Daniel R Doerge

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint DNA adducts derived from administration of acrylamide and glycidamide to mice and rats
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    Mutat Res 580:131-41. 2005
  2. doi request reprint Pharmacokinetics of bisphenol A in serum and adipose tissue following intravenous administration to adult female CD-1 mice
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Toxicol Lett 211:114-9. 2012
  3. doi request reprint Lactational transfer of bisphenol A in Sprague-Dawley rats
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCRT Road, Jefferson, AR 72079, USA
    Toxicol Lett 199:372-6. 2010
  4. doi request reprint Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 247:158-65. 2010
  5. doi request reprint Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 248:1-11. 2010
  6. doi request reprint Using dietary exposure and physiologically based pharmacokinetic/pharmacodynamic modeling in human risk extrapolations for acrylamide toxicity
    Daniel R Doerge
    National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    J Agric Food Chem 56:6031-8. 2008
  7. doi request reprint Bioavailability of soy isoflavones through placental/lactational transfer and soy food
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 254:145-7. 2011
  8. doi request reprint Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague-Dawley rats
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 255:261-70. 2011
  9. doi request reprint Pharmacokinetics of bisphenol A in neonatal and adult CD-1 mice: inter-species comparisons with Sprague-Dawley rats and rhesus monkeys
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Toxicol Lett 207:298-305. 2011
  10. ncbi request reprint Urinary excretion of acrylamide and metabolites in Fischer 344 rats and B6C3F(1) mice administered a single dose of acrylamide
    Daniel R Doerge
    National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Toxicol Lett 169:34-42. 2007

Detail Information

Publications93

  1. ncbi request reprint DNA adducts derived from administration of acrylamide and glycidamide to mice and rats
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    Mutat Res 580:131-41. 2005
    ..The kinetic/biomarker approaches described here may represent a meaningful way to extrapolate cancer risks to actual human exposures from food, which are much lower...
  2. doi request reprint Pharmacokinetics of bisphenol A in serum and adipose tissue following intravenous administration to adult female CD-1 mice
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Toxicol Lett 211:114-9. 2012
    ..These plasma and tissue kinetics are consistent with rapid equilibria and underscore the non-persistent nature of BPA, particularly when compared with slowly metabolized lipophilic organic pollutants like halogenated dibenzodioxins...
  3. doi request reprint Lactational transfer of bisphenol A in Sprague-Dawley rats
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCRT Road, Jefferson, AR 72079, USA
    Toxicol Lett 199:372-6. 2010
    ..Alternatively, studies that include lactational exposure and report minimal effects from BPA should consider the possibility that inadequate internal exposures were achieved during the critical postnatal period...
  4. doi request reprint Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 247:158-65. 2010
    ..These findings emphasize the importance of matching aglycone BPA internal dosimetry with receptor affinities in experimental animal studies reporting toxicity...
  5. doi request reprint Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 248:1-11. 2010
    ....
  6. doi request reprint Using dietary exposure and physiologically based pharmacokinetic/pharmacodynamic modeling in human risk extrapolations for acrylamide toxicity
    Daniel R Doerge
    National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    J Agric Food Chem 56:6031-8. 2008
    ..These results suggest that a more holistic analysis of dietary cancer risks may be appropriate, by which potential risks from AA should be considered in conjunction with other risks and benefits from foods...
  7. doi request reprint Bioavailability of soy isoflavones through placental/lactational transfer and soy food
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 254:145-7. 2011
    ..The information derived from these studies makes it possible to predict internal exposures of children to genistein from soy infant formula, which is manufactured using SPI...
  8. doi request reprint Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague-Dawley rats
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 255:261-70. 2011
    ....
  9. doi request reprint Pharmacokinetics of bisphenol A in neonatal and adult CD-1 mice: inter-species comparisons with Sprague-Dawley rats and rhesus monkeys
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Toxicol Lett 207:298-305. 2011
    ..On the other hand in all adults of all species studied, including humans, a low oral dose of BPA produced similarly small internal exposures for the unconjugated form, reflecting the dominant effect of presystemic Phase II metabolism...
  10. ncbi request reprint Urinary excretion of acrylamide and metabolites in Fischer 344 rats and B6C3F(1) mice administered a single dose of acrylamide
    Daniel R Doerge
    National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Toxicol Lett 169:34-42. 2007
    ..These results suggest that urinary measurements of AA and its metabolites may be useful for prediction of internal exposures to AA and GA...
  11. ncbi request reprint DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide
    Linda S Von Tungeln
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Int J Cancer 124:2006-15. 2009
    ..These data suggest that the mutagenic response in neonatal mice treated on PNDs 1, 8 and 15 is due to glycidamide, whereas mutations resulting from dosing on PNDs 1-8 are due to another mechanism...
  12. ncbi request reprint Relationships between biomarkers of exposure and toxicokinetics in Fischer 344 rats and B6C3F1 mice administered single doses of acrylamide and glycidamide and multiple doses of acrylamide
    Eden Tareke
    National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 217:63-75. 2006
    ..06-0.3 adducts/10(8) nucleotides. This approach may prove useful in extrapolating human cancer risks from findings in rodent bioassays...
  13. doi request reprint The genotoxicity of acrylamide and glycidamide in big blue rats
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Toxicol Sci 115:412-21. 2010
    ..Although the genotoxicity in tumor target tissue was weak, in combination with the responses in surrogate tissues, the results are consistent with AA being a gene mutagen in the rat via metabolism to GA...
  14. ncbi request reprint Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats
    Daniel R Doerge
    National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 208:199-209. 2005
    ..These findings provide additional information needed to assess genotoxic risks from the low levels of AA that are pervasive in the food supply...
  15. ncbi request reprint Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine
    Linda S Von Tungeln
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA
    Environ Mol Mutagen 48:258-69. 2007
    ..These data indicate that AZT, 3TC, and the combination of AZT and 3TC are transplacental mutagens and that the increase in mutants resulting from AZT is due mainly to large-scale genetic alterations...
  16. doi request reprint High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of pyrrolizidine alkaloid-derived DNA adducts in vitro and in vivo
    Peter P Fu
    National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Chem Res Toxicol 23:637-52. 2010
    ..When applied to liver samples from rats treated with the pyrrolizidine alkaloids riddelliine and monocrotaline, the method provided significant new information regarding the mechanism of DNA adduct formation...
  17. doi request reprint The genetic toxicology of methylphenidate hydrochloride in non-human primates
    Suzanne M Morris
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States
    Mutat Res 673:59-66. 2009
    ..3 microg/ml. No significant increases in the frequencies of MN-RETs, HPRT mutants, or chromosome aberrations were detected in the treated animals compared to the control animals over the 20-month exposure period...
  18. ncbi request reprint Toxicokinetics of acrylamide and glycidamide in B6C3F1 mice
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 202:258-67. 2005
    ..These findings are critical to the assessment of genotoxicity of AA at low doses in the food supply, which appears to depend on total exposure to GA...
  19. ncbi request reprint Riddelliine N-oxide is a phytochemical and mammalian metabolite with genotoxic activity that is comparable to the parent pyrrolizidine alkaloid riddelliine
    Ming W Chou
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol Lett 145:239-47. 2003
    ..Results presented in this paper indicate that riddelliine N-oxide, through its conversion to riddelliine, is also a potential genotoxic hepatocarcinogen...
  20. ncbi request reprint Metabolism of pigment yellow 74 by rat and human microsomal proteins
    Yanyan Cui
    Division of Biochemical Toxicology, HFT 110, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Drug Metab Dispos 33:1459-65. 2005
    ..These results demonstrate that the tattoo pigment PY74 is metabolized in vitro by P450 to metabolites that should be available for phase II metabolism and excretion...
  21. doi request reprint Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay
    Linda S Von Tungeln
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Int J Cancer 131:2008-15. 2012
    ..These results, combined with our previous data on DNA adduct formation and mutation induction, suggest that the carcinogenicity of acrylamide is dependent on its metabolism to glycidamide, a pathway that is deficient in neonatal mice...
  22. doi request reprint Pharmacokinetics, dose-range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice
    Mugimane G Manjanatha
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA
    Environ Mol Mutagen 49:585-93. 2008
    ..05). There was no significant increase in either the Hprt mutant frequency or the micronucleus frequency in the treated animals. These results indicated that although MPH induced liver hypertrophy in mice, no genotoxicity was observed...
  23. pmc Potential neurotoxicity of ketamine in the developing rat brain
    Xiaoju Zou
    Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Toxicol Sci 108:149-58. 2009
    ..Ketamine-induced cell death appears to be apoptotic in nature and closely associated with enhanced NMDA receptor subunit mRNA expression...
  24. ncbi request reprint Determination of acrylamide and glycidamide serum toxicokinetics in B6C3F1 mice using LC-ES/MS/MS
    Nathan C Twaddle
    Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Cancer Lett 207:9-17. 2004
    ....
  25. ncbi request reprint Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine
    Qingsu Xia
    Division of Biochemical Toxicology, National Center for Toxicological Research, 3, 900 NCTR Road, HFT0 110, Jefferson, AR 72079, USA
    Cancer Lett 231:138-45. 2006
    ..When incubated in the presence of calf thymus DNA, the same DHP-derived DNA adducts were formed. These results suggest that these DHP-derived DNA adducts are potential biomarkers of exposure and tumorigenicity for all types of PAs...
  26. ncbi request reprint Lactational transfer of the soy isoflavone, genistein, in Sprague-Dawley rats consuming dietary genistein
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Reprod Toxicol 21:307-12. 2006
    ....
  27. pmc Mutagenicity of acrylamide and glycidamide in the testes of big blue mice
    Rui Sheng Wang
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Toxicol Sci 117:72-80. 2010
    ..These results suggest that AA possesses mutagenic effects on testes by virtue of its metabolism to GA, possibly targeting spermatogonial stem cells, but possibly via different pathways when compared mutations in liver...
  28. doi request reprint Pharmacokinetic modeling: prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans
    Jeffrey W Fisher
    Food and Drug Administration, National Center for Toxicological Research, Division of Biochemical Toxicology, 3900 NCTR Road, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 257:122-36. 2011
    ..The use of the current non-human primate BPA model parameters provides more confidence in predicting the aglycone BPA in serum levels in humans after oral ingestion of BPA...
  29. doi request reprint In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
    Wei Ding
    Division of Genetic and Molecular Toxicology, US FDA National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 261:164-71. 2012
    ....
  30. doi request reprint Flow cytometric detection of Pig-A mutant red blood cells using an erythroid-specific antibody: application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats
    Vasily N Dobrovolsky
    Division of Genetic and Reproductive Toxicology National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    Environ Mol Mutagen 51:138-45. 2010
    ..2005]: Cancer Lett 230: 284-291) cannot be reproduced in animal models, suggesting that MPH at clinically relevant levels may be nongenotoxic in humans...
  31. ncbi request reprint Physiologically based pharmacokinetic/pharmacodynamic model for acrylamide and its metabolites in mice, rats, and humans
    John F Young
    Division of Biometry and Risk Assessment, National Center for Toxicological Research Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Chem Res Toxicol 20:388-99. 2007
    ..The steady-state human liver GA-DNA adduct level from exposure to background levels of AA in the diet was predicted to be between 0.06 and 0.26 adducts per 10(8) nucleotides...
  32. ncbi request reprint Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 mice
    Frederick A Beland
    Division of Biochemical Toxicology, HFT 110, National Center for Toxicological Research, Jefferson, AR 72079, United States
    Food Chem Toxicol 43:1-19. 2005
    ..In male mice a different relationship was observed: ethanol caused a dose-related decrease in alveolar/bronchiolar and harderian gland adenoma or carcinoma in mice administered 30 ppm urethane...
  33. ncbi request reprint High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of benzo[a]pyrene-DNA adducts
    Frederick A Beland
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Chem Res Toxicol 18:1306-15. 2005
    ..The results further suggest that dG-BPDE may contribute only a small fraction of the total DNA adducts detected by other DNA adduct methodologies in individuals exposed to PAHs...
  34. doi request reprint Quantification of deuterated bisphenol A in serum, tissues, and excreta from adult Sprague-Dawley rats using liquid chromatography with tandem mass spectrometry
    Nathan C Twaddle
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Rapid Commun Mass Spectrom 24:3011-20. 2010
    ..Such studies conducted in experimental animal models, in conjunction with properly validated human biomonitoring data, will be the basis for PBPK modeling of BPA in environmentally exposed humans...
  35. doi request reprint Carcinogenicity of acrylamide in B6C3F(1) mice and F344/N rats from a 2-year drinking water exposure
    Frederick A Beland
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States
    Food Chem Toxicol 51:149-59. 2013
    ..These results, combined with previous mechanistic studies, provide strong support for the concept that acrylamide is activated to a carcinogen through metabolism to glycidamide...
  36. ncbi request reprint Electrospray ionization-tandem mass spectrometry and 32P-postlabeling analyses of tamoxifen-DNA adducts in humans
    Frederick A Beland
    Division of Biochemical Toxicology, HFT 110, National Center for Toxicological Research, 3900 NCTR Rd, Jefferson, AR 72079, USA
    J Natl Cancer Inst 96:1099-104. 2004
    ..However, these findings have been controversial. We used electrospray ionization-tandem mass spectrometry (ES-MS/MS) and 32P-postlabeling analyses to investigate the presence of tamoxifen-DNA adducts in human endometrial tissue...
  37. doi request reprint Genotoxicity of furan in Big Blue rats
    L Patrice McDaniel
    National Center for Toxicological Research, Jefferson, AR 72079, USA
    Mutat Res 742:72-8. 2012
    ....
  38. ncbi request reprint Quantification of tamoxifen and metabolites and soy isoflavones in human plasma using liquid chromatography with electrospray ionization tandem mass spectrometry
    Lee D Williams
    US Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Rd, Jefferson, AR 72079, USA
    J AOAC Int 89:1168-73. 2006
    ..These procedures enable future investigations of the possible impact of diet on the outcome of breast cancer therapy...
  39. ncbi request reprint Inhibition of extrahepatic human cytochromes P450 1A1 and 1B1 by metabolism of isoflavones found in Trifolium pratense (red clover)
    Dean W Roberts
    Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    J Agric Food Chem 52:6623-32. 2004
    ..Biochanin A and/or formononetin may exert anticarcinogenic effects directly by acting as competitive substrates for CYP1B1 or indirectly through their metabolites daidzein and genistein, which inhibit CYP1B1...
  40. ncbi request reprint Identification of DNA adducts derived from riddelliine, a carcinogenic pyrrolizidine alkaloid
    Ming W Chou
    National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Chem Res Toxicol 16:1130-7. 2003
    ....
  41. ncbi request reprint DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice
    Gonçalo Gamboa da Costa
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Chem Res Toxicol 16:1328-37. 2003
    ..These results increase our understanding of the mutagenic potential of GA and provide further evidence for a genotoxic mechanism in AA carcinogenesis...
  42. ncbi request reprint Improving LC-MS sensitivity through increases in chromatographic performance: comparisons of UPLC-ES/MS/MS to HPLC-ES/MS/MS
    Mona I Churchwell
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 825:134-43. 2005
    ..Overall, the improvements in LC-MS method sensitivity, speed, and resolution provided by UPLC show that further advances can be made in analytical methodology to add significant value to hypothesis-driven research...
  43. doi request reprint Concurrent determination of bisphenol A pharmacokinetics in maternal and fetal rhesus monkeys
    Tucker A Patterson
    Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 267:41-8. 2013
    ..This study in a non-human primate model provides additional pharmacokinetic data for use in PBPK modeling of perinatal exposures to BPA from food contact, medical devices, and other environmental sources...
  44. ncbi request reprint Multiresidue confirmation of beta-agonists in bovine retina and liver using LC-ES/MS/MS
    Lee D Williams
    National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 813:35-45. 2004
    ..25-0.8 ppb in liver and 0.1-1 ppb in retina. This method should be useful in supporting regulatory enforcement programs that monitor beta-agonist misuse...
  45. ncbi request reprint Photodecomposition of Pigment Yellow 74, a pigment used in tattoo inks
    Yanyan Cui
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Photochem Photobiol 80:175-84. 2004
    ..The data also suggest that the use of PY74 in tattoo inks could potentially result in the formation of photolysis products, resulting in toxicity at the tattoo site after irradiation with sunlight or more intense light sources...
  46. ncbi request reprint Liquid chromatographic-mass spectrometric determination of the metabolism and disposition of the anti-retroviral nucleoside analogs zidovudine and lamivudine in C57BL/6N and B6C3F1 mice
    Lee D Williams
    Biochemical Toxicology Division, National Center for Toxicological Research, FDA, HFT 110, 3900 NCTR Road, Jefferson, AR 72079, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 798:55-62. 2003
    ..The method described provides a means to evaluate thoroughly metabolism and disposition of anti-retroviral nucleoside analogs in maternal and fetal mice for comprehensive studies of genotoxicity...
  47. ncbi request reprint Dietary modulation of p-nonylphenol-induced polycystic kidneys in male Sprague-Dawley rats
    Steven Cooper
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Toxicol Sci 91:631-42. 2006
    ..Thus, diet can significantly modulate the development of PKD induced by dietary NP in rats. Soy components, as well as other complex dietary factors, may account for the level of protection afforded by the P5001 diet...
  48. pmc Comparison of life-stage-dependent internal dosimetry for bisphenol A, ethinyl estradiol, a reference estrogen, and endogenous estradiol to test an estrogenic mode of action in Sprague Dawley rats
    Mona I Churchwell
    U S Food and Drug Administration, National Center for Toxicological Research, Division of Biochemical Toxicology, 3900 NCTR Road, Jefferson, Arkansas 72079
    Toxicol Sci 139:4-20. 2014
    ..Such evaluations of estrogenic internal dosimetry and comprehensive evaluation of contamination impact should aid in extrapolating risks from human BPA exposures. ..
  49. ncbi request reprint Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells
    Nan Mei
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, United States
    Food Chem Toxicol 46:628-36. 2008
    ....
  50. ncbi request reprint Inactivation of thyroid peroxidase by soy isoflavones, in vitro and in vivo
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 777:269-79. 2002
    ..This paper reviews the evidence in humans and animals for anti-thyroid effects of soy and its principal isoflavones, genistein and daidzein...
  51. ncbi request reprint Mass spectrometric determination of p-nonylphenol metabolism and disposition following oral administration to Sprague-Dawley rats
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Reprod Toxicol 16:45-56. 2002
    ..These data provide a basis for future correlations of biologic effects observed following dietary exposure in rats with those predicted from environmental exposures to humans...
  52. doi request reprint Prediction and evaluation of route dependent dosimetry of BPA in rats at different life stages using a physiologically based pharmacokinetic model
    XiaoXia Yang
    Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 270:45-59. 2013
    ..A comparison of the dosimetry of BPA across immature rats and monkeys suggests that dose adjustments would be necessary to extrapolate toxicity studies from neonatal rats to infant humans...
  53. doi request reprint A comparison of methylphenidate-, amphetamine-, and methamphetamine-induced hyperthermia and neurotoxicity in male Sprague-Dawley rats during the waking (lights off) cycle
    Mark S Levi
    Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079 9502, USA
    Neurotoxicol Teratol 34:253-62. 2012
    ..However, the 10-fold lower potency was in large part due to lower plasma levels produced by MPH compared to either AMPH or METH...
  54. ncbi request reprint Toxicokinetics of riddelliine, a carcinogenic pyrrolizidine alkaloid, and metabolites in rats and mice
    Lee Williams
    National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Toxicol Appl Pharmacol 182:98-104. 2002
    ..It is concluded that factors other than toxicokinetics are responsible for the observed species/sex specificity of gross toxicity or liver tumor induction in rats and mice...
  55. ncbi request reprint Pharmacokinetic analysis in serum of genistein administered subcutaneously to neonatal mice
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Cancer Lett 184:21-7. 2002
    ..These results are consistent with a diminished capacity for enzymatic conjugation of genistein, based on the ontogeny, as an important determinant of estrogenicity in neonatal mice...
  56. ncbi request reprint Comparison of the toxicity of several fumonisin derivatives in a 28-day feeding study with female B6C3F(1) mice
    Paul C Howard
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Toxicol Appl Pharmacol 185:153-65. 2002
    ..These results suggest that, of the naturally occurring fumonisins, fumonisin B(1) is the principal hepatotoxic derivative in the B6C3F(1) mouse...
  57. ncbi request reprint The mRNA expression and histological integrity in rat forebrain motor and sensory regions are minimally affected by acrylamide exposure through drinking water
    John F Bowyer
    US Food and Drug Administration, National Center for Toxicological Research, Division of Neurotoxicology, 3900 NCTR Road, Jefferson, AR 72079, USA
    Toxicol Appl Pharmacol 240:401-11. 2009
    ....
  58. ncbi request reprint Determination using liquid-chromatography-electrospray tandem mass spectroscopy of ethinylestradiol serum pharmacokinetics in adult Sprague-Dawley rats
    Nathan C Twaddle
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 793:309-15. 2003
    ..The pharmacokinetic analysis of EE2 will be useful for comparing the toxicological effects of EE2 to those of other environmental estrogens in related rodent endocrine disruptor studies...
  59. doi request reprint Pyrrolizidine alkaloid-derived DNA adducts as a common biological biomarker of pyrrolizidine alkaloid-induced tumorigenicity
    Qingsu Xia
    National Center for Toxicological Research, Jefferson, Arkansas 72079, United States
    Chem Res Toxicol 26:1384-96. 2013
    ..To date, this is the first finding that a set of exogenous DNA adducts are commonly formed from a series of tumorigenic xenobiotics. ..
  60. ncbi request reprint Quantification of O6-methyl and O6-ethyl deoxyguanosine adducts in C57BL/6N/Tk+/- mice using LC/MS/MS
    Mona I Churchwell
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 844:60-6. 2006
    ..These methods should be useful for evaluations of DNA adducts in relation to cellular processes that modify carcinogenic and toxicological responses in experimental animals and humans...
  61. ncbi request reprint High-throughput quantification of soy isoflavones in human and rodent blood using liquid chromatography with electrospray mass spectrometry and tandem mass spectrometry detection
    Nathan C Twaddle
    National Center for Toxicological Research, Jefferson, AR, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 777:139-45. 2002
    ....
  62. ncbi request reprint Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
    Mugimane G Manjanatha
    Division of Genetic and Reproductive Toxicology, US FDA National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Environ Mol Mutagen 47:6-17. 2006
    ..The results indicate that both AA and GA are genotoxic in mice. The MFs and types of mutations induced by AA and GA in the liver are consistent with AA exerting its genotoxicity in BB mice via metabolism to GA...
  63. ncbi request reprint Quantification of rat brain neurotransmitters and metabolites using liquid chromatography/electrospray tandem mass spectrometry and comparison with liquid chromatography/electrochemical detection
    Eden Tareke
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    Rapid Commun Mass Spectrom 21:3898-904. 2007
    ..This methodology may be particularly useful for applications in which simultaneous determinations are required for drugs and their affected neurotransmitters in specific brain regions...
  64. ncbi request reprint Metabolism of biochanin A and formononetin by human liver microsomes in vitro
    William H Tolleson
    Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    J Agric Food Chem 50:4783-90. 2002
    ....
  65. ncbi request reprint Ketamine-induced neuronal cell death in the perinatal rhesus monkey
    William Slikker
    Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079 0502, USA
    Toxicol Sci 98:145-58. 2007
    ..However, a shorter duration of ketamine anesthesia (3 h) did not result in neuronal cell death in the 5-day-old monkey...
  66. ncbi request reprint Autoclave sterilization produces acrylamide in rodent diets: implications for toxicity testing
    Nathan C Twaddle
    National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    J Agric Food Chem 52:4344-9. 2004
    ..e., control groups) is not known, the reduction of endogenous AA through the use of a suitable irradiated diet was deemed to be critical for ongoing studies of AA carcinogenicity and neurotoxicity...
  67. doi request reprint Preweaning behaviors, developmental landmarks, and acrylamide and glycidamide levels after pre- and postnatal acrylamide treatment in rats
    Sherry A Ferguson
    Division of Neurotoxicology, National Center for Toxicological Research FDA, United States
    Neurotoxicol Teratol 32:373-82. 2010
    ..These data extend those of our previous study (Garey et al., 2005 [14]) and demonstrate that overt preweaning neurobehavioral effects are apparent in rats exposed to acrylamide pre- and postnatally, but only at the highest doses tested...
  68. ncbi request reprint Quantification of multiple DNA adducts formed through oxidative stress using liquid chromatography and electrospray tandem mass spectrometry
    Mona I Churchwell
    National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
    Chem Res Toxicol 15:1295-301. 2002
    ..This methodology should prove useful in hypothesis-driven studies of cancer etiology in laboratory animals and humans...
  69. doi request reprint Benzocaine-induced methemoglobinemia in an acute-exposure rat model
    Linda S Von Tungeln
    Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
    Food Chem Toxicol 49:2530-5. 2011
    ..These data were used to estimate the potential impact of benzocaine residues in fish and suggest that the consumption of fish treated with benzocaine hydrochloride will not cause methemoglobinemia in humans...
  70. pmc Goitrogenic and estrogenic activity of soy isoflavones
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA
    Environ Health Perspect 110:349-53. 2002
    ..Rigorous, high-quality experimental and human research into soy toxicity is the best way to address these concerns. Similar studies in wildlife populations are also appropriate...
  71. ncbi request reprint Liquid chromatography/electrospray tandem mass spectrometric analysis of incurred ractopamine residues in livestock tissues
    Mona I Churchwell
    National Center for Toxicological Research, Jefferson, AR 72079, USA
    Rapid Commun Mass Spectrom 16:1261-5. 2002
    ..The high sensitivity and specificity for measurement and confirmation of ractopamine residues suggests this method will be applicable for regulatory residue surveillance programs...
  72. ncbi request reprint Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype
    Vasily N Dobrovolsky
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, 3900 NCTR Rd, HFT 120, Jefferson, AR 72079, USA
    Biochim Biophys Acta 1724:163-72. 2005
    ..On this basis, the most significant function of the kynurenine pathway and Afmid in mice may be in eliminating toxic metabolites and to a lesser extent in providing intermediates for other processes...
  73. ncbi request reprint DNA damage and DNA adduct formation in rat tissues following oral administration of acrylamide
    Isabelle Manière
    Agence Francaise de Securite Sanitaire des Aliments, Laboratoire d Etudes et de Recherches sur les Médicaments Vétérinaires et les Désinfectants, BP 90203, 35302 Fougeres Cedex, France
    Mutat Res 580:119-29. 2005
    ..Only weak and transient DNA damage was recorded in the liver, bone marrow and adrenals. The DNA-damaging effect of the compound observed in the blood leukocytes could be a simple biomarker of acrylamide exposure and genotoxicity...
  74. ncbi request reprint Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adducts
    Burhan I Ghanayem
    Laboratory of Pharmacology and Chemistry, National Toxicology Program, NIEHS NIH, Research Triangle Park, NC 27709, USA
    Toxicol Sci 88:311-8. 2005
    ..In conclusion, current work demonstrated that CYP2E1 is the primary enzyme responsible for the epoxidation of AA to GA, which leads to the formation of GA-DNA and HGB adducts...
  75. ncbi request reprint Cytogenetic damage induced by acrylamide and glycidamide in mammalian cells: correlation with specific glycidamide-DNA adducts
    Célia Martins
    Department of Genetics, Faculty of Medical Sciences, New University of Lisbon, 1349 008 Lisboa, Portugal
    Toxicol Sci 95:383-90. 2007
    ..These data suggest that the induction of SCEs by AA is associated with the metabolism of AA to GA and subsequent formation of depurinating DNA adducts; however, other mechanisms must be involved in the induction of CAs...
  76. ncbi request reprint Soy processing affects metabolism and disposition of dietary isoflavones in ovariectomized BALB/c mice
    Clinton D Allred
    Department of Food Science and Human Nutrition, University of Illinois, Urbana Champaign, IL 61801, USA
    J Agric Food Chem 53:8542-50. 2005
    ....
  77. ncbi request reprint Tamoxifen, soy, and lifestyle factors in Asian American women with breast cancer
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    J Clin Oncol 25:3024-30. 2007
    ....
  78. ncbi request reprint Total synthesis of (S)-equol
    Jennifer M Heemstra
    Obiter Research, LLC, 2004 South Wright Street Extended, Suite 110, Urbana, Illinois 61802, USA
    Org Lett 8:5441-3. 2006
    ..Key features of this method include its brevity, its scalability, and the low cost of starting materials. [reaction: see text]...
  79. ncbi request reprint Effect of N,N-didesmethyltamoxifen upon DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen
    Gonçalo Gamboa da Costa
    Centro de Quimica Estrutural, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Av Rovisco Pais, 1049 001 Lisboa, Portugal
    Cancer Lett 257:191-8. 2007
    ..These results indicate that, with this experimental model, N,N-didesmethyltamoxifen does not impair the metabolism of tamoxifen to a reactive electrophile...
  80. ncbi request reprint A dietary supplement for female sexual dysfunction, Avlimil, stimulates the growth of estrogen-dependent breast tumors (MCF-7) implanted in ovariectomized athymic nude mice
    Young H Ju
    Department of Food Science and Human Nutrition, University of Illinois, 905 S Goodwin, Room 580 Bevier Hall, Urbana, IL 61801, United States
    Food Chem Toxicol 46:310-20. 2008
    ....
  81. ncbi request reprint Metabolism and pharmacokinetics of the combination Zidovudine plus Lamivudine in the adult Erythrocebus patas monkey determined by liquid chromatography-tandem mass spectrometric analysis
    Rao L Divi
    Carcinogen DNA Interactions Section, LCBG, CCR, National Cancer Institute, Bldg 37 Rm 4032 NIH, 37 Convent Drive, Bethesda, MD 20892 4255, USA
    Toxicol Appl Pharmacol 226:206-11. 2008
    ..This study shows similar metabolism and pharmacokinetics for oral administration of AZT/3TC in the adult patas monkey, other primate species and humans. The data validate the use of the patas monkey for studies of NRTI toxicity...
  82. doi request reprint Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism
    Christopher R Cederroth
    Department of Genetic Medicine and Development, National Centre of Competence in Research Frontiers in Genetics, University of Geneva, 1211 Geneva 4, Switzerland
    Diabetes 57:1176-85. 2008
    ..Here, we investigate the mechanisms mediating the action of dietary phytoestrogens on lipid and glucose metabolism in rodents...
  83. ncbi request reprint Quantification of tamoxifen DNA adducts using on-line sample preparation and HPLC-electrospray ionization tandem mass spectrometry
    Gonçalo Gamboa da Costa
    Centro de Quimica Estrutural, Complexo I, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisboa, Portugal
    Chem Res Toxicol 16:357-66. 2003
    ....
  84. ncbi request reprint Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Biol Reprod 75:477-86. 2006
    ..1 for all). These findings indicate that high doses of dietary soy isoflavonoids have minimal uterotrophic or mammotrophic effects in an established primate model...
  85. ncbi request reprint Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta
    Rajeev S Muthyala
    Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, USA
    Bioorg Med Chem 12:1559-67. 2004
    ..The availability and the in vitro characterization of the equol enantiomers should enable their biological effects to be studied in detail...
  86. ncbi request reprint Characterization of N-glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human liver: importance of UDP-glucuronosyltransferase 1A4
    Doris Wiener
    Cancer Epidemiology and Prevention Program, H Lee Moffitt Cancer Center, Department of Interdisciplinary Oncology, University of South Florida, Tampa, USA
    Drug Metab Dispos 32:72-9. 2004
    ..These results demonstrate the importance of N-glucuronidation in the metabolism of NNAL and the role of UGT1A4 in this pathway...
  87. ncbi request reprint Dietary genistein results in larger MNU-induced, estrogen-dependent mammary tumors following ovariectomy of Sprague-Dawley rats
    Clinton D Allred
    Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
    Carcinogenesis 25:211-8. 2004
    ..The data suggest that in an endogenous estrogen environment similar to that of a postmenopausal woman, dietary genistein can stimulate the growth of a mammary carcinogen MNU-induced estrogen-dependent mammary tumors...
  88. ncbi request reprint Formation of tamoxifen-DNA adducts in multiple organs of adult female cynomolgus monkeys dosed with tamoxifen for 30 days
    Laura J Schild
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4255, USA
    Cancer Res 63:5999-6003. 2003
    ..2-0.4 adducts/10(8) nucleotides). This study indicates that cynomolgus monkeys are capable of metabolizing TAM to genotoxic intermediates that form TAM-DNA adducts in multiple tissues...
  89. ncbi request reprint Soy processing influences growth of estrogen-dependent breast cancer tumors
    Clinton D Allred
    Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
    Carcinogenesis 25:1649-57. 2004
    ..Collectively, these findings suggest that for postmenopausal women with estrogen-dependent breast cancer, the consumption of foods containing soy flour is more advisable than consuming isoflavones in more purified forms...
  90. ncbi request reprint The soy isoflavone genistein decreases adipose deposition in mice
    Afia Naaz
    Department of Veterinary Biosciences, University of Illinois, Urbana, Illinois 61802, USA
    Endocrinology 144:3315-20. 2003
    ..79 +/- 0.32 microM, 2.55 +/- 0.18 microM, and 3.81 +/- 0.39 microM, respectively. These results indicate dietary genistein at 500-1500 ppm produces antilipogenic effects in mice at serum levels that humans are realistically exposed to...
  91. ncbi request reprint Estrogenicity of the isoflavone metabolite equol on reproductive and non-reproductive organs in mice
    Vimal Selvaraj
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    Biol Reprod 71:966-72. 2004
    ....
  92. pmc Regulation of gene expression and inhibition of experimental prostate cancer bone metastasis by dietary genistein
    Yiwei Li
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neoplasia 6:354-63. 2004
    ..Genistein may thus be a promising agent for the prevention and/or treatment of prostate cancer...
  93. ncbi request reprint Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice
    Young H Ju
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Cancer Res 62:2474-7. 2002
    ..g., pS2, PR, and cyclin D1). Therefore, caution is warranted for postmenopausal women consuming dietary genistein while on TAM therapy for E-responsive breast cancer...