for these cytokines may provide novel targets for inhibiting the growth of certain types of cancer...
  3. ncbi request reprint Suppressor of cytokine signaling-1 is an IL-4-inducible gene in macrophages and feedback inhibits IL-4 signaling
    H Dickensheets
    Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    Genes Immun 8:21-7. 2007
    ..Our findings demonstrate that, like IFN-gamma, IL-4 also induces expression of SOCS-1 in macrophages, and SOCS-1 feedback inhibits expression of STAT6-responsive genes...
  4. ncbi request reprint Differential regulation of IL-1 production in human monocytes by IFN-gamma and IL-4
    R P Donnelly
    Division of Cytokine Biology, Food and Drug Administration, Bethesda, MD 20892
    J Immunol 145:569-75. 1990
    ..Together these findings demonstrate that the relative levels of IFN-gamma and IL-4 may profoundly influence the state of monocyte activation by differentially regulating the expression of IL-1...
  5. ncbi request reprint Inhibition of IL-4-inducible gene expression in human monocytes by type I and type II interferons
    H L Dickensheets
    Division of Cytokine Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    J Leukoc Biol 65:307-12. 1999
    ....
  6. pmc Distinct and overlapping genomic profiles and antiviral effects of Interferon-λ and -α on HCV-infected and noninfected hepatoma cells
    A Kohli
    Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA
    J Viral Hepat 19:843-53. 2012
    ..The findings from our comparative analysis of IFN-α and IFN-λ in HCV-infected and noninfected cells support the clinical use of IFN-λ as a potential alternative to IFN-α in the treatment of chronic hepatitis C...
  7. pmc Leishmania donovani-induced expression of suppressor of cytokine signaling 3 in human macrophages: a novel mechanism for intracellular parasite suppression of activation
    Sylvie Bertholet
    Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Infect Immun 71:2095-101. 2003
    ..The induction of SOCS3 provides a potent inhibitory mechanism by which intracellular microorganisms may suppress macrophage activation and interfere with the host immune response...
  8. ncbi request reprint IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex
    Sergei V Kotenko
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Nat Immunol 4:69-77. 2003
    ..This receptor-ligand system may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs...
  9. ncbi request reprint Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-Maf fibrosarcoma
    Shanjin Cao
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Immunol 169:5715-25. 2002
    ..However, IL-10-mediated inhibition of IL-12 production remains intact, indicating the existence of alternative mediators in the absence of c-Maf, consistent with the observation that a functional AP-1 is required for this pathway...
  10. ncbi request reprint Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2
    Faruk Sheikh
    Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Immunol 172:2006-10. 2004
    ..IL-10, IL-19, IL-20, IL-22, and IL-24 fail to signal through the combination of IL-10R2 and IL-20R1 proteins, demonstrating that this receptor combination is unique and specific for IL-26...
  11. pmc IFNalpha and IFNlambda differ in their antiproliferative effects and duration of JAK/STAT signaling activity
    Stephen G Maher
    Department of Surgery, Trinity College Dublin, Dublin, Ireland
    Cancer Biol Ther 7:1109-15. 2008
    ..Thus our data demonstrate that the duration of IFNlambda signaling is different from that of IFNalpha, and that IFNlambda could be a suitable cytokine to evaluate for cancer therapy...
  12. ncbi request reprint General nature of the STAT3-activated anti-inflammatory response
    Karim C El Kasmi
    Department of Infectious Diseases, St Jude s Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 177:7880-8. 2006
    ..We conclude that the AIR is a generic cytokine signaling pathway dependent on STAT3 but not unique to the IL-10R...
  13. ncbi request reprint Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex
    Sung Il Yoon
    Department of Microbiology and Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 281:35088-96. 2006
    ..These studies highlight the importance of structure in regulating low affinity protein-protein interactions and IL-10 signal transduction...
  14. pmc Alpha and lambda interferon together mediate suppression of CD4 T cells induced by respiratory syncytial virus
    Bo Chi
    Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA
    J Virol 80:5032-40. 2006
    ..Defining the mechanism of RSV-induced suppression may guide vaccine design and provide insight into previously uncharacterized human T-cell responses and activities of interferons...
  15. ncbi request reprint Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma
    Ahmed Lasfar
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey 07103, USA
    Cancer Res 66:4468-77. 2006
    ..IFN-lambda2 cells, suggesting that IFN-lambdas engage host mechanisms to inhibit melanoma growth. These in vivo experiments show the antitumor activities of IFN-lambdas and suggest their strong therapeutic potential...
  16. pmc Induction of uteroglobin-related protein 2 (Ugrp2) gene expression by the Th2 cytokines IL-4 and IL-13
    Atsushi Yamada
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 175:5708-15. 2005
    ..These results indicate that Ugrp2 expression is enhanced by IL-4 and IL-13 through STAT6 binding to the proximal SBE located in the Ugrp2 gene promoter...
  17. ncbi request reprint Human interleukin-19 and its receptor: a potential role in the induction of Th2 responses
    Grant Gallagher
    Department of Oral Biology, University of Medicine and Dentistry of New Jersey, Room C 636, MSB, 185 South Orange Avenue, Newark, NJ 07103, USA
    Int Immunopharmacol 4:615-26. 2004
    ..Furthermore, in whole PBMC cultures, IL-19 up-regulated IL-4 and down-regulated IFNgamma in a dose-dependent manner. These results are presented here in review format, in the context of an overall discussion of IL-19 and its receptor...
  18. ncbi request reprint Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1
    Achara Srisodsai
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:54358-68. 2004
    ..1-dependent pathway. The results further suggest that UGRP1 might be a target for IL-10 anti-inflammatory activities in the lung...