R P Donnelly
Affiliation: Food and Drug Administration
- The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytesR P Donnelly
Division of Cytokine Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
J Interferon Cytokine Res 19:563-73. 1999..Thus, the ability of IL-10 to inhibit gene expression in monocytes is associated with its ability to rapidly induce synthesis of SOCS-3...
- The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chainRaymond P Donnelly
Division of Therapeutic Proteins, HFM 538, 1401 Rockville Pike, Rockville, MD 20852, USA
J Leukoc Biol 76:314-21. 2004..Consequently, the receptors for these cytokines may provide novel targets for inhibiting the growth of certain types of cancer...
- Suppressor of cytokine signaling-1 is an IL-4-inducible gene in macrophages and feedback inhibits IL-4 signalingH Dickensheets
Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
Genes Immun 8:21-7. 2007..Our findings demonstrate that, like IFN-gamma, IL-4 also induces expression of SOCS-1 in macrophages, and SOCS-1 feedback inhibits expression of STAT6-responsive genes...
- Differential regulation of IL-1 production in human monocytes by IFN-gamma and IL-4R P Donnelly
Division of Cytokine Biology, Food and Drug Administration, Bethesda, MD 20892
J Immunol 145:569-75. 1990..Together these findings demonstrate that the relative levels of IFN-gamma and IL-4 may profoundly influence the state of monocyte activation by differentially regulating the expression of IL-1...
- Inhibition of IL-4-inducible gene expression in human monocytes by type I and type II interferonsH L Dickensheets
Division of Cytokine Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
J Leukoc Biol 65:307-12. 1999....
- Distinct and overlapping genomic profiles and antiviral effects of Interferon-λ and -α on HCV-infected and noninfected hepatoma cellsA Kohli
Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA
J Viral Hepat 19:843-53. 2012..The findings from our comparative analysis of IFN-α and IFN-λ in HCV-infected and noninfected cells support the clinical use of IFN-λ as a potential alternative to IFN-α in the treatment of chronic hepatitis C...
- Leishmania donovani-induced expression of suppressor of cytokine signaling 3 in human macrophages: a novel mechanism for intracellular parasite suppression of activationSylvie Bertholet
Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Infect Immun 71:2095-101. 2003..The induction of SOCS3 provides a potent inhibitory mechanism by which intracellular microorganisms may suppress macrophage activation and interfere with the host immune response...
- IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complexSergei V Kotenko
Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
Nat Immunol 4:69-77. 2003..This receptor-ligand system may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs...
- Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-Maf fibrosarcomaShanjin Cao
Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
J Immunol 169:5715-25. 2002..However, IL-10-mediated inhibition of IL-12 production remains intact, indicating the existence of alternative mediators in the absence of c-Maf, consistent with the observation that a functional AP-1 is required for this pathway...
- Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2Faruk Sheikh
Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
J Immunol 172:2006-10. 2004..IL-10, IL-19, IL-20, IL-22, and IL-24 fail to signal through the combination of IL-10R2 and IL-20R1 proteins, demonstrating that this receptor combination is unique and specific for IL-26...
- IFNalpha and IFNlambda differ in their antiproliferative effects and duration of JAK/STAT signaling activityStephen G Maher
Department of Surgery, Trinity College Dublin, Dublin, Ireland
Cancer Biol Ther 7:1109-15. 2008..Thus our data demonstrate that the duration of IFNlambda signaling is different from that of IFNalpha, and that IFNlambda could be a suitable cytokine to evaluate for cancer therapy...
- General nature of the STAT3-activated anti-inflammatory responseKarim C El Kasmi
Department of Infectious Diseases, St Jude s Children s Research Hospital, Memphis, TN 38105, USA
J Immunol 177:7880-8. 2006..We conclude that the AIR is a generic cytokine signaling pathway dependent on STAT3 but not unique to the IL-10R...
- Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complexSung Il Yoon
Department of Microbiology and Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Biol Chem 281:35088-96. 2006..These studies highlight the importance of structure in regulating low affinity protein-protein interactions and IL-10 signal transduction...
- Alpha and lambda interferon together mediate suppression of CD4 T cells induced by respiratory syncytial virusBo Chi
Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA
J Virol 80:5032-40. 2006..Defining the mechanism of RSV-induced suppression may guide vaccine design and provide insight into previously uncharacterized human T-cell responses and activities of interferons...
- Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanomaAhmed Lasfar
Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey 07103, USA
Cancer Res 66:4468-77. 2006..IFN-lambda2 cells, suggesting that IFN-lambdas engage host mechanisms to inhibit melanoma growth. These in vivo experiments show the antitumor activities of IFN-lambdas and suggest their strong therapeutic potential...
- Induction of uteroglobin-related protein 2 (Ugrp2) gene expression by the Th2 cytokines IL-4 and IL-13Atsushi Yamada
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 175:5708-15. 2005..These results indicate that Ugrp2 expression is enhanced by IL-4 and IL-13 through STAT6 binding to the proximal SBE located in the Ugrp2 gene promoter...
- Human interleukin-19 and its receptor: a potential role in the induction of Th2 responsesGrant Gallagher
Department of Oral Biology, University of Medicine and Dentistry of New Jersey, Room C 636, MSB, 185 South Orange Avenue, Newark, NJ 07103, USA
Int Immunopharmacol 4:615-26. 2004..Furthermore, in whole PBMC cultures, IL-19 up-regulated IL-4 and down-regulated IFNgamma in a dose-dependent manner. These results are presented here in review format, in the context of an overall discussion of IL-19 and its receptor...
- Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1Achara Srisodsai
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:54358-68. 2004..1-dependent pathway. The results further suggest that UGRP1 might be a target for IL-10 anti-inflammatory activities in the lung...