Research Topics

Daniel R Doerge

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. Kundu P, Neese S, Bandara S, Monaikul S, Helferich W, Doerge D, et al. The effects of the botanical estrogen, isoliquiritigenin on delayed spatial alternation. Neurotoxicol Teratol. 2018;66:55-62 pubmed publisher
    ..This work suggests that ISL may not carry the cognitive risks associated with most other estrogenic compounds tested to date. ..
  2. Doerge D, Woodling K, Churchwell M, Fleck S, Helferich W. Pharmacokinetics of isoflavones from soy infant formula in neonatal and adult rhesus monkeys. Food Chem Toxicol. 2016;92:165-76 pubmed publisher
    ..These findings are consistent with immaturity of metabolic and/or physiological systems in developing non-human primates that reduces total clearance of soy isoflavones from the body. ..
  3. Fleck S, Churchwell M, Doerge D, Teeguarden J. Urine and serum biomonitoring of exposure to environmental estrogens II: Soy isoflavones and zearalenone in pregnant women. Food Chem Toxicol. 2016;95:19-27 pubmed publisher
    ..The average total urinary concentration was 0.10 ?g/L for ZEN and 0.11 ?g/L for ?-ZEL. ..
  4. Doerge D, Twaddle N, Vanlandingham M, Brown R, Fisher J. Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague-Dawley rats. Toxicol Appl Pharmacol. 2011;255:261-70 pubmed publisher
    ....
  5. Fleck S, Churchwell M, Doerge D. Metabolism and pharmacokinetics of zearalenone following oral and intravenous administration in juvenile female pigs. Food Chem Toxicol. 2017;106:193-201 pubmed publisher
    ..The apparent similarities of reductive and Phase II conjugation metabolism of ZEN between pigs and humans support the use of juvenile female pigs as a sensitive model for risk assessments of estrogenic effects from dietary ZEN. ..
  6. Twaddle N, Vanlandingham M, Churchwell M, Doerge D. Metabolism and disposition of arsenic species from controlled oral dosing with sodium arsenite in adult female CD-1 mice. I. Pilot study to determine dosing, analytical measurements, and sampling strategies. Food Chem Toxicol. 2018;111:482-493 pubmed publisher
    ....

Detail Information

Publications6

  1. Kundu P, Neese S, Bandara S, Monaikul S, Helferich W, Doerge D, et al. The effects of the botanical estrogen, isoliquiritigenin on delayed spatial alternation. Neurotoxicol Teratol. 2018;66:55-62 pubmed publisher
    ..This work suggests that ISL may not carry the cognitive risks associated with most other estrogenic compounds tested to date. ..
  2. Doerge D, Woodling K, Churchwell M, Fleck S, Helferich W. Pharmacokinetics of isoflavones from soy infant formula in neonatal and adult rhesus monkeys. Food Chem Toxicol. 2016;92:165-76 pubmed publisher
    ..These findings are consistent with immaturity of metabolic and/or physiological systems in developing non-human primates that reduces total clearance of soy isoflavones from the body. ..
  3. Fleck S, Churchwell M, Doerge D, Teeguarden J. Urine and serum biomonitoring of exposure to environmental estrogens II: Soy isoflavones and zearalenone in pregnant women. Food Chem Toxicol. 2016;95:19-27 pubmed publisher
    ..The average total urinary concentration was 0.10 ?g/L for ZEN and 0.11 ?g/L for ?-ZEL. ..
  4. Doerge D, Twaddle N, Vanlandingham M, Brown R, Fisher J. Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague-Dawley rats. Toxicol Appl Pharmacol. 2011;255:261-70 pubmed publisher
    ....
  5. Fleck S, Churchwell M, Doerge D. Metabolism and pharmacokinetics of zearalenone following oral and intravenous administration in juvenile female pigs. Food Chem Toxicol. 2017;106:193-201 pubmed publisher
    ..The apparent similarities of reductive and Phase II conjugation metabolism of ZEN between pigs and humans support the use of juvenile female pigs as a sensitive model for risk assessments of estrogenic effects from dietary ZEN. ..
  6. Twaddle N, Vanlandingham M, Churchwell M, Doerge D. Metabolism and disposition of arsenic species from controlled oral dosing with sodium arsenite in adult female CD-1 mice. I. Pilot study to determine dosing, analytical measurements, and sampling strategies. Food Chem Toxicol. 2018;111:482-493 pubmed publisher
    ....